AutismKB 2.0

Annotation Detail for CD2AP


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CD2AP ( CMS,DKFZp586H0519 )
Gene Full Name: CD2-associated protein
Band: 6p12.3
Quick LinksEntrez ID:23607; OMIM: 604241; Uniprot ID:CD2AP_HUMAN; ENSEMBL ID: ENSG00000198087; HGNC ID: 14258
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05100Bacterial invasion of epithelial cells
Pathway IDPathway Name
Interactions of the immunoglobulin superfamily (IgSF) member proteins
Pathway IDPathway Name
200132Nephrin/Neph1 signaling in the kidney podocyte
200151VEGFR1 specific signals
No data
No data
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Glomerulosclerosis, focal segmental, 3
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CD2AP mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CD2AP mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of CD2AP mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CD2AP mRNAaffects expression 16483693
C057862 cyanoginosin LR cyanoginosin LR results in increased expression of CD2AP mRNAincreases expression 17654400
D004317 Doxorubicin Doxorubicin results in increased expression of CD2AP mRNAincreases expression 16636307
D004317 Doxorubicin Doxorubicin results in increased expression of CD2AP proteinincreases expression 16636307
D004317 Doxorubicin Lisinopril inhibits the reaction [Doxorubicin results in increased expression of CD2AP protein]decreases reaction|increases expression 16636307
D004317 Doxorubicin Prednisone affects the reaction [Doxorubicin results in increased expression of CD2AP mRNA]affects reaction|increases expression 16636307
D004317 Doxorubicin Prednisone inhibits the reaction [Doxorubicin results in increased expression of CD2AP protein]decreases reaction|increases expression 16636307
D004317 Doxorubicin Tretinoin affects the reaction [Doxorubicin results in increased expression of CD2AP mRNA]affects reaction|increases expression 16636307
D004317 Doxorubicin Tretinoin inhibits the reaction [Doxorubicin results in increased expression of CD2AP protein]decreases reaction|increases expression 16636307
D017706 Lisinopril Lisinopril inhibits the reaction [Doxorubicin results in increased expression of CD2AP protein]decreases reaction|increases expression 16636307
D011241 Prednisone Prednisone affects the reaction [Doxorubicin results in increased expression of CD2AP mRNA]affects reaction|increases expression 16636307
D011241 Prednisone Prednisone inhibits the reaction [Doxorubicin results in increased expression of CD2AP protein]decreases reaction|increases expression 16636307
D011691 Puromycin Puromycin results in decreased expression of CD2AP mRNAdecreases expression 15673299
D014212 Tretinoin Tretinoin affects the reaction [Doxorubicin results in increased expression of CD2AP mRNA]affects reaction|increases expression 16636307
D014212 Tretinoin Tretinoin inhibits the reaction [Doxorubicin results in increased expression of CD2AP protein]decreases reaction|increases expression 16636307
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 11.9618287403
MESH:D000138 Acidosis Lisinopril 11.9620061926
MESH:D000230 Adenocarcinoma Doxorubicin 2.6017418594
MESH:D000419 Albuminuria Doxorubicin 4.7421441931
MESH:D000505 Alopecia Tretinoin 3.7515955085
MESH:D000544 Alzheimer Disease marker/mechanism 21460841 21460840
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.1816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001471 Barrett Esophagus Tretinoin 4.6016935849
MESH:D001607 Berylliosis Prednisone 5.6418757698
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.7816206674 16197459
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.9614601052
MESH:D001932 Brain Neoplasms Doxorubicin 3.9717150277
MESH:D001943 Breast Neoplasms Doxorubicin 2.3015668708 18695136 15136595 15939500 18628466 16826403 17983394 16264153 17369602 16595493 16096432 15634643 11325840 15993339 19526202 16322301 15994142 15692762 16115903 16935488 18382427 15567936 17426702 18234424
MESH:D001943 Breast Neoplasms Tretinoin 2.3016166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8316813970
MESH:D002276 Carcinoid Tumor Doxorubicin 5.0816051944
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4216168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.1316705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.1316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.133084413
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 9.1316023760 18059187 17876044 16234567
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 9.131917145
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.2316201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 4.936189445
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.9316096774 16051514
MESH:D009202 Cardiomyopathies Doxorubicin 3.6417519947 17924179 18627295 17928571 16269455 16952015 17351982 16651473 16364871 15792986 15505089 16731534 17131338 15811867 16109756 16612575 17007740 17382496 15476868 17974986 17308081 16278810 17329180 16242529 16455267
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9916243910 17334414
MESH:D002386 Cataract Acetaminophen 7.5410977129
MESH:D002386 Cataract Tretinoin 7.5417460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.886135515
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8316129372
MESH:D002822 Choriocarcinoma Tretinoin 5.4216461808
MESH:D002972 Cleft Palate Tretinoin 2.739407595
MESH:D003092 Colitis Tretinoin 3.9217035595
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418259882 18802399
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.829142499 17551590 9125849 8800419 14991402 10589399 9664655 9211117 9224671 16925845
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.6318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.6318551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.5421346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.5421346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.5411739529 19085960 11529661 16177239 12594235 12705907 19923254 16081117 12540782 17522070 15619225 11421492 19164858 14725611 19420014 16781746 17906064 11834606 11743745 16227642 18713872 11461765 11287661 18071297 14550746 14986274 12153990 19416960 19739265 16109766 2444490 12958197 10663392 16485898 10915739 10774834 17562736 19370779 16393943 12392966 15968718
MESH:D056486 Drug-Induced Liver Injury cyanoginosin LR 12.5417654400
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 12.5417416283
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Doxorubicin 3.7918602426
MESH:D004489 Edema, Cardiac Tretinoin 4.7318230668
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.9517359293
MESH:D016889 Endometrial Neoplasms Tretinoin 7.9516569247
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.4218037988
MESH:D004802 Eosinophilia Prednisone 5.5816111148
MESH:D005124 Eye Abnormalities Tretinoin 3.7016938888 9664655
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.8319069698
MESH:D005355 Fibrosis Tretinoin 3.7317994277
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005909 Glioblastoma Doxorubicin 7.6017150277
MESH:D005909 Glioblastoma Tretinoin 7.6017312396
MESH:D005923 Glomerulosclerosis, Focal Segmental marker/mechanism
MESH:D006258 Head and Neck Neoplasms Doxorubicin 8.2215692506
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.2216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4216084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.9814991402 9664655
MESH:D006331 Heart Diseases Doxorubicin 3.6018674790 16244371 17875725 16144979 16707910 17888722 16244372 16330681 16495754 16879835 18006777 12587719 14766674
MESH:D006333 Heart Failure Doxorubicin 3.4417481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.0715692506
MESH:D006689 Hodgkin Disease Doxorubicin 8.6417606976 18501091 15147373
MESH:D006689 Hodgkin Disease Prednisone 8.6416135485 17606976 16794504
MESH:D006930 Hyperalgesia Acetaminophen 8.0916870215
MESH:D006930 Hyperalgesia Tretinoin 8.0916870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7816778211
MESH:D007024 Hypotension, Orthostatic Lisinopril 6.9815811171
MESH:D007249 Inflammation Prednisone 4.3616111148
MESH:D007410 Intestinal Diseases Tretinoin 3.9817994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.0715992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 10.9512587719 15629191
MESH:D007674 Kidney Diseases Doxorubicin 10.9516775033 15699352 15369732
MESH:D007674 Kidney Diseases Lisinopril 10.9512164870
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.3316707910
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.8516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.8516705839
MESH:D007938 Leukemia Tretinoin 2.8417143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.4216085563
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8719285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1019850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2617217047 17301526 15748426 19075265 17107899 16766008 16331271 16788101 16140955 19225113 19642359 16935935 17339181 17368321 17649720 12679006 17712046 17506722 16891316 19029980 9834237 17361223 19035177 17294898 16823087
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.439224671
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.9916595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Lisinopril 3.9917900296
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.9918397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 1.6619784758 19460945 11587558 12969438 16611625 19014921 16610002 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4017185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.217678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.412876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 6.4117085340 16842330
MESH:D008175 Lung Neoplasms Doxorubicin 2.156189445 17418594
MESH:D008223 Lymphoma Doxorubicin 3.5816098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.9317654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.7815621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 3.1315458769
MESH:D008527 Medulloblastoma Tretinoin 2.8417453147
MESH:D008545 Melanoma Doxorubicin 3.5216827129
MESH:D008545 Melanoma Tretinoin 3.5216752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008591 Meningomyelocele Tretinoin 4.6416940565
MESH:D008654 Mesothelioma Doxorubicin 3.1217638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.6715792986
MESH:D052016 Mucositis Doxorubicin 5.0317415656
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1717596541
MESH:D009203 Myocardial Infarction Doxorubicin 3.0115857846 19429709
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.1518551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.157678174 18551238
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0118259882
MESH:D009369 Neoplasms Tretinoin 2.4816946489 16594593
MESH:D009401 Nephrosis Doxorubicin 4.9816899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.1515640375 16889571
MESH:D009421 Nervous System Malformations Tretinoin 3.989125849
MESH:D009436 Neural Tube Defects Tretinoin 3.169142499
MESH:D009447 Neuroblastoma Doxorubicin 3.3415555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.4312819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.4316049721
MESH:D012516 Osteosarcoma Doxorubicin 4.2515930896
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3916936753
MESH:D010146 Pain Acetaminophen 7.0716870215
MESH:D010146 Pain Tretinoin 7.0716870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5115976015
MESH:D003557 Phyllodes Tumor Doxorubicin 5.4217983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.4217638057
MESH:D011471 Prostatic Neoplasms Doxorubicin 4.0216729912 15897917 18437689 16868541 15749863 16888761
MESH:D011471 Prostatic Neoplasms Prednisone 4.0216888761
MESH:D011507 Proteinuria Lisinopril 17.0620061926 12164870 16636307
MESH:D011507 Proteinuria Prednisone 17.0616636307
MESH:D011507 Proteinuria Tretinoin 17.0616636307
MESH:D011625 Pterygium Tretinoin 5.0316723453
MESH:D011658 Pulmonary Fibrosis Lisinopril 4.9816458281
MESH:D051437 Renal Insufficiency Doxorubicin 4.4417922066
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2816116481 16283617
MESH:D012509 Sarcoma Doxorubicin 4.1517203757 17710206 18313854 16767912 15625365 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.4416326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.0317846226
MESH:D012640 Seizures 2,4-dinitrotoluene 6.2518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.2518551238
MESH:D012878 Skin Neoplasms Doxorubicin 6.1415692506
MESH:D012878 Skin Neoplasms Tretinoin 6.1416467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.7817203757 15625365 16767912
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms Doxorubicin 7.7517909728 16010429
MESH:D013964 Thyroid Neoplasms Tretinoin 7.7516026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.9516051514
MESH:D014376 Tuberculosis Tretinoin 3.3316040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.7016049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.7016049721
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 8.7017653716
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.8010091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.8010091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8416129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.8816752155
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.4417638931 16364871 17334414 17678736
MESH:D014820 Vitiligo Tretinoin 4.2516761959
MESH:D009396 Wilms Tumor Tretinoin 4.1216287080
Pathway ID Pathway Name
KEGG:05100 Bacterial invasion of epithelial cells
REACT:23853 Interactions of the immunoglobulin superfamily (IgSF) member proteins
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26208
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved