AutismKB 2.0

Annotation Detail for SRRM2


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Basic Information Top
Gene Symbol:SRRM2 ( 300-KD,CWF21,Cwc21,DKFZp667L0421,DKFZp686O15166,FLJ21926,FLJ22250,KIAA0324,MGC40295,SRL300,SRm300 )
Gene Full Name: serine/arginine repetitive matrix 2
Band: 16p13.3
Quick LinksEntrez ID:23524; OMIM: 606032; Uniprot ID:SRRM2_HUMAN; ENSEMBL ID: ENSG00000167978; HGNC ID: 16639
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SRRM2 mRNAaffects expression 21346803
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of SRRM2 mRNAincreases expression 20504355
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SRRM2 mRNAdecreases expression 20018196
19150397
D004958 Estradiol Estradiol results in decreased expression of SRRM2 mRNAdecreases expression 20106945
D007657 Ketone Bodies Ketone Bodies results in increased expression of SRRM2 mRNAincreases expression 16807920
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of SRRM2 mRNAaffects cotreatment|decreases expression 19244175
C004648 testosterone enanthate testosterone enanthate affects the expression of SRRM2 mRNAaffects expression 17440010
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of SRRM2 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of SRRM2 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4520127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.4511473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.786695378
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0317474063 20146248
MESH:D001943 Breast Neoplasms Estradiol 2.0318497071 16675129 14630087 12948864 19861407 17018787 17289903 17261762
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8016111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.2416050911
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.0516705839
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.0516924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.1820889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.1818566989
MESH:D003092 Colitis Selenium 4.0917936198
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.3218551238
MESH:D003928 Diabetic Nephropathies Estradiol 3.6319279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 4.1318551238 21346803
MESH:D056486 Drug-Induced Liver Injury Selenium 4.1315131321
MESH:C538011 Eales disease Vitamin E 5.089068938
MESH:D016889 Endometrial Neoplasms Estradiol 3.1319148513 18566989 11473722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5216530937
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 7.0720471113
MESH:D006330 Heart Defects, Congenital Vitamin E 7.0716080930
MESH:D006333 Heart Failure Selenium 3.2117162251
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7716863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 5.4115709030
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.1217440010
MESH:D019584 Hot Flashes Estradiol 11.3417088409
MESH:D019584 Hot Flashes Vitamin E 11.3414716179
MESH:D007251 Influenza, Human Selenium 12.2516624496
MESH:D007251 Influenza, Human Vitamin E 12.2516624496
MESH:D007333 Insulin Resistance Estradiol 3.1116393666 16627594
MESH:D007674 Kidney Diseases Estradiol 6.5315618244
MESH:D007674 Kidney Diseases Vitamin E 6.5312488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.1316518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.0416705839
MESH:D007680 Kidney Neoplasms Estradiol 8.0415610895
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.5614716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.5616169303
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1120195826 21137059
MESH:D008171 Lung Diseases Vitamin E 3.3316863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4820064080 18816296 18520028 18569708 20869020 20464547 17053015 20135361 6695378
MESH:D008175 Lung Neoplasms Vitamin E 2.4811062179
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.5117203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.5115318939
MESH:D020149 Manganese Poisoning Estradiol 4.8619453300
MESH:D008654 Mesothelioma Selenium 2.8715107826
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4616810080
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.2018551238
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2711141357
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0717289903
MESH:D009421 Nervous System Malformations Estradiol 3.9311399458 16427766
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6616049721 12819281
MESH:D010051 Ovarian Neoplasms Estradiol 2.2819401270
MESH:D010954 Plasmacytoma Selenium 5.2715087411
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1320887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.4817292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.4816740699
MESH:D011471 Prostatic Neoplasms Vitamin E 2.4815084515
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6818551238
MESH:D012871 Skin Diseases Vitamin E 2.4918709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4610029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D020521 Stroke Vitamin E 3.7116517955
MESH:D013978 Tibial Fractures Estradiol 5.0619048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2416049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2417053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6510091137
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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