AutismKB 2.0

Annotation Detail for NTSR2


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Basic Information Top
Gene Symbol:NTSR2 ( NTR2 )
Gene Full Name: neurotensin receptor 2
Band: 2p25.1
Quick LinksEntrez ID:23620; OMIM: 605538; Uniprot ID:NTR2_HUMAN; ENSEMBL ID: ENSG00000169006; HGNC ID: 8040
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of NTSR2 mRNAaffects expression 21346803
D002713 Chlorine Chlorine results in decreased expression of NTSR2 mRNAdecreases expression 18636392
D002713 Chlorine [Ozone co-treated with Chlorine] affects the expression of NTSR2 mRNAaffects cotreatment|affects expression 18636392
D003993 Dibutyl Phthalate Dibutyl Phthalate results in increased expression of NTSR2 mRNAincreases expression 15620428
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in decreased expression of NTSR2 mRNAaffects cotreatment|decreases expression 17183730
D010126 Ozone [Ozone co-treated with Chlorine] affects the expression of NTSR2 mRNAaffects cotreatment|affects expression 18636392
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in decreased expression of NTSR2 mRNAaffects cotreatment|decreases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.958875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2519490988
MESH:D055371 Acute Lung Injury Chlorine 4.6720601635
MESH:D000544 Alzheimer Disease Ozone 2.4915513908
MESH:D000550 Amblyopia Valproic Acid 5.7517688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.8317497229
MESH:D001172 Arthritis, Rheumatoid Ozone 2.6115570426
MESH:D001249 Asthma Ozone 2.7117854713 16373670
MESH:D001321 Autistic Disorder Valproic Acid 1.9918177632 15238991 18558336 17507914 19232924 17157402 18940202 20603192 16609825 18316065 18775368 19460635 18985861 18396377 17688650
MESH:D001714 Bipolar Disorder Valproic Acid 3.2120046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.598888407
MESH:D016535 Bronchial Hyperreactivity Ozone 3.9314754758 18417511 19059883 18315731 16777450 17626835 15516495
MESH:D002100 Cachexia Ozone 5.2016183385
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 1.7816705839
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.986135515
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8020734317
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.908888407 16575769 17688650
MESH:D003456 Cryptorchidism Dibutyl Phthalate 5.8316037377
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.4418551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.1818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.1819641884 1733752
MESH:D004417 Dyspnea Chlorine 5.1420016425
MESH:D004421 Dystonia Valproic Acid 4.401851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.5717275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.443922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0720417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.876426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.717750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.533659116
MESH:D005234 Fatty Liver Valproic Acid 3.6214986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.4116575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.5118558336 8888407
MESH:D005739 Gas Poisoning Chlorine 5.5320016425
MESH:D006849 Hydrocephalus Valproic Acid 5.3317688650
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 5.0416612254
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.2416705839
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1917596541 16294345
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.247678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.722876786 2876784 6135515
MESH:D008171 Lung Diseases Ozone 3.578266340 19066396
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7817228818
MESH:D055370 Lung Injury Ozone 4.2620417186
MESH:D008175 Lung Neoplasms Ozone 2.108597069 7614698
MESH:D008679 Metaplasia Ozone 5.6310496685
MESH:D008881 Migraine Disorders Valproic Acid 3.4118803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.358888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3117596541
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.3218551238 7678174
MESH:D009436 Neural Tube Defects Valproic Acid 3.3216359493 8888407
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7416049721
MESH:D010538 Peritonitis Ozone 4.5516369182
MESH:D011014 Pneumonia Ozone 4.8618381685 18929643 18007984
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.2920603192
MESH:D019310 Pseudolymphoma Valproic Acid 5.0611422049 12752131
MESH:D012120 Respiration Disorders Chlorine 5.7318579056
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.5319155313
MESH:D012559 Schizophrenia Valproic Acid 2.1015737665 19110320
MESH:D012640 Seizures 2,6-dinitrotoluene 6.6318551238
MESH:D012640 Seizures Valproic Acid 6.6311044598 15475178 3137016 11738929 14763951 16876388 17978042 1511512
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0219490988
MESH:D013226 Status Epilepticus Valproic Acid 5.0612833885
MESH:D014178 Translocation, Genetic Valproic Acid 5.7517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.983119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3916049721
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.068888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7810091137
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB01106 partial antagonist Levocabastine Histamine H1 Antagonists;Histamine H1 Antagonists, Non-Sedating
No data
No data
No data

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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