AutismKB 2.0

Annotation Detail for HSPBP1


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Basic Information Top
Gene Symbol:HSPBP1 ( FES1 )
Gene Full Name: HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
Band: 19q13.42
Quick LinksEntrez ID:23640; OMIM: 612939; Uniprot ID:HPBP1_HUMAN; ENSEMBL ID: ENSG00000133265; HGNC ID: 24989
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04141Protein processing in endoplasmic reticulum
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of HSPBP1 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of HSPBP1 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HSPBP1 mRNAaffects expression 16483693
C017947 sodium arsenite sodium arsenite results in increased expression of HSPBP1 proteinincreases expression 19072884
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 4.587525203
MESH:D000138 Acidosis Ammonium Chloride 4.1918287403
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.4215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.6316712894 17306315
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.1816705839
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.1817306315 16507464 15276417
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4618572023
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.8414694615
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.2519524636 20056578
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.5315095906
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.5818551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 4.4118551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 4.4121346803
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.3116452187
MESH:D006689 Hodgkin Disease sodium arsenite 3.5212676792
MESH:D007248 Infertility, Male sodium arsenite 3.2412646999 15346721
MESH:D007674 Kidney Diseases sodium arsenite 3.0020008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.3216705839
MESH:D008113 Liver Neoplasms sodium arsenite 2.4816712894 15276417
MESH:D008171 Lung Diseases sodium arsenite 3.4219095001
MESH:D008175 Lung Neoplasms sodium arsenite 1.9017306315 17077188 16712894 19931552 15276417
MESH:D008545 Melanoma sodium arsenite 2.0719082730 16487513
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.4918551238
MESH:D009369 Neoplasms sodium arsenite 2.6611559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.2220056578
MESH:D009436 Neural Tube Defects sodium arsenite 3.3812854658
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 10.4712819281 16049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 10.4714694615
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.5315276417 17306315
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2416039940
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7918551238
MESH:D012878 Skin Neoplasms sodium arsenite 2.8519524636 18572023
MESH:D016135 Spinal Dysraphism sodium arsenite 4.1012854658
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.5116049721
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.5116452187 17306315 11723127 16712894
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.9510091137
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.1611813266
MESH:D014652 Vascular Diseases sodium arsenite 5.0617056641
Pathway ID Pathway Name
KEGG:04141 Protein processing in endoplasmic reticulum
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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