AutismKB 2.0

Annotation Detail for CLCF1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CLCF1 ( BSF-3,BSF3,CISS2,CLC,NNT-1,NNT1,NR6 )
Gene Full Name: cardiotrophin-like cytokine factor 1
Band: 11q13.2
Quick LinksEntrez ID:23529; OMIM: 607672; Uniprot ID:CLCF1_HUMAN; ENSEMBL ID: ENSG00000175505; HGNC ID: 17412
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04630Jak-STAT signaling pathway
hsa04060Cytokine-cytokine receptor interaction
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Cold-induced sweating syndrome 1
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CLCF1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CLCF1 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of CLCF1 mRNAaffects expression 21346803
C014347 decitabine decitabine results in increased expression of CLCF1 mRNAincreases expression 19194470
D004112 Dimercaprol Dimercaprol inhibits the reaction [Mustard Gas results in increased expression of CLCF1 mRNA]decreases reaction|increases expression 16377760
D007213 Indomethacin Indomethacin inhibits the reaction [Mustard Gas results in increased expression of CLCF1 mRNA]decreases reaction|increases expression 16377760
D009151 Mustard Gas Dimercaprol inhibits the reaction [Mustard Gas results in increased expression of CLCF1 mRNA]decreases reaction|increases expression 16377760
D009151 Mustard Gas Indomethacin inhibits the reaction [Mustard Gas results in increased expression of CLCF1 mRNA]decreases reaction|increases expression 16377760
D009151 Mustard Gas Mustard Gas results in increased expression of CLCF1 mRNAincreases expression 16377760
C006253 pirinixic acid pirinixic acid results in increased expression of CLCF1 mRNAincreases expression 18445702
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 4.287525203
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Indomethacin 2.8316537180
MESH:D000236 Adenoma Indomethacin 3.5811497255
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D016301 Alveolar Bone Loss Indomethacin 5.7517225004
MESH:D000544 Alzheimer Disease Indomethacin 2.7415579461 17627676
MESH:D001014 Aortic Aneurysm Indomethacin 5.1310231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 5.1810388637
MESH:D018771 Arthralgia Indomethacin 5.552160914
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.8711248219
MESH:D001249 Asthma Mustard Gas 2.7710378619
MESH:D001477 Bartter Syndrome Indomethacin 5.2910684365
MESH:D001768 Blister Mustard Gas 5.5019167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D001929 Brain Edema Indomethacin 5.4011481608
MESH:D002545 Brain Ischemia Indomethacin 4.7512524144
MESH:D001943 Breast Neoplasms decitabine 2.4819208741 18320071
MESH:D001943 Breast Neoplasms Indomethacin 2.4817401462
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.5015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.3510378619 17687719
MESH:D002056 Burns Indomethacin 5.0110459503
MESH:D002100 Cachexia Indomethacin 5.3415141370 16537180 11239499 15625704
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.8316705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.8316705839
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 4.8316391822
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 5.0611053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.6918791128 14736730 11352223
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.4717341418
MESH:D002294 Carcinoma, Squamous Cell decitabine 5.1719215824
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 5.1712636206 15482327
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.7614694615
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.936135515
MESH:D002764 Cholecystitis Indomethacin 5.5511181007
MESH:D002779 Cholestasis pirinixic acid 3.0019176532
OMIM:610313 COLD-INDUCED SWEATING SYNDROME 2 marker/mechanism
MESH:D003110 Colonic Neoplasms decitabine 4.1217616700
MESH:D003110 Colonic Neoplasms Indomethacin 4.1211260862 15936596 15637740 15963497 15625704 15786552
MESH:D015179 Colorectal Neoplasms decitabine 2.8118981723
MESH:D015179 Colorectal Neoplasms Indomethacin 2.8117054584 12606626 11197048 18059344
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.3715095906
MESH:D018352 Coronavirus Infections Indomethacin 6.0917302372
