AutismKB 2.0

Annotation Detail for PRAME


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Basic Information Top
Gene Symbol:PRAME ( CT130,MAPE,OIP4 )
Gene Full Name: preferentially expressed antigen in melanoma
Band: 22q11.22
Quick LinksEntrez ID:23532; OMIM: 606021; Uniprot ID:PRAME_HUMAN; ENSEMBL ID: ENSG00000185686; HGNC ID: 9336
Relate to Another Database: SFARIGene; denovo-db
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Chemical ID Chemical Name Interaction Interaction Action Publication
C103303 alitretinoin alitretinoin promotes the reaction [RARA protein binds to PRAME protein]affects binding|increases reaction 16179254
D002794 Choline Choline affects the expression of PRAME mRNAaffects expression 17616785
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of PRAME mRNAaffects cotreatment|decreases expression 17404688
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of PRAME mRNAaffects cotreatment|decreases expression 17404688
D014212 Tretinoin PRAME protein results in decreased activity of Tretinoindecreases activity 16179254
D014212 Tretinoin Tretinoin promotes the reaction [RARA protein binds to PRAME protein]affects binding|increases reaction 16179254
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Estradiol 2.1611473722
MESH:D000505 Alopecia Tretinoin 3.9015955085
MESH:D001169 Arthritis, Experimental Tretinoin 3.2816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3316292516
MESH:D001249 Asthma Tretinoin 2.4316456186
MESH:D001321 Autistic Disorder Choline 3.3316818868
MESH:D001471 Barrett Esophagus Tretinoin 4.8416935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.9816197459 16206674
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.9517868700
MESH:D001930 Brain Injuries Progesterone 4.7415665606 15845082 15380490
MESH:D001943 Breast Neoplasms alitretinoin 2.0516344269
MESH:D001943 Breast Neoplasms Estradiol 2.0519861407 16675129 18497071 14630087 17289903 17261762 17018787 12948864
MESH:D001943 Breast Neoplasms Progesterone 2.0516175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tretinoin 2.0516443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.1316813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.0016111702
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.7716168501
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.1416924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.141917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung marker/mechanism 16179254
MESH:D002292 Carcinoma, Renal Cell marker/mechanism 16179254
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3716051514 16096774
MESH:D002386 Cataract Tretinoin 3.2817460283
MESH:D002471 Cell Transformation, Neoplastic Estradiol 3.0018566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.1316129372
MESH:D002822 Choriocarcinoma Tretinoin 5.7716461808
MESH:D002972 Cleft Palate Tretinoin 2.799407595
MESH:D003092 Colitis Tretinoin 4.1917035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8310589399 9664655 17551590 14991402 16925845 9224671 8800419 9142499 9125849 9211117
MESH:D002658 Developmental Disabilities Choline 4.9016818868
MESH:D003928 Diabetic Nephropathies Estradiol 3.7419279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.9817187935
MESH:D004489 Edema, Cardiac Tretinoin 5.0818230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.2217692515
MESH:D016889 Endometrial Neoplasms Estradiol 8.1411473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 8.1416569247
MESH:D004715 Endometriosis Progesterone 4.1116134523
MESH:D005124 Eye Abnormalities Tretinoin 3.849664655 16938888
MESH:D005355 Fibrosis Tretinoin 3.9917994277
MESH:D005909 Glioblastoma Tretinoin 3.2217312396
MESH:D006258 Head and Neck Neoplasms marker/mechanism 16179254
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.7716084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0514991402 9664655
MESH:D006558 Herpes Genitalis Estradiol 5.6415709030
MESH:D019584 Hot Flashes Estradiol 4.3617088409
MESH:D006930 Hyperalgesia Tretinoin 3.5016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.0516778211
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.8915869954
MESH:D007249 Inflammation Progesterone 2.7515869954
MESH:D007333 Insulin Resistance Estradiol 3.1816393666 16627594
MESH:D007410 Intestinal Diseases Tretinoin 4.2517994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.2715992940 17551590
MESH:D017492 Keratosis, Seborrheic alitretinoin 6.1816144296
MESH:D007674 Kidney Diseases Estradiol 2.7615618244
MESH:D007680 Kidney Neoplasms Estradiol 3.2815610895
MESH:D007938 Leukemia marker/mechanism 16179254
MESH:D007938 Leukemia Tretinoin 2.9217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.0716482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1216294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3716331271 16823087 17301526 17339181 19029980 17294898 19225113 17217047 17368321 16140955 16891316 17361223 17506722 16788101 12679006 9834237 16935935 19642359 16766008 17649720 19075265 19035177 15748426 17107899 17712046
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.559224671
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.5514659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.5516248980 18397230
MESH:D008175 Lung Neoplasms alitretinoin 2.6516413115
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.7711408345 16891317 11807958 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.7717203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 5.0919453300
MESH:D008527 Medulloblastoma marker/mechanism 16179254
MESH:D008527 Medulloblastoma Tretinoin 2.9017453147
MESH:D008545 Melanoma marker/mechanism 16179254
MESH:D008545 Melanoma Tretinoin 1.9816752155
MESH:D008591 Meningomyelocele Tretinoin 4.9116940565
MESH:D009101 Multiple Myeloma marker/mechanism 16179254
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2617596541
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.5516810080
MESH:D009369 Neoplasms alitretinoin 5.9016946489
MESH:D009369 Neoplasms Tretinoin 5.9016946489 16594593
MESH:D009389 Neovascularization, Pathologic Estradiol 4.2717289903
MESH:D009421 Nervous System Malformations Estradiol 11.1816427766 11399458
MESH:D009421 Nervous System Malformations Tretinoin 11.189125849
MESH:D009436 Neural Tube Defects Tretinoin 3.279142499
MESH:D010051 Ovarian Neoplasms Estradiol 8.4219401270
MESH:D010051 Ovarian Neoplasms Progesterone 8.4217393432 16525653
MESH:D010051 Ovarian Neoplasms Tretinoin 8.4216936753
MESH:D010146 Pain Tretinoin 3.2016870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5615976015
MESH:D017499 Porokeratosis alitretinoin 6.6216144296
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.2620887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0316740699
MESH:D011507 Proteinuria Tretinoin 4.0116636307
MESH:D011625 Pterygium Tretinoin 5.3316723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.5016116481 16283617
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9518045962
MESH:D012509 Sarcoma marker/mechanism 16179254
MESH:D012878 Skin Neoplasms Tretinoin 2.7516467112
MESH:D013119 Spinal Cord Injuries Progesterone 4.8216503802 15862959
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2916026305 17045167
MESH:D013978 Tibial Fractures Estradiol 5.3019048282
MESH:D014062 Tongue Neoplasms Tretinoin 4.1416051514
MESH:D014376 Tuberculosis Tretinoin 3.4316040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.0216129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.2216752155
MESH:D014820 Vitiligo Tretinoin 4.5016761959
MESH:D009396 Wilms Tumor Tretinoin 4.2916287080
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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