AutismKB 2.0

Annotation Detail for LY96


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Basic Information Top
Gene Symbol:LY96 ( ESOP-1,MD-2,MD2,ly-96 )
Gene Full Name: lymphocyte antigen 96
Band: 8q21.11
Quick LinksEntrez ID:23643; OMIM: 605243; Uniprot ID:LY96_HUMAN; ENSEMBL ID: ENSG00000154589; HGNC ID: 17156
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05145Toxoplasmosis
hsa04620Toll-like receptor signaling pathway
hsa05130Pathogenic Escherichia coli infection
Pathway IDPathway Name
Signaling in Immune system
Pathway IDPathway Name
200177Endogenous TLR signaling
Pathway IDPathway Name
P00054Toll receptor signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of LY96 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of LY96 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of LY96 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of LY96 mRNAincreases expression 20106945
D016572 Cyclosporine Cyclosporine results in increased expression of LY96 mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of LY96 mRNAdecreases expression 18042831
D008070 Lipopolysaccharides LY96 exon mutant form results in decreased susceptibility to Lipopolysaccharidesdecreases response to substance 16367934
D008070 Lipopolysaccharides LY96 protein mutant form results in decreased susceptibility to Lipopolysaccharidesdecreases response to substance 16367934
D008070 Lipopolysaccharides LY96 protein results in increased susceptibility to Lipopolysaccharidesincreases response to substance 16367934
C002950 methylformamide methylformamide affects the expression of LY96 mRNAaffects expression 17040096
C002950 methylformamide methylformamide analog affects the expression of LY96 mRNAaffects expression 17040096
C041786 palm oil palm oil results in decreased expression of LY96 mRNAdecreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of LY96 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of LY96 mRNAincreases expression 19482888
19270015
C024746 tobacco tar tobacco tar results in decreased expression of LY96 mRNAdecreases expression 19559774
D015032 Zinc Zinc affects the expression of LY96 mRNAaffects expression 16979875
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.596195326
MESH:D000169 Acrodermatitis Zinc 5.5616889938 17190629 17202136
MESH:D055371 Acute Lung Injury Lipopolysaccharides 4.1511850527 18653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120127859 20464547
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.803712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.806695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.1217620307
MESH:D000544 Alzheimer Disease Zinc 2.7717119284 16410023 16325427 16580781
MESH:D000755 Anemia, Sickle Cell Zinc 5.0316916123
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001161 Arteriosclerosis Dietary Fats 4.0315238619
MESH:D001249 Asthma Zinc 2.9817085522
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.1911289319 1440618
MESH:D001930 Brain Injuries Zinc 4.8317109824
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.1020146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 2.1020435547
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.697296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.693084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.6912907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.6917173139 1701930 6705139 20007298 20935162
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.727296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8920419170
MESH:D002294 Carcinoma, Squamous Cell Zinc 4.8916543248
MESH:D002318 Cardiovascular Diseases Zinc 3.7316936243
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.747505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.7412371664
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 11.7419559774
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.394080065
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.1519486331 9022650
MESH:D002779 Cholestasis Cyclosporine 8.1519486331
MESH:D019465 Craniofacial Abnormalities Zinc 2.4319302082
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.948156756 11906362 12868966 2524372 11298694 14531868 8970840 18759878
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.613621924 2952479
MESH:D003920 Diabetes Mellitus Zinc 4.3016479319
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.818291058 6482804 18692083 9022650 18289764 7440962 9653073 16192314 9328219 1440618 6679447 11289319 18648102
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8115968718 16109766 11421492 17906064 17522070 11834606 11739529 16081117 16485898 16781746 18713872 14986274 15619225 19739265 12392966 18071297 12594235 16177239 2444490 19416960 16393943 10915739 17562736 19085960 19420014 12705907 10774834 16227642 19164858 12958197 11529661 14725611 19370779 11287661 19923254 11461765 12540782 10663392 14550746 11743745 12153990
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D050171 Dyslipidemias Dietary Fats 3.5318367378
MESH:D004421 Dystonia Phenobarbital 4.121851702
MESH:D019446 Endotoxemia Lipopolysaccharides 4.5517637181 15821434 15328337
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.253659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.043922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9420417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.646401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.397750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.173659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.443581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.4416530937
MESH:D004938 Esophageal Neoplasms Zinc 7.4416543248
MESH:D005234 Fatty Liver Cyclosporine 8.1019224547
MESH:D005234 Fatty Liver Dietary Fats 8.1017967931 19004024 18296743 19551842
MESH:D005334 Fever Lipopolysaccharides 4.129205823 11852909
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.196705139
MESH:D005355 Fibrosis Cyclosporine 9.1612639820 12168785
MESH:D005355 Fibrosis Dietary Fats 9.1618296743
MESH:D005756 Gastritis Acetaminophen 11.7616983495
MESH:D005756 Gastritis Zinc 11.7617241300
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.157505956
MESH:D006130 Growth Disorders Zinc 4.0317217573
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7120471113
MESH:D006333 Heart Failure Zinc 3.6717162251
MESH:D006335 Heart Injuries Zinc 5.9417074742
MESH:D016481 Helicobacter Infections Zinc 4.6517241300
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.4916366002
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.646705139
MESH:D006527 Hepatolenticular Degeneration Zinc 4.8317276780
MESH:D006529 Hepatomegaly Phenobarbital 3.6216109766
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7021332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.7321332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0815034207
MESH:D006973 Hypertension Cyclosporine 2.1310903974
MESH:D007249 Inflammation Dietary Fats 5.4720412841
MESH:D007249 Inflammation Lipopolysaccharides 5.4717237260 9205823 12878042 17963957 17255318
MESH:D007333 Insulin Resistance Dietary Fats 3.1711836018 18457598
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.7517255318
MESH:D007511 Ischemia Zinc 4.7716584753
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.198074119 9022650
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Acetaminophen 10.4315629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 10.4318776723 10903974 8314463
MESH:D007674 Kidney Diseases Zinc 10.4316960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.5316518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.586582329
MESH:D007680 Kidney Neoplasms Cyclosporine 7.5812371664
MESH:D007970 Leukopenia Lipopolysaccharides 4.8515821434
MESH:D008103 Liver Cirrhosis Dietary Fats 6.8518296743
MESH:D008103 Liver Cirrhosis Phenobarbital 6.8521047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2615034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 2.2612878042
MESH:D008107 Liver Diseases Acetaminophen 4.0116610002 19460945 11587558 19784758 16611625 12587719 19014921 12969438
MESH:D008107 Liver Diseases Phenobarbital 4.0119363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3416871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.6818177683 2125692 15890375 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.6821137059 20195826
MESH:D008113 Liver Neoplasms Phenobarbital 7.6819812893 19073162 19482888 21047994 15975961 8742319
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.273712494 598648 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.278603461
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.272563599 1399818 18308698 17172636 6150874
MESH:D055370 Lung Injury Lipopolysaccharides 4.1521114838
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.4414755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4418569708 18520028 18816296 6695378 20464547 20869020 17053015 20135361 20064080
MESH:D008325 Mammary Neoplasms, Experimental Zinc 3.3612773700
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.6317484760
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.513581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2211141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3818481113 19348381
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.986679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D009765 Obesity Dietary Fats 2.3119632207 17217161 11836018 21332399 16723640 18674790 18457598 20518802 20132043
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.524026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.193988306
MESH:D010018 Osteomalacia Phenobarbital 4.5217016548
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5316965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.627296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.646228378
MESH:D011014 Pneumonia Lipopolysaccharides 4.7111605937 12224865
MESH:D011230 Precancerous Conditions Cyclosporine 9.3012371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.302563599
MESH:D011225 Pre-Eclampsia Zinc 4.2617114810
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.3517292933
MESH:D011471 Prostatic Neoplasms Zinc 3.3516606632 16517595 16700911 12429649
MESH:D019310 Pseudolymphoma Phenobarbital 4.6712752131
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.8010835634
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 9.283692021
MESH:D012162 Retinal Degeneration Zinc 9.2816584753
MESH:D012640 Seizures Phenobarbital 2.7611442880 3137016 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.986407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4110029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.2715821434
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.436582329 3712494 6587162 7505956 1399818
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.431399818
MESH:D014062 Tongue Neoplasms Zinc 4.5016543248
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.108074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1017053015
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D015430 Weight Gain Dietary Fats 3.8316723640
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
Pathway ID Pathway Name
KEGG:05130 Pathogenic Escherichia coli infection
REACT:6900 Signaling in Immune system
KEGG:04620 Toll-like receptor signaling pathway
KEGG:05145 Toxoplasmosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134924906
    • No data
    No data
    Releated drug ID Related drug Name
    PA449972imiquimod
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02767 - 3-Hydroxy-Myristic Acid
    DB03017 - Lauric Acid
    DB08231 - MYRISTIC ACID
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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