Gene Symbol:	FOSB ( AP-1,DKFZp686C0818,G0S3,GOS3,GOSB,MGC42291 )
Gene Full Name:	FBJ murine osteosarcoma viral oncogene homolog B
Band:	19q13.32
Quick Links	Entrez ID:2354; OMIM: 164772; Uniprot ID:FOSB_HUMAN; ENSEMBL ID: ENSG00000125740; HGNC ID: 3797
Relate to Another Database:	SFARIGene; denovo-db

Chemical ID	Chemical Name	Interaction	Interaction Action	Publication
C031278	2-chloroethyl ethyl sulfide	2-chloroethyl ethyl sulfide results in increased activity of FOSB protein	increases activity	18675330
C031278	2-chloroethyl ethyl sulfide	2-chloroethyl ethyl sulfide results in increased expression of FOSB protein	increases expression	18675330
C020922	4-O-methyl-12-O-tetradecanoylphorbol 13-acetate	4-O-methyl-12-O-tetradecanoylphorbol 13-acetate results in increased expression of FOSB mRNA	increases expression	17324382
C020922	4-O-methyl-12-O-tetradecanoylphorbol 13-acetate	4-O-methyl-12-O-tetradecanoylphorbol 13-acetate results in increased expression of FOSB protein	increases expression	17324382
D000082	Acetaminophen	Acetaminophen affects the expression of FOSB mRNA	affects expression	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of FOSB mRNA	increases expression	11264010
D000638	Amiodarone	Amiodarone results in increased expression of FOSB mRNA	increases expression	19774075
D003913	Dextroamphetamine	Dextroamphetamine results in increased expression of FOSB mRNA	increases expression	12558987
D003913	Dextroamphetamine	Dextroamphetamine affects the expression of FOSB protein	affects expression	12726824
D003913	Dextroamphetamine	Dextroamphetamine deficiency affects the reaction [Dextroamphetamine affects the expression of FOSB protein]	affects expression\|affects reaction	12726824
D003913	Dextroamphetamine	Dextroamphetamine results in increased expression of FOSB protein	increases expression	16678866
D003913	Dextroamphetamine	[Phencyclidine co-treated with Dextroamphetamine] results in increased expression of FOSB protein	affects cotreatment\|increases expression	16678866
D000661	Amphetamine	Amphetamine promotes the reaction [JUN protein binds to FOSB protein]	affects binding\|increases reaction	15814102
D000661	Amphetamine	Amphetamine results in increased activity of [JUN protein binds to FOSB protein]	affects binding\|increases activity	15814102
D000661	Amphetamine	Amphetamine results in increased expression of FOSB protein	increases expression	15814102
D000661	Amphetamine	Amphetamine results in increased expression of FOSB mRNA	increases expression	19710318
D000661	Amphetamine	SCH 23390 inhibits the reaction [Amphetamine results in increased expression of FOSB mRNA]	decreases reaction\|increases expression	19710318
D000661	Amphetamine	Amphetamine promotes the reaction [FOSB protein alternative form binds to FOS promoter]	affects binding\|increases reaction	18632938
D000661	Amphetamine	Amphetamine results in increased expression of FOSB mRNA	increases expression	17324382
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of FOSB mRNA	decreases expression	19410645
D017638	Asbestos, Crocidolite	Asbestos, Crocidolite results in increased expression of FOSB mRNA	increases expression	18687144
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of FOSB mRNA	increases expression	20064835
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of FOSB mRNA	affects expression	20382639
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of FOSB mRNA	increases expression	19150397
D003024	Clozapine	Clozapine results in increased expression of FOSB protein alternative form	increases expression	15579174
D003024	Clozapine	DRD3 protein affects the reaction [Clozapine results in increased expression of FOSB protein alternative form]	affects reaction\|increases expression	15579174
D003024	Clozapine	Clozapine results in decreased expression of FOSB mRNA	decreases expression	12093589
D003024	Clozapine	Clozapine results in increased expression of FOSB mRNA	increases expression	12093589 19695244 12243769
D003024	Clozapine	Clozapine results in increased expression of FOSB protein	increases expression	11259127
D003042	Cocaine	Cocaine results in increased expression of FOSB protein	increases expression	15814102
C007262	deoxynivalenol	deoxynivalenol affects the activity of FOSB protein	affects activity	10662601
C020735	dibutyldichlorotin	dibutyldichlorotin results in increased expression of FOSB mRNA	increases expression	10722888
D004958	Estradiol	Estradiol results in increased expression of FOSB mRNA	increases expression	19153601
D004958	Estradiol	Estradiol affects the expression of FOSB mRNA	affects expression	15598610
D005576	Forskolin	Forskolin results in increased expression of FOSB mRNA	increases expression	17324382
D005576	Forskolin	Forskolin results in increased expression of FOSB protein	increases expression	17324382
D006220	Haloperidol	Haloperidol results in increased expression of FOSB protein alternative form	increases expression	15579174
D006220	Haloperidol	8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Haloperidol results in increased expression of FOSB mRNA]	decreases reaction\|increases expression	19695244
D006220	Haloperidol	Haloperidol results in increased expression of FOSB mRNA	increases expression	19695244 12243769
D006220	Haloperidol	Haloperidol results in increased expression of FOSB protein	increases expression	11180499
C475919	hydroxytamoxifen	GPR30 protein affects the reaction [hydroxytamoxifen results in increased expression of FOSB mRNA]	affects reaction\|increases expression	19153601
C475919	hydroxytamoxifen	hydroxytamoxifen results in increased expression of FOSB mRNA	increases expression	19153601
D007052	Ibuprofen	Ibuprofen results in increased expression of FOSB mRNA	increases expression	17070997
C051890	irinotecan	irinotecan metabolite results in increased expression of FOSB mRNA	increases expression	15956246
C051890	irinotecan	irinotecan results in increased expression of FOSB mRNA	increases expression	15956246
C119620	kenpaullone	kenpaullone results in increased expression of FOSB mRNA	increases expression	17993264
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of FOSB mRNA	increases expression	12057914
D047311	Luteolin	Luteolin results in decreased activity of FOSB protein	decreases activity	16343431
C521676	N-((2,2-dimethyl-2,3-dihydro-benzofuran-7-yloxy)ethyl)-3-(cyclopent-1-enyl)-benzylamine	N-((2,2-dimethyl-2,3-dihydro-benzofuran-7-yloxy)ethyl)-3-(cyclopent-1-enyl)-benzylamine results in increased expression of FOSB mRNA	increases expression	19695244
C521676	N-((2,2-dimethyl-2,3-dihydro-benzofuran-7-yloxy)ethyl)-3-(cyclopent-1-enyl)-benzylamine	WAY 100635 promotes the reaction [N-((2,2-dimethyl-2,3-dihydro-benzofuran-7-yloxy)ethyl)-3-(cyclopent-1-enyl)-benzylamine results in increased expression of FOSB mRNA]	increases expression\|increases reaction	19695244
D009538	Nicotine	Nicotine results in increased expression of FOSB protein	increases expression	17324382
D009569	Nitric Oxide	Nitric Oxide results in increased activity of FOSB protein	increases activity	15949472
D017371	8-Hydroxy-2-(di-n-propylamino)tetralin	8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Haloperidol results in increased expression of FOSB mRNA]	decreases reaction\|increases expression	19695244
D010622	Phencyclidine	[Phencyclidine co-treated with Dextroamphetamine] results in increased expression of FOSB protein	affects cotreatment\|increases expression	16678866
D010622	Phencyclidine	Phencyclidine results in increased expression of FOSB protein	increases expression	16678866
D010656	Phenylephrine	Phenylephrine results in increased activity of FOSB protein	increases activity	15949472
C121565	pifithrin	pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FOSB mRNA]	decreases reaction\|increases expression	20064835
C534628	SCH 23390	SCH 23390 inhibits the reaction [Amphetamine results in increased expression of FOSB mRNA]	decreases reaction\|increases expression	19710318
C110881	S-nitro-N-acetylpenicillamine	S-nitro-N-acetylpenicillamine results in increased activity of FOSB protein	increases activity	15949472
C009277	sodium arsenate	sodium arsenate results in increased expression of FOSB mRNA	increases expression	11353140
C017947	sodium arsenite	sodium arsenite results in increased activity of FOSB protein	increases activity	12220541
C017947	sodium arsenite	sodium arsenite results in increased expression of FOSB mRNA	increases expression	11353140 16014739
D013749	Tetrachlorodibenzodioxin	pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FOSB mRNA]	decreases reaction\|increases expression	20064835
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of FOSB protein	affects expression	16985168
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of FOSB mRNA	affects expression	16962184
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of FOSB protein	increases expression	17148446
D013849	Thimerosal	Thimerosal results in increased expression of FOSB mRNA	increases expression	16870260
C024746	tobacco tar	tobacco tar results in decreased expression of FOSB mRNA	decreases expression	19559774
D014050	Toluene	Toluene results in increased expression of FOSB mRNA	increases expression	16737738
D002762	Cholecalciferol	Cholecalciferol results in increased expression of FOSB mRNA	increases expression	17170073
C090413	WAY 100635	WAY 100635 promotes the reaction [N-((2,2-dimethyl-2,3-dihydro-benzofuran-7-yloxy)ethyl)-3-(cyclopent-1-enyl)-benzylamine results in increased expression of FOSB mRNA]	increases expression\|increases reaction	19695244

Disease ID	Disease Name	Inference Chemical Name	Inference Score	Publication
MESH:D000014	Abnormalities, Drug-Induced	Tetrachlorodibenzodioxin	2.43	11752688 15322242 14514962
MESH:D058186	Acute Kidney Injury	Ibuprofen	8.17	6375363
MESH:D058186	Acute Kidney Injury	pifithrin	8.17	17670903
MESH:D055371	Acute Lung Injury	Lipopolysaccharides	3.64	18653653 11850527
MESH:D000230	Adenocarcinoma	arsenic trioxide	9.16	19825857 11798837
MESH:D000230	Adenocarcinoma	Benzo(a)pyrene	9.16	20127859 20464547
MESH:D000230	Adenocarcinoma	Estradiol	9.16	11473722
MESH:D000230	Adenocarcinoma	Ibuprofen	9.16	10697514
MESH:D000236	Adenoma	Benzo(a)pyrene	2.40	6695378
MESH:D018248	Adenoma, Liver Cell	Tetrachlorodibenzodioxin	2.95	16835633
MESH:D000310	Adrenal Gland Neoplasms	sodium arsenite	4.26	15276417
MESH:D018246	Adrenocortical Adenoma	sodium arsenite	4.46	17306315 16712894
MESH:D000380	Agranulocytosis	Clozapine	4.63	12649775 14617031 16160616
MESH:D000544	Alzheimer Disease	Ibuprofen	6.34	18351690
MESH:D000544	Alzheimer Disease	Nicotine	6.34	16627626
MESH:D000544	Alzheimer Disease	Nitric Oxide	6.34	17556102
MESH:D019969	Amphetamine-Related Disorders	Amphetamine	5.62	18475255 16916582 16459022 15010207
MESH:D000707	Anaphylaxis	Ibuprofen	4.82	9532969
MESH:D000740	Anemia	Tetrachlorodibenzodioxin	2.58	11748828
MESH:D000799	Angioedema	Acetaminophen	3.40	10982225
MESH:D000855	Anorexia	Amphetamine	4.64	12183048 12005258 16101753 16084549
MESH:D017544	Aortic Aneurysm, Abdominal	Benzo(a)pyrene	3.65	19183758
MESH:D001145	Arrhythmias, Cardiac	Amiodarone	7.91	20041841 18218290 18057881
MESH:D001145	Arrhythmias, Cardiac	Phenylephrine	7.91	17460149
MESH:D001281	Atrial Fibrillation	Amiodarone	3.58	18651412 19698954
MESH:D001321	Autistic Disorder	Acetaminophen	2.13	18445737
MESH:D001321	Autistic Disorder	Haloperidol	2.13	18080171 19368416
MESH:D001327	Autoimmune Diseases	Cholecalciferol	4.61	16142846
MESH:D001778	Blood Coagulation Disorders	Amiodarone	13.15	19483382
MESH:D001778	Blood Coagulation Disorders	arsenic trioxide	13.15	16206674
MESH:D001778	Blood Coagulation Disorders	Tetrachlorodibenzodioxin	13.15	12125929
MESH:D001836	Body Weight Changes	Tetrachlorodibenzodioxin	3.35	15340226
MESH:D001848	Bone Diseases, Developmental	Tetrachlorodibenzodioxin	2.48	15746008
MESH:D001919	Bradycardia	Phenylephrine	4.11	15306635
MESH:D002545	Brain Ischemia	Ibuprofen	4.45	15837124
MESH:D001943	Breast Neoplasms	Benzo(a)pyrene	1.91	20146248 17474063
MESH:D001943	Breast Neoplasms	Estradiol	1.91	17289903 19861407 12948864 18497071 17261762 16675129 17018787 14630087
MESH:D001943	Breast Neoplasms	Nitric Oxide	1.91	15631943
MESH:D001943	Breast Neoplasms	Tetrachlorodibenzodioxin	1.91	20435547
MESH:D002051	Burkitt Lymphoma	arsenic trioxide	3.93	11589617

Releated disease ID	Related disease Name
PA447199	Bipolar Disorder
PA447216	Schizophrenia

AutismKB 2.0

Annotation Detail for FOSB

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics