AutismKB 2.0

Annotation Detail for OPN3


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Basic Information Top
Gene Symbol:OPN3 ( ECPN )
Gene Full Name: opsin 3
Band: 1q43
Quick LinksEntrez ID:23596; OMIM: 606695; Uniprot ID:OPN3_HUMAN; ENSEMBL ID: ENSG00000054277; HGNC ID: 14007
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Signaling by GPCR
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of OPN3 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of OPN3 mRNAincreases expression 20106945
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of OPN3 mRNAdecreases expression 15336504
D003520 Cyclophosphamide OPN3 protein affects the susceptibility to Cyclophosphamideaffects response to substance 16217747
D016572 Cyclosporine Cyclosporine results in decreased expression of OPN3 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of OPN3 mRNAdecreases expression 18042831
D007501 Iron Iron deficiency results in decreased expression of OPN3 mRNAdecreases expression 20368581
C041786 palm oil palm oil results in decreased expression of OPN3 mRNAdecreases expression 18042831
D011374 Progesterone Progesterone results in increased expression of OPN3 mRNAincreases expression 18037150
C017947 sodium arsenite sodium arsenite results in increased expression of OPN3 mRNAincreases expression 19072884
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of OPN3 mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0415322242 14514962 11752688
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.736695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.9215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.1217306315 16712894
MESH:D019896 alpha 1-Antitrypsin Deficiency Iron 5.8516640825
MESH:D000544 Alzheimer Disease Iron 3.0316640825 16563566
MESH:D000740 Anemia Iron 9.3716566752 16434484
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.3711748828
MESH:D018798 Anemia, Iron-Deficiency Iron 4.7817147795 17163184 16569441 17162259 17375513
MESH:D000756 Anemia, Sideroblastic Iron 4.9516910769
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001145 Arrhythmias, Cardiac Iron 4.5016604332
MESH:D001161 Arteriosclerosis Cyclophosphamide 10.9215014928
MESH:D001161 Arteriosclerosis Dietary Fats 10.9215238619
MESH:D001260 Ataxia Telangiectasia Iron 5.6415336622
MESH:D050197 Atherosclerosis Iron 3.7816640825 16632123
MESH:D001321 Autistic Disorder Acetaminophen 2.1418445737
MESH:D001321 Autistic Disorder Iron 2.1417352947
MESH:D001424 Bacterial Infections Iron 5.3916640825
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.5617868700
MESH:D001930 Brain Injuries Progesterone 4.4315665606 15380490 15845082
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3820146248 17474063
MESH:D001943 Breast Neoplasms Cyclophosphamide 2.3815136595 11325840 16978400 18234424 17020986 17388661 15093573 18323546 12006526
MESH:D001943 Breast Neoplasms Dietary Fats 2.3820435547
MESH:D001943 Breast Neoplasms Progesterone 2.3815562024 17614352 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3820435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.763084413
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 4.7619701751
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 4.7615276417 17306315 16507464
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 5.0816152834
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 3.5916201981
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7220419170
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.7218572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4416120746 18850075 18670907
MESH:D009202 Cardiomyopathies Iron 4.1316640825
MESH:D002311 Cardiomyopathy, Dilated Iron 3.5016604332
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.9712371664
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.9720056578 19524636
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Cyclosporine 3.0219486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1515340226 8697196 12621046 16354765 15668235
MESH:D003110 Colonic Neoplasms Iron 2.9116640825
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 15322242 10048152
MESH:D003556 Cystitis Cyclophosphamide 5.2010498854 16413132 15276878 17010015 17979934 16614059 11948286 18093676 18710439 18372110 16989017 18433785 12161096 12913760 10700343 16651033 18295254 12388444 15643279 18483878
MESH:D003920 Diabetes Mellitus Iron 4.5816640825 16604332
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 4.1815331540 11751995 10990075
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 6.1018772604
MESH:D003922 Diabetes Mellitus, Type 1 Iron 6.1016506275
MESH:D003924 Diabetes Mellitus, Type 2 Iron 4.6516506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.6517107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.6717187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.6811834606 15619225 18071297 11287661 12958197 12392966 19085960 10663392 16485898 11529661 16081117 2444490 17562736 19923254 14986274 19420014 12594235 19739265 17522070 11739529 16781746 11743745 11421492 10774834 19416960 18713872 16393943 14550746 16177239 12153990 14725611 17906064 19370779 10915739 19164858 12540782 12705907 16227642 16109766 15968718 11461765
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.6820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5518367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1216714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.9417692515
MESH:D004715 Endometriosis Progesterone 9.3716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.3710568697 9294722
MESH:D004802 Eosinophilia Cyclophosphamide 4.3911006010
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0416530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Cyclosporine 14.0719224547
MESH:D005234 Fatty Liver Dietary Fats 14.0717967931 18296743 19551842 19004024
MESH:D005234 Fatty Liver Iron 14.0716640825
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Cyclosporine 15.7812639820 12168785
MESH:D005355 Fibrosis Dietary Fats 15.7818296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.7820067830
MESH:D005621 Friedreich Ataxia Iron 5.6016604332 16640825
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8716452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D018316 Gliosarcoma Cyclophosphamide 5.7111389073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 5.2111014644 15172196 16376943
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6710048152 11294989
MESH:D006432 Hemochromatosis Iron 4.5916574947 17236123 17053826 17255318 16640825 16604332
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006467 Hemophilia A Cyclophosphamide 5.4711918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006486 Hemosiderosis Iron 5.4316604332
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.7514986274
MESH:D006525 Hepatitis, Viral, Human Iron 5.6916640825
MESH:D006527 Hepatolenticular Degeneration Iron 5.1117182432
MESH:D006529 Hepatomegaly Iron 9.3416890145
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.3416120746 12621046 15340226
MESH:D015658 HIV Infections Iron 3.7416597321
MESH:D006689 Hodgkin Disease Cyclophosphamide 8.0317606976 16135485
MESH:D006689 Hodgkin Disease sodium arsenite 8.0312676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2616959395 18606429 15340226 8697196 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7321332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.7621332399
MESH:D006973 Hypertension Cyclosporine 5.1010903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1018670907 18850075
MESH:D007006 Hypogonadism Iron 4.5016640825
MESH:D007037 Hypothyroidism Iron 5.2616640825
MESH:D007154 Immune System Diseases Cyclophosphamide 5.5516076520
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.5815869954
MESH:D007248 Infertility, Male Cyclophosphamide 7.3616517039 7193160
MESH:D007248 Infertility, Male sodium arsenite 7.3615346721 12646999
MESH:D007249 Inflammation Dietary Fats 8.7120412841
MESH:D007249 Inflammation Progesterone 8.7115869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.7112200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 3.1918457598 11836018
MESH:D019189 Iron Metabolism Disorders Iron 5.1917163184
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Acetaminophen 10.4515629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 10.4518776723 10903974 8314463
MESH:D007674 Kidney Diseases sodium arsenite 10.4520008137
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8512371664
MESH:D007938 Leukemia Cyclophosphamide 3.5510602166
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.5518172266 17296974 17008537 17658394 17802794 18587576
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 4.1910373061
MESH:D007970 Leukopenia Cyclophosphamide 5.1611830472 10052129
MESH:D020961 Lewy Body Disease Iron 5.6016563566
MESH:D008103 Liver Cirrhosis Dietary Fats 7.2118296743
MESH:D008103 Liver Cirrhosis Iron 7.2116640825
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Acetaminophen 1.6619460945 16611625 19014921 11587558 12969438 12587719 19784758 16610002
MESH:D008108 Liver Diseases, Alcoholic Iron 5.1816737972 17207112
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3717185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.1421137059 20195826
MESH:D008113 Liver Neoplasms Iron 11.1416640825 20302851
MESH:D008113 Liver Neoplasms sodium arsenite 11.1416712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.1416984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1912151625
MESH:D008171 Lung Diseases sodium arsenite 3.2619095001
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9918816296 6695378 18520028 20869020 18569708 17053015 20464547 20064080 20135361
MESH:D008175 Lung Neoplasms Iron 4.9916640825
MESH:D008175 Lung Neoplasms sodium arsenite 4.9917077188 16712894 15276417 17306315 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9911884234 19555203
MESH:D008223 Lymphoma Cyclophosphamide 3.9312854902
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.7516675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 4.2811911406
MESH:D008268 Macular Degeneration Iron 4.0516640825
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 2.9517203775 11408345
MESH:D008545 Melanoma sodium arsenite 2.0519082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 11.4319513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 11.4316388313
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D020528 Multiple Sclerosis, Chronic Progressive Iron 5.8917086897
MESH:D009181 Mycoses Iron 5.6916640825
MESH:D017202 Myocardial Ischemia Iron 9.5516604332
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.5512213967
MESH:D015428 Myocardial Reperfusion Injury Iron 4.3716604332
MESH:D009369 Neoplasms Benzo(a)pyrene 8.7411141357
MESH:D009369 Neoplasms Cyclophosphamide 8.7418854779
MESH:D009369 Neoplasms sodium arsenite 8.7411559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8420056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 9.9019348381 18481113
MESH:D009404 Nephrotic Syndrome Iron 9.9017178036
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.2312854658
MESH:D009447 Neuroblastoma Cyclophosphamide 3.708761367 16115947 15176712
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.9118514411
MESH:D019636 Neurodegenerative Diseases Iron 8.9117296847 16604332
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 5.0812837982 8761367
MESH:D009503 Neutropenia Cyclophosphamide 4.478291058
MESH:D009765 Obesity Dietary Fats 2.3111836018 20518802 16723640 17217161 18457598 21332399 18674790 19632207 20132043
MESH:D009845 Oligospermia Cyclophosphamide 4.9016517039
MESH:D010003 Osteoarthritis Iron 4.0416640825
MESH:D010024 Osteoporosis Iron 3.9416640825 16648989
MESH:D010051 Ovarian Neoplasms Progesterone 5.0817393432 16525653
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.0817306315 15276417
MESH:D010146 Pain Acetaminophen 7.2416870215
MESH:D010146 Pain Cyclophosphamide 7.2412161096 18093676
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 3.2311332152
MESH:D010212 Papilloma Iron 4.6612065085
MESH:D020447 Parasomnias Iron 6.2417352947
MESH:D010300 Parkinson Disease Iron 3.3616563566 16640825
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D010900 Pituitary Diseases Iron 5.8916604332
MESH:D011041 Poisoning Iron 4.4416604332
MESH:D017119 Porphyria Cutanea Tarda Iron 11.5716640825
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 11.5718163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.8721297632
MESH:D011225 Pre-Eclampsia Iron 4.5316640825
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811118676 11399792 11896295 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6117292933
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.6117136230
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.6116039940
MESH:D011528 Protozoan Infections Iron 6.2416640825
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.3316636934
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012148 Restless Legs Syndrome Iron 4.6516930377
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9018045962
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.9716636934
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 18.5910029692 19755658
MESH:D012878 Skin Neoplasms Iron 18.5912065085
MESH:D012878 Skin Neoplasms sodium arsenite 18.5919524636 18572023
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 18.598532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 18.5916192470
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.7116517039
MESH:D013119 Spinal Cord Injuries Progesterone 4.4715862959 16503802
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9012854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013398 Sudden Infant Death Iron 5.6416640825
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 5.2512837982
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D014376 Tuberculosis Iron 4.1716597321
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.7017053015
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 8.7014692829
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.7011723127 17306315 16452187 16712894
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9011813266
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D014652 Vascular Diseases sodium arsenite 4.6217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D015430 Weight Gain Dietary Fats 3.8616723640
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
Pathway ID Pathway Name
REACT:14797 Signaling by GPCR
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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