AutismKB 2.0

Annotation Detail for FAM89B


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Basic Information Top
Gene Symbol:FAM89B ( MTVR1 )
Gene Full Name: family with sequence similarity 89, member B
Band: 11q13.1
Quick LinksEntrez ID:23625; OMIM: NA; Uniprot ID:FA89B_HUMAN; ENSEMBL ID: ENSG00000176973; HGNC ID: 16708
Relate to Another Database: SFARIGene; denovo-db
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Chemical ID Chemical Name Interaction Interaction Action Publication
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FAM89B mRNAaffects binding|decreases expression|increases activity 19710929
D014635 Valproic Acid Valproic Acid results in increased expression of FAM89B mRNAincreases expression 19101580
D014810 Vitamin E Vitamin E results in increased expression of FAM89B mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 4.238875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.4119490988
MESH:D055371 Acute Lung Injury pirinixic acid 3.6418653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.2216434500
MESH:D000550 Amblyopia Valproic Acid 6.1017688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.9417497229
MESH:D001321 Autistic Disorder Valproic Acid 1.9819232924 18316065 18940202 17507914 17688650 20603192 18177632 15238991 17157402 18396377 18775368 19460635 18985861 18558336 16609825
MESH:D001714 Bipolar Disorder Valproic Acid 3.2620046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.6319483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.668888407
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.5816050911
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8320734317
MESH:D002779 Cholestasis pirinixic acid 3.1519176532
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.8116575769 17688650 8888407
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.8119769572
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5918249437
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.2619641884 1733752
MESH:D004421 Dystonia Valproic Acid 4.581851702
MESH:C538011 Eales disease Vitamin E 5.579068938
MESH:D004487 Edema pirinixic acid 2.9612083418
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.813659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.7816628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.1218234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 4.006426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.957750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.813659116
MESH:D005234 Fatty Liver pirinixic acid 9.3720131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 9.3714986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.7516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.718888407 18558336
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1816080930
MESH:D006333 Heart Failure pirinixic acid 2.7820558911
MESH:D006529 Hepatomegaly pirinixic acid 3.6419772884 16221962 19176532 18467677
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.8216490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.8414716179
MESH:D006849 Hydrocephalus Valproic Acid 5.6117688650
MESH:D006943 Hyperglycemia pirinixic acid 3.6320558911
MESH:D007251 Influenza, Human Vitamin E 5.0816624496
MESH:D007333 Insulin Resistance pirinixic acid 2.9016306350
MESH:D007674 Kidney Diseases Vitamin E 3.0312488133
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.2017596541 16294345
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4815474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4816169303
MESH:D008113 Liver Neoplasms pirinixic acid 1.9416377806 15890375 20007298
MESH:D008171 Lung Diseases Vitamin E 3.4516863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 5.1317228818
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D008881 Migraine Disorders Valproic Acid 3.5018803445 18765137
MESH:D009135 Muscular Diseases pirinixic acid 4.1616239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.518888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3717596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2916411023
MESH:D009369 Neoplasms pirinixic acid 2.1217405874
MESH:D009436 Neural Tube Defects Valproic Acid 3.398888407 16359493
MESH:D009765 Obesity pirinixic acid 1.8920558911
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.5720603192
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2415084515
MESH:D019310 Pseudolymphoma Valproic Acid 5.4111422049 12752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.5619058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.7019155313
MESH:D012559 Schizophrenia Valproic Acid 2.1115737665 19110320
MESH:D012640 Seizures Valproic Acid 3.0214763951 11738929 17978042 15475178 1511512 16876388 3137016 11044598
MESH:D012871 Skin Diseases Vitamin E 2.5218709164
MESH:D016135 Spinal Dysraphism Valproic Acid 4.1319490988
MESH:D013226 Status Epilepticus Valproic Acid 5.4112833885
MESH:D020521 Stroke Vitamin E 3.8816517955
MESH:D014178 Translocation, Genetic Valproic Acid 6.1017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 5.263119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.308888407
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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