Annotation Detail for EDC4
Basic Information Top
| Gene Symbol: | EDC4 ( Ge-1,HEDLS,RCD-8 ) |
|---|---|
| Gene Full Name: | enhancer of mRNA decapping 4 |
| Band: | 16q22.1 |
| Quick Links | Entrez ID:23644; OMIM: 606030; Uniprot ID:EDC4_HUMAN; ENSEMBL ID: ENSG00000038358; HGNC ID: 17157 |
| Relate to Another Database: | SFARIGene; denovo-db |
| No data |
| Pathway ID | Pathway Name |
|---|---|
| hsa03018 | RNA degradation |
| Pathway ID | Pathway Name |
|---|---|
| Metabolism of RNA |
| No data |
| No data |
| Pathway ID | Pathway Name |
|---|---|
| 500857 | mRNA Decay by 5' to 3' Exoribonuclease |
Related Diseases/Disorders| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D000082 | Acetaminophen | Acetaminophen affects the expression of EDC4 mRNA | affects expression | 17562736 |
| D019833 | Genistein | Genistein results in decreased expression of EDC4 mRNA | decreases expression | 16705744 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000230 | Adenocarcinoma | Genistein | 2.56 | 11473722 | |
| MESH:D000799 | Angioedema | Acetaminophen | 4.91 | 10982225 | |
| MESH:D001321 | Autistic Disorder | Acetaminophen | 1.39 | 18445737 | |
| MESH:D001943 | Breast Neoplasms | Genistein | 2.48 | 16541309 16873071 17200150 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Acetaminophen | 3.13 | 3084413 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Genistein | 3.13 | 16924424 | |
| MESH:D002318 | Cardiovascular Diseases | Genistein | 3.63 | 16332659 | |
| MESH:D002386 | Cataract | Acetaminophen | 2.83 | 10977129 | |
| MESH:D003110 | Colonic Neoplasms | Genistein | 2.34 | 17182828 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Genistein | 2.57 | 16647724 | |
| MESH:D056486 | Drug-Induced Liver Injury | Acetaminophen | 1.68 | 11529661 15968718 12540782 18071297 12153990 14725611 14550746 16227642 10774834 11461765 16485898 17906064 19370779 16177239 12594235 12705907 17562736 19416960 16393943 16081117 19164858 11834606 10663392 16781746 19923254 11743745 2444490 18713872 11421492 19085960 15619225 10915739 14986274 11739529 12392966 11287661 17522070 19739265 12958197 16109766 19420014 | |
| MESH:D056487 | Drug-Induced Liver Injury, Chronic | Acetaminophen | 5.17 | 19426721 | |
| MESH:D004714 | Endometrial Hyperplasia | Genistein | 5.48 | 16402032 | |
| MESH:D016889 | Endometrial Neoplasms | Genistein | 3.66 | 11473722 | |
| MESH:D005756 | Gastritis | Acetaminophen | 4.74 | 16983495 | |
| MESH:D005909 | Glioblastoma | Genistein | 3.55 | 16598420 | |
| MESH:D006930 | Hyperalgesia | Acetaminophen | 3.11 | 16870215 | |
| MESH:D007674 | Kidney Diseases | Acetaminophen | 2.44 | 15629191 12587719 | |
| MESH:D007938 | Leukemia | Genistein | 3.22 | 17468513 18980019 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Genistein | 2.07 | 17823541 | |
| MESH:D008107 | Liver Diseases | Acetaminophen | 1.71 | 16610002 11587558 19460945 12587719 12969438 16611625 19784758 19014921 | |
| MESH:D017114 | Liver Failure, Acute | Acetaminophen | 3.74 | 16871587 17185352 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Genistein | 3.23 | 14578162 12929590 | |
| MESH:D008546 | Melanoma, Experimental | Acetaminophen | 4.33 | 19513568 | |
| MESH:D009203 | Myocardial Infarction | Genistein | 3.02 | 17141266 | |
| MESH:D015428 | Myocardial Reperfusion Injury | Genistein | 4.04 | 17141266 | |
| MESH:D009421 | Nervous System Malformations | Genistein | 4.71 | 16427766 | |
| MESH:D019636 | Neurodegenerative Diseases | Acetaminophen | 3.31 | 18514411 | |
| MESH:D010024 | Osteoporosis | Genistein | 3.52 | 19401787 | |
| MESH:D015663 | Osteoporosis, Postmenopausal | Genistein | 4.69 | 16169203 | |
| MESH:D010051 | Ovarian Neoplasms | Genistein | 2.71 | 19005980 | |
| MESH:D010146 | Pain | Acetaminophen | 2.82 | 16870215 | |
| MESH:D011471 | Prostatic Neoplasms | Genistein | 3.39 | 15378649 15256057 16925846 | |
| MESH:D014581 | Urticaria | Acetaminophen | 3.58 | 10982225 |
| Pathway ID | Pathway Name |
|---|---|
| REACT:21257 | Metabolism of RNA |
| KEGG:03018 | RNA degradation |