AutismKB 2.0

Annotation Detail for POLA2


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Basic Information Top
Gene Symbol:POLA2 ( FLJ21662,FLJ37250 )
Gene Full Name: polymerase (DNA directed), alpha 2 (70kD subunit)
Band: 11q13.1
Quick LinksEntrez ID:23649; OMIM: NA; Uniprot ID:DPOA2_HUMAN; ENSEMBL ID: ENSG00000014138; HGNC ID: 30073
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00240Pyrimidine metabolism
hsa03030DNA replication
hsa00230Purine metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Cell Cycle, Mitotic
DNA Replication
Chromosome Maintenance
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of POLA2 mRNAaffects expression 16483693
D002995 Clofibric Acid Clofibric Acid affects the expression of POLA2 mRNAaffects expression 17602206
D003474 Curcumin Curcumin results in decreased expression of POLA2 mRNAdecreases expression 18299980
D016572 Cyclosporine Cyclosporine results in decreased expression of POLA2 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of POLA2 mRNAincreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of POLA2 mRNAaffects expression 17351261
D005472 Fluorouracil POLA2 protein affects the susceptibility to Fluorouracilaffects response to substance 15548681
C041786 palm oil palm oil results in increased expression of POLA2 mRNAincreases expression 18042831
C076994 perfluorooctane sulfonic acid perfluorooctane sulfonic acid results in increased expression of POLA2 mRNAincreases expression 16221955
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of POLA2 mRNAaffects binding|decreases expression|increases activity 19710929
D012643 Selenium Selenium results in increased expression of POLA2 mRNAincreases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of POLA2 mRNAincreases expression 16960034
19465110
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of POLA2 mRNAincreases expression 16960034
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of POLA2 mRNAdecreases expression 17951470
D014212 Tretinoin Tretinoin results in decreased expression of POLA2 mRNAdecreases expression 18230668
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9311752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0417505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3814692618
MESH:D000230 Adenocarcinoma Fluorouracil 4.3817638652
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.1816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.1816835633
MESH:D019973 Alcohol-Related Disorders Curcumin 5.1817887948
MESH:D000505 Alopecia Tretinoin 3.6615955085
MESH:D000544 Alzheimer Disease Curcumin 2.6315590663
MESH:D000740 Anemia Fluorouracil 8.8517963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.8511748828
MESH:D001161 Arteriosclerosis Dietary Fats 10.1515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.1511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.3115885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.3116412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.7716807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.7716292516
MESH:D001249 Asthma Tretinoin 2.3616456186
MESH:D050197 Atherosclerosis Curcumin 3.3518704882
MESH:D001327 Autoimmune Diseases Curcumin 4.5619761891
MESH:D001471 Barrett Esophagus Tretinoin 4.4716935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.6019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.6012125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.6016206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D002545 Brain Ischemia Curcumin 4.4116770732
MESH:D001932 Brain Neoplasms Curcumin 3.9917596214
MESH:D001943 Breast Neoplasms Curcumin 2.3519250217 18593918 18462866 16243823
MESH:D001943 Breast Neoplasms Dietary Fats 2.3520435547
MESH:D001943 Breast Neoplasms Fluorouracil 2.3516557594 18357371 16595493 16110121 18608205 15136595 19217205
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3520435547
MESH:D001943 Breast Neoplasms Tretinoin 2.3516873071 16166294 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6716813970
MESH:D002276 Carcinoid Tumor Fluorouracil 4.7616051944
MESH:D002277 Carcinoma Curcumin 14.2318593918
MESH:D002277 Carcinoma Fluorouracil 14.2317121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 14.2316835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2616168501
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 3.1517971768 16332177 17045692 17088986 16799960 18930000
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.151917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.9918414057
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0418695887
MESH:D002294 Carcinoma, Squamous Cell Curcumin 7.7118462866
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.7116280240 17066447 18986760 16757204
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.7116096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3918670907 18850075 16120746
MESH:D002386 Cataract Tretinoin 3.1217460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.5612371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6716129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002779 Cholestasis Cyclosporine 13.5819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.5816919318 11677210 16105132 17681005 17333356 17110522 15861022
MESH:D002779 Cholestasis pirinixic acid 13.5819176532
MESH:D002822 Choriocarcinoma Tretinoin 5.2616461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.8315668235 15340226 16354765 8697196 12621046
MESH:D002972 Cleft Palate Tretinoin 5.839407595
MESH:D003092 Colitis Curcumin 16.4918200517 16804969 16782535
MESH:D003092 Colitis Selenium 16.4917936198
MESH:D003092 Colitis Tretinoin 16.4917035595
MESH:D003103 Coloboma Curcumin 4.6018809619
MESH:D003110 Colonic Neoplasms Curcumin 3.9616340194 19359593
MESH:D003110 Colonic Neoplasms Fluorouracil 3.9616510598 17169374 17725105 17172411 15001691 18772588 17016597 17287894 17018589 16340194
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017255274 16524972 18448328 18509181 17594712 16303861 15289873 15148649 18949393 20501625 18288408 17695437 17016601 18383874 17094418 16282729 16331619 17454858 16391804 18802399 14970324 17401013
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1114669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 4.9718497527
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4615322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.468800419 16925845 9142499 17551590 9664655 10589399 9211117 14991402 9224671 9125849
MESH:D007644 Darier Disease Fluorouracil 4.8716733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.4518403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4517107852
MESH:D003928 Diabetic Nephropathies Curcumin 4.0618204486
MESH:D056486 Drug-Induced Liver Injury Selenium 3.8215131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D004381 Duodenal Ulcer Curcumin 4.1117351913
MESH:D050171 Dyslipidemias Dietary Fats 3.4918367378
MESH:D004487 Edema pirinixic acid 6.7212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.7211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.2715322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 12.2718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2512538720
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1416569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.079294722 10568697
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.4616337965 16785472 15173087 17638652 16481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.9711564622
MESH:D005124 Eye Abnormalities Tretinoin 8.9716938888 9664655
MESH:D005234 Fatty Liver Curcumin 25.2719297423
MESH:D005234 Fatty Liver Cyclosporine 25.2719224547
MESH:D005234 Fatty Liver Dietary Fats 25.2717967931 19551842 18296743 19004024
MESH:D005234 Fatty Liver Ethinyl Estradiol 25.2715345470
MESH:D005234 Fatty Liver pirinixic acid 25.2720131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005355 Fibrosis Curcumin 28.6118705752
MESH:D005355 Fibrosis Cyclosporine 28.6112168785 12639820
MESH:D005355 Fibrosis Dietary Fats 28.6118296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 28.6120067830
MESH:D005355 Fibrosis Tretinoin 28.6117994277
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.7718462866
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.308708960
MESH:D005909 Glioblastoma Curcumin 12.2917596214
MESH:D005909 Glioblastoma perfluorooctane sulfonic acid 12.2917162496
MESH:D005909 Glioblastoma Tretinoin 12.2917312396
MESH:D005910 Glioma Fluorouracil 2.8916145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006258 Head and Neck Neoplasms Curcumin 13.2118829502 18462866
MESH:D006258 Head and Neck Neoplasms Fluorouracil 13.2115102660 18337622 15162350
MESH:D006258 Head and Neck Neoplasms Tretinoin 13.2116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2616084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6210048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.629664655 14991402
MESH:D006333 Heart Failure pirinixic acid 7.0620558911
MESH:D006333 Heart Failure Selenium 7.0617162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5015720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006529 Hepatomegaly pirinixic acid 8.5016221962 19772884 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.5015340226 12621046 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.1117701891
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1418606429 16354765 15340226 16959395 8697196
MESH:D006930 Hyperalgesia Tretinoin 3.2516870215
MESH:D006937 Hypercholesterolemia Curcumin 9.4218704882
MESH:D006937 Hypercholesterolemia Dietary Fats 9.4221332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6416778211
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.6721332399
MESH:D006973 Hypertension Cyclosporine 5.0110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0118670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5217937319
MESH:D007249 Inflammation Curcumin 8.5118403477 17151092 16956363
