AutismKB 2.0

Annotation Detail for BRD4


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Basic Information Top
Gene Symbol:BRD4 ( CAP,HUNK1,HUNKI,MCAP )
Gene Full Name: bromodomain containing 4
Band: 19p13.12
Quick LinksEntrez ID:23476; OMIM: 608749; Uniprot ID:BRD4_HUMAN; ENSEMBL ID: ENSG00000141867; HGNC ID: 13575
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of BRD4 mRNAincreases expression 18648102
D001241 Aspirin Aspirin results in increased expression of BRD4 mRNAincreases expression 11906190
C406082 monomethylarsonous acid monomethylarsonous acid results in increased expression of BRD4 mRNAincreases expression 20024957
C006253 pirinixic acid pirinixic acid results in increased expression of BRD4 mRNAincreases expression 18445702
D013467 Sulindac Sulindac results in decreased expression of BRD4 mRNAdecreases expression 11906190
C025643 vinclozolin vinclozolin affects the expression of BRD4 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 6.0214745880
MESH:D058186 Acute Kidney Injury Sulindac 4.647897758
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D000230 Adenocarcinoma Sulindac 3.1711910360
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.563712494
MESH:D000236 Adenoma Sulindac 7.5610223192
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.9019003578 12394442 11535846 16460482 11874996 17611924 15623613
MESH:D001008 Anxiety Disorders vinclozolin 3.8919015723
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.9712372130 20485159
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.5411289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D001913 Bowen's Disease Sulindac 5.8711207687
MESH:D001932 Brain Neoplasms Aspirin 4.7215481559
MESH:D001943 Breast Neoplasms Aspirin 2.8415161893
MESH:D001943 Breast Neoplasms Sulindac 2.8416642371
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.777296757 3581430
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.807296757
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.787505956
MESH:D002471 Cell Transformation, Neoplastic monomethylarsonous acid 7.7819716837
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.629022650 19486331
MESH:D002779 Cholestasis pirinixic acid 8.6219176532
MESH:D003110 Colonic Neoplasms Aspirin 4.5212411196
MESH:D003110 Colonic Neoplasms Sulindac 4.5212902858 12458338
MESH:D015179 Colorectal Neoplasms Aspirin 3.1817047198
MESH:D015179 Colorectal Neoplasms Sulindac 3.1810666051 11076880 18059344 11197048
MESH:D003456 Cryptorchidism vinclozolin 4.7214966744
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.218156756 18759878 12868966 2524372 11906362 8970840 11298694 14531868
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.843621924 2952479
MESH:D003930 Diabetic Retinopathy Sulindac 5.5617621415 12861449
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.036679447 9653073 9328219 16192314 18692083 18289764 7440962 11289319 6482804 18648102 8291058 9022650 1440618
MESH:D004487 Edema Aspirin 8.1917259670
MESH:D004487 Edema pirinixic acid 8.1912083418
MESH:D004715 Endometriosis Sulindac 4.7815652904
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.993581430
MESH:D004938 Esophageal Neoplasms Sulindac 4.9912235107
MESH:D005234 Fatty Liver pirinixic acid 3.0919236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.546705139
MESH:D018221 Fibromatosis, Abdominal Sulindac 5.9414745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 5.5919069698
MESH:D005764 Gastroesophageal Reflux Sulindac 5.3911910360
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.4016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.8216417039
MESH:D005909 Glioblastoma Aspirin 4.1412870263
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.397505956
MESH:D006261 Headache Aspirin 5.4815240983
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.896705139
MESH:D006529 Hepatomegaly pirinixic acid 3.4116221962 19772884 19176532 18467677
MESH:D012001 Hyperacusis Aspirin 6.2815240983
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3615034207
MESH:D007248 Infertility, Male vinclozolin 3.2416467254
MESH:D007249 Inflammation Sulindac 3.443291741
MESH:D007333 Insulin Resistance pirinixic acid 2.8216306350
MESH:D007414 Intestinal Neoplasms Sulindac 4.9410213222 10223192 12628509 12351151 12584176 12663524
MESH:D007417 Intestinal Polyps Sulindac 5.3411245490 12394442
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.548074119 9022650
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.236582329
MESH:D007984 Leydig Cell Tumor vinclozolin 5.1916417039
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 9.1115034207 9327722
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 9.1112468960
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Sulindac 3.0914986274 16867024
MESH:D008113 Liver Neoplasms pirinixic acid 1.9115890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.713712494 598648 1399818 6587162
MESH:D008175 Lung Neoplasms Sulindac 2.6919359593 15713900
MESH:D008545 Melanoma Sulindac 2.8616642371
MESH:D008881 Migraine Disorders Aspirin 4.2815240983
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction Aspirin 6.3012692751
MESH:D009203 Myocardial Infarction pirinixic acid 6.3019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009325 Nausea Aspirin 5.7315240983
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.573581430
MESH:D009369 Neoplasms pirinixic acid 2.0817405874
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.106679447
MESH:D019636 Neurodegenerative Diseases Sulindac 4.5416850258 17266991
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.724026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.543988306
MESH:D010003 Osteoarthritis Aspirin 4.237009135
MESH:D010146 Pain Aspirin 8.356995502 6363464
MESH:D010146 Pain Sulindac 8.353291741
MESH:D010190 Pancreatic Neoplasms Sulindac 3.4411504793 16820089
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.907296757
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 6.0011156591
MESH:D020795 Photophobia Aspirin 6.2815240983
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.996228378
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.3618042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.4018220299
MESH:D011472 Prostatitis vinclozolin 5.4018629315
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.613692021
MESH:D012220 Rhinitis Aspirin 4.6812372130
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 5.6812269725
MESH:D012871 Skin Diseases monomethylarsonous acid 3.4417431481
MESH:D020521 Stroke Aspirin 4.6316403987
MESH:D013927 Thrombosis Aspirin 4.8017672075
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.121399818 6582329 3712494 7505956 6587162
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.788074119
MESH:D001749 Urinary Bladder Neoplasms monomethylarsonous acid 5.7820375083
MESH:D014581 Urticaria Aspirin 4.7920485159 10982225
MESH:D014594 Uterine Neoplasms Sulindac 4.9818645019
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
KEGG:00030 Pentose phosphate pathway
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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