AutismKB 2.0

Annotation Detail for QPRT


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:QPRT ( QPRTase )
Gene Full Name: quinolinate phosphoribosyltransferase
Band: 16p11.2
Quick LinksEntrez ID:23475; OMIM: 606248; Uniprot ID:NADC_HUMAN; ENSEMBL ID: ENSG00000103485; HGNC ID: 9755
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
NADSYN-PWYNAD biosynthesis II (from tryptophan)
PWY-5653NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde
PYRIDNUCSYN-PWYNAD biosynthesis I (from aspartate)
Pathway IDPathway Name
hsa00760Nicotinate and nicotinamide metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of vitamins and cofactors
No data
No data
Pathway IDPathway Name
500913Nicotinate metabolism
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of QPRT mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of QPRT proteinaffects expression 20106945
C068073 Am 580 Am 580 results in decreased expression of QPRT mRNAdecreases expression 16982809
D001151 Arsenic QPRT mRNA results in decreased susceptibility to Arsenicdecreases response to substance 17976673
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of QPRT mRNAaffects cotreatment|decreases expression 18164116
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of QPRT mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in decreased expression of QPRT mRNAdecreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of QPRT mRNAaffects cotreatment|decreases expression 18164116
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of QPRT mRNAaffects cotreatment|affects expression 17602206
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of QPRT mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of QPRT mRNAdecreases expression 16807375
C089730 rosiglitazone rosiglitazone results in decreased expression of QPRT mRNAdecreases expression 16982809
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000236 Adenoma beta-Naphthoflavone 7.1919389873
MESH:D000236 Adenoma Diethylnitrosamine 7.196695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.9019061943 18056438 16434500 19052882 17162532 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.9016434500
MESH:D018246 Adrenocortical Adenoma Arsenic 5.4817306315
MESH:D000544 Alzheimer Disease rosiglitazone 2.8819621015
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D020261 Arsenic Poisoning Arsenic 2.9112569548 18414634 16835338 16251483
MESH:D050197 Atherosclerosis Arsenic 3.3419371607 12928151
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3219483382
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2117474063
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6817687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.783084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.7812907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Arsenic 6.7817306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.7820432363 18506893 18494052 19052882 16569478 19394651 21159647 3084413 18971187 20524982 19418558 17173139 3581430 17428255 19208518 18788625 20512989 17138121 20214788 16878318 16935385 16288022 19822196 17055752 16698587 17978847 16830150 18393292 20007298 19519916 19107877 18785209 19383236 20084675 20514400 19539802 20727157 19701751 16540662 11831363 18978308 17761372 20101231 10672840 19335982 18210153 17162532 20935162 18665156 19919837 16681979 19171122 16328049 16807293 18691550 18056438 16502159 16779866 10737359
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7317687452 18922899 15504454
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.2418640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.5615738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.4618022660 16973168
MESH:D002386 Cataract Acetaminophen 8.0010977129
MESH:D002386 Cataract Am 580 8.0017460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.9912371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.9917174075 2727394 7505956 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8419052882
MESH:D002779 Cholestasis Cyclosporine 8.1819486331
MESH:D002779 Cholestasis pirinixic acid 8.1819176532
MESH:D003092 Colitis Am 580 5.1717035595
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003920 Diabetes Mellitus rosiglitazone 4.4517446233
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.8120387270
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 4.8112642470
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8914550746 10774834 12705907 19420014 19085960 19923254 11529661 12392966 12153990 16393943 10915739 17522070 16227642 2444490 16109766 17562736 16081117 11743745 19416960 11739529 11461765 16485898 16177239 19164858 10663392 12594235 19739265 15619225 12958197 18713872 17906064 19370779 14725611 15968718 16781746 11421492 11287661 18071297 12540782 14986274 11834606
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.8919107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004487 Edema pirinixic acid 7.5812083418
MESH:D004487 Edema rosiglitazone 7.5812083418
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3816302075
MESH:D005234 Fatty Liver Cyclosporine 20.2819224547
MESH:D005234 Fatty Liver Diethylnitrosamine 20.2821071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 20.2819236843 20131406
MESH:D005234 Fatty Liver rosiglitazone 20.2819196556
MESH:D005355 Fibrosis Cyclosporine 3.3612639820 12168785
MESH:D005534 Foot Diseases Arsenic 5.826392382
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006529 Hepatomegaly pirinixic acid 3.2118467677 19772884 19176532 16221962
MESH:D006930 Hyperalgesia Acetaminophen 8.3516870215
MESH:D006930 Hyperalgesia rosiglitazone 8.3512083418
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.6217050553
MESH:D006973 Hypertension Arsenic 5.499931084 11953799 16076760
MESH:D006973 Hypertension Cyclosporine 5.4910903974
MESH:D006987 Hypesthesia Arsenic 5.8216093927
MESH:D007249 Inflammation Diethylnitrosamine 5.6418785209
MESH:D007249 Inflammation rosiglitazone 5.6412083418
MESH:D007333 Insulin Resistance pirinixic acid 7.8616306350
MESH:D007333 Insulin Resistance rosiglitazone 7.8616306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007642 Keratosis Arsenic 5.2312749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 6.1015629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.1018776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8812371664
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.6617339181
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9120032147 18665156 18522880 19638242 18407596
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.6515474484
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 2.6515980055 17347453
MESH:D008107 Liver Diseases Acetaminophen 6.7712969438 16610002 19784758 16611625 19014921 11587558 19460945 12587719
MESH:D008107 Liver Diseases Arsenic 6.7711134558
MESH:D008107 Liver Diseases Diethylnitrosamine 6.7717034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4017185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 18.789163691 18177683 2125692 15890375
MESH:D008113 Liver Neoplasms Arsenic 18.7816368122
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 18.7819389873 21295105
MESH:D008113 Liver Neoplasms Clofibric Acid 18.7817602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 18.7819256749 19642983 12112319 2862719 21278145 19254457 19812893 19090486 20452335 2422723 18644402 20583210 9163691 19551842 19690152 21167192 18754104 18648771 20405173 15175105 20492335 21071580 10737359 19255062 19638242 20434301 19499222 16942905 12771043 19850985 20137499 20118626 19426721 20101389 18978307 20501860 19427195 19294768 19996281 18977376 19833225 15885732 19073162 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 18.7820007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.558603461
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 10.5518164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.553124819 18775883 18282651 19009564 2563599 19539802 19126423 16267830 17854601 18544905 17174075 18079962 21159647 18164116 19519916 18253720 9362446 17942915 18308698 16842330 19004024 18093689
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.6114755239
MESH:D008175 Lung Neoplasms Arsenic 3.6117976673 17306315 19168569
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.6121163286 20970405 6695378 20512841
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 3.4916827153
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.5217261469
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D017202 Myocardial Ischemia Arsenic 4.1215371236
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.623581430 9029167
MESH:D009369 Neoplasms pirinixic acid 2.0217405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4418481113 19348381
MESH:D009436 Neural Tube Defects Arsenic 3.5616620997
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.6718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.6720387270
MESH:D020078 Neurogenic Inflammation Arsenic 4.5617056641
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3820387270
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010051 Ovarian Neoplasms Arsenic 2.7917306315
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4716540662
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.3816093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.2316905509 6392382 15371236
MESH:D011230 Precancerous Conditions Cyclosporine 9.4612371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.462563599
MESH:D011471 Prostatic Neoplasms Arsenic 3.5816140617
MESH:D011507 Proteinuria Arsenic 4.1921343184
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012871 Skin Diseases Arsenic 2.7817548696 18709164 17453740 19834688 17938729 6392382 16353154 17050553 15952646 16759981 16702368
MESH:D012878 Skin Neoplasms Arsenic 3.0817976673 16251483 17050553 15504454 19538983 17029826
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.117505956
MESH:D001749 Urinary Bladder Neoplasms Arsenic 2.8717306315 15987713 11144890 17976673 19429237 19322015 18640142
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D014652 Vascular Diseases Arsenic 4.9717056641
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
REACT:11193 Metabolism of vitamins and cofactors
KEGG:00760 Nicotinate and nicotinamide metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34096
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA448055l-alanine
    PA10090l-glutamine
    PA10323l-tryptophan
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00627 binder Vitamin C with Niacin and Niacinamide-Liq Vitamins (Vitamin B Complex);Vasodilator Agents;Antilipemic Agents;Vitamin B Complex
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved