AutismKB 2.0

Annotation Detail for HEY2


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Basic Information Top
Gene Symbol:HEY2 ( CHF1,GRIDLOCK,GRL,HERP1,HESR2,HRT2,MGC10720,bHLHb32 )
Gene Full Name: hairy/enhancer-of-split related with YRPW motif 2
Band: 6q22.31
Quick LinksEntrez ID:23493; OMIM: 604674; Uniprot ID:HEY2_HUMAN; ENSEMBL ID: ENSG00000135547; HGNC ID: 4881
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200196Notch-mediated HES/HEY network
Pathway IDPathway Name
P00045Notch signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HEY2 mRNAaffects expression 16483693
C006680 baicalein baicalein results in increased expression of HEY2 mRNAincreases expression 19160421
C006680 baicalein N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HEY2 mRNA]decreases reaction|increases expression 19160421
C038044 baicalin baicalin results in increased expression of HEY2 mRNAincreases expression 19160421
C038044 baicalin N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HEY2 mRNA]decreases reaction|increases expression 19160421
D009151 Mustard Gas Mustard Gas results in increased expression of HEY2 mRNAincreases expression 15674844
D009534 Niclosamide Niclosamide results in increased expression of HEY2 mRNAincreases expression 19160421
D009534 Niclosamide N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Niclosamide results in increased expression of HEY2 mRNA]decreases reaction|increases expression 19160421
C419410 N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HEY2 mRNA]decreases reaction|increases expression 19160421
C419410 N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HEY2 mRNA]decreases reaction|increases expression 19160421
C419410 N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Niclosamide results in increased expression of HEY2 mRNA]decreases reaction|increases expression 19160421
D010656 Phenylephrine HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]decreases reaction|increases expression 16603706
D010656 Phenylephrine HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]decreases reaction|increases expression 16603706
D010656 Phenylephrine HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]decreases reaction|increases expression 16603706
D010656 Phenylephrine HEY2 protein results in decreased susceptibility to Phenylephrinedecreases response to substance 16603706
D010656 Phenylephrine Phenylephrine results in decreased expression of HEY2 mRNAdecreases expression 16603706
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of HEY2 mRNAdecreases expression 16714409
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1814514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.3417460149
MESH:D001249 Asthma Mustard Gas 2.7710378619
MESH:D001768 Blister Mustard Gas 5.5019167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001919 Bradycardia Phenylephrine 4.8815306635
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6820435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.5015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.3517687719 10378619
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006332 Cardiomegaly Phenylephrine 7.2817287366 15728586 16170337 17124262 11754973 11179087
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.2818850075 18670907 16120746
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D016770 Ciliophora Infections Niclosamide 6.1112113305
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1916354765 8697196 12621046 15340226 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2714669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004487 Edema Mustard Gas 7.6511402378 9260866 11428631 11428647
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.6512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2815322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2510568697 9294722
MESH:D004890 Erythema Mustard Gas 5.509357497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005355 Fibrosis baicalein 17.1719474275
MESH:D005355 Fibrosis baicalin 17.1719474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 17.1720067830
MESH:D005393 Fish Diseases Niclosamide 6.0712113305
MESH:D005909 Glioblastoma baicalein 4.9919804834
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4410048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2015340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.428697196 16959395 15340226 16354765 18606429
MESH:D006973 Hypertension Phenylephrine 5.5612717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.5618850075 18670907
MESH:D006984 Hypertrophy Phenylephrine 4.8018502941 12791704
MESH:D007249 Inflammation Mustard Gas 5.4211402378 9260866 9357497 11428620 11428631 17524151 11428647 16001271 8975870
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4212878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D008106 Liver Cirrhosis, Experimental baicalin 3.1218187930
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.1212878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.7916984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2412151625
MESH:D008171 Lung Diseases Mustard Gas 3.6018702808 18161513
MESH:D008175 Lung Neoplasms Mustard Gas 2.463148597 8781369
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4611884234 19555203
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009503 Neutropenia Mustard Gas 4.2316761898 7688884
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D011041 Poisoning Mustard Gas 4.0615727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311896295 11222880 11399792 11118676
MESH:D011471 Prostatic Neoplasms baicalin 5.2215714805
MESH:D011537 Pruritus Mustard Gas 4.4318058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 3.0010334151 17894541 17720292 17620002 17266442
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012852 Sinusitis Phenylephrine 5.047327846
MESH:D012871 Skin Diseases Mustard Gas 2.7612880345 15451306 16961503
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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