AutismKB 2.0

Annotation Detail for NNT


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Basic Information Top
Gene Symbol:NNT ( MGC126502,MGC126503 )
Gene Full Name: nicotinamide nucleotide transhydrogenase
Band: 5p12
Quick LinksEntrez ID:23530; OMIM: 607878; Uniprot ID:NNTM_HUMAN; ENSEMBL ID: ENSG00000112992; HGNC ID: 7863
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00760Nicotinate and nicotinamide metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Pyruvate metabolism and Citric Acid (TCA) cycle
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NNT mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of NNT mRNAaffects expression 21346803
D000638 Amiodarone Amiodarone results in increased expression of NNT mRNAincreases expression 17991464
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of NNT mRNAdecreases expression 15336504
D016572 Cyclosporine Cyclosporine results in decreased expression of NNT mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of NNT mRNAincreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of NNT mRNAaffects expression 16079270
D008694 Methamphetamine Methamphetamine results in increased expression of NNT mRNAincreases expression 19149911
C041786 palm oil palm oil results in increased expression of NNT mRNAincreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of NNT mRNAaffects binding|increases activity|increases expression 19710929
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in increased expression of NNT mRNAaffects cotreatment|increases expression 19465110
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NNT mRNAincreases expression 16922920
C024746 tobacco tar tobacco tar results in increased expression of NNT mRNAincreases expression 19559774
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0014514962 11752688 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.4216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.4216835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.9018218290 20041841 18057881
MESH:D001161 Arteriosclerosis Dietary Fats 10.3815238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.3811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001281 Atrial Fibrillation Amiodarone 3.9819698954 18651412
MESH:D001778 Blood Coagulation Disorders Amiodarone 15.9719483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.9719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.9712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001943 Breast Neoplasms Dietary Fats 1.9820435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9820435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.0016705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.0016705839
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9219225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.2418974383
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.746135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.7412371664
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 11.7419559774
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Cyclosporine 13.8219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.8217681005 17110522 16105132 15861022 16919318 17333356 11677210
MESH:D002779 Cholestasis pirinixic acid 13.8219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1415668235 8697196 12621046 15340226 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1614669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.3618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.3618551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.2318551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.2321346803 18551238
MESH:D056486 Drug-Induced Liver Injury Amiodarone 9.2315265979 18218290
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.2320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5318367378
MESH:D004487 Edema pirinixic acid 6.9012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.9011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0818230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3112538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1210568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Amiodarone 25.8914986274
MESH:D005234 Fatty Liver Cyclosporine 25.8919224547
MESH:D005234 Fatty Liver Dietary Fats 25.8917967931 19004024 19551842 18296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 25.8915345470
MESH:D005234 Fatty Liver pirinixic acid 25.8920131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005355 Fibrosis Cyclosporine 15.5612168785 12639820
MESH:D005355 Fibrosis Dietary Fats 15.5618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.5620067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3811294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly Amiodarone 15.2615265979
MESH:D006529 Hepatomegaly pirinixic acid 15.2619772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.2616120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.228697196 15340226 16354765 18606429 16959395
MESH:D006937 Hypercholesterolemia Amiodarone 9.548137927 9751232
MESH:D006937 Hypercholesterolemia Dietary Fats 9.5421332399
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006948 Hyperkinesis Methamphetamine 5.6617658665
MESH:D006949 Hyperlipidemias Dietary Fats 3.7321332399
MESH:D006973 Hypertension Cyclosporine 5.0710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0718670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516569931 16945680
MESH:D007037 Hypothyroidism Amiodarone 4.6517991464 18020914
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5617937319
MESH:D007249 Inflammation Dietary Fats 5.0920412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0912878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 7.4818457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.4816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4018776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.9116705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.9116705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.9112371664
MESH:D008064 Lipidoses Amiodarone 3.5917567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9318296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1612878042
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.557678174
MESH:D008113 Liver Neoplasms pirinixic acid 7.5515890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.5516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.952876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9512151625
MESH:D008133 Long QT Syndrome Amiodarone 3.6617391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.4412587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.6518516814
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009181 Mycoses Amiodarone 5.0817974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.8718551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.877678174 18551238
MESH:D009369 Neoplasms pirinixic acid 1.9917405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3818481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D009765 Obesity Dietary Fats 4.5218674790 20518802 17217161 18457598 21332399 16723640 19632207 20132043 11836018
MESH:D009765 Obesity pirinixic acid 4.5220558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.2312819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.2316049721
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411118676 11896295 11399792 11222880
MESH:D011537 Pruritus Ethinyl Estradiol 3.4716919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8912490602 11597910 12832656
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012640 Seizures 2,4-dinitrotoluene 6.1118551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.1118551238
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.2418724381
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.758532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1216709447
MESH:D013276 Stomach Ulcer Amiodarone 3.4218087811
MESH:D013610 Tachycardia Amiodarone 4.4211238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.3219225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Amiodarone 12.6419731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 12.6412697716
MESH:D013971 Thyrotoxicosis Amiodarone 5.0018020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.3411989578 17467628
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.1416049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.1416049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.5110091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.5110091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6515869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D015430 Weight Gain Dietary Fats 3.8316723640
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
KEGG:00760 Nicotinate and nicotinamide metabolism
REACT:1046 Pyruvate metabolism and Citric Acid (TCA) cycle
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00157 - NADH Dietary supplement;Micronutrient
DB01763 - Tatp
DB03461 - 2'-Monophosphoadenosine 5'-Diphosphoribose
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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