AutismKB 2.0

Annotation Detail for ACAP2


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Basic Information Top
Gene Symbol:ACAP2 ( CENTB2,CNT-B2,KIAA0041 )
Gene Full Name: ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
Band: 3q29
Quick LinksEntrez ID:23527; OMIM: 607766; Uniprot ID:ACAP2_HUMAN; ENSEMBL ID: ENSG00000114331; HGNC ID: 16469
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04144Endocytosis
No data
Pathway IDPathway Name
200060Arf6 signaling events
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ACAP2 mRNAaffects expression 17562736
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ACAP2 mRNAaffects cotreatment|decreases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ACAP2 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ACAP2 mRNAdecreases expression 19150397
D003010 Clorgyline Clorgyline results in increased expression of ACAP2 mRNAincreases expression 19691856
D016572 Cyclosporine Cyclosporine results in increased expression of ACAP2 mRNAincreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ACAP2 mRNAaffects cotreatment|decreases expression 18164116
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 12.076695378
MESH:D000236 Adenoma beta-Naphthoflavone 12.0719389873
MESH:D000236 Adenoma Diethylnitrosamine 12.076695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.3018056438 19052882 17620307 16434500 17162532 19061943
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0617474063 20146248
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.0617474063
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.963084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 2.9618393292 19539802 16779866 17978847 19052882 16328049 19383236 18506893 19822196 16502159 3084413 19701751 19519916 18788625 20935162 20727157 17761372 19919837 11831363 18210153 16807293 16878318 20084675 20514400 20101231 16288022 17428255 17173139 21159647 19171122 19107877 17138121 18494052 18691550 17162532 10737359 20007298 16830150 20432363 16698587 18785209 16935385 19394651 18056438 3581430 19418558 20524982 10672840 19335982 18971187 16540662 20214788 18978308 17055752 16681979 18665156 19208518 20512989 16569478
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1120419170
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 12.2420889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 12.2412371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 12.247505956 21159647 2727394 17174075
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9319052882
MESH:D002779 Cholestasis Cyclosporine 3.1219486331
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2420387270
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9711287661 19164858 18071297 15619225 12153990 19923254 19416960 2444490 18713872 14550746 10915739 11739529 17906064 11743745 10663392 19420014 11461765 11529661 19739265 12540782 11421492 12594235 16227642 12705907 16393943 16177239 12958197 14725611 15968718 10774834 12392966 17522070 19370779 14986274 19085960 17562736 11834606 16109766 16781746 16081117 16485898
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.9719107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.5616302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5420426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5416530937
MESH:D005234 Fatty Liver Cyclosporine 8.6719224547
MESH:D005234 Fatty Liver Diethylnitrosamine 8.6720387270 21071580
MESH:D005355 Fibrosis Cyclosporine 3.5012168785 12639820
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7820471113
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006973 Hypertension Cyclosporine 2.1810903974
MESH:D007249 Inflammation Diethylnitrosamine 2.5018785209
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007674 Kidney Diseases Acetaminophen 6.2815629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.2818776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9712371664
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9618407596 18665156 20032147 18522880 19638242
MESH:D008107 Liver Diseases Acetaminophen 4.1019014921 12969438 16610002 19460945 19784758 11587558 16611625 12587719
MESH:D008107 Liver Diseases Diethylnitrosamine 4.1017034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 8.0320195826 21137059
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 8.0321295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 8.0316942905 19090486 19256749 19850985 9163691 18648771 18754104 19551842 19427195 19996281 19073162 20434301 10737359 21167192 20405173 18977376 18978307 2422723 20501860 19254457 15885732 2862719 20118626 20101389 19833225 19255062 18644402 15175105 20452335 20583210 19812893 21071580 20492335 19642983 21047994 19294768 21278145 19426721 19499222 19638242 20137499 12771043 19690152 12112319
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 6.6718164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.6719009564 18079962 16267830 18544905 19539802 18164116 17854601 17942915 19519916 3124819 19004024 21159647 18282651 18253720 18308698 19126423 2563599 18775883 9362446 17174075 16842330 18093689
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4418569708 20464547 18816296 17053015 20869020 18520028 6695378 20135361 20064080
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.446695378 21163286 20512841 20970405
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.663581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2811141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5319348381 18481113
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.9718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.9720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.5620387270
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5016540662
MESH:D011230 Precancerous Conditions Cyclosporine 9.7912371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.792563599
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.4917292933
MESH:D011471 Prostatic Neoplasms Clorgyline 3.4919691856
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4819755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.382093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3818456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.197505956
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2617053015
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
Pathway ID Pathway Name
KEGG:04144 Endocytosis
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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