AutismKB 2.0

Annotation Detail for CASP14


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Basic Information Top
Gene Symbol:CASP14 ( MGC119078,MGC119079 )
Gene Full Name: caspase 14, apoptosis-related cysteine peptidase
Band: 19p13.12
Quick LinksEntrez ID:23581; OMIM: 605848; Uniprot ID:CASPE_HUMAN; ENSEMBL ID: ENSG00000105141; HGNC ID: 1502
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of CASP14 mRNAaffects expression 17562736
D000111 Acetylcysteine Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CASP14 protein]decreases reaction|increases expression 16137721
D005665 Furosemide Furosemide affects the expression of CASP14 mRNAaffects expression 17497460
D007530 Isoflurane Isoflurane results in decreased expression of CASP14 mRNAdecreases expression 16978161
D010424 Pentobarbital Pentobarbital results in decreased expression of CASP14 mRNAdecreases expression 16978161
D011794 Quercetin Quercetin results in decreased expression of CASP14 mRNAdecreases expression 17103110
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CASP14 mRNAincreases expression 12167310
17035482
D014028 Tobacco Smoke Pollution Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CASP14 protein]decreases reaction|increases expression 16137721
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in increased expression of CASP14 proteinincreases expression 16137721
C088658 zoledronic acid zoledronic acid results in decreased expression of CASP14 mRNAdecreases expression 19036117
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1311752688 15322242 14514962
MESH:D058186 Acute Kidney Injury zoledronic acid 4.6719715164
MESH:D000210 Acute-Phase Reaction zoledronic acid 5.7720200999
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.8515814487
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.4517084956
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001008 Anxiety Disorders Pentobarbital 4.8911141031 18313124
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 3.2219898480
MESH:D001260 Ataxia Telangiectasia Quercetin 5.2615336622
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001327 Autoimmune Diseases Quercetin 4.6719761891
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001859 Bone Neoplasms zoledronic acid 5.1819442620 15867366 17312309 16778634 16121404 11697798
MESH:D001862 Bone Resorption zoledronic acid 4.9111869084 18496637 15845617 16769263 8053405 18404659
MESH:D001943 Breast Neoplasms Quercetin 2.0318628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0320435547
MESH:D001943 Breast Neoplasms zoledronic acid 2.0316096432 18695136
MESH:D002105 Cadmium Poisoning Quercetin 5.8616962696
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.093084413
MESH:D006528 Carcinoma, Hepatocellular Quercetin 3.0912508355 19519916
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 6.3411212258
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 6.3419233551
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.2117234771
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 3.9318507039
MESH:D002294 Carcinoma, Squamous Cell Acetylcysteine 5.5217015178
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 5.5211212258
MESH:D006332 Cardiomegaly Quercetin 7.1519794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.1516120746 18850075 18670907
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic Acetylcysteine 4.0018226522
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.188697196 12621046 16354765 15340226 15668235
MESH:D003110 Colonic Neoplasms Quercetin 2.4517148506 19056647 16640504 11134977 19440933 17191121 15741050
MESH:D015179 Colorectal Neoplasms Quercetin 2.1918852136 18095365
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003550 Cystic Fibrosis Acetylcysteine 4.5719747007
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.9019496084
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5716227642 19420014 11834606 10915739 19416960 19739265 11461765 11743745 18071297 14550746 14986274 12540782 12705907 12153990 15968718 12594235 11421492 19164858 17522070 19923254 16781746 11529661 14725611 10663392 12958197 11739529 15619225 17906064 16109766 2444490 16485898 11287661 19085960 18713872 12392966 16177239 16393943 19370779 16081117 10774834 17562736
MESH:D056486 Drug-Induced Liver Injury Acetylcysteine 6.5711287661
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004417 Dyspnea Furosemide 5.2616935035
MESH:D004487 Edema Furosemide 7.7911834646
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.7912711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2215322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005264 Femoral Fractures zoledronic acid 6.1116234978
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Quercetin 9.6419474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.6420067830
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005909 Glioblastoma Quercetin 3.5219804834
MESH:D005910 Glioma Quercetin 3.1217643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D034381 Hearing Loss Furosemide 5.0117868369
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4311294989 10048152
MESH:D006333 Heart Failure Furosemide 4.1816845234 12660669 16011733
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1515340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.368697196 15340226 16959395 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 8.5616870215
MESH:D006930 Hyperalgesia zoledronic acid 8.5616769263
MESH:D006934 Hypercalcemia Furosemide 12.0017652376
MESH:D006934 Hypercalcemia zoledronic acid 12.0018089816 19622757
MESH:D053565 Hypercalciuria Furosemide 5.9417652376
MESH:D006943 Hyperglycemia Quercetin 4.2218262572 11834736
MESH:D006962 Hyperparathyroidism, Secondary Furosemide 6.1915086907
MESH:D006973 Hypertension Quercetin 5.4518356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.4518850075 18670907
MESH:D046110 Hypertension, Pregnancy-Induced Furosemide 5.5416612254
MESH:D006996 Hypocalcemia zoledronic acid 6.5112669777
MESH:C537153 Hypomagnesemia primary Furosemide 5.9411041285
MESH:D007019 Hypoproteinemia Furosemide 6.1916096441
MESH:D007022 Hypotension Furosemide 10.6111041285
MESH:D007022 Hypotension Isoflurane 10.6112967683
MESH:D007024 Hypotension, Orthostatic Furosemide 5.7315811171
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.5712878042 12200463
MESH:D007249 Inflammation Tobacco Smoke Pollution 5.5718590791
MESH:D007251 Influenza, Human Quercetin 4.8216624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007627 Keloid Quercetin 5.2117086741
MESH:D007674 Kidney Diseases Acetaminophen 10.8815629191 12587719
MESH:D007674 Kidney Diseases Furosemide 10.8811041285
MESH:D007674 Kidney Diseases Quercetin 10.8816962696
MESH:D007938 Leukemia Quercetin 3.2517468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 4.9718089816
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 2.5012741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.5012878042
MESH:D008107 Liver Diseases Acetaminophen 1.6719014921 11587558 12969438 19784758 19460945 12587719 16611625 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4316871587 17185352
MESH:D008113 Liver Neoplasms Quercetin 4.7818980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7816984957
MESH:D008114 Liver Neoplasms, Experimental Quercetin 6.3319519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.3312151625
MESH:D008171 Lung Diseases Acetylcysteine 4.1812815614
MESH:D008175 Lung Neoplasms Quercetin 3.6716280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.6719555203 11884234
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 3.6711091918 3440675 12111688 16288123
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 3.8417312309
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008654 Mesothelioma zoledronic acid 3.8216675582
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 4.5015006635
MESH:D009101 Multiple Myeloma zoledronic acid 4.2216996129 18089719 19621390
MESH:D009203 Myocardial Infarction Quercetin 3.0619595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.9519207477
MESH:D009362 Neoplasm Metastasis Acetylcysteine 6.7414720322
MESH:D009362 Neoplasm Metastasis zoledronic acid 6.7417312309 15867366 19139120
MESH:D009369 Neoplasms Quercetin 2.8815185748
MESH:D009397 Nephrocalcinosis Furosemide 6.1915086907
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009436 Neural Tube Defects Acetylcysteine 4.1519446573
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D020078 Neurogenic Inflammation Quercetin 4.5817929310
MESH:D053206 Nocturnal Enuresis Furosemide 6.1917945291
MESH:D010014 Osteolysis zoledronic acid 5.6515867366
MESH:D010024 Osteoporosis zoledronic acid 4.1517882678
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.4419495926
MESH:D010051 Ovarian Neoplasms Quercetin 2.7819005980
MESH:D010146 Pain Acetaminophen 7.5416870215
MESH:D010146 Pain zoledronic acid 7.5416475674
MESH:D010190 Pancreatic Neoplasms Quercetin 2.9116965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D010538 Peritonitis Isoflurane 5.4817414419
MESH:D011141 Polyuria Furosemide 5.9417945291
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011230 Precancerous Conditions Quercetin 4.1619056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811222880 11896295 11399792 11118676
MESH:D011471 Prostatic Neoplasms Quercetin 3.7214715546 17292933
MESH:D011471 Prostatic Neoplasms zoledronic acid 3.7219103299 12438248
MESH:D012021 Reflex, Abnormal Pentobarbital 6.3110930210
MESH:D015427 Reperfusion Injury Furosemide 4.0016526316
MESH:D012128 Respiratory Distress Syndrome, Adult Acetylcysteine 10.4612210543
MESH:D012128 Respiratory Distress Syndrome, Adult Furosemide 10.4615912074 16096441 12394941
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.8818410779
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012512 Sarcoma, Ewing's zoledronic acid 5.1716121404
MESH:D012554 Schistosomiasis japonica Quercetin 5.8616862918
MESH:D012640 Seizures Pentobarbital 4.029754883 10087439
MESH:D018805 Sepsis Isoflurane 5.1617414419
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.1916192470
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 6.1918590791
MESH:D013274 Stomach Neoplasms Furosemide 2.8617052386
MESH:D013276 Stomach Ulcer Acetylcysteine 4.2017918041
MESH:D013375 Substance Withdrawal Syndrome Pentobarbital 5.179754883 11529278
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D001749 Urinary Bladder Neoplasms Quercetin 5.8216720314
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 5.8212846360
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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