AutismKB 2.0

Annotation Detail for SLC16A8


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Basic Information Top
Gene Symbol:SLC16A8 ( MCT3,REMP )
Gene Full Name: solute carrier family 16, member 8 (monocarboxylic acid transporter 3)
Band: 22q13.1
Quick LinksEntrez ID:23539; OMIM: 610409; Uniprot ID:MOT3_HUMAN; ENSEMBL ID: ENSG00000100156; HGNC ID: 16270
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Transmembrane transport of small molecules
Pyruvate metabolism and Citric Acid (TCA) cycle
Hemostasis
Bile salt and organic anion SLC transporters
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of SLC16A8 mRNAincreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC16A8 mRNAaffects expression 16483693
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SLC16A8 mRNAincreases expression 15576828
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SLC16A8 mRNAaffects binding|decreases expression|increases activity 19710929
C025299 polyphenols polyphenols results in decreased expression of SLC16A8 mRNAdecreases expression 16293270
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.1018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.5517505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8814692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.933712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.0216434500
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8615885639
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.631440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5219483382
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.773581430 7296757
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.817296757
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.997505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 14.9219486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 14.9216105132 15861022 17681005 17110522 11677210 16919318 17333356
MESH:D002779 Cholestasis pirinixic acid 14.9219176532
MESH:D003110 Colonic Neoplasms polyphenols 2.7216293270
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.282524372 8156756 8970840 18759878 14531868 12868966 11298694 11906362
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.893621924 2952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.417440962 18289764 6679447 9022650 18692083 16192314 9328219 6482804 11289319 1440618 9653073 18648102 8291058
MESH:D056486 Drug-Induced Liver Injury polyphenols 4.4119370779
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.6312538720
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.173581430
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.8115345470
MESH:D005234 Fatty Liver pirinixic acid 8.8119236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.636705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.447505956
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.956705139
MESH:D006529 Hepatomegaly pirinixic acid 3.4818467677 16221962 19176532 19772884
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.4215034207
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2916945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7117937319
MESH:D007249 Inflammation polyphenols 3.2216366677
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.638074119 9022650
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.276582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4015034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases polyphenols 2.8516698588
MESH:D008113 Liver Neoplasms pirinixic acid 1.9216377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.731399818 598648 3712494 6587162
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.583581430
MESH:D009369 Neoplasms pirinixic acid 2.0917405874
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.136679447
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.774026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.633988306
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0911578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.977296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.086228378
MESH:D011537 Pruritus Ethinyl Estradiol 3.8516919318 15861022
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.643692021
MESH:D013088 Spermatocele Ethinyl Estradiol 4.5516709447
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.8617997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4815669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.151399818 3712494 6582329 7505956 6587162
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.398074119
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.7414692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9115869587 14671159
Pathway ID Pathway Name
REACT:20633 Bile salt and organic anion SLC transporters
REACT:604 Hemostasis
REACT:1046 Pyruvate metabolism and Citric Acid (TCA) cycle
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00119 - Pyruvic acid Dietary supplement;Micronutrient
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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