MESH:D007249 Inflammation Dietary Fats 8.5120412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.5112200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.2318200517 18596194
MESH:D007251 Influenza, Human Selenium 4.2916624496
MESH:D007333 Insulin Resistance Dietary Fats 7.3611836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.3616306350
MESH:D007410 Intestinal Diseases Tretinoin 3.8417994277
MESH:D007414 Intestinal Neoplasms Curcumin 4.2710783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.1216580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.1215992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5415604871
MESH:D007674 Kidney Diseases Cyclosporine 2.378314463 18776723 10903974
MESH:D007676 Kidney Failure, Chronic Selenium 3.9416518626
MESH:D007680 Kidney Neoplasms Cyclosporine 7.5512371664
MESH:D007680 Kidney Neoplasms Fluorouracil 7.5516985049
MESH:D007889 Leiomyoma Curcumin 4.6318555241
MESH:D007938 Leukemia Curcumin 6.5818462866
MESH:D007938 Leukemia Tretinoin 6.5817143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.2616106398
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7516482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0819850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1917294898 17217047 16935935 15748426 16140955 17339181 17649720 17107899 17301526 17712046 16891316 9834237 17361223 16331271 19029980 19642359 17506722 16823087 12679006 17368321 19225113 19075265 16788101 19035177 16766008
MESH:D015458 Leukemia, T-Cell Curcumin 4.8316106398
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.349224671
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9018296743
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 5.0018705752 17355460 18006644
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.0015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0012878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 5.0016248980 18397230
MESH:D008107 Liver Diseases Curcumin 2.6216956363
MESH:D008113 Liver Neoplasms Clofibric Acid 10.8717602206
MESH:D008113 Liver Neoplasms Fluorouracil 10.8717045692 15113037 16603448 18383874
MESH:D008113 Liver Neoplasms pirinixic acid 10.8715890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.8716984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1412151625
MESH:D008175 Lung Neoplasms Curcumin 3.5019359593 18462866 16243823
MESH:D008175 Lung Neoplasms Fluorouracil 3.5015246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5011884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.8715086387
MESH:D008223 Lymphoma Curcumin 3.6218462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.7716173963
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.7915318939
MESH:D008527 Medulloblastoma Tretinoin 2.8017453147
MESH:D008545 Melanoma Curcumin 3.5118462866 17885582
MESH:D008545 Melanoma Tretinoin 3.5116752155
MESH:D008569 Memory Disorders Curcumin 4.2217263510
MESH:D008591 Meningomyelocele Tretinoin 4.5016940565
MESH:D008654 Mesothelioma Selenium 2.8115107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8816801185
MESH:D009062 Mouth Neoplasms Fluorouracil 3.6716757204 18986760
MESH:D009101 Multiple Myeloma Curcumin 3.5519372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.0017962980
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1117596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9916411023
MESH:D009361 Neoplasm Invasiveness Curcumin 4.4318495463
MESH:D009369 Neoplasms Fluorouracil 8.4018239605 18600527 16928823
MESH:D009369 Neoplasms pirinixic acid 8.4017405874
MESH:D009369 Neoplasms Tretinoin 8.4016946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.6312497104
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3319348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.7314600291
MESH:D009421 Nervous System Malformations Tretinoin 9.739125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.7318462866
MESH:D009436 Neural Tube Defects Tretinoin 3.099142499
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4716436463
MESH:D009765 Obesity Curcumin 7.5119297423
MESH:D009765 Obesity Dietary Fats 7.5118457598 21332399 19632207 11836018 18674790 20132043 16723640 17217161 20518802
MESH:D009765 Obesity pirinixic acid 7.5120558911
MESH:D010024 Osteoporosis Curcumin 3.5018719352
MESH:D010051 Ovarian Neoplasms Curcumin 5.0819020741 18462866
MESH:D010051 Ovarian Neoplasms Tretinoin 5.0816936753
MESH:D010146 Pain Tretinoin 2.9516870215
MESH:D010190 Pancreatic Neoplasms Curcumin 8.8119401701 17440100 19196508
MESH:D010190 Pancreatic Neoplasms Fluorouracil 8.8116929163 16500647 15113037 19003803
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.8115976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D010954 Plasmacytoma Selenium 4.9915087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2712371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2711399792 11118676 11896295 11222880
MESH:D011471 Prostatic Neoplasms Curcumin 3.4811398177 10851300 15129424 12497104 18226269 18156803 18769126
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.4818626508 19082440
MESH:D011507 Proteinuria Tretