AutismKB 2.0

Annotation Detail for SLC39A14


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Basic Information Top
Gene Symbol:SLC39A14 ( KIAA0062,LZT-Hs4,NET34,ZIP14,cig19 )
Gene Full Name: solute carrier family 39 (zinc transporter), member 14
Band: 8p21.3
Quick LinksEntrez ID:23516; OMIM: 608736; Uniprot ID:S39AE_HUMAN; ENSEMBL ID: ENSG00000104635; HGNC ID: 20858
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Transmembrane transport of small molecules
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SLC39A14 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of SLC39A14 mRNAincreases expression 18648102
C002850 4,7-diphenylphenanthroline sulfonate 4,7-diphenylphenanthroline sulfonate inhibits the reaction [SLC39A14 protein results in increased uptake of Iron]decreases reaction|increases uptake 16950869
D000082 Acetaminophen Acetaminophen affects the expression of SLC39A14 mRNAaffects expression 17562736
D000111 Acetylcysteine Acetylcysteine results in increased expression of SLC39A14 mRNAincreases expression 16084531
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of SLC39A14 mRNAincreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SLC39A14 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of SLC39A14 mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of SLC39A14 mRNAdecreases expression 18042831
C045651 epigallocatechin gallate epigallocatechin gallate results in increased expression of SLC39A14 mRNAincreases expression 16084531
D007501 Iron 4,7-diphenylphenanthroline sulfonate inhibits the reaction [SLC39A14 protein results in increased uptake of Iron]decreases reaction|increases uptake 16950869
D007501 Iron SLC39A14 protein results in increased uptake of Ironincreases uptake 16950869
D008070 Lipopolysaccharides Lipopolysaccharides promotes the reaction [IL6 protein results in increased expression of SLC39A14 mRNA]increases expression|increases reaction 17126599
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of and affects the localization of SLC39A14 proteinaffects localization|increases expression 15863613
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of SLC39A14 mRNAincreases expression 15863613
D008345 Manganese Manganese results in increased expression of SLC39A14 mRNAincreases expression 17065364
C025340 manganese chloride manganese chloride results in increased expression of SLC39A14 mRNAincreases expression 17065364
C041786 palm oil palm oil results in decreased expression of SLC39A14 mRNAdecreases expression 18042831
D010615 Phenacetin Phenacetin results in increased expression of SLC39A14 mRNAincreases expression 17082564
C030299 phenylhydrazine phenylhydrazine results in increased expression of SLC39A14 mRNAincreases expression 17082564
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SLC39A14 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of SLC39A14 mRNAincreases expression 18445702
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of SLC39A14 mRNAaffects binding|decreases expression 16214954
D014425 Turpentine Turpentine results in increased expression of and affects the localization of SLC39A14 proteinaffects localization|increases expression 15863613
D015032 Zinc SLC39A14 protein results in increased transport of Zincincreases transport 18326752
D015032 Zinc SLC39A14 protein affects the import of Zincaffects import 15863613
D015032 Zinc SLC39A14 protein results in increased uptake of Zincincreases uptake 16950869
D015032 Zinc Zinc affects the expression of SLC39A14 mRNAaffects expression 17085522
D015032 Zinc SLC39A14 protein results in increased uptake of Zincincreases uptake 17126599
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7414514962 15322242 11752688
MESH:D000169 Acrodermatitis Zinc 5.2916889938 17202136 17190629
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.6911850527 18653653
MESH:D055371 Acute Lung Injury pirinixic acid 8.6918653653
MESH:D000210 Acute-Phase Reaction Turpentine 6.0716044259
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.693712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.5416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.5416835633
MESH:D019896 alpha 1-Antitrypsin Deficiency Iron 5.5416640825
MESH:D000544 Alzheimer Disease Iron 4.5816563566 16640825
MESH:D000544 Alzheimer Disease Zinc 4.5816325427 17119284 16410023 16580781
MESH:D000740 Anemia Iron 20.5116566752 16434484
MESH:D000740 Anemia Phenacetin 20.512444515
MESH:D000740 Anemia phenylhydrazine 20.512444515
MESH:D000740 Anemia Tetrachlorodibenzodioxin 20.5111748828
MESH:D000743 Anemia, Hemolytic Phenacetin 10.7117082564 17698508 1949026
MESH:D000743 Anemia, Hemolytic phenylhydrazine 10.7117698508 17084956 17082564
MESH:D018798 Anemia, Iron-Deficiency Iron 4.5516569441 17375513 17147795 17162259 17163184
MESH:D000755 Anemia, Sickle Cell Zinc 4.7916916123
MESH:D000756 Anemia, Sideroblastic Iron 17.3116910769
MESH:D000756 Anemia, Sideroblastic Manganese 17.3116910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 17.3116910769
MESH:D000799 Angioedema Acetaminophen 3.7410982225
MESH:D001145 Arrhythmias, Cardiac Iron 4.2716604332
MESH:D001161 Arteriosclerosis Dietary Fats 3.7815238619
MESH:D001249 Asthma epigallocatechin gallate 5.3416516891
MESH:D001249 Asthma Zinc 5.3417085522
MESH:D001260 Ataxia Telangiectasia Iron 5.3415336622
MESH:D050197 Atherosclerosis Iron 3.6416640825 16632123
MESH:D001321 Autistic Disorder Acetaminophen 2.1418445737
MESH:D001321 Autistic Disorder Iron 2.1417352947
MESH:D001327 Autoimmune Diseases epigallocatechin gallate 4.9619761891
MESH:D001424 Bacterial Infections Iron 5.0916640825
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.9111289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.4319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.4312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6915746008
MESH:D001930 Brain Injuries Zinc 4.5817109824
MESH:D001943 Breast Neoplasms Dietary Fats 2.0120435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0120435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6716124888 16192424 16011737 3786805 16097048 15721981 16227642 10355542 15700767 16050911 18705752 15673190
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7116835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.4016705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.407296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.403084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.4018788625
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.627296757
MESH:D002294 Carcinoma, Squamous Cell Acetylcysteine 5.1317015178
MESH:D002294 Carcinoma, Squamous Cell Zinc 5.1316543248
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3116120746 18850075 18670907
MESH:D009202 Cardiomyopathies Iron 3.9716640825
MESH:D002311 Cardiomyopathy, Dilated Iron 3.4216604332
MESH:D002318 Cardiovascular Diseases Zinc 3.5816936243
MESH:D002386 Cataract Acetaminophen 2.5210977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 15.436135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 15.437505956
MESH:D002471 Cell Transformation, Neoplastic Acetylcysteine 15.4318226522
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.4312371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0716835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.909022650 19486331
MESH:D002779 Cholestasis Cyclosporine 12.9019486331
MESH:D002779 Cholestasis pirinixic acid 12.9019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0615668235 12621046 16354765 15340226 8697196
MESH:D003110 Colonic Neoplasms Iron 2.8716640825
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6410048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Zinc 2.6419302082
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.9118551238
MESH:D003550 Cystic Fibrosis Acetylcysteine 4.2819747007
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.708156756 2524372 12868966 11906362 8970840 11298694 14531868 18759878
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.393621924 2952479
MESH:D003920 Diabetes Mellitus Iron 9.3216604332 16640825
MESH:D003920 Diabetes Mellitus Zinc 9.3216479319
MESH:D003922 Diabetes Mellitus, Type 1 Iron 3.3216506275
MESH:D003924 Diabetes Mellitus, Type 2 epigallocatechin gallate 7.1716988119
MESH:D003924 Diabetes Mellitus, Type 2 Iron 7.1716506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.1717107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 14.8418551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 14.8411289319 9328219 9022650 18692083 6482804 18289764 16192314 6679447 9653073 7440962 8291058 1440618 18648102
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 14.8416393943 14725611 19739265 16227642 19416960 17522070 17906064 12958197 10915739 10774834 12594235 16081117 17562736 11421492 11743745 12392966 12153990 12705907 16485898 16109766 11739529 14986274 2444490 15619225 19420014 19085960 19923254 15968718 18071297 16177239 12540782 16781746 14550746 11834606 11461765 11287661 10663392 11529661 18713872 19164858 19370779
MESH:D056486 Drug-Induced Liver Injury Acetylcysteine 14.8411287661
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 14.844309450 10915739 19336974 19085960 16227642 2869522 7440962 10092053 17522070 21278145 11566570 15968718 15998439 16177239 9327722 3732212 7179309 15027814 6884620 3786805 7120509 6623471
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.8420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6811462148
MESH:D050171 Dyslipidemias Dietary Fats 3.3718367378
MESH:D004487 Edema pirinixic acid 6.2012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.2012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8018230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.929294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 4.2915821434 17637181 15328337
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.583581430
MESH:D004938 Esophageal Neoplasms Zinc 4.5816543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9311564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 23.5815959796 16045604 12795759 17595544 19224547 16239168 61145 12631006
MESH:D005234 Fatty Liver Cyclosporine 23.5819224547
MESH:D005234 Fatty Liver Dietary Fats 23.5819004024 18296743 19551842 17967931
MESH:D005234 Fatty Liver Iron 23.5816640825
MESH:D005234 Fatty Liver pirinixic acid 23.5820131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3511858732
MESH:D005334 Fever Lipopolysaccharides 3.919205823 11852909
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.916705139
MESH:D005355 Fibrosis Carbon Tetrachloride 20.2418705752
MESH:D005355 Fibrosis Cyclosporine 20.2412639820 12168785
MESH:D005355 Fibrosis Dietary Fats 20.2418296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 20.2420067830
MESH:D005621 Friedreich Ataxia Iron 5.3216640825 16604332
MESH:D005756 Gastritis Acetaminophen 10.8116983495
MESH:D005756 Gastritis Zinc 10.8117241300
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.118708960
MESH:D005909 Glioblastoma Manganese 3.8417043766
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.937505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4910696789
MESH:D006130 Growth Disorders Zinc 3.8917217573
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2711294989 10048152
MESH:D006333 Heart Failure pirinixic acid 6.9220558911
MESH:D006333 Heart Failure Zinc 6.9217162251
MESH:D006335 Heart Injuries Zinc 5.6617074742
MESH:D016481 Helicobacter Infections Zinc 4.4317241300
MESH:D006432 Hemochromatosis Iron 4.4117255318 16574947 16640825 17053826 16604332 17236123
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3115720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.2816366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2311000095
MESH:D006486 Hemosiderosis Iron 5.1116604332
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.876705139
MESH:D006505 Hepatitis Carbon Tetrachloride 8.8719110552 19900420
MESH:D006525 Hepatitis, Viral, Human Iron 5.3616640825
MESH:D006527 Hepatolenticular Degeneration Iron 10.9317182432
MESH:D006527 Hepatolenticular Degeneration Zinc 10.9317276780
MESH:D006529 Hepatomegaly Iron 13.8616890145
MESH:D006529 Hepatomegaly pirinixic acid 13.8618467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.8612621046 15340226 16120746
MESH:D015658 HIV Infections Iron 3.6116597321
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9416959395 8697196 18606429 16354765 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.6116870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4216899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4921332399
MESH:D006943 Hyperglycemia pirinixic acid 3.0820558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.5121332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8315034207
MESH:D006973 Hypertension Cyclosporine 4.8110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8118850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9815338365
MESH:D007006 Hypogonadism Iron 4.3216640825
MESH:D007037 Hypothyroidism Iron 4.9716640825
MESH:D007249 Inflammation Dietary Fats 8.0120412841
MESH:D007249 Inflammation Lipopolysaccharides 8.019205823 17255318 17237260 17963957 12878042
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.0112878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 7.0118457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.0116306350
MESH:D019189 Iron Metabolism Disorders Iron 11.2417163184
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 11.2417255318
MESH:D007511 Ischemia Zinc 4.5216584753
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.919022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2316580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3415604871
MESH:D007674 Kidney Diseases Acetaminophen 9.7112587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.718314463 10903974 18776723
MESH:D007674 Kidney Diseases Zinc 9.7116960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.3216518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.8316705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 11.836582329
MESH:D007680 Kidney Neoplasms Cyclosporine 11.8312371664
MESH:D007970 Leukopenia Lipopolysaccharides 4.5915821434
MESH:D020961 Lewy Body Disease Iron 5.3216563566
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.7911408273 17157831 16239168 16943688 21278145 16221502 17174718 17334410 11903743
MESH:D008103 Liver Cirrhosis Dietary Fats 10.7918296743
MESH:D008103 Liver Cirrhosis Iron 10.7916640825
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.6020821823 12958196 16097048 18187930 16011737 14748882 14716833 17805973 18006644 17525996 15650968 18376398 18481824 14716496 17721639 12898905 13678700 12632514 17944888 12546737 18420326 17481882 18279442 17714472 16638106 17557913 18054572 18251166 17565644 18472332 18205269 15362042 17698563 17640975 18263696 17869086 17900296 17761835 14620537 18418968 14512876 15876570 18395095 12649538 18317297 12586293 18166357 18472094 15925388 17766677 12445418 18277467 15893842 16192424 16033810 18395914 12609069 16027843 11481614 15123356 17922224 17631135 15052691 12632512 15057751 12667390 12389079 15730626 15959796 12741479 17976157 17708605 16136751 18210741 14724832 15818738 16116963 18429990 18705752 18339082 10355542 16015684 15370692 16248980 15931870 18156304 12445421 15996030 12666154 18412020 15338365 17823541 15673190
MESH:D008106 Liver Cirrhosis, Experimental epigallocatechin gallate 6.6017481882
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 6.6012878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.6015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.6012878042
MESH:D008107 Liver Diseases Acetaminophen 3.8019014921 19460945 16610002 12969438 19784758 12587719 16611625 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.8016964402 15830285 16246199 15720792 17285989
MESH:D008108 Liver Diseases, Alcoholic Iron 4.9017207112 16737972
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0515123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.0816871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.0814706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 13.807678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 13.8019294768
MESH:D008113 Liver Neoplasms Iron 13.8020302851 16640825
MESH:D008113 Liver Neoplasms pirinixic acid 13.8015890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.8016984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 13.532876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 13.53598648 1399818 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 13.5312014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.5312151625
MESH:D008171 Lung Diseases Acetylcysteine 3.9812815614
MESH:D055370 Lung Injury Lipopolysaccharides 3.9021114838
MESH:D008175 Lung Neoplasms Iron 2.5516640825
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5511884234 19555203
MESH:D008268 Macular Degeneration Iron 3.9216640825
MESH:D008325 Mammary Neoplasms, Experimental Zinc 3.2312773700
MESH:D020149 Manganese Poisoning Manganese 5.4119453300 16551646 16568477
MESH:D008545 Melanoma epigallocatechin gallate 2.9711746506 17992120
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4619513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6816801185
MESH:D008708 Methemoglobinemia Phenacetin 4.854834387 1949026 16296465 3537620
MESH:D009069 Movement Disorders Manganese 4.9116551646
MESH:D020528 Multiple Sclerosis, Chronic Progressive Iron 5.5717086897
MESH:D009134 Muscular Atrophy, Spinal epigallocatechin gallate 5.3817962980
MESH:D009135 Muscular Diseases pirinixic acid 3.4016239165
MESH:D009181 Mycoses Iron 5.3616640825
MESH:D009203 Myocardial Infarction pirinixic acid 2.1019151258
MESH:D017202 Myocardial Ischemia Iron 8.8816604332
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.8812213967
MESH:D015428 Myocardial Reperfusion Injury Iron 8.3316604332
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.3316411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.7518551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.933581430
MESH:D009362 Neoplasm Metastasis Acetylcysteine 5.9314720322
MESH:D009369 Neoplasms pirinixic acid 1.9017405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 9.1719348381 18481113
MESH:D009404 Nephrotic Syndrome Iron 9.1717178036
MESH:D009410 Nerve Degeneration Manganese 4.1916551646
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.346679447
MESH:D009436 Neural Tube Defects Acetylcysteine 7.3419446573
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.2118514411
MESH:D019636 Neurodegenerative Diseases Iron 8.2116604332 17296847
MESH:D009765 Obesity Dietary Fats 4.3417217161 21332399 11836018 18674790 18457598 20132043 20518802 19632207 16723640
MESH:D009765 Obesity pirinixic acid 4.3420558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.5516049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.556482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.913988306
MESH:D010003 Osteoarthritis Iron 3.9016640825
MESH:D010024 Osteoporosis Iron 3.7916640825 16648989
MESH:D010146 Pain Acetaminophen 2.3016870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 9.107296757
MESH:D010212 Papilloma Iron 9.1012065085
MESH:D020447 Parasomnias Iron 5.9117352947
MESH:D010300 Parkinson Disease Iron 5.7816640825 16563566
MESH:D010300 Parkinson Disease Manganese 5.7811181820
MESH:D020734 Parkinsonian Disorders Manganese 4.3716140633
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1412520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.366228378
MESH:D010900 Pituitary Diseases Iron 5.5716604332
MESH:D011014 Pneumonia Lipopolysaccharides 4.4512224865 11605937
MESH:D011041 Poisoning Iron 4.1916604332
MESH:D017119 Porphyria Cutanea Tarda Iron 10.6616640825
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 10.6618163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1312371664
MESH:D011225 Pre-Eclampsia Iron 9.2516640825
MESH:D011225 Pre-Eclampsia Zinc 9.2517114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0811222880 11896295 11399792 11118676
MESH:D011471 Prostatic Neoplasms Zinc 3.8516517595 16606632 12429649 16700911
MESH:D011528 Protozoan Infections Iron 5.9116640825
MESH:D011565 Psoriasis Cyclosporine 2.1916882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.3319058328
MESH:D012128 Respiratory Distress Syndrome, Adult Acetylcysteine 4.4212210543
MESH:D012130 Respiratory Hypersensitivity marker/mechanism 17085522
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.6610835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7318990726
MESH:D012148 Restless Legs Syndrome Iron 4.4616930377
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.733692021
MESH:D012162 Retinal Degeneration Zinc 8.7316584753
MESH:D012640 Seizures 2,6-dinitrotoluene 2.4618551238
MESH:D012878 Skin Neoplasms Iron 9.2512065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.258532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.2516192470
MESH:D013276 Stomach Ulcer Acetylcysteine 3.9017918041
MESH:D013398 Sudden Infant Death Iron 5.3416640825
MESH:D013436 Sulfhemoglobinemia Phenacetin 6.45978859
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.0715821434
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.803712494 1399818 6587162 6582329 7505956
MESH:D014062 Tongue Neoplasms Zinc 4.3016543248
MESH:D014376 Tuberculosis Iron 4.0216597321
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.2416049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.248074119
MESH:D001749 Urinary Bladder Neoplasms Phenacetin 8.2411144890
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.2110091137
MESH:D014581 Urticaria Acetaminophen 2.8710982225
MESH:D014605 Uveitis Cyclosporine 3.881336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4912125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1415886252
MESH:D015430 Weight Gain Dietary Fats 3.6416723640
MESH:D014985 Xerophthalmia Cyclosporine 4.3417120751
Pathway ID Pathway Name
REACT:15518 Transmembrane transport of small molecules
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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