AutismKB 2.0

Annotation Detail for LRRC8B


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Basic Information Top
Gene Symbol:LRRC8B ( KIAA0231,MGC42220,TA-LRRP,TALRRP )
Gene Full Name: leucine rich repeat containing 8 family, member B
Band: 1p22.2
Quick LinksEntrez ID:23507; OMIM: 612888; Uniprot ID:LRC8B_HUMAN; ENSEMBL ID: ENSG00000197147; HGNC ID: 30692
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Desease IDDesease Name
H00085Agammaglobulinemias
Immune system diseases
Primary immunodeficiency
No data
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of LRRC8B mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in decreased expression of LRRC8B mRNAdecreases expression 20458559
C004648 testosterone enanthate testosterone enanthate affects the expression of LRRC8B mRNAaffects expression 17440010
C025643 vinclozolin vinclozolin affects the expression of LRRC8B mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3611798837 19825857
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D001008 Anxiety Disorders vinclozolin 3.9719015723
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 4.1016206674
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.7911589617
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.033084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.0315553829 15073043 11135700 14691202 16217749
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.6019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.5112490120
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.6912609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D003456 Cryptorchidism vinclozolin 4.8514966744
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.5615213294
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6711834606 18713872 12153990 12594235 16227642 14550746 19416960 16393943 18071297 19164858 11461765 19420014 10915739 11529661 17906064 2444490 14986274 16177239 12705907 19923254 19739265 19085960 15968718 19370779 12540782 17562736 17522070 15619225 14725611 16109766 11421492 16081117 16781746 10774834 11287661 10663392 12958197 12392966 11739529 11743745 16485898
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3812903497
MESH:D005234 Fatty Liver arsenic trioxide 3.7115073043
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.7716904648
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.5716973722
MESH:D005832 Genital Diseases, Male vinclozolin 6.0216417039
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.4717440010
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D007248 Infertility, Male vinclozolin 3.2916467254
MESH:D007674 Kidney Diseases Acetaminophen 2.4012587719 15629191
MESH:D007938 Leukemia arsenic trioxide 3.0015070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.2217077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.9416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.7214633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.1919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1916467208 20471514 19850784 17050201 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4616823087 12679006 19035177 12018890 19642359 16331271 15213294 16330433 19225113 9834237 16891316 15622746 17712046 15748426 12712474 15336539 16966277 17869043 17107899 17217047 19075265 11161223 17649720 16112521 11468182
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.8616882451
MESH:D007984 Leydig Cell Tumor vinclozolin 5.3616417039
MESH:D008107 Liver Diseases Acetaminophen 1.7019784758 12587719 12969438 11587558 19460945 16610002 19014921 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6316871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 2.4614682389
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.9620377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.6615213294
MESH:D008175 Lung Neoplasms arsenic trioxide 1.8719825857 11798837
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3819417148 15949261 19549372 14977855 11468182
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.4018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3416105982 16882451
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.4716624393
MESH:D009436 Neural Tube Defects arsenic trioxide 3.3610525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.5019769630 12452020 16624393
MESH:D010146 Pain Acetaminophen 2.7316870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6315580305
MESH:D010235 Paraganglioma arsenic trioxide 4.6319927285
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.5319015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.5718220299
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2119131511
MESH:D011472 Prostatitis vinclozolin 5.5718629315
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.4716646077
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.3919014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.5915213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.6011780464 20435036 12845720 12973940
MESH:D014581 Urticaria Acetaminophen 3.4410982225
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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