AutismKB 2.0

Annotation Detail for CARHSP1


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Basic Information Top
Gene Symbol:CARHSP1 ( CRHSP-24,CSDC1,MGC111446 )
Gene Full Name: calcium regulated heat stable protein 1, 24kDa
Band: 16p13.2
Quick LinksEntrez ID:23589; OMIM: NA; Uniprot ID:CHSP1_HUMAN; ENSEMBL ID: ENSG00000153048; HGNC ID: 17150
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CARHSP1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CARHSP1 mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of CARHSP1 mRNAincreases expression 16788091
D000082 Acetaminophen Acetaminophen affects the expression of CARHSP1 mRNAaffects expression 17562736
C014347 decitabine decitabine results in increased expression of CARHSP1 mRNAincreases expression 17908484
D004041 Dietary Fats Dietary Fats results in decreased expression of CARHSP1 mRNAdecreases expression 18042831
D002117 Calcitriol Calcitriol results in increased expression of CARHSP1 mRNAincreases expression 16002434
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of CARHSP1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CARHSP1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CARHSP1 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of CARHSP1 mRNAdecreases expression 17108234
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of CARHSP1 mRNAincreases expression 17616710
C041786 palm oil palm oil results in decreased expression of CARHSP1 mRNAdecreases expression 18042831
C006253 pirinixic acid pirinixic acid results in increased expression of CARHSP1 mRNAincreases expression 17426115
18301758
D013629 Tamoxifen Tamoxifen affects the expression of CARHSP1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CARHSP1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CARHSP1 mRNAdecreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6814745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9611752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.3016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.3016835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001161 Arteriosclerosis Dietary Fats 10.2615238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.2611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms Calcitriol 2.3611237771
MESH:D001943 Breast Neoplasms decitabine 2.3618320071 19208741
MESH:D001943 Breast Neoplasms Dietary Fats 2.3620435547
MESH:D001943 Breast Neoplasms Tamoxifen 2.3616202921 20135344 20544844 11161223 19142967 18425577 19084267 20005174 15565566 18351453 19155303 19289846 15668708 18984771 18629630 19059307 18855134 19103187 19115204 17440819 16273361 17261762 19189210 19410462 18821012 19244106 20065188 21138602 17893378 20390343 16873071 16818667 19200415 19288272 20859285 19011961 17242785 21152245 19487384 19066611 17049068 18997820 19189212 18815881 19221464
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3620435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6119066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.6516705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.6516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.653084413
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.6516924424
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.9611237771
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.9619215824
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6917572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.826135515
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.9415861022 17333356 11677210 17110522 16919318 17681005 16105132
MESH:D002779 Cholestasis pirinixic acid 7.9419176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1315668235 15340226 16354765 12621046 8697196
MESH:D003110 Colonic Neoplasms decitabine 2.3517616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.2518551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.2518551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4719031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5519279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.1318551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.1318551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.1315968718 12153990 14986274 11739529 19416960 12594235 18071297 15619225 11461765 11743745 16227642 19420014 11834606 19164858 11421492 19739265 16781746 10663392 17522070 12540782 14725611 11287661 12705907 14550746 16109766 18713872 12392966 17906064 12958197 10915739 16393943 11529661 2444490 19085960 17562736 10774834 16485898 16177239 19370779 19923254 16081117
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.1320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5118367378
MESH:D004487 Edema pirinixic acid 6.8112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0415322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 15.9215138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 15.9212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 15.9219031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.2519294695
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1017893378 20544844 16202921 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.109294722 10568697
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 2.7915878914 16704527 15264214 16805852 15623463 15150132 16510608 15547721 15547733
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Dietary Fats 19.4519004024 17967931 19551842 18296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.4515345470
MESH:D005234 Fatty Liver pirinixic acid 19.4519236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 19.4514986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2816709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3019069698
MESH:D005355 Fibrosis Dietary Fats 8.9718296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9720067830
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.5419215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3711294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5820558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly pirinixic acid 8.6119176532 18467677 16221962 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.6112621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1816959395 16354765 8697196 18606429 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6721332399
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.7021332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male decitabine 6.9017581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.9017937319
MESH:D007249 Inflammation Dietary Fats 8.5120412841
MESH:D007249 Inflammation Tamoxifen 8.5119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.5112200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 7.4218457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.4216306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2412587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.8116705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.8116705839
MESH:D007680 Kidney Neoplasms Tamoxifen 12.8118625569
MESH:D007938 Leukemia decitabine 3.1118980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 4.0819117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3918460780 18704418 19010910 18206229 17679729 19387464
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.6018055864
MESH:D008064 Lipidoses Tamoxifen 3.2117567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9218296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4315474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.4318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4312878042
MESH:D008107 Liver Diseases Acetaminophen 1.6512969438 11587558 19014921 12587719 19460945 16611625 16610002 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3116871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.917678174
MESH:D008113 Liver Neoplasms pirinixic acid 10.9116377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 10.9116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.9116984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.902876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9012151625
MESH:D008175 Lung Neoplasms Tamoxifen 2.2718625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2719555203 11884234
MESH:D008223 Lymphoma decitabine 3.4719470736
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.8819428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6719196723 19196722 16827153 11731420 14580682
MESH:D020149 Manganese Poisoning Tamoxifen 4.6819453300
MESH:D008545 Melanoma decitabine 3.4416505122 17785578
MESH:D008545 Melanoma Tamoxifen 3.4412393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3015990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D009101 Multiple Myeloma decitabine 3.4018172295
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4316882708 19010910 18608210 19157545
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0116411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.7418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.747678174 18551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5419410462
MESH:D009369 Neoplasms decitabine 5.1519470736 19116145 17925555
MESH:D009369 Neoplasms pirinixic acid 5.1517405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1319200415 19189210 19196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D009765 Obesity Dietary Fats 4.4918457598 17217161 16723640 20518802 11836018 18674790 20132043 21332399 19632207
MESH:D009765 Obesity pirinixic acid 4.4920558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.1416049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.1416049721
MESH:D010051 Ovarian Neoplasms decitabine 2.6719331143 19259094
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010190 Pancreatic Neoplasms decitabine 2.7919294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111896295 11222880 11118676 11399792
MESH:D055728 Primary Myelofibrosis decitabine 4.8317616702
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.9015572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.3212479363 18247401 16289102 16644109 15754350
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.3215067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.4315861022 16919318
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.4919155313
MESH:D012640 Seizures 2,4-dinitrotoluene 6.0518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.0518551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.0116709447
MESH:D013088 Spermatocele Tamoxifen 12.0116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1519457130
MESH:D013274 Stomach Neoplasms decitabine 2.7619037991
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.7612958204 17575124
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms decitabine 3.3917967635
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.1816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.1816049721
MESH:D001749 Urinary Bladder Neoplasms decitabine 12.1819087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 12.1817572228 8653321 16712894
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.3910091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.3910091137
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D014604 Uveal Neoplasms decitabine 5.0517785578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D015430 Weight Gain Dietary Fats 3.8116723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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