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.9418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.9418551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003967 Diarrhea Indomethacin 4.077237001 7907874
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.6718551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.6721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 6.6721346803
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.4918043480 18446180 17190690 12774134 16326151 16133044
MESH:D004381 Duodenal Ulcer Indomethacin 4.4210671773 17202747 17151854 16699067 17329845 17351913 17045617 11595431 11991626 11535926 11595415
MESH:D004487 Edema Indomethacin 13.037907874 8985016 16100529 19703484 8273558 10653021 7990266
MESH:D004487 Edema Mustard Gas 13.0311428631 11402378 11428647 9260866
MESH:D004487 Edema pirinixic acid 13.0312083418
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.4919294695
MESH:D004715 Endometriosis Indomethacin 4.3715652904
MESH:D019446 Endotoxemia Indomethacin 4.8418509659
MESH:D004751 Enteritis Indomethacin 5.1216328016 10567023 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 5.2917980183
MESH:D004802 Eosinophilia Indomethacin 4.3611298111
MESH:D004890 Erythema Mustard Gas 5.509357497
MESH:D004938 Esophageal Neoplasms Indomethacin 2.8511005569
MESH:D005234 Fatty Liver pirinixic acid 3.0120131406 19236843
MESH:D005334 Fever Indomethacin 4.3511852909 10431976 17627676
MESH:D005354 Fibrosarcoma Indomethacin 5.2310962813
MESH:D005355 Fibrosis Indomethacin 4.3817994277
MESH:D005499 Folliculitis Indomethacin 5.5511298111
MESH:D005756 Gastritis Indomethacin 5.1215046732
MESH:D005909 Glioblastoma Indomethacin 3.7112870263
MESH:D005910 Glioma Indomethacin 3.3018371953 16487511
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.4811849393
MESH:D006073 Gout Indomethacin 5.6911248219
MESH:D006258 Head and Neck Neoplasms decitabine 8.5519215824
MESH:D006258 Head and Neck Neoplasms Indomethacin 8.5515482327
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.8115633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.9615135802
MESH:D006529 Hepatomegaly pirinixic acid 3.3016221962 19176532 19772884 18467677
MESH:D006930 Hyperalgesia Indomethacin 3.9612727271
MESH:D034321 Hyperamylasemia Indomethacin 6.0917883296
MESH:D006940 Hyperemia Indomethacin 5.3412524144
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006949 Hyperlipidemias Indomethacin 4.4217546600
MESH:D007077 Ileal Diseases Indomethacin 5.4010574470 18306037
MESH:D007079 Ileitis Indomethacin 5.6916133968 10651667 10647630
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.7516133044
MESH:D007248 Infertility, Male decitabine 3.3517581917
MESH:D007249 Inflammation Indomethacin 5.8312568917 3291741 7812673
MESH:D007249 Inflammation Mustard Gas 5.839260866 9357497 11428620 8975870 11428631 17524151 11428647 11402378 16001271
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007410 Intestinal Diseases Indomethacin 4.6317329856 11686837 11713966 15831440 17994277 10210152 15610444 11855677 18236018
MESH:D019586 Intracranial Hypertension Indomethacin 5.7515241188
MESH:D007579 Jejunal Diseases Indomethacin 5.4018306037 10574470 16133968
MESH:D007674 Kidney Diseases Indomethacin 3.3917190690
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.0416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.0416705839
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 4.1012228301 10320625 11703811
MESH:D007938 Leukemia decitabine 3.1818980019 19235587
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 4.1010785260 15631656 16572323
MESH:D007951 Leukemia, Myeloid decitabine 4.2417236224 18454857 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.3018704418 19010910 17679729 18206229 18460780 19387464
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 4.3018360721
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.8418055864
MESH:D007964 Leukocytosis Indomethacin 5.7516537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 6.0917980183
MESH:D008101 Liver Abscess, Amebic Indomethacin 6.0911479899
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 2.6118194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.6115474484
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.677678174
