AutismKB 2.0

Annotation Detail for FPGS


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Basic Information Top
Gene Symbol:FPGS ( - )
Gene Full Name: folylpolyglutamate synthase
Band: 9q34.11
Quick LinksEntrez ID:2356; OMIM: 136510; Uniprot ID:FOLC_HUMAN; ENSEMBL ID: ENSG00000136877; HGNC ID: 3824
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-2161folate polyglutamylation I
Pathway IDPathway Name
hsa01100Metabolic pathways
hsa00790Folate biosynthesis
Pathway IDPathway Name
Metabolism of vitamins and cofactors
No data
Pathway IDPathway Name
P02742Tetrahydrofolate biosynthesis
Pathway IDPathway Name
501009Metabolism of folate and pterines
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of FPGS mRNAaffects expression 17562736
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of FPGS mRNAaffects expression 17555576
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FPGS mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of FPGS mRNAdecreases expression 17108234
D005472 Fluorouracil FPGS protein results in increased susceptibility to Fluorouracilincreases response to substance 15542523
D005492 Folic Acid Folic Acid affects the expression of FPGS mRNAaffects expression 17311948
C056933 fumonisin B1 fumonisin B1 results in decreased expression of FPGS mRNAdecreases expression 16221962
C085586 pemetrexed FPGS protein results in increased susceptibility to pemetrexedincreases response to substance 17575230
C006253 pirinixic acid pirinixic acid results in increased expression of FPGS mRNAincreases expression 15302862
18301758
D014284 Triiodothyronine Triiodothyronine results in increased expression of FPGS mRNAincreases expression 15953391
D013629 Tamoxifen Tamoxifen affects the expression of FPGS mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FPGS mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of FPGS mRNAincreases expression 15328365
D002762 Cholecalciferol Cholecalciferol results in decreased expression of FPGS mRNAdecreases expression 16508948
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7614745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0415322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D058186 Acute Kidney Injury Folic Acid 4.4716595132 17003819 16316344
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4414692618
MESH:D000230 Adenocarcinoma Fluorouracil 4.4417638652
MESH:D000236 Adenoma Folic Acid 3.8716963246
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.5616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.5616835633
MESH:D000544 Alzheimer Disease Folic Acid 3.0717116317
MESH:D000740 Anemia Fluorouracil 9.1216511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.1211748828
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D001321 Autistic Disorder Acetaminophen 2.1618445737
MESH:D001321 Autistic Disorder Folic Acid 2.1621388746
MESH:D001327 Autoimmune Diseases Cholecalciferol 5.2016142846
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.2419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.2412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Fluorouracil 2.4215136595 18608205 16595493 16110121 19217205 16557594 18357371
MESH:D001943 Breast Neoplasms Folic Acid 2.4216777985
MESH:D001943 Breast Neoplasms pemetrexed 2.4217465208 17575230
MESH:D001943 Breast Neoplasms Tamoxifen 2.4217049068 11161223 19103187 19011961 20390343 15565566 20065188 15668708 19289846 19155303 18425577 18629630 19244106 19084267 18984771 20135344 19066611 19142967 21138602 16202921 18821012 18351453 19059307 20544844 18855134 19221464 18997820 17893378 19288272 19200415 16273361 19189210 16873071 17261762 20859285 21152245 19410462 19189212 16818667 19115204 17242785 18815881 19487384 17440819 20005174
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.4220435547
MESH:D002276 Carcinoid Tumor Fluorouracil 4.8916051944
MESH:D002277 Carcinoma Fluorouracil 8.5617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.5616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6819066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.673084413
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.6716332177 17971768 17045692 17088986 16799960 18930000
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.6716924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung pemetrexed 4.7112023789
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0718695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5216757204 16280240 17066447 18986760
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4416120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Folic Acid 4.0416755160
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0917333356 16105132 17110522 17681005 15861022 11677210 16919318
MESH:D002779 Cholestasis pirinixic acid 8.0919176532
MESH:D002971 Cleft Lip Folic Acid 4.0421254359
MESH:D002972 Cleft Palate Folic Acid 6.278946559 21254359
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.2715668235 15340226 12621046 8697196 16354765
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2517725105 17169374 16510598 15001691 17172411 17018589 17016597 18772588 17287894 16340194
MESH:D015179 Colorectal Neoplasms marker/mechanism 15814641
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.8816303861 17255274 18509181 14970324 17016601 16391804 15148649 17094418 20501625 18288408 17454858 17594712 16282729 18949393 16331619 16524972 17401013 18448328 18383874 15289873 18802399 17695437
MESH:D015179 Colorectal Neoplasms Folic Acid 2.8816963246 17245555 17116713 16985020 17087956
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D007644 Darier Disease Fluorouracil 4.9916733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5419031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 4.6716886840
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.6717107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6019279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4619085960 17906064 12594235 10663392 12540782 12705907 11739529 11287661 14550746 10915739 19923254 16081117 19370779 14986274 2444490 16227642 15968718 11834606 16485898 19416960 11529661 11461765 16177239 18071297 10774834 19739265 19420014 16781746 12153990 16109766 12392966 14725611 18713872 11421492 19164858 17522070 16393943 12958197 15619225 17562736 11743745
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 6.4616221962
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004487 Edema pirinixic acid 7.0012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.0011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1216714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.4912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.4919031437
MESH:D016889 Endometrial Neoplasms Folic Acid 8.0617301261
MESH:D016889 Endometrial Neoplasms Tamoxifen 8.0619155303 17893378 20544844 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.159294722 10568697
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.4815173087 16481741 16337965 17638652 16785472
MESH:D017889 Exfoliation Syndrome Folic Acid 5.6916504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.8715345470
MESH:D005234 Fatty Liver pirinixic acid 13.8720131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 13.8719224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.7214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3819069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1220067830
MESH:D005756 Gastritis Acetaminophen 12.0116983495
MESH:D005756 Gastritis Folic Acid 12.0117171786
MESH:D005901 Glaucoma Folic Acid 5.2316504073
MESH:D005910 Glioma Fluorouracil 2.9216145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4815102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Folic Acid 7.0917286298 16524890
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 7.0911294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly fumonisin B1 15.5516221962
MESH:D006529 Hepatomegaly pirinixic acid 15.5519772884 19176532 16221962 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.5515340226 12621046 16120746
MESH:D006679 HIV Seropositivity Folic Acid 5.6917209195
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2616354765 18606429 8697196 15340226 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D020138 Hyperhomocysteinemia Folic Acid 4.6216433478 16397167 16755160 16865747 16395265
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5717937319
MESH:D007249 Inflammation Tamoxifen 5.1119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1112200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7216306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2712587719 15629191
MESH:D007680 Kidney Neoplasms Fluorouracil 7.9016985049
MESH:D007680 Kidney Neoplasms Tamoxifen 7.9018625569
MESH:D008064 Lipidoses Tamoxifen 3.2515342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4615474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.4618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4612878042
MESH:D008107 Liver Diseases Acetaminophen 4.3612969438 16610002 19460945 11587558 19014921 12587719 19784758 16611625
MESH:D008107 Liver Diseases Folic Acid 4.3616877991
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3716871587 17185352
MESH:D008113 Liver Neoplasms Fluorouracil 11.0817045692 16603448 15113037 18383874
MESH:D008113 Liver Neoplasms pirinixic acid 11.0820007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 11.0816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.0816984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1912151625
MESH:D008175 Lung Neoplasms Fluorouracil 3.4815246190
MESH:D008175 Lung Neoplasms Tamoxifen 3.4818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4819555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9915086387
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.3717718048
MESH:D008228 Lymphoma, Non-Hodgkin marker/mechanism 17119116
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.9519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7111731420 19196722 14580682 19196723 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.7619453300
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.8916832597
MESH:D008545 Melanoma Tamoxifen 1.9012393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3815990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D009062 Mouth Neoplasms Fluorouracil 3.7416757204 18986760
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009369 Neoplasms Fluorouracil 5.1918600527 16928823 18239605
MESH:D009369 Neoplasms pirinixic acid 5.1917405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.2219189210 19200415 19196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D009436 Neural Tube Defects Folic Acid 4.0417438019
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5316436463
MESH:D009503 Neutropenia Folic Acid 10.7616322990
MESH:D009503 Neutropenia pemetrexed 10.7616322990
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7119003803 16929163 15113037 16500647
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811118676 11896295 11222880 11399792
MESH:D011471 Prostatic Neoplasms Cholecalciferol 2.6917024972
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.6919082440 18626508
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.6915067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.5115861022 16919318
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1416160472 15538739 18286688 18722050
MESH:D051437 Renal Insufficiency Folic Acid 4.9515728788
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012559 Schizophrenia Folic Acid 2.9116641680
MESH:D012871 Skin Diseases Folic Acid 3.2818709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.3016709447
MESH:D013088 Spermatocele Tamoxifen 12.3016709447
MESH:D013118 Spinal Cord Diseases Folic Acid 5.6916361298
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.2319457130
MESH:D013274 Stomach Neoplasms Fluorouracil 3.8717172411 19015929 18567086 16951190 17498489 18396642 17522103 15786421 19084572 16424979
MESH:D013274 Stomach Neoplasms Folic Acid 3.8717171786
MESH:D013274 Stomach Neoplasms pemetrexed 3.8715958060
MESH:D020521 Stroke Folic Acid 4.4416517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1216280240
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.408653321 16712894 17572228
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0116803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6815869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
Pathway ID Pathway Name
KEGG:00790 Folate biosynthesis
KEGG:01100 Metabolic pathways
REACT:11193 Metabolism of vitamins and cofactors
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA167
    • No data
    Releated disease ID Related disease Name
    PA443622Carcinoma, Non-Small-Cell Lung
    PA444750Leukemia
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA443434Arthritis, Rheumatoid
    PA446108Colorectal Neoplasms
    Releated drug ID Related drug Name
    PA128406956fluorouracil
    PA450198leucovorin
    PA449789glycine
    PA451330l-serine
    PA449014cisplatin
    PA450947phenytoin
    PA450428methotrexate
    PA452621antineoplastic agents
    PA10810pemetrexed
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00142 - L-Glutamic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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