AutismKB 2.0

Annotation Detail for PPP1R15A


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Basic Information Top
Gene Symbol:PPP1R15A ( GADD34 )
Gene Full Name: protein phosphatase 1, regulatory (inhibitor) subunit 15A
Band: 19q13.2
Quick LinksEntrez ID:23645; OMIM: 611048; Uniprot ID:PR15A_HUMAN; ENSEMBL ID: ENSG00000087074; HGNC ID: 14375
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04141Protein processing in endoplasmic reticulum
No data
Pathway IDPathway Name
200123BMP receptor signaling
200195TGF-beta receptor signaling
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of PPP1R15A mRNAincreases expression 20713471
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PPP1R15A mRNAaffects expression 21346803
C026137 3-hydroxyacetanilide 3-hydroxyacetanilide results in increased expression of PPP1R15A mRNAincreases expression 18544908
C406734 4-methylene-2-octyl-5-oxofuran-3-carboxylic acid [4-methylene-2-octyl-5-oxofuran-3-carboxylic acid co-treated with Thapsigargin] results in increased expression of PPP1R15A mRNAaffects cotreatment|increases expression 17283163
C120508 A 192621 A 192621 results in increased expression of PPP1R15A mRNAincreases expression 19040731
D000082 Acetaminophen Acetaminophen affects the expression of PPP1R15A mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of PPP1R15A mRNAincreases expression 18544908
11264010
D000082 Acetaminophen Acetaminophen results in increased expression of PPP1R15A mRNAincreases expression 18346771
C061133 Am 80 Am 80 results in increased expression of PPP1R15A mRNAincreases expression 17229644
D000638 Amiodarone Amiodarone results in increased expression of PPP1R15A mRNAincreases expression 19774075
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PPP1R15A mRNAaffects expression 16483693
D000968 Antimycin A Antimycin A results in increased expression of PPP1R15A mRNAincreases expression 19304788
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of PPP1R15A mRNAincreases expression 18687144
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PPP1R15A mRNAincreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PPP1R15A mRNAincreases expression 19150397
C006780 bisphenol A bisphenol A affects the expression of PPP1R15A mRNAaffects expression 20170705
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of PPP1R15A mRNAincreases expression 15336504
D002104 Cadmium Cadmium results in increased expression of PPP1R15A mRNAincreases expression 21172416
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of PPP1R15A mRNAincreases expression 18346771
D016572 Cyclosporine Cyclosporine results in increased expression of PPP1R15A mRNAincreases expression 20106945
C014347 decitabine [decitabine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PPP1R15A mRNAaffects cotreatment|decreases expression 15251184
C014347 decitabine decitabine results in decreased expression of PPP1R15A mRNAdecreases expression 15251184
D004041 Dietary Fats Dietary Fats results in decreased expression of PPP1R15A mRNAdecreases expression 18042831
D004178 Diquat Diquat results in increased expression of PPP1R15A mRNAincreases expression 21172416
C045651 epigallocatechin gallate epigallocatechin gallate results in increased expression of PPP1R15A mRNAincreases expression 18851785
D004958 Estradiol Estradiol results in increased expression of PPP1R15A mRNAincreases expression 19153601
20106945
D004958 Estradiol Estradiol affects the expression of PPP1R15A mRNAaffects expression 15598610
D005472 Fluorouracil Fluorouracil results in increased expression of PPP1R15A mRNAincreases expression 16709241
15331170
D005472 Fluorouracil PPP1R15A protein affects the susceptibility to Fluorouracilaffects response to substance 15331170
C065180 fluvastatin [zoledronic acid co-treated with fluvastatin] results in increased expression of PPP1R15A mRNAaffects cotreatment|increases expression 16996129
C056507 gemcitabine gemcitabine results in increased expression of PPP1R15A mRNAincreases expression 17039268
D005912 Gliotoxin Gliotoxin results in increased expression of PPP1R15A mRNAincreases expression 18346771
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of PPP1R15Aincreases expression 18687144
C475919 hydroxytamoxifen GPR30 protein affects the reaction [hydroxytamoxifen results in increased expression of PPP1R15A mRNA]affects reaction|increases expression 19153601
C475919 hydroxytamoxifen hydroxytamoxifen results in increased expression of PPP1R15A mRNAincreases expression 19153601
D007213 Indomethacin Indomethacin results in increased expression of PPP1R15A mRNAincreases expression 16184411
C482199 lipopolysaccharide, E coli O55-B5 lipopolysaccharide, E coli O55-B5 results in increased expression of PPP1R15A mRNAincreases expression 18346771
D008628 Mercury Mercury results in decreased expression of PPP1R15A mRNAdecreases expression 16823088
D008701 Methapyrilene Methapyrilene results in increased expression of PPP1R15A mRNAincreases expression 17450226
16393664
C016599 mono-(2-ethylhexyl)phthalate mono-(2-ethylhexyl)phthalate results in increased expression of PPP1R15A mRNAincreases expression 16809437
D009151 Mustard Gas Mustard Gas affects the expression of PPP1R15A mRNAaffects expression 15651846
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of PPP1R15A mRNAincreases expression 17616710
D010100 Oxygen Oxygen deficiency results in increased expression of PPP1R15A mRNAincreases expression 17914565
C041786 palm oil palm oil results in decreased expression of PPP1R15A mRNAdecreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of PPP1R15A mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of PPP1R15A mRNAdecreases expression 19270015
D010634 Phenobarbital Phenobarbital results in increased expression of PPP1R15A mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in decreased expression of PPP1R15A mRNAdecreases expression 20059764
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of PPP1R15A mRNA]decreases expression|increases reaction 20059764
D011374 Progesterone Progesterone results in increased expression of PPP1R15A mRNAincreases expression 18037150
D020849 Raloxifene Raloxifene results in increased expression of PPP1R15A mRNAincreases expression 16497877
D020849 Raloxifene Raloxifene affects the expression of PPP1R15A mRNAaffects expression 16079270
D012402 Rotenone Rotenone results in increased expression of PPP1R15A mRNAincreases expression 19304788
C064116 S-(1,1,2,2-tetrafluoroethyl)cysteine S-(1,1,2,2-tetrafluoroethyl)cysteine results in increased expression of PPP1R15A mRNAincreases expression 16678137
C002979 selenomethylselenocysteine selenomethylselenocysteine results in increased expression of PPP1R15A mRNAincreases expression 10656618
D012906 Smoke Smoke results in increased expression of PPP1R15A mRNAincreases expression 18206657
C017947 sodium arsenite sodium arsenite results in increased expression of PPP1R15A proteinincreases expression 12606582
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PPP1R15A mRNAincreases expression 16697128
20106945
D013749 Tetrachlorodibenzodioxin [decitabine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PPP1R15A mRNAaffects cotreatment|decreases expression 15251184
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PPP1R15A mRNAdecreases expression 15251184
D019284 Thapsigargin [4-methylene-2-octyl-5-oxofuran-3-carboxylic acid co-treated with Thapsigargin] results in increased expression of PPP1R15A mRNAaffects cotreatment|increases expression 17283163
D019284 Thapsigargin Thapsigargin results in increased expression of PPP1R15A proteinincreases expression 12606582
C088658 zoledronic acid [zoledronic acid co-treated with fluvastatin] results in increased expression of PPP1R15A mRNAaffects cotreatment|increases expression 16996129
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 6.566195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 6.5615322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.0318287403
MESH:D058186 Acute Kidney Injury zoledronic acid 4.0019715164
MESH:D055371 Acute Lung Injury Oxygen 7.6116759491
MESH:D055371 Acute Lung Injury pirinixic acid 7.6118653653
MESH:D000210 Acute-Phase Reaction zoledronic acid 4.9520200999
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 8.8320127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 8.8311473722
MESH:D000230 Adenocarcinoma Fluorouracil 8.8317638652
MESH:D000230 Adenocarcinoma Indomethacin 8.8316537180
MESH:D000236 Adenoma Benzo(a)pyrene 5.776695378
MESH:D000236 Adenoma Indomethacin 5.7711497255
MESH:D018248 Adenoma, Liver Cell Phenobarbital 14.2417620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 14.2416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 14.2416835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.1615276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.3616712894 17306315
MESH:D000419 Albuminuria Raloxifene 4.0917451421 17308373
MESH:D016301 Alveolar Bone Loss Indomethacin 4.8317225004
MESH:D000544 Alzheimer Disease Indomethacin 3.9815579461 17627676
MESH:D000544 Alzheimer Disease Raloxifene 3.9815800139
MESH:D000740 Anemia Fluorouracil 7.1616511603 15504547 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.1611748828
MESH:D000799 Angioedema Acetaminophen 3.3110982225
MESH:D000860 Anoxia Oxygen 4.5320872349
MESH:D001014 Aortic Aneurysm Indomethacin 4.3510231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 10.0019183758
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 10.0010388637
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.3518218290 18057881 20041841
MESH:D001161 Arteriosclerosis Dietary Fats 3.3815238619
MESH:D018771 Arthralgia Indomethacin 4.632160914
MESH:D001172 Arthritis, Rheumatoid Am 80 4.8016819260
MESH:D001172 Arthritis, Rheumatoid Indomethacin 4.8011248219
MESH:D001249 Asthma epigallocatechin gallate 4.7316516891
MESH:D001249 Asthma Mustard Gas 4.7310378619
MESH:D050197 Atherosclerosis Am 80 9.4416484594
MESH:D050197 Atherosclerosis Cadmium 9.4415687053
MESH:D050197 Atherosclerosis Oxygen 9.4416391483
MESH:D001281 Atrial Fibrillation Amiodarone 3.5019698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 2.1518445737
MESH:D001321 Autistic Disorder Mercury 2.1517497416
MESH:D001327 Autoimmune Diseases epigallocatechin gallate 9.5419761891
MESH:D001327 Autoimmune Diseases Mercury 9.5416634805
MESH:D001477 Bartter Syndrome Indomethacin 4.4710684365
MESH:D001768 Blister Mustard Gas 4.6319167455
MESH:D001778 Blood Coagulation Disorders Amiodarone 12.5819483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 12.5819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 12.5812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4115746008
MESH:D001859 Bone Neoplasms zoledronic acid 4.4719442620 15867366 11697798 17312309 16121404 16778634
MESH:D001862 Bone Resorption bisphenol A 8.2311985600
MESH:D001862 Bone Resorption zoledronic acid 8.2318496637 18404659 8053405 11869084 16769263 15845617
MESH:D001929 Brain Edema Indomethacin 4.4911481608
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.8017868700
MESH:D001930 Brain Injuries Progesterone 9.2515845082 15380490 15665606
MESH:D001930 Brain Injuries Raloxifene 9.2516580743
MESH:D002545 Brain Ischemia Indomethacin 3.8912524144
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 13.0611921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 13.0617474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 13.0617123778
MESH:D001943 Breast Neoplasms decitabine 13.0618320071 19208741
MESH:D001943 Breast Neoplasms Dietary Fats 13.0620435547
MESH:D001943 Breast Neoplasms Estradiol 13.0614630087 17289903 17261762 12948864 16675129 19861407 17018787 18497071
MESH:D001943 Breast Neoplasms Fluorouracil 13.0615136595 16110121 19217205 18357371 16595493 18608205 16557594
MESH:D001943 Breast Neoplasms gemcitabine 13.0617039268 18382427
MESH:D001943 Breast Neoplasms Indomethacin 13.0617401462
MESH:D001943 Breast Neoplasms Oxygen 13.0617263869
MESH:D001943 Breast Neoplasms Progesterone 13.0616175315 17614352 15562024
MESH:D001943 Breast Neoplasms Raloxifene 13.0617595753 17242785 15572757 17440819 16912660 17952589 16837676 17049068 17893378 15758505 17261762 15775269
MESH:D001943 Breast Neoplasms selenomethylselenocysteine 13.0618855134
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 13.0620435547
MESH:D001943 Breast Neoplasms zoledronic acid 13.0618695136 16096432
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.6315286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.4410378619 17687719
MESH:D002056 Burns Indomethacin 4.1910459503
MESH:D002100 Cachexia Indomethacin 4.4811239499 16537180 15141370 15625704
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9316111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.2715700767 18705752 16050911 16097048 15673190 10355542 15721981 16124888 3786805 16011737 16192424 16227642
MESH:D002276 Carcinoid Tumor Fluorouracil 4.1316051944
MESH:D002277 Carcinoma Fluorouracil 6.7917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.7916835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 14.9516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 14.953084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 14.9518788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 14.9516924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 14.9517971768 16332177 17088986 17045692 16799960 18930000
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 14.9516391822
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 14.951701930 17173139 20007298 6705139 20935162
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 14.9517306315 16507464 15276417
MESH:D002278 Carcinoma in Situ bisphenol A 4.4617123778
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.2011053908
MESH:D018276 Carcinoma, Medullary Indomethacin 4.8218791128 14736730 11352223
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 3.3419233551
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 9.3818695887
MESH:D002292 Carcinoma, Renal Cell Indomethacin 9.3817341418
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 9.3818507039
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 12.3620419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 12.3619215824
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 12.3616280240 16757204 18986760 17066447
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 12.3615482327 12636206
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 12.3618572023
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 3.6117572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.0618850075 18670907 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 5.4615710769 19225199
MESH:D002311 Cardiomyopathy, Dilated Mercury 5.4610334427
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 6.3316936243
MESH:D002318 Cardiovascular Diseases Raloxifene 6.3315775269
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.5618974383
MESH:D002386 Cataract Acetaminophen 2.2610977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 17.1420889678
MESH:D002471 Cell Transformation, Neoplastic Cadmium 17.1417332340
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 17.1412371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 17.1418566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 17.1420056578 19524636
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.744080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.7216835633
MESH:D002764 Cholecystitis Indomethacin 4.6311181007
MESH:D002779 Cholestasis Cyclosporine 6.4419486331
MESH:D002779 Cholestasis pirinixic acid 6.4419176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.8612621046 15340226 15668235 8697196 16354765
MESH:D003072 Cognition Disorders Raloxifene 4.1015800139
MESH:D003110 Colonic Neoplasms decitabine 5.1817616700
MESH:D003110 Colonic Neoplasms Fluorouracil 5.1817725105 15001691 17169374 17172411 17016597 18772588 17018589 16510598 16340194 17287894
MESH:D003110 Colonic Neoplasms Indomethacin 5.1811260862 15637740 15625704 15786552 15963497 15936596
MESH:D015179 Colorectal Neoplasms decitabine 3.1918981723
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.1915148649 16282729 18802399 17094418 16303861 16391804 16331619 16524972 18288408 14970324 17594712 17255274 18509181 17695437 18383874 18448328 17454858 18949393 20501625 15289873 17016601 17401013
MESH:D015179 Colorectal Neoplasms Indomethacin 3.1912606626 17054584 18059344 11197048
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6114669216 17141729
MESH:D003327 Coronary Disease fluvastatin 4.4616142594
MESH:D018352 Coronavirus Infections Indomethacin 5.1817302372
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2320055451 10048152 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.5018551238
MESH:D007644 Darier Disease Fluorouracil 4.2616733453
MESH:D003865 Depressive Disorder, Major Raloxifene 3.7217474826
MESH:D017449 Dermatitis, Allergic Contact Mercury 3.3116823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1618249437
MESH:D003924 Diabetes Mellitus, Type 2 epigallocatechin gallate 4.0916988119
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0917107852
MESH:D003928 Diabetic Nephropathies Estradiol 7.5319279558
MESH:D003928 Diabetic Nephropathies Raloxifene 7.5315920148 17308373 17451421
MESH:D003929 Diabetic Neuropathies Progesterone 3.9817187935
MESH:D003967 Diarrhea Indomethacin 3.317907874 7237001
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.7718551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.7719370779 19416960 19164858 14986274 11739529 16781746 15968718 17906064 19085960 12958197 12594235 19739265 11743745 18071297 10774834 17522070 17562736 16227642 16485898 16081117 16177239 10663392 16393943 12153990 19420014 11287661 18713872 10915739 16109766 11461765 12540782 14725611 2444490 11421492 19923254 11834606 15619225 12705907 11529661 14550746 12392966
MESH:D056486 Drug-Induced Liver Injury Amiodarone 15.7715265979 18218290
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 15.776623471 11566570 9327722 3732212 21278145 3786805 4309450 10092053 15968718 7179309 16177239 6884620 19085960 19336974 17522070 2869522 7440962 7120509 10915739 15027814 15998439 16227642
MESH:D056486 Drug-Induced Liver Injury Diquat 15.7718164269 18445702
MESH:D056486 Drug-Induced Liver Injury Gliotoxin 15.7719739265
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.7720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.3611462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.6218043480 18446180 16133044 17190690 12774134 16326151
MESH:D004381 Duodenal Ulcer Indomethacin 3.6417351913 17045617 11595415 17202747 10671773 11535926 17151854 17329845 16699067 11595431 11991626
MESH:D050171 Dyslipidemias Dietary Fats 3.0718367378
MESH:D004417 Dyspnea Oxygen 4.3020016425
MESH:D004421 Dystonia Phenobarbital 3.521851702
MESH:D004487 Edema Indomethacin 16.708985016 7907874 8273558 7990266 10653021 19703484 16100529
MESH:D004487 Edema Mustard Gas 16.7011428631 9260866 11402378 11428647
MESH:D004487 Edema pirinixic acid 16.7012083418
MESH:D004487 Edema Raloxifene 16.7015860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 16.7012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.3618230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Am 80 12.7516819260
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 12.7517692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 12.7515845917
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.5819294695
MESH:D016889 Endometrial Neoplasms Estradiol 2.6311473722 19148513 18566989
MESH:D004715 Endometriosis Indomethacin 12.6515652904
MESH:D004715 Endometriosis Progesterone 12.6516134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 12.659294722 10568697
MESH:D019446 Endotoxemia Indomethacin 3.9818509659
MESH:D004751 Enteritis Indomethacin 4.2110567023 17763956 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.4717980183
MESH:D004802 Eosinophilia Indomethacin 3.5511298111
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.593659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.343922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.6020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.106401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.747750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.493659116
MESH:D004890 Erythema Mustard Gas 4.639357497
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 12.0420426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 12.0416530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 12.0416481741 16785472 16337965 17638652 15173087
MESH:D004938 Esophageal Neoplasms Indomethacin 12.0411005569
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 12.0415264214 15547733 16805852 15878914 15623463 16510608 15547721 15150132 16704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6111564622
MESH:D005234 Fatty Liver 4-methylene-2-octyl-5-oxofuran-3-carboxylic acid 29.7514736702
MESH:D005234 Fatty Liver Amiodarone 29.7514986274
MESH:D005234 Fatty Liver Carbon Tetrachloride 29.7516045604 12795759 12631006 15959796 16239168 61145 17595544 19224547
MESH:D005234 Fatty Liver Cyclosporine 29.7519224547
MESH:D005234 Fatty Liver Dietary Fats 29.7518296743 19004024 19551842 17967931
MESH:D005234 Fatty Liver pirinixic acid 29.7520131406 19236843
MESH:D005234 Fatty Liver Raloxifene 29.7517473493
MESH:D005264 Femoral Fractures zoledronic acid 5.3016234978
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9411858732
MESH:D005334 Fever Indomethacin 3.6611852909 17627676 10431976
MESH:D005354 Fibrosarcoma Indomethacin 4.3710962813
MESH:D005355 Fibrosis Carbon Tetrachloride 22.2918705752
MESH:D005355 Fibrosis Cyclosporine 22.2912639820 12168785
MESH:D005355 Fibrosis Dietary Fats 22.2918296743
MESH:D005355 Fibrosis Indomethacin 22.2917994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 22.2920067830
MESH:D005499 Folliculitis Indomethacin 4.6311298111
MESH:D005739 Gas Poisoning Oxygen 4.6820016425
MESH:D005756 Gastritis Acetaminophen 16.0616983495
MESH:D005756 Gastritis Diquat 16.0615046732
MESH:D005756 Gastritis Indomethacin 16.0615046732
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.1516452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.698708960
MESH:D005909 Glioblastoma Indomethacin 3.2112870263
MESH:D005910 Glioma Fluorouracil 5.4616145905
MESH:D005910 Glioma Indomethacin 5.4618371953 16487511
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.8611849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0510696789
MESH:D006073 Gout Indomethacin 4.8211248219
MESH:D006258 Head and Neck Neoplasms decitabine 10.9119215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 10.9115162350 18337622 15102660
MESH:D006258 Head and Neck Neoplasms Indomethacin 10.9115482327
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.4520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.4510048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.1611110106
MESH:D006333 Heart Failure pirinixic acid 2.2020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.8915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8611000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.1015633222
MESH:D006505 Hepatitis Carbon Tetrachloride 3.1019900420 19110552
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.1815135802
MESH:D006529 Hepatomegaly Amiodarone 16.4715265979
MESH:D006529 Hepatomegaly Phenobarbital 16.4716109766
MESH:D006529 Hepatomegaly pirinixic acid 16.4718467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 16.4716120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.4915709030
MESH:D006689 Hodgkin Disease sodium arsenite 2.7212676792
MESH:D019584 Hot Flashes Estradiol 3.2217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5116354765 15340226 16959395 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 10.7916870215
MESH:D006930 Hyperalgesia Indomethacin 10.7912727271
MESH:D006930 Hyperalgesia zoledronic acid 10.7916769263
MESH:D034321 Hyperamylasemia Indomethacin 5.1817883296
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.0016899240
MESH:D006934 Hypercalcemia zoledronic acid 4.5718089816 19622757
MESH:D006937 Hypercholesterolemia Amiodarone 7.608137927 9751232
MESH:D006937 Hypercholesterolemia Dietary Fats 7.6021332399
MESH:D006940 Hyperemia Indomethacin 4.4812524144
MESH:D006943 Hyperglycemia pirinixic acid 2.7320558911
MESH:D006949 Hyperlipidemias Dietary Fats 7.7321332399
MESH:D006949 Hyperlipidemias Indomethacin 7.7317546600
MESH:D006973 Hypertension Cyclosporine 7.2410903974
MESH:D006973 Hypertension Raloxifene 7.2417577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.2418670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.5715338365
MESH:D006996 Hypocalcemia zoledronic acid 5.6512669777
MESH:D007037 Hypothyroidism Amiodarone 4.0017991464 18020914
MESH:D007077 Ileal Diseases Indomethacin 4.4910574470 18306037
MESH:D007079 Ileitis Indomethacin 4.8210647630 16133968 10651667
MESH:D007235 Infant, Premature, Diseases Indomethacin 4.8316133044
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.8915869954
MESH:D007248 Infertility, Male decitabine 9.3617581917
MESH:D007248 Infertility, Male Diquat 9.364850670
MESH:D007248 Infertility, Male sodium arsenite 9.3615346721 12646999
MESH:D007249 Inflammation Dietary Fats 12.7120412841
MESH:D007249 Inflammation Indomethacin 12.717812673 12568917 3291741
MESH:D007249 Inflammation Mustard Gas 12.7117524151 11428647 9260866 9357497 11428620 11402378 8975870 11428631 16001271
MESH:D007249 Inflammation Progesterone 12.7115869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 12.7112878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 14.6916393666
MESH:D007333 Insulin Resistance Dietary Fats 14.6911836018 18457598
MESH:D007333 Insulin Resistance Estradiol 14.6916393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 14.6916306350
MESH:D007410 Intestinal Diseases Indomethacin 3.8111686837 10210152 17994277 15831440 18236018 17329856 11855677 15610444 11713966
MESH:D019586 Intracranial Hypertension Indomethacin 4.8315241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.8616580747
MESH:D007579 Jejunal Diseases Indomethacin 4.4916133968 10574470 18306037
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.9015604871
MESH:D007674 Kidney Diseases Acetaminophen 23.9015629191 12587719
MESH:D007674 Kidney Diseases Cadmium 23.9016226777 16962696 16322080
MESH:D007674 Kidney Diseases Cyclosporine 23.9018776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 23.9015618244
MESH:D007674 Kidney Diseases Indomethacin 23.9017190690
MESH:D007674 Kidney Diseases Mercury 23.9017934191
MESH:D007674 Kidney Diseases sodium arsenite 23.9020008137
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 3.8016518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 14.2216705839
MESH:D007680 Kidney Neoplasms Cyclosporine 14.2212371664
MESH:D007680 Kidney Neoplasms Estradiol 14.2215610895
MESH:D007680 Kidney Neoplasms Fluorouracil 14.2216985049
MESH:D007889 Leiomyoma Raloxifene 4.0116973256
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.4711703811 12228301 10320625
MESH:D007938 Leukemia decitabine 2.7918980019 19235587
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 4.3018089816
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.5310785260 16572323 15631656
MESH:D007951 Leukemia, Myeloid decitabine 3.5318454857 19117987 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.7719387464 18704418 18460780 19010910 18206229 17679729
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 3.7718360721
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 4.9218055864
MESH:D015473 Leukemia, Promyelocytic, Acute Am 80 4.2816531727 16819260
MESH:D007964 Leukocytosis Indomethacin 4.8316537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.1817980183
MESH:D008064 Lipidoses Amiodarone 3.1317567588 15342952
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.1811479899
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 9.2111903743 16239168 17174718 16943688 17157831 17334410 16221502 11408273 21278145
MESH:D008103 Liver Cirrhosis Dietary Fats 9.2118296743
MESH:D008103 Liver Cirrhosis Phenobarbital 9.2121047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 7.6112389079 16248980 14724832 18317297 12445418 17640975 16136751 16027843 14748882 15123356 17481882 15362042 14512876 17631135 17557913 18279442 17869086 16097048 18472332 18339082 14620537 18395095 15893842 16033810 15370692 17766677 20821823 17525996 17698563 15959796 15818738 12632512 12546737 18156304 12666154 10355542 17714472 17761835 18395914 17721639 15730626 17708605 15931870 18429990 14716496 18187930 18006644 18418968 15925388 12667390 11481614 15338365 15673190 16116963 12649538 18263696 17565644 12445421 18412020 17900296 18376398 16011737 18054572 18210741 17823541 17976157 16015684 15876570 16638106 18420326 18481824 12741479 18251166 17944888 12898905 12609069 12632514 15057751 18166357 14716833 17922224 18705752 18472094 12958196 18277467 15996030 15650968 13678700 12586293 18205269 15052691 17805973 16192424
MESH:D008106 Liver Cirrhosis, Experimental epigallocatechin gallate 7.6117481882
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 7.6114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 7.6118194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 7.6115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 7.6112878042
MESH:D008107 Liver Diseases Acetaminophen 5.5019460945 16610002 12969438 16611625 19014921 11587558 12587719 19784758
MESH:D008107 Liver Diseases Carbon Tetrachloride 5.5017285989 16246199 16964402 15830285 15720792
MESH:D008107 Liver Diseases Phenobarbital 5.5019363144
MESH:D017093 Liver Failure Carbon Tetrachloride 3.6515123358
MESH:D017114 Liver Failure, Acute Acetaminophen 7.8817185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 7.8816899240 14706259
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 21.8920195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 21.8919294768
MESH:D008113 Liver Neoplasms Fluorouracil 21.8918383874 15113037 16603448 17045692
MESH:D008113 Liver Neoplasms Methapyrilene 21.8915890375
MESH:D008113 Liver Neoplasms Phenobarbital 21.8915975961 19482888 19812893 21047994 19073162 8742319
MESH:D008113 Liver Neoplasms pirinixic acid 21.8916377806 15890375 20007298
MESH:D008113 Liver Neoplasms sodium arsenite 21.8915276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 21.8916984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 7.8115583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 7.811399818 18308698 6150874 2563599 17172636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 7.8112151625
MESH:D008133 Long QT Syndrome Amiodarone 3.1717391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 10.2812587719
MESH:D008171 Lung Diseases Mustard Gas 10.2818702808 18161513
MESH:D008171 Lung Diseases sodium arsenite 10.2819095001
MESH:D017563 Lung Diseases, Interstitial Amiodarone 3.9418516814
MESH:D055370 Lung Injury Asbestos, Crocidolite 7.7917365036
MESH:D055370 Lung Injury Oxygen 7.7918339021
MESH:D008175 Lung Neoplasms 4-methylene-2-octyl-5-oxofuran-3-carboxylic acid 11.4518413838
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 11.456695378 18569708 18520028 18816296 20464547 20869020 17053015 20064080 20135361
MESH:D008175 Lung Neoplasms Fluorouracil 11.4515246190
MESH:D008175 Lung Neoplasms Indomethacin 11.4516537180 11497255 11053908
MESH:D008175 Lung Neoplasms Mustard Gas 11.458781369 3148597
MESH:D008175 Lung Neoplasms Smoke 11.4511091918
MESH:D008175 Lung Neoplasms sodium arsenite 11.4515276417 17077188 16712894 19931552 17306315
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 11.4519555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.2615086387
MESH:D008223 Lymphoma decitabine 3.0419470736
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 15.1311921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 15.1317203775 16891317 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 15.1311408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental selenomethylselenocysteine 15.1315318939
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 15.1317312309
MESH:D020149 Manganese Poisoning Estradiol 3.9419453300
MESH:D008545 Melanoma decitabine 4.6016505122 17785578
MESH:D008545 Melanoma epigallocatechin gallate 4.6011746506 17992120
MESH:D008545 Melanoma sodium arsenite 4.6019082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0519513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 5.8916166281 18303189 16966607
MESH:D008654 Mesothelioma zoledronic acid 5.8916675582
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.2516801185
MESH:D008881 Migraine Disorders Indomethacin 3.2911903285
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.0115863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 12.0516381670
MESH:D009062 Mouth Neoplasms Fluorouracil 12.0516757204 18986760
MESH:D009062 Mouth Neoplasms Indomethacin 12.0512636206
MESH:D009101 Multiple Myeloma Am 80 18.6517229644
MESH:D009101 Multiple Myeloma decitabine 18.6518172295
MESH:D009101 Multiple Myeloma fluvastatin 18.6516996129
MESH:D009101 Multiple Myeloma Raloxifene 18.6516497877
MESH:D009101 Multiple Myeloma zoledronic acid 18.6518089719 16996129 19621390
MESH:D009134 Muscular Atrophy, Spinal epigallocatechin gallate 4.9617962980
MESH:D009135 Muscular Diseases pirinixic acid 2.9916239165
MESH:D009181 Mycoses Amiodarone 4.3617974566 12754197
MESH:D009190 Myelodysplastic Syndromes decitabine 3.0619010910 16882708 18608210 19157545
MESH:D009203 Myocardial Infarction pirinixic acid 1.9119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 6.8916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 6.8916411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 3.9517484760
MESH:D009232 Myxoma Raloxifene 5.0116343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.3318551238
MESH:D009362 Neoplasm Metastasis Indomethacin 5.5611053908 11239499 16537180
MESH:D009362 Neoplasm Metastasis zoledronic acid 5.5615867366 17312309 19139120
MESH:D009369 Neoplasms Benzo(a)pyrene 12.6811141357
MESH:D009369 Neoplasms decitabine 12.6817925555 19116145 19470736
MESH:D009369 Neoplasms Fluorouracil 12.6818600527 18239605 16928823
MESH:D009369 Neoplasms pirinixic acid 12.6817405874
MESH:D009369 Neoplasms sodium arsenite 12.6811559025
MESH:D009374 Neoplasms, Experimental Indomethacin 7.5710663608 15625704
MESH:D009374 Neoplasms, Experimental sodium arsenite 7.5720056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2117289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.9017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.8418481113 19348381
MESH:D009410 Nerve Degeneration Rotenone 3.4715790535 17356569 18619942
MESH:D009421 Nervous System Malformations bisphenol A 13.4616427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 13.4611399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 13.4614600291
MESH:D009436 Neural Tube Defects sodium arsenite 2.7912854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 6.9718514411
MESH:D019636 Neurodegenerative Diseases Indomethacin 6.9712349958
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.0716436463
MESH:D009503 Neutropenia Mustard Gas 3.497688884 16761898
MESH:D009765 Obesity 4-methylene-2-octyl-5-oxofuran-3-carboxylic acid 6.7314736702
MESH:D009765 Obesity Dietary Fats 6.7319632207 20132043 18674790 11836018 21332399 18457598 20518802 16723640 17217161
MESH:D009765 Obesity pirinixic acid 6.7320558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.636374098
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 2.9716049721 12819281
MESH:D010003 Osteoarthritis Indomethacin 3.337009135
MESH:D010014 Osteolysis zoledronic acid 4.8415867366
MESH:D010018 Osteomalacia Phenobarbital 3.8417016548
MESH:D010024 Osteoporosis Raloxifene 6.4815775268 17882678 19059307
MESH:D010024 Osteoporosis zoledronic acid 6.4817882678
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.7415579764 17823083 15758505 17893378
MESH:D010049 Ovarian Diseases bisphenol A 4.4611985600
MESH:D010051 Ovarian Neoplasms decitabine 9.6819331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 9.6819401270
MESH:D010051 Ovarian Neoplasms Progesterone 9.6817393432 16525653
MESH:D010051 Ovarian Neoplasms sodium arsenite 9.6817306315 15276417
MESH:D010146 Pain Acetaminophen 8.9416870215
MESH:D010146 Pain Indomethacin 8.9413679232 17440234 3291741 17627676
MESH:D010146 Pain zoledronic acid 8.9416475674
MESH:D010149 Pain, Postoperative Indomethacin 4.1412538197 18702446
MESH:D010190 Pancreatic Neoplasms decitabine 10.5919294695
MESH:D010190 Pancreatic Neoplasms Fluorouracil 10.5919003803 16929163 15113037 16500647
MESH:D010190 Pancreatic Neoplasms gemcitabine 10.5911504793 16929163 18992248 18383843 17440100
MESH:D010190 Pancreatic Neoplasms Phenobarbital 10.5916965848
MESH:D010195 Pancreatitis Indomethacin 3.4415028970 17883296
MESH:D010212 Papilloma Hydrogen Peroxide 3.5812065085
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.1816537180
MESH:D010300 Parkinson Disease Rotenone 2.7711535288 18191903 19232380 16412576 11445065 16140633 18619942 19114014 15451049
MESH:D020734 Parkinsonian Disorders Indomethacin 7.8512349958
MESH:D020734 Parkinsonian Disorders Rotenone 7.8515574749 18197244 15795934 15927086
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.1811903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7112520081
MESH:D010437 Peptic Ulcer Indomethacin 4.6211148446
MESH:D010518 Periodontitis Indomethacin 4.3817225004
MESH:D016491 Peripheral Vascular Diseases Cadmium 4.8515687053
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.3810923243
MESH:D011041 Poisoning Mustard Gas 3.3215727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0618163543
MESH:D011230 Precancerous Conditions Cyclosporine 7.4912371664
MESH:D011230 Precancerous Conditions Phenobarbital 7.492563599
MESH:D047928 Premature Birth Indomethacin 4.6117000239
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 7.7610548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 7.7611222880 11896295 11399792 11118676
MESH:D055728 Primary Myelofibrosis decitabine 4.2117616702
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 8.9820887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 8.9820887781
MESH:D011471 Prostatic Neoplasms Am 80 2.7016289102
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.7017292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.7016740699
MESH:D011471 Prostatic Neoplasms Cadmium 2.7017075824
MESH:D011471 Prostatic Neoplasms Estradiol 2.7016740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.7018626508 19082440
MESH:D011471 Prostatic Neoplasms Raloxifene 2.7016536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.7016039940
MESH:D011471 Prostatic Neoplasms zoledronic acid 2.7012438248 19103299
MESH:D011507 Proteinuria Indomethacin 3.6811849393
MESH:D011537 Pruritus Mustard Gas 3.5718058305
MESH:D019310 Pseudolymphoma Phenobarbital 3.9612752131
MESH:D011565 Psoriasis Am 80 5.4416819260
MESH:D011565 Psoriasis Cyclosporine 5.4416882103
MESH:D011629 Puberty, Precocious bisphenol A 4.2610548101
MESH:D011658 Pulmonary Fibrosis Amiodarone 8.0111597910 12832656 12490602
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 8.0117322281 17975199 15814490 17365031
MESH:D011658 Pulmonary Fibrosis Mustard Gas 8.0117620002 17894541 17720292 10334151 17266442
MESH:D011693 Purpura Raloxifene 5.0115770314
MESH:D012004 Rectal Neoplasms Fluorouracil 3.5616160472 18286688 18722050 15538739
MESH:D015427 Reperfusion Injury pirinixic acid 2.1119058328
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 4.0317627322 18339021
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3318990726
MESH:D012208 Rhabdomyosarcoma decitabine 3.9219155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6518045962
MESH:D012512 Sarcoma, Ewing's zoledronic acid 4.4316121404
MESH:D012640 Seizures 2,4-dinitrotoluene 4.7118551238
MESH:D012640 Seizures Phenobarbital 4.714039156 11442880 16876388 3137016
MESH:D003294 Seizures, Febrile Phenobarbital 4.296407741
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.5618724381
MESH:D012871 Skin Diseases Mustard Gas 2.5616961503 15451306 12880345
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 15.0110029692 19755658
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 15.0112065085
MESH:D012878 Skin Neoplasms sodium arsenite 15.0118572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 15.018532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 15.0116192470
MESH:D013119 Spinal Cord Injuries Progesterone 3.7516503802 15862959
MESH:D016135 Spinal Dysraphism sodium arsenite 3.3812854658
MESH:D013272 Stomach Diseases Indomethacin 3.8917638125 18209964 16280098 10486359 18545984 10215738 15038085 17207306 16113693 15472012 16184426 10192188 17160473
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 5.662093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 5.6619037991
MESH:D013274 Stomach Neoplasms Fluorouracil 5.6617522103 18396642 15786421 19015929 19084572 16951190 16424979 18567086 17172411 17498489
MESH:D013274 Stomach Neoplasms Indomethacin 5.6615609394
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 5.6617575124 12958204
MESH:D013276 Stomach Ulcer Amiodarone 5.9618087811
MESH:D013276 Stomach Ulcer Indomethacin 5.9612077510 14567935 17627676 18193104 16631530 12787963 12500499 11595415 17895592 18087811 17977527 12467913 10750652 17657623 16150113 16169175 18431645 17654042 16755016 18209962 1323529 18181030 10423059 11729361 15255614 18726076 16397915 11595431 18237397 16934674 18543354 12498302 10878458 17918041 11145282 18299717 17135157 11906479 15138204 16252198 15104355 11523592
MESH:D020521 Stroke Raloxifene 3.4016837676
MESH:D019966 Substance-Related Disorders bisphenol A 3.4616684133 16045194
MESH:D013398 Sudden Infant Death Oxygen 5.0212563064
MESH:D013610 Tachycardia Amiodarone 3.7911238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.6919225199
MESH:D013959 Thyroid Diseases Amiodarone 10.2619731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.2612697716
MESH:D013964 Thyroid Neoplasms decitabine 9.7417967635
MESH:D013964 Thyroid Neoplasms Indomethacin 9.7418791128 11352223 14736730
MESH:D013964 Thyroid Neoplasms Phenobarbital 9.741399818
MESH:D013971 Thyrotoxicosis Amiodarone 4.3418020914 19584973
MESH:D013978 Tibial Fractures Estradiol 11.9219048282
MESH:D013978 Tibial Fractures Raloxifene 11.9219048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.5316280240
MESH:D016171 Torsades de Pointes Amiodarone 3.6717467628 11989578
MESH:D014456 Ulcer Indomethacin 4.3710574470 17380554
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 13.2916049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 13.2917053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 13.2919087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 13.2917572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 13.2916712894 16452187 11723127 17306315
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.7910091137
MESH:D014581 Urticaria Acetaminophen 2.5010982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 7.9616803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 7.9611813266
MESH:D014591 Uterine Diseases bisphenol A 4.4714652134
MESH:D014604 Uveal Neoplasms decitabine 4.3717785578
MESH:D014605 Uveitis Cyclosporine 3.451336536
MESH:D014652 Vascular Diseases sodium arsenite 3.9017056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0512125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.6716837676
MESH:D014839 Vomiting Indomethacin 4.2111897121
MESH:D014846 Vulvar Neoplasms Raloxifene 5.0116343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7115886252
MESH:D015430 Weight Gain Dietary Fats 3.2916723640
MESH:D014985 Xerophthalmia Cyclosporine 3.9017120751
Pathway ID Pathway Name
KEGG:04141 Protein processing in endoplasmic reticulum
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33632
    • No data
    Releated disease ID Related disease Name
    PA445062Neoplasms
    Releated drug ID Related drug Name
    PA449014cisplatin
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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