MESH:D008113 Liver Neoplasms pirinixic acid 4.6716377806 15890375 20007298
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.682876784 6135515 2876786
MESH:D008171 Lung Diseases Mustard Gas 3.6018702808 18161513
MESH:D008175 Lung Neoplasms Indomethacin 2.8816537180 11497255 11053908
MESH:D008175 Lung Neoplasms Mustard Gas 2.883148597 8781369
MESH:D008223 Lymphoma decitabine 3.5819470736
MESH:D008545 Melanoma decitabine 2.2716505122 17785578
MESH:D008881 Migraine Disorders Indomethacin 3.8411903285
MESH:D009062 Mouth Neoplasms Indomethacin 4.1712636206
MESH:D009101 Multiple Myeloma decitabine 3.5118172295
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.5119010910 16882708 19157545 18608210
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.5018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.507678174 18551238
MESH:D009362 Neoplasm Metastasis Indomethacin 3.2516537180 11053908 11239499
MESH:D009369 Neoplasms decitabine 5.3717925555 19116145 19470736
MESH:D009369 Neoplasms pirinixic acid 5.3717405874
MESH:D009374 Neoplasms, Experimental Indomethacin 4.4410663608 15625704
MESH:D019636 Neurodegenerative Diseases Indomethacin 4.1412349958
MESH:D009503 Neutropenia Mustard Gas 4.237688884 16761898
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.556374098
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 16.5316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 16.5316049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 16.5314694615
MESH:D010003 Osteoarthritis Indomethacin 3.807009135
MESH:D010051 Ovarian Neoplasms decitabine 2.7119259094 19331143
MESH:D010146 Pain Indomethacin 3.6613679232 3291741 17627676 17440234
MESH:D010149 Pain, Postoperative Indomethacin 5.0618702446 12538197
MESH:D010190 Pancreatic Neoplasms decitabine 2.8419294695
MESH:D010195 Pancreatitis Indomethacin 4.1817883296 15028970
MESH:D010257 Paraneoplastic Syndromes Indomethacin 6.0916537180
MESH:D020734 Parkinsonian Disorders Indomethacin 4.3512349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 6.0911903285
MESH:D010437 Peptic Ulcer Indomethacin 5.4911148446
MESH:D010518 Periodontitis Indomethacin 5.2917225004
MESH:D011041 Poisoning Mustard Gas 4.0615727166
MESH:D047928 Premature Birth Indomethacin 5.4317000239
MESH:D055728 Primary Myelofibrosis decitabine 5.0317616702
MESH:D011507 Proteinuria Indomethacin 4.4211849393
MESH:D011537 Pruritus Mustard Gas 4.4318058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 3.0010334151 17266442 17620002 17894541 17720292
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012208 Rhabdomyosarcoma decitabine 4.6619155313
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3918551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3918551238
MESH:D012871 Skin Diseases Mustard Gas 2.7615451306 12880345 16961503
MESH:D013272 Stomach Diseases Indomethacin 4.7515038085 18209964 10486359 16280098 17160473 17638125 10215738 10192188 15472012 18545984 17207306 16113693 16184426
MESH:D013274 Stomach Neoplasms decitabine 2.8019037991
MESH:D013274 Stomach Neoplasms Indomethacin 2.8015609394
MESH:D013276 Stomach Ulcer Indomethacin 3.8216397915 16934674 11595415 16252198 18299717 10878458 15138204 1323529 12077510 18237397 18087811 18193104 12498302 17654042 11729361 15255614 12467913 10423059 14567935 11145282 16150113 18209962 16631530 12787963 17627676 17657623 17977527 18726076 10750652 16169175 18431645 18181030 11906479 12500499 18543354 11595431 15104355 11523592 17135157 17918041 16755016 17895592
MESH:D013964 Thyroid Neoplasms decitabine 8.1217967635
MESH:D013964 Thyroid Neoplasms Indomethacin 8.1218791128 14736730 11352223
MESH:D014456 Ulcer Indomethacin 5.2317380554 10574470
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.8216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.8216049721
MESH:D001749 Urinary Bladder Neoplasms decitabine 8.8217616700 19087683
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.1410091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.1410091137
MESH:D014604 Uveal Neoplasms decitabine 5.2917785578
MESH:D014839 Vomiting Indomethacin 5.1211897121
Pathway ID Pathway Name
KEGG:04060 Cytokine-cytokine receptor interaction
KEGG:04630 Jak-STAT signaling pathway
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved