AutismKB 2.0

Annotation Detail for GTPBP4


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Basic Information Top
Gene Symbol:GTPBP4 ( CRFG,FLJ10686,FLJ10690,FLJ39774,NGB,NOG1 )
Gene Full Name: GTP binding protein 4
Band: 10p15.3
Quick LinksEntrez ID:23560; OMIM: NA; Uniprot ID:NOG1_HUMAN; ENSEMBL ID: ENSG00000107937; HGNC ID: 21535
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of GTPBP4 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of GTPBP4 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of GTPBP4 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of GTPBP4 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GTPBP4 mRNAdecreases expression 19150397
D016572 Cyclosporine Cyclosporine results in increased expression of GTPBP4 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of GTPBP4 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of GTPBP4 mRNAincreases expression 17942748
D005472 Fluorouracil GTPBP4 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D018038 Sodium Selenite Sodium Selenite results in increased expression of GTPBP4 mRNAincreases expression 18175754
D013629 Tamoxifen Tamoxifen affects the expression of GTPBP4 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GTPBP4 mRNAincreases expression 17942748
D014241 Trichloroethylene Trichloroethylene results in decreased expression of GTPBP4 mRNAdecreases expression 17905399
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7214745880
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 9.007525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.0011752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4214692618
MESH:D000230 Adenocarcinoma Fluorouracil 4.4217638652
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5316835633
MESH:D000740 Anemia Fluorouracil 9.0317963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.0311748828
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001943 Breast Neoplasms Fluorouracil 2.0119217205 16110121 15136595 16595493 18608205 16557594 18357371
MESH:D001943 Breast Neoplasms Tamoxifen 2.0119487384 18855134 17440819 17893378 17242785 18815881 19288272 15668708 21152245 18351453 20390343 19155303 19200415 19011961 19059307 19084267 19066611 20135344 17261762 11161223 19244106 18629630 19289846 16202921 18997820 19221464 20859285 19142967 20005174 19189212 17049068 19115204 18425577 20544844 18821012 16873071 16818667 15565566 20065188 19189210 16273361 18984771 19103187 21138602 19410462
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0120435547
MESH:D001943 Breast Neoplasms Trichloroethylene 2.0115986119
MESH:D002276 Carcinoid Tumor Fluorouracil 4.8416051944
MESH:D002277 Carcinoma Fluorouracil 8.4817121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.4816835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6419066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.0416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.0416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.043084413
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 9.0416799960 17045692 18930000 16332177 17088986 17971768
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 9.0416924424
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0618695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5217066447 16757204 18986760 16280240
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218850075 18670907 16120746
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.6314694615
MESH:D002386 Cataract Acetaminophen 7.6310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.586135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.5820889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.5812371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Cyclosporine 8.0519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0516105132 11677210 17681005 17333356 16919318 17110522 15861022
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8915894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1415668235 8697196 12621046 15340226 16354765
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2515001691 17287894 17725105 17172411 16510598 16340194 18772588 17169374 17018589 17016597
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017094418 17255274 17594712 15148649 15289873 17401013 17016601 16331619 16391804 14970324 18288408 18383874 18949393 18509181 18448328 16303861 17695437 16282729 18802399 17454858 20501625 16524972
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 9.5215095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.5214669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.3618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.3618551238
MESH:D007644 Darier Disease Fluorouracil 4.9516733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5019031437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8716285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5719279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 19.1918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 19.1921346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 19.1921346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 19.1910915739 15968718 11287661 17906064 12705907 12958197 18071297 11461765 11834606 19739265 19923254 19416960 10663392 16781746 11739529 17522070 16393943 19085960 18713872 11421492 12540782 14725611 19370779 14986274 2444490 16081117 12594235 16109766 11743745 16177239 19164858 16227642 16485898 10774834 11529661 12153990 14550746 19420014 15619225 12392966 17562736
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 19.1915131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 19.1920420201
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 19.197120509
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0816714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.3712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.3719031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1116202921 19155303 20544844 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1210568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.6020426865
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.6016337965 16785472 15173087 16481741 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Cyclosporine 13.7119224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.7115345470
MESH:D005234 Fatty Liver Tamoxifen 13.7119224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3016709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3419069698
MESH:D005355 Fibrosis Cyclosporine 8.9512168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9520067830
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D005910 Glioma Fluorouracil 2.9116145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4618337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3811294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0315340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.228697196 16959395 15340226 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006973 Hypertension Cyclosporine 5.0710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0718670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5617937319
MESH:D007249 Inflammation Tamoxifen 5.0719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0712878042 12200463
MESH:D007333 Insulin Resistance Sodium Selenite 3.3414714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Acetaminophen 5.9915629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 5.9918776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 24.3716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 24.3716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 24.3712371664
MESH:D007680 Kidney Neoplasms Fluorouracil 24.3716985049
MESH:D007680 Kidney Neoplasms Tamoxifen 24.3718625569
MESH:D008064 Lipidoses Tamoxifen 3.2317567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3118564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3112878042
MESH:D008107 Liver Diseases Acetaminophen 1.6519784758 16611625 19460945 16610002 12969438 11587558 19014921 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3417185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.027678174
MESH:D008113 Liver Neoplasms Fluorouracil 11.0215113037 17045692 18383874 16603448
MESH:D008113 Liver Neoplasms Tamoxifen 11.0216684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.0216984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.332876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.3312151625
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 10.337955063
MESH:D008175 Lung Neoplasms Fluorouracil 3.4615246190
MESH:D008175 Lung Neoplasms Tamoxifen 3.4618625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4611884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9515086387
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1814737004
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.9119428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6911731420 19196723 14580682 19196722 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.7219453300
MESH:D008545 Melanoma Tamoxifen 1.8919393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009062 Mouth Neoplasms Fluorouracil 3.7116757204 18986760
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.8718551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.877678174 18551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009369 Neoplasms Fluorouracil 5.7418600527 16928823 18239605
MESH:D009369 Neoplasms Trichloroethylene 5.7411911487
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1719189210 19196722 19200415
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3819348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5116436463
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 15.7712819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 15.7716049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 15.7714694615
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7015113037 16929163 16500647 19003803
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411896295 11222880 11399792 11118676
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.5819082440 18626508
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.5818760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5815067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.4715861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1115538739 16160472 18286688 18722050
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012640 Seizures 2,4-dinitrotoluene 6.1118551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.1118551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.1516709447
MESH:D013088 Spermatocele Tamoxifen 12.1516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1919457130
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0015786421 17522103 19084572 16424979 17498489 19015929 18567086 18396642 17172411 16951190
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D014062 Tongue Neoplasms Fluorouracil 4.0916280240
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.5216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.5216049721
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.5217572228 16712894 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.5110091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.5110091137
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.9816803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
Pathway ID Pathway Name
KEGG:03008 Ribosome biogenesis in eukaryotes
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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