AutismKB 2.0

Annotation Detail for AMACR


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Basic Information Top
Gene Symbol:AMACR ( CBAS4,RACE,RM )
Gene Full Name: alpha-methylacyl-CoA racemase
Band: 5p13.2
Quick LinksEntrez ID:23600; OMIM: 604489; Uniprot ID:AMACR_HUMAN; ENSEMBL ID: ENSG00000082196,ENSG00000242110; HGNC ID: 451
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00120Primary bile acid biosynthesis
hsa01100Metabolic pathways
hsa04146Peroxisome
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
No data
No data
Pathway IDPathway Name
500829Synthesis of bile acids and bile salts via 24-hydroxycholesterol
500820Beta-oxidation of pristanoyl-CoA
500827Synthesis of bile acids and bile salts
500828Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Related Diseases/Disorders Top
Desease IDDesease Name
H00407Peroxisomal beta-oxidation enzyme deficiency
Peroxisomal diseases
Genetic disorders
No data
Desease Name
prostate cancer
CANCER
No data
Desease Name
Alpha-methylacyl-CoA racemase deficiency
Bile acid synthesis defect, congenital, 4
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of AMACR mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of AMACR mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of AMACR mRNAdecreases expression 15084756
D000643 Ammonium Chloride Ammonium Chloride affects the expression of AMACR mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of AMACR mRNAincreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of AMACR mRNAincreases expression 19150397
C053541 bicalutamide bicalutamide results in decreased expression of AMACR mRNAdecreases expression 15638997
D002713 Chlorine Chlorine results in increased expression of AMACR mRNAincreases expression 18636392
D002713 Chlorine [Ozone co-treated with Chlorine] results in increased expression of AMACR mRNAaffects cotreatment|increases expression 18636392
D016572 Cyclosporine Cyclosporine results in decreased expression of AMACR mRNAdecreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of AMACR mRNAdecreases expression 19638242
D004128 Dimethylnitrosamine Dimethylnitrosamine results in decreased expression of AMACR mRNAdecreases expression 17072980
D004958 Estradiol Estradiol results in decreased expression of AMACR mRNAdecreases expression 20106945
C039281 furan furan results in decreased expression of AMACR mRNAdecreases expression 15120968
C029424 hydrazine hydrazine results in decreased expression of AMACR mRNAdecreases expression 15370871
D007052 Ibuprofen AMACR gene SNP affects the susceptibility to Ibuprofenaffects response to substance 17680641
D007052 Ibuprofen AMACR protein results in increased metabolism of and results in increased activity of Ibuprofenincreases activity|increases metabolic processing 17680641
D007052 Ibuprofen AMACR protein results in increased metabolism of Ibuprofenincreases metabolic processing 17684125
D008701 Methapyrilene Methapyrilene results in decreased expression of AMACR mRNAdecreases expression 15120968
D010126 Ozone [Ozone co-treated with Chlorine] results in increased expression of AMACR mRNAaffects cotreatment|increases expression 18636392
D017239 Paclitaxel Paclitaxel results in increased expression of AMACR mRNAincreases expression 15585946
C006253 pirinixic acid pirinixic acid results in increased expression of AMACR mRNAincreases expression 17426115
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.5218287403
MESH:D058186 Acute Kidney Injury Ibuprofen 4.416375363
MESH:D055371 Acute Lung Injury Chlorine 9.0120601635
MESH:D055371 Acute Lung Injury pirinixic acid 9.0118653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 10.1720464547 20127859
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 10.1716033868
MESH:D000230 Adenocarcinoma Estradiol 10.1711473722
MESH:D000230 Adenocarcinoma Ibuprofen 10.1710697514
MESH:D000236 Adenoma marker/mechanism 17684125
MESH:D000236 Adenoma Benzo(a)pyrene 11.096695378
MESH:D000236 Adenoma Diethylnitrosamine 11.0910737359 6695378
MESH:D000236 Adenoma Dimethylnitrosamine 11.0919555203
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.9817162532 19061943 18056438 19052882 16434500 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.9816434500
MESH:D000544 Alzheimer Disease Ibuprofen 4.5718351690
MESH:D000544 Alzheimer Disease Ozone 4.5715513908
MESH:D000707 Anaphylaxis Ibuprofen 5.219532969
MESH:D000799 Angioedema Acetaminophen 3.8110982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0319183758
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5515570426
MESH:D001249 Asthma Ozone 2.6216373670 17854713
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:C535444 Bile acid synthesis defect, congenital, 4 marker/mechanism
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.1119483382
MESH:D001859 Bone Neoplasms Paclitaxel 4.5315867366
MESH:D002545 Brain Ischemia Ibuprofen 4.8515837124
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9717474063 20146248
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9717474063
MESH:D001943 Breast Neoplasms Estradiol 1.9717261762 16675129 19861407 12948864 17289903 14630087 18497071 17018787
MESH:D001943 Breast Neoplasms Paclitaxel 1.9718223236 18323546 11325840 16273361 18234424 16244791 16115903 15136595
MESH:D016535 Bronchial Hyperreactivity Ozone 3.6418315731 16777450 19059883 15516495 17626835 14754758 18417511
MESH:D002100 Cachexia Ibuprofen 12.4515141370
MESH:D002100 Cachexia Ozone 12.4516183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4316111702
MESH:D002277 Carcinoma Dimethylnitrosamine 3.9919555203
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.8016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.803084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.8019519916 20512989 19394651 18971187 19335982 18691550 16779866 20432363 3581430 19919837 18978308 10737359 20084675 20101231 18785209 18056438 20007298 19418558 16807293 16681979 16540662 18788625 21159647 20727157 16830150 10672840 19822196 19208518 16698587 16328049 17428255 16502159 3084413 16935385 19052882 19383236 17173139 16569478 11831363 16878318 16288022 20514400 18210153 18494052 20935162 17055752 18506893 19107877 19539802 20214788 19171122 17162532 17978847 18393292 20524982 17761372 17138121 18665156 19701751
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.8016924424
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 8.8016313753
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7720419170
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 4.7716033868
MESH:D002386 Cataract Acetaminophen 2.5510977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 20.766135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 20.7620889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 20.7612371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 20.762727394 7505956 17174075 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 20.7618566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.6519052882
MESH:D002779 Cholestasis Cyclosporine 7.6519486331
MESH:D002779 Cholestasis pirinixic acid 7.6519176532
MESH:D015179 Colorectal Neoplasms marker/mechanism 17684125
MESH:D015179 Colorectal Neoplasms Paclitaxel 2.4418802399
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.9818551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4018249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.1820387270
MESH:D003928 Diabetic Nephropathies Estradiol 3.3719279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.9021346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.9019739265 16393943 11287661 10663392 11834606 18713872 14986274 11529661 10915739 11743745 12958197 17562736 16109766 11739529 16177239 18071297 19085960 12540782 17906064 12705907 16081117 19370779 16227642 11461765 19420014 12392966 10774834 12153990 17522070 19416960 19923254 14550746 19164858 16485898 15968718 16781746 12594235 14725611 15619225 2444490 11421492
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.9019107877
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 8.908172417
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0719426721
MESH:D004374 Ductus Arteriosus, Patent Ibuprofen 5.5816133044 18446180 18450898
MESH:D004417 Dyspnea Chlorine 4.6020016425
MESH:D004487 Edema pirinixic acid 2.4412083418
MESH:D016889 Endometrial Neoplasms Estradiol 2.9518566989 11473722 19148513
MESH:D004715 Endometriosis Ibuprofen 4.5715652904
MESH:D019446 Endotoxemia Ibuprofen 4.9311545620
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0916302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.3620426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 10.3616530937
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 10.3617016578
MESH:D004938 Esophageal Neoplasms Paclitaxel 10.3616481741
MESH:D005234 Fatty Liver Cyclosporine 12.8219224547
MESH:D005234 Fatty Liver Diethylnitrosamine 12.8221071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 12.8219236843 20131406
MESH:D005334 Fever Ibuprofen 4.5416997862
MESH:D005355 Fibrosis Cyclosporine 3.1012639820 12168785
MESH:D005739 Gas Poisoning Chlorine 4.9820016425
MESH:D005756 Gastritis Acetaminophen 3.6516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.188708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6320471113
MESH:D006333 Heart Failure pirinixic acid 2.5120558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3915720958
MESH:D006529 Hepatomegaly pirinixic acid 2.9618467677 19772884 16221962 19176532
MESH:D015417 Hereditary Sensory and Motor Neuropathy marker/mechanism
MESH:D006558 Herpes Genitalis Estradiol 5.0015709030
MESH:D019584 Hot Flashes Estradiol 3.7217088409
MESH:D006930 Hyperalgesia Acetaminophen 2.6616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.1420558911
MESH:D006973 Hypertension Cyclosporine 2.0810903974
MESH:D006984 Hypertrophy Ibuprofen 4.9316672835
MESH:D007235 Infant, Premature, Diseases Ibuprofen 5.8116133044
MESH:D007249 Inflammation Diethylnitrosamine 5.4018785209
MESH:D007249 Inflammation Ibuprofen 5.403291741
MESH:D007333 Insulin Resistance Estradiol 7.1016393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.1016306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4115604871
MESH:D007674 Kidney Diseases Acetaminophen 9.8312587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.838314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 9.8315618244
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.1516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.1512371664
MESH:D007680 Kidney Neoplasms Estradiol 12.1515610895
MESH:D008080 Liposarcoma Paclitaxel 4.7817353645
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8018407596 19638242 18665156 20032147 18522880
MESH:D008106 Liver Cirrhosis, Experimental marker/mechanism 17072980
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 3.5118567088 14643895 17196135 15369754 17640959 14726149 15842777 15383259 15798949 17203207 12918455 17201889 15733078 16570917 15504291 16009107 18629640 17724770 16270385 14568256 15086199 15723089 15366600 15161499 18210741 16603200 17534399 15571005 18237412 15591649 15793283 17666798 15138612 14659978 18371158 17465448 15298665 15864749 18637143 18095165 15339415 15099470 16544323 16627068 15744066 17432682 18239293 17881167 15763062 17198567 15577212 17719030 17036385 18672772 14709902 15942678 18364076 15492853 15081153 12925901 16169303 15067225 16042886 17348192 15479170
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5114659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5115474484
MESH:D008107 Liver Diseases Acetaminophen 3.8719014921 16611625 11587558 12969438 16610002 19784758 12587719 19460945
MESH:D008107 Liver Diseases Diethylnitrosamine 3.8717034775
MESH:D017114 Liver Failure, Acute Acetaminophen 9.5416871587 17185352
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 9.5417457977
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 17.797678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 17.7921137059 20195826
MESH:D008113 Liver Neoplasms Diethylnitrosamine 17.7920452335 20405173 19812893 19427195 18648771 19073162 20118626 2862719 15885732 21167192 19850985 21071580 2422723 19642983 20101389 19833225 19254457 21047994 18978307 16942905 20434301 19255062 19294768 19996281 15175105 20583210 19551842 10737359 19090486 20492335 20501860 19426721 18977376 9163691 19690152 19256749 19638242 18644402 12112319 20137499 18754104 12771043 19499222 21278145
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 17.7915890375 3113478
MESH:D008113 Liver Neoplasms Methapyrilene 17.7915890375
MESH:D008113 Liver Neoplasms pirinixic acid 17.7920007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.796135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 9.7921159647 18775883 2563599 18253720 17854601 18164116 19009564 17942915 19539802 9362446 18079962 16842330 18544905 18308698 19004024 3124819 17174075 19519916 16267830 18093689 19126423 18282651
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 9.791848544 15603536 6150874
MESH:D008171 Lung Diseases Ozone 3.358266340 19066396
MESH:D055370 Lung Injury Ozone 3.8120417186
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.8517053015 20869020 18520028 20135361 20464547 18569708 6695378 18816296 20064080
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.8520970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 4.8516061637 11884234 19555203
MESH:D008175 Lung Neoplasms Ozone 4.858597069 7614698
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 4.0514749477
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.2717203775 16891317 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Ibuprofen 6.2710697514
MESH:D020149 Manganese Poisoning Estradiol 4.4519453300
MESH:D008545 Melanoma Paclitaxel 2.5816342250 12025231 12040289
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5319513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7616801185
MESH:D008679 Metaplasia Ozone 5.0810496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1516381670
MESH:D009101 Multiple Myeloma Paclitaxel 3.6514749477
MESH:D009135 Muscular Diseases pirinixic acid 3.4716239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1219151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.1316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.1316411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.8318551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.933581430 9029167
MESH:D009362 Neoplasm Metastasis Paclitaxel 5.9315867366
MESH:D009369 Neoplasms Benzo(a)pyrene 4.7511141357
MESH:D009369 Neoplasms pirinixic acid 4.7517405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7017289903
MESH:D009395 Nephritis, Interstitial Ibuprofen 4.966375363
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2419348381 18481113
MESH:D009410 Nerve Degeneration Ibuprofen 4.3510961664
MESH:D009421 Nervous System Malformations Estradiol 3.6111399458 16427766
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.0618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.0620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0920387270
MESH:D009765 Obesity pirinixic acid 1.8020558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.3916049721
MESH:D010003 Osteoarthritis Ibuprofen 4.107009135
MESH:D010014 Osteolysis Paclitaxel 4.9415867366
MESH:D010051 Ovarian Neoplasms Estradiol 5.0019401270
MESH:D010051 Ovarian Neoplasms Paclitaxel 5.0011161223
MESH:D010146 Pain Acetaminophen 6.8416870215
MESH:D010146 Pain Ibuprofen 6.843291741
MESH:D010149 Pain, Postoperative Ibuprofen 5.1116678543
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.5716540662
MESH:D010190 Pancreatic Neoplasms Ibuprofen 5.5712384795
MESH:D010538 Peritonitis Ozone 4.0916369182
MESH:D011014 Pneumonia Ozone 4.3618381685 18929643 18007984
MESH:D011230 Precancerous Conditions Cyclosporine 8.8212371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.822563599
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8420887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 17173048
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.9017292933
MESH:D011471 Prostatic Neoplasms bicalutamide 1.9015638997 19240160 18487222 17914592 19011039
MESH:D011471 Prostatic Neoplasms Estradiol 1.9016740699
MESH:D011471 Prostatic Neoplasms Ibuprofen 1.9017409433
MESH:D011471 Prostatic Neoplasms Paclitaxel 1.9016356831 17172428 16729912 17136230
MESH:D011507 Proteinuria Ibuprofen 4.596375363
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.3619058328
MESH:D012120 Respiration Disorders Chlorine 5.1818579056
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5018551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.3510029692 19755658
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.2412587719
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.7320155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.7318456281
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 4.7316033868
MESH:D013274 Stomach Neoplasms Paclitaxel 4.7318396642 18506536
MESH:D024801 Tauopathies Paclitaxel 4.7816930453
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.957505956
MESH:D013978 Tibial Fractures Estradiol 4.6619048282
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 4.9116049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.9117053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.2810091137
MESH:D014581 Urticaria Acetaminophen 2.9410982225
MESH:D014605 Uveitis Cyclosporine 3.961336536
MESH:D020301 Vasospasm, Intracranial Ibuprofen 5.1519057314
MESH:D014985 Xerophthalmia Cyclosporine 4.4117120751
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:04146 Peroxisome
KEGG:00120 Primary bile acid biosynthesis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24757
    • No data
    No data
    Releated drug ID Related drug Name
    PA449789glycine
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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