Annotation Detail for CHST5
Basic Information Top
| Gene Symbol: | CHST5 ( FLJ22167,I-GlcNAc-6-ST,MGC74625 ) |
|---|---|
| Gene Full Name: | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 |
| Band: | 16q23.1 |
| Quick Links | Entrez ID:23563; OMIM: 604817; Uniprot ID:CHST5_HUMAN; ENSEMBL ID: ENSG00000135702; HGNC ID: 1973 |
| Relate to Another Database: | SFARIGene; denovo-db |
Related Pathway Information| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D000082 | Acetaminophen | Acetaminophen affects the expression of CHST5 mRNA | affects expression | 17562736 |
| C526219 | apple polyphenol extract | apple polyphenol extract results in increased expression of CHST5 mRNA | increases expression | 16369997 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in decreased expression of CHST5 mRNA | decreases expression | 20064835 |
| D007632 | Keratan Sulfate | CHST5 protein results in increased sulfation of and results in increased chemical synthesis of Keratan Sulfate | increases chemical synthesis|increases sulfation | 12218059 |
| C037199 | poly-N-acetyllactosamine | CHST5 protein results in increased sulfation of poly-N-acetyllactosamine | increases sulfation | 12218059 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000230 | Adenocarcinoma | Benzo(a)pyrene | 2.05 | 20127859 20464547 | |
| MESH:D000236 | Adenoma | Benzo(a)pyrene | 2.84 | 6695378 | |
| MESH:D000799 | Angioedema | Acetaminophen | 4.45 | 10982225 | |
| MESH:D017544 | Aortic Aneurysm, Abdominal | Benzo(a)pyrene | 4.56 | 19183758 | |
| MESH:D001321 | Autistic Disorder | Acetaminophen | 1.40 | 18445737 | |
| MESH:D001943 | Breast Neoplasms | Benzo(a)pyrene | 2.00 | 20146248 17474063 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Acetaminophen | 1.40 | 3084413 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Benzo(a)pyrene | 2.13 | 20419170 | |
| MESH:D002386 | Cataract | Acetaminophen | 2.77 | 10977129 | |
| MESH:D056486 | Drug-Induced Liver Injury | Acetaminophen | 1.66 | 19164858 19416960 11834606 12705907 19923254 10663392 16227642 18071297 12958197 12540782 16081117 11743745 12594235 16393943 16109766 10774834 19420014 11461765 14986274 17562736 15619225 19370779 2444490 12153990 11421492 18713872 17906064 11739529 16177239 14550746 15968718 16485898 19085960 12392966 11287661 11529661 19739265 10915739 17522070 16781746 14725611 | |
| MESH:D056487 | Drug-Induced Liver Injury, Chronic | Acetaminophen | 4.71 | 19426721 | |
| MESH:D004938 | Esophageal Neoplasms | Benzo(a)pyrene | 2.07 | 16530937 | |
| MESH:D005756 | Gastritis | Acetaminophen | 4.29 | 16983495 | |
| MESH:D006330 | Heart Defects, Congenital | Benzo(a)pyrene | 2.82 | 20471113 | |
| MESH:D006930 | Hyperalgesia | Acetaminophen | 2.99 | 16870215 | |
| MESH:D007674 | Kidney Diseases | Acetaminophen | 2.38 | 12587719 15629191 | |
| MESH:D008107 | Liver Diseases | Acetaminophen | 1.69 | 12969438 11587558 16611625 19014921 19784758 12587719 19460945 16610002 | |
| MESH:D017114 | Liver Failure, Acute | Acetaminophen | 3.58 | 17185352 16871587 | |
| MESH:D008113 | Liver Neoplasms | Benzo(a)pyrene | 2.14 | 20195826 21137059 | |
| MESH:D008175 | Lung Neoplasms | Benzo(a)pyrene | 1.57 | 20464547 20869020 18520028 18816296 17053015 20064080 20135361 6695378 18569708 | |
| MESH:D008546 | Melanoma, Experimental | Acetaminophen | 4.05 | 19513568 | |
| MESH:D009062 | Mouth Neoplasms | Benzo(a)pyrene | 3.46 | 16381670 | |
| MESH:D009369 | Neoplasms | Benzo(a)pyrene | 2.31 | 11141357 | |
| MESH:D019636 | Neurodegenerative Diseases | Acetaminophen | 3.18 | 18514411 | |
| MESH:D010146 | Pain | Acetaminophen | 2.69 | 16870215 | |
| MESH:D011471 | Prostatic Neoplasms | Benzo(a)pyrene | 2.91 | 17292933 | |
| MESH:D012878 | Skin Neoplasms | Benzo(a)pyrene | 2.51 | 10029692 19755658 | |
| MESH:D013274 | Stomach Neoplasms | Benzo(a)pyrene | 1.56 | 2093021 20155912 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Benzo(a)pyrene | 2.29 | 17053015 | |
| MESH:D014581 | Urticaria | Acetaminophen | 3.38 | 10982225 |
| Pathway ID | Pathway Name |
|---|---|
| KEGG:00533 | Glycosaminoglycan biosynthesis - keratan sulfate |