AutismKB 2.0

Annotation Detail for SUZ12


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Basic Information Top
Gene Symbol:SUZ12 ( CHET9,JJAZ1,KIAA0160 )
Gene Full Name: suppressor of zeste 12 homolog (Drosophila)
Band: 17q11.2
Quick LinksEntrez ID:23512; OMIM: 606245; Uniprot ID:SUZ12_HUMAN; ENSEMBL ID: ENSG00000178691; HGNC ID: 17101
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
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Desease Name
Endometrial stromal tumors
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of SUZ12 mRNAdecreases expression 20406850
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SUZ12 mRNAdecreases expression 19150397
C006780 bisphenol A bisphenol A affects the expression of SUZ12 mRNAaffects expression 20170705
D003474 Curcumin Curcumin results in decreased expression of SUZ12 mRNAdecreases expression 18421014
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SUZ12 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SUZ12 mRNAaffects cotreatment|increases expression 17942748
C011890 kojic acid kojic acid results in decreased expression of SUZ12 mRNAdecreases expression 16595896
C030589 methylmercury cysteine methylmercury cysteine results in decreased expression of SUZ12 mRNAdecreases expression 19465457
C006253 pirinixic acid pirinixic acid results in increased expression of SUZ12 mRNAincreases expression 17426115
D012643 Selenium Selenium results in decreased expression of SUZ12 mRNAdecreases expression 19244175
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SUZ12 mRNAaffects cotreatment|increases expression 17942748
D014810 Vitamin E Vitamin E results in decreased expression of SUZ12 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0411752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8414692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.5616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.5616835633
MESH:D019973 Alcohol-Related Disorders Curcumin 5.3017887948
MESH:D000544 Alzheimer Disease Curcumin 2.6415590663
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7616807698
MESH:D050197 Atherosclerosis Curcumin 3.4018704882
MESH:D001327 Autoimmune Diseases Curcumin 4.6719761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.2419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.2412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001862 Bone Resorption bisphenol A 4.0011985600
MESH:D002545 Brain Ischemia Curcumin 4.5216770732
MESH:D001932 Brain Neoplasms Curcumin 4.0717596214
MESH:D001943 Breast Neoplasms bisphenol A 1.9317123778
MESH:D001943 Breast Neoplasms Curcumin 1.9319250217 18593918 16243823 18462866
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9320435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1116050911
MESH:D002277 Carcinoma Curcumin 8.6618593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.6616835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 1.7716705839
MESH:D002278 Carcinoma in Situ bisphenol A 5.1817123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0218414057
MESH:D002294 Carcinoma, Squamous Cell Curcumin 2.7918462866
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.966135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.9620889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0917681005 17333356 16919318 11677210 16105132 15861022 17110522
MESH:D002779 Cholestasis pirinixic acid 8.0919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.158697196 12621046 16354765 15340226 15668235
MESH:D003092 Colitis Curcumin 10.2616804969 18200517 16782535
MESH:D003092 Colitis Selenium 10.2617936198
MESH:D003103 Coloboma Curcumin 4.6918809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5219359593 16340194
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 5.0718497527
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5210048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5219769572
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1918551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.5118403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.5117107852
MESH:D003928 Diabetic Nephropathies Curcumin 4.1318204486
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.4118551238 21346803
MESH:D056486 Drug-Induced Liver Injury Selenium 6.4115131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004381 Duodenal Ulcer Curcumin 4.2117351913
MESH:C538011 Eales disease Vitamin E 4.929068938
MESH:D004487 Edema pirinixic acid 7.0012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.0011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1218230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3512538720
MESH:D016889 Endometrial Neoplasms marker/mechanism 18264096
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1510568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1020426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Curcumin 13.9519297423
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.9515345470
MESH:D005234 Fatty Liver pirinixic acid 13.9519236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Curcumin 9.3818705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.3820067830
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.8718462866
MESH:D005909 Glioblastoma Curcumin 3.5617596214
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006258 Head and Neck Neoplasms Curcumin 3.7518829502 18462866
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8011294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 6.8016080930
MESH:D006333 Heart Failure pirinixic acid 7.2220558911
MESH:D006333 Heart Failure Selenium 7.2217162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly pirinixic acid 8.8519176532 19772884 16221962 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.8515340226 16120746 12621046
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.2217701891
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7416863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.1914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2618606429 15340226 16354765 8697196 16959395
MESH:D006937 Hypercholesterolemia Curcumin 4.1918704882
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5717937319
MESH:D007249 Inflammation Curcumin 5.3116956363 18403477 17151092
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3112200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.2618596194 18200517
MESH:D007251 Influenza, Human Selenium 11.7016624496
MESH:D007251 Influenza, Human Vitamin E 11.7016624496
MESH:D007333 Insulin Resistance bisphenol A 7.6116393666
MESH:D007333 Insulin Resistance pirinixic acid 7.6116306350
MESH:D007414 Intestinal Neoplasms Curcumin 4.3510783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007674 Kidney Diseases Vitamin E 2.8812488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0216518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.0916705839
MESH:D007889 Leiomyoma Curcumin 4.7218555241
MESH:D007938 Leukemia Curcumin 3.3018462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.3416106398
MESH:D015458 Leukemia, T-Cell Curcumin 4.9216106398
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 5.0718006644 18705752 17355460
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.0715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0712878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 5.0716169303
MESH:D008107 Liver Diseases Curcumin 2.6416956363
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.607678174
MESH:D008113 Liver Neoplasms pirinixic acid 7.6016377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.6016984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.376135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental kojic acid 10.3718544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.3712151625
MESH:D008171 Lung Diseases Vitamin E 3.2716863852
MESH:D008175 Lung Neoplasms Curcumin 3.5419359593 18462866 16243823
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5411884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 3.5411062179
MESH:D008223 Lymphoma Curcumin 3.6818462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.8716173963
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8515318939
MESH:D008545 Melanoma Curcumin 2.4317885582 18462866
MESH:D008569 Memory Disorders Curcumin 4.3117263510
MESH:D008654 Mesothelioma Selenium 2.8415107826
MESH:D009101 Multiple Myeloma Curcumin 3.6119372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.1117962980
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.0518551238 7678174
MESH:D009361 Neoplasm Invasiveness Curcumin 4.5318495463
MESH:D009369 Neoplasms pirinixic acid 2.0117405874
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.7512497104
MESH:D009421 Nervous System Malformations bisphenol A 10.1311399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.1314600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.8518462866
MESH:D009765 Obesity Curcumin 4.7119297423
MESH:D009765 Obesity pirinixic acid 4.7120558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5616049721
MESH:D010024 Osteoporosis Curcumin 3.5518719352
MESH:D010049 Ovarian Diseases bisphenol A 5.1811985600
MESH:D010051 Ovarian Neoplasms Curcumin 2.8519020741 18462866
MESH:D010190 Pancreatic Neoplasms Curcumin 2.9819196508 17440100 19401701
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D010954 Plasmacytoma Selenium 5.1115087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 10.1610548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.1611222880 11118676 11896295 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.3520887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.6416740699
MESH:D011471 Prostatic Neoplasms Curcumin 2.6411398177 18226269 18769126 15129424 10851300 12497104 18156803
MESH:D011471 Prostatic Neoplasms Vitamin E 2.6415084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.5116919318 15861022
MESH:D011629 Puberty, Precocious bisphenol A 4.9810548101
MESH:D011656 Pulmonary Emphysema Curcumin 4.6619168576
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.1718379247 10666014
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012509 Sarcoma Curcumin 4.2518462866
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6218551238
MESH:D018805 Sepsis Curcumin 4.1918389075
MESH:D012871 Skin Diseases Vitamin E 2.4718709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1616709447
MESH:D013276 Stomach Ulcer Curcumin 3.6316631530 19188055
MESH:D020521 Stroke Vitamin E 3.6316517955
MESH:D019966 Substance-Related Disorders bisphenol A 4.1816045194 16684133
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.4016049721
MESH:D001749 Urinary Bladder Neoplasms Curcumin 5.4018593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.4618462866
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5110091137
MESH:D014591 Uterine Diseases bisphenol A 5.2314652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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