AutismKB 2.0

Annotation Detail for PDSS1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PDSS1 ( COQ1,DPS,MGC70953,RP13-16H11.3,SPS,TPRT,TPT,hDPS1 )
Gene Full Name: prenyl (decaprenyl) diphosphate synthase, subunit 1
Band: 10p12.1
Quick LinksEntrez ID:23590; OMIM: 607429; Uniprot ID:DPS1_HUMAN; ENSEMBL ID: ENSG00000148459; HGNC ID: 17759
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5120geranylgeranyldiphosphate biosynthesis
PWY-5910superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
Pathway IDPathway Name
hsa00900Terpenoid backbone biosynthesis
No data
No data
Pathway IDPathway Name
P00014Cholesterol biosynthesis
No data
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Coenzyme Q10 deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C015001 arsenite [arsenite co-treated with Benzo(a)pyrene] results in decreased expression of PDSS1 mRNAaffects cotreatment|decreases expression 15894712
C015001 arsenite arsenite results in decreased expression of PDSS1 mRNAdecreases expression 15894712
D001564 Benzo(a)pyrene [arsenite co-treated with Benzo(a)pyrene] results in decreased expression of PDSS1 mRNAaffects cotreatment|decreases expression 15894712
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PDSS1 mRNAdecreases expression 15894712
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PDSS1 mRNAdecreases expression 20382639
D016572 Cyclosporine Cyclosporine results in decreased expression of PDSS1 mRNAdecreases expression 20106945
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PDSS1 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PDSS1 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of PDSS1 mRNAincreases expression 18301758
17950772
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of PDSS1 mRNA]increases expression|increases reaction 17950772
D014635 Valproic Acid Valproic Acid results in decreased expression of PDSS1 mRNAdecreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.958875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2519490988
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.826695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D000550 Amblyopia Valproic Acid 5.7517688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.8317497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4919183758
MESH:D001321 Autistic Disorder Valproic Acid 1.9918396377 18316065 19232924 18177632 17688650 17507914 18775368 18558336 16609825 20603192 18940202 15238991 17157402 18985861 19460635
MESH:D001714 Bipolar Disorder Valproic Acid 3.2117594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.598888407
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0020146248 17474063
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1220419170
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2620889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.2612371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8020734317
MESH:D002779 Cholestasis Cyclosporine 8.5319486331
MESH:D002779 Cholestasis pirinixic acid 8.5319176532
OMIM:607426 COENZYME Q10 DEFICIENCY marker/mechanism
MESH:D003110 Colonic Neoplasms arsenite 2.6215037631
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 16575769 8888407
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.2419641884 1733752
MESH:D004421 Dystonia Valproic Acid 4.401851702
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.573659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.4416628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0718234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.876254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.717750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.533659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5720426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5716530937
MESH:D005234 Fatty Liver arsenite 21.6618296743
MESH:D005234 Fatty Liver Cyclosporine 21.6619224547
MESH:D005234 Fatty Liver pirinixic acid 21.6619236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 21.6619224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.4116575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.518888407 18558336
MESH:D005355 Fibrosis arsenite 10.3218296743
MESH:D005355 Fibrosis Cyclosporine 10.3212168785 12639820
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8020471113
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006529 Hepatomegaly pirinixic acid 3.4119176532 18467677 16221962 19772884
MESH:D006849 Hydrocephalus Valproic Acid 5.3317688650
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D006973 Hypertension Cyclosporine 2.1910903974
MESH:D007333 Insulin Resistance pirinixic acid 2.8216306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.5018776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0012371664
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1917596541 16294345
MESH:D008103 Liver Cirrhosis arsenite 3.5718296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.7021137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 4.7020007298 15890375 16377806
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7817228818
MESH:D008175 Lung Neoplasms arsenite 2.6716809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.6718816296 20135361 18569708 6695378 20064080 18520028 20869020 17053015 20464547
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D008881 Migraine Disorders Valproic Acid 3.4118803445 18765137
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4316381670
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.358888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3117596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009369 Neoplasms Benzo(a)pyrene 5.2811141357
MESH:D009369 Neoplasms pirinixic acid 5.2817405874
MESH:D009389 Neovascularization, Pathologic arsenite 4.8715738583
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5719348381 18481113
MESH:D009436 Neural Tube Defects Valproic Acid 3.328888407 16359493
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D011230 Precancerous Conditions Cyclosporine 3.5112371664
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.2920603192
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9217292933
MESH:D019310 Pseudolymphoma Valproic Acid 5.0612752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.5319155313
MESH:D012559 Schizophrenia Valproic Acid 2.1019110320 15737665
MESH:D012640 Seizures Valproic Acid 2.943137016 1511512 14763951 11044598 16876388 11738929 17978042 15475178
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4919755658 10029692
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0219490988
MESH:D013226 Status Epilepticus Valproic Acid 5.0612833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D014178 Translocation, Genetic Valproic Acid 5.7517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.983119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2817053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.068888407
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
Pathway ID Pathway Name
KEGG:00900 Terpenoid backbone biosynthesis
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved