AutismKB 2.0

Annotation Detail for SKIV2L2


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Basic Information Top
Gene Symbol:SKIV2L2 ( Dob1,KIAA0052,MGC142069,Mtr4,fSAP118 )
Gene Full Name: superkiller viralicidic activity 2-like 2 (S. cerevisiae)
Band: 5q11.2
Quick LinksEntrez ID:23517; OMIM: NA; Uniprot ID:SK2L2_HUMAN; ENSEMBL ID: ENSG00000039123; HGNC ID: 18734
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of SKIV2L2 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of SKIV2L2 mRNAincreases expression 20458559
C011890 kojic acid kojic acid results in decreased expression of SKIV2L2 mRNAdecreases expression 16595896
C010327 salinomycin salinomycin results in decreased expression of SKIV2L2 mRNAdecreases expression 19682730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3611798837 19825857
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 4.1016206674
MESH:D001943 Breast Neoplasms salinomycin 3.3119682730
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.7911589617
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.033084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.0316217749 14691202 15553829 11135700 15073043
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.6019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.5112490120
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.6912609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.5615213294
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6714725611 11421492 11739529 17522070 12153990 19923254 12958197 10774834 19416960 19370779 11461765 16393943 18071297 19420014 18713872 15968718 11529661 19164858 16081117 2444490 16109766 15619225 19739265 12392966 12540782 16485898 17906064 12594235 14986274 17562736 19085960 11287661 10663392 16177239 12705907 10915739 16227642 11834606 14550746 16781746 11743745
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3812903497
MESH:D005234 Fatty Liver arsenic trioxide 3.7115073043
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.7716904648
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D007674 Kidney Diseases Acetaminophen 2.4015629191 12587719
MESH:D007938 Leukemia arsenic trioxide 3.0015070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.2217077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.9416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.7214633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.1919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1917050201 16467208 20471514 19850784 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4619642359 15622746 19075265 17712046 17649720 15336539 15213294 16331271 16891316 16330433 9834237 15748426 16823087 17217047 19225113 17869043 12679006 17107899 11468182 12018890 16112521 12712474 16966277 11161223 19035177
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.8616882451
MESH:D008107 Liver Diseases Acetaminophen 1.7012587719 19014921 11587558 19784758 16611625 12969438 16610002 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6316871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 2.4614682389
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 7.0220377131
MESH:D008114 Liver Neoplasms, Experimental kojic acid 7.0218544905
MESH:D008133 Long QT Syndrome arsenic trioxide 3.6615213294
MESH:D008175 Lung Neoplasms arsenic trioxide 1.8711798837 19825857
MESH:D008325 Mammary Neoplasms, Experimental salinomycin 4.0019682730
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3819417148 11468182 15949261 19549372 14977855
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.4018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3416882451 16105982
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.4716624393
MESH:D009436 Neural Tube Defects arsenic trioxide 3.3610525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.5012452020 16624393 19769630
MESH:D010146 Pain Acetaminophen 2.7316870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6315580305
MESH:D010235 Paraganglioma arsenic trioxide 4.6319927285
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2119131511
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.4716646077
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.3919014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.5915213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.6020435036 11780464 12845720 12973940
MESH:D014581 Urticaria Acetaminophen 3.4410982225
Pathway ID Pathway Name
KEGG:03018 RNA degradation
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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