AutismKB 2.0

Annotation Detail for DAPK2


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Basic Information Top
Gene Symbol:DAPK2 ( DRP-1,DRP1,MGC119312 )
Gene Full Name: death-associated protein kinase 2
Band: 15q22.31
Quick LinksEntrez ID:23604; OMIM: NA; Uniprot ID:DAPK2_HUMAN; ENSEMBL ID: ENSG00000035664; HGNC ID: 2675
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05219Bladder cancer
hsa05200Pathways in cancer
Pathway IDPathway Name
Apoptosis
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of DAPK2 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of DAPK2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of DAPK2 mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone results in increased expression of DAPK2 mRNAincreases expression 19774075
C014347 decitabine decitabine results in increased expression of DAPK2 mRNAincreases expression 19037991
D004041 Dietary Fats Dietary Fats results in increased expression of DAPK2 mRNAincreases expression 18042831
D005665 Furosemide Furosemide affects the expression of DAPK2 mRNAaffects expression 17497460
C041786 palm oil palm oil results in increased expression of DAPK2 mRNAincreases expression 18042831
D010672 Phenytoin Phenytoin results in decreased expression of DAPK2 mRNAdecreases expression 14741686
C006253 pirinixic acid pirinixic acid results in decreased expression of DAPK2 mRNAdecreases expression 17426115
C006253 pirinixic acid pirinixic acid results in increased expression of DAPK2 mRNAincreases expression 18301758
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DAPK2 mRNAincreases expression 15310856
C012589 trichostatin A trichostatin A results in increased expression of DAPK2 mRNAincreases expression 16865256
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 15.347525203
MESH:D000014 Abnormalities, Drug-Induced Phenytoin 15.349677735 3425630 10563481 9118846 8986270 6195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 15.3414514962 15322242 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.4216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.4216835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.9020041841 18218290 18057881
MESH:D001161 Arteriosclerosis Dietary Fats 4.0315238619
MESH:D050197 Atherosclerosis Phenytoin 3.9815136057
MESH:D001281 Atrial Fibrillation Amiodarone 3.9819698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 15.9719483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.9719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.9712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001943 Breast Neoplasms decitabine 1.8819208741 18320071
MESH:D001943 Breast Neoplasms Dietary Fats 1.8820435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8820435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 2.8616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.863084413
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6219215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218850075 18670907 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9215710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.2418974383
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.6314694615
MESH:D002386 Cataract Acetaminophen 7.6310977129
MESH:D002493 Central Nervous System Diseases Phenytoin 5.444080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis pirinixic acid 2.9119176532
OMIM:601042 CHOREOATHETOSIS/SPASTICITY, EPISODIC Phenytoin 6.0211748493
MESH:D002971 Cleft Lip Phenytoin 4.202227380
MESH:D002972 Cleft Palate Phenytoin 6.302227380 6862529 6856622 3877104 10789828 1687470
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.3016354765 8697196 12621046 15340226 15668235
MESH:D003103 Coloboma Phenytoin 5.269212184
MESH:D003110 Colonic Neoplasms decitabine 2.3517616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 16.2315095906
MESH:D000013 Congenital Abnormalities Phenytoin 16.2310627286
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 16.2317141729 14669216
MESH:D019465 Craniofacial Abnormalities Phenytoin 2.8719952982 8986270 9212184
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.8720055451 10048152 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1518551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
OMIM:607208 DRAVET SYNDROME Phenytoin 5.5311748493
MESH:D003875 Drug Eruptions Phenytoin 5.6415024534
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.3518551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 12.3521346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.3512392966 16227642 18071297 17906064 11739529 11834606 11461765 19085960 16485898 15968718 17562736 16177239 11529661 16081117 19416960 12958197 19420014 10915739 12153990 14725611 11743745 19739265 16393943 11287661 18713872 16109766 10774834 16781746 12540782 14986274 10663392 11421492 19370779 15619225 14550746 19923254 12705907 12594235 2444490 19164858 17522070
MESH:D056486 Drug-Induced Liver Injury Amiodarone 12.3518218290 15265979
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.3520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5318367378
MESH:D004417 Dyspnea Furosemide 5.1116935035
MESH:D004487 Edema Furosemide 12.1711834646
MESH:D004487 Edema pirinixic acid 12.1712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.1712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0815322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Phenytoin 4.8017654737
MESH:D004701 Endocrine Gland Neoplasms decitabine 14.6219294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 14.6219294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.129294722 10568697
MESH:D004816 Epidermal Necrolysis, Toxic Phenytoin 5.3220235791
MESH:D004820 Epidermolysis Bullosa Phenytoin 6.411399206 6251365
MESH:D004828 Epilepsies, Partial Phenytoin 5.0917116037 11558140
MESH:D004827 Epilepsy Phenytoin 3.9911434505 821787 20417680
MESH:D017029 Epilepsy, Complex Partial Phenytoin 5.447750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenytoin 5.223659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Amiodarone 13.8014986274
MESH:D005234 Fatty Liver Dietary Fats 13.8019551842 19004024 18296743 17967931
MESH:D005234 Fatty Liver pirinixic acid 13.8020131406 19236843
MESH:D005313 Fetal Death Phenytoin 11.2110627286
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 11.2111858732
MESH:D005355 Fibrosis Dietary Fats 9.0918296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.0920067830
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005885 Gingival Hyperplasia Phenytoin 5.829029455
MESH:D019214 Gingival Overgrowth Phenytoin 6.4114659971 16390469
MESH:D005909 Glioblastoma trichostatin A 3.9018801729
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.5619215824
MESH:D034381 Hearing Loss Furosemide 4.9317868369
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3811294989 10048152
MESH:D006333 Heart Failure Furosemide 7.5312660669 16011733 16845234
MESH:D006333 Heart Failure pirinixic acid 7.5320558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly Amiodarone 15.2615265979
MESH:D006529 Hepatomegaly pirinixic acid 15.2618467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.2615340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2215340226 16959395 8697196 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006934 Hypercalcemia Furosemide 5.1817652376
MESH:D053565 Hypercalciuria Furosemide 5.8117652376
MESH:D006937 Hypercholesterolemia Amiodarone 9.548137927 9751232
MESH:D006937 Hypercholesterolemia Dietary Fats 9.5421332399
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D020138 Hyperhomocysteinemia Phenytoin 4.7710459572
MESH:D006949 Hyperlipidemias Dietary Fats 3.7321332399
MESH:D006962 Hyperparathyroidism, Secondary Furosemide 6.0515086907
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9418850075 18670907
MESH:D046110 Hypertension, Pregnancy-Induced Furosemide 5.4216612254
MESH:C537153 Hypomagnesemia primary Furosemide 5.8111041285
MESH:D007019 Hypoproteinemia Furosemide 6.0516096441
MESH:D007022 Hypotension Furosemide 4.7311041285
MESH:D007024 Hypotension, Orthostatic Furosemide 5.5915811171
MESH:D007037 Hypothyroidism Amiodarone 4.6517991464 18020914
MESH:D007248 Infertility, Male decitabine 3.2717581917
MESH:D007249 Inflammation Dietary Fats 5.0920412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0912200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 7.4818457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.4816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007674 Kidney Diseases Acetaminophen 6.5215629191 12587719
MESH:D007674 Kidney Diseases Furosemide 6.5211041285
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.0616705839
MESH:D007938 Leukemia decitabine 3.1218980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 4.1118454857 19117987 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.3319387464 19010910 18206229 17679729 18704418 18460780
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 4.3318206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.6418055864
MESH:D008064 Lipidoses Amiodarone 3.5917567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9318296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1612878042
MESH:D008107 Liver Diseases Acetaminophen 4.4019784758 16611625 12969438 16610002 11587558 12587719 19460945 19014921
MESH:D008107 Liver Diseases Phenytoin 4.4014986274
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3416871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 4.3720007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.3716984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1712151625
MESH:D008133 Long QT Syndrome Amiodarone 3.6617391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.4412587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.6518516814
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008223 Lymphoma decitabine 3.4919470736
MESH:D008545 Melanoma decitabine 3.7817785578 16505122
MESH:D008545 Melanoma trichostatin A 3.7816505122
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008607 Mental Retardation Phenytoin 3.709212184
MESH:D009101 Multiple Myeloma decitabine 7.9218172295
MESH:D009101 Multiple Myeloma trichostatin A 7.9218172295
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009181 Mycoses Amiodarone 5.0817974566 12754197
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4419157545 19010910 16882708 18608210
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenytoin 5.6817484760
MESH:D009224 Myotonia Congenita Phenytoin 5.561896199
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0118551238
MESH:D009369 Neoplasms decitabine 5.1917925555 19470736 19116145
MESH:D009369 Neoplasms pirinixic acid 5.1917405874
MESH:D009397 Nephrocalcinosis Furosemide 6.0515086907
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D009436 Neural Tube Defects Phenytoin 4.209118846
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D053206 Nocturnal Enuresis Furosemide 6.0517945291
MESH:D009765 Obesity Dietary Fats 4.5218674790 18457598 20132043 17217161 19632207 11836018 20518802 21332399 16723640
MESH:D009765 Obesity pirinixic acid 4.5220558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.4816049721 12819281
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 9.4814694615
MESH:D010018 Osteomalacia Phenytoin 5.5617016548
MESH:D010051 Ovarian Neoplasms decitabine 5.3719259094 19331143
MESH:D010051 Ovarian Neoplasms trichostatin A 5.3719331143
MESH:D010146 Pain Acetaminophen 7.2916870215
MESH:D010146 Pain Phenytoin 7.2915215642
MESH:D010190 Pancreatic Neoplasms decitabine 5.8019294695
MESH:D010190 Pancreatic Neoplasms trichostatin A 5.8019294695
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D017689 Polydactyly Phenytoin 5.149212184
MESH:D011141 Polyuria Furosemide 5.8117945291
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411222880 11896295 11399792 11118676
MESH:D055728 Primary Myelofibrosis decitabine 12.9017616702
MESH:D055728 Primary Myelofibrosis trichostatin A 12.9017616702
MESH:D011471 Prostatic Neoplasms trichostatin A 4.0218798265 19789329
MESH:D019310 Pseudolymphoma Phenytoin 5.721419762 8603615 12752131
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8912490602 11597910 12832656
MESH:D015427 Reperfusion Injury Furosemide 6.9716526316
MESH:D015427 Reperfusion Injury pirinixic acid 6.9719058328
MESH:D012128 Respiratory Distress Syndrome, Adult Furosemide 4.7315912074 16096441 12394941
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.5219155313
MESH:D012640 Seizures 2,4-dinitrotoluene 6.5518551238
MESH:D012640 Seizures Phenytoin 6.559844417 3137016 3691417 15946322 19919933 11044598 16876388 10029267
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.2418724381
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0916192470
MESH:D013262 Stevens-Johnson Syndrome Phenytoin 5.2920235791
MESH:D013274 Stomach Neoplasms decitabine 2.9619037991
MESH:D013274 Stomach Neoplasms Furosemide 2.9617052386
MESH:D013276 Stomach Ulcer Amiodarone 3.4218087811
MESH:D013610 Tachycardia Amiodarone 4.4211238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.3219225199
MESH:D013959 Thyroid Diseases Amiodarone 12.6419731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 12.6412697716
MESH:D013964 Thyroid Neoplasms decitabine 3.4117967635
MESH:D013971 Thyrotoxicosis Amiodarone 5.0019584973 18020914
MESH:D016171 Torsades de Pointes Amiodarone 4.3417467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.3016049721
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.3019087683 17616700
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4710091137
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014604 Uveal Neoplasms decitabine 5.0917785578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D015430 Weight Gain Dietary Fats 3.8316723640
Pathway ID Pathway Name
REACT:578 Apoptosis
KEGG:05219 Bladder cancer
KEGG:05200 Pathways in cancer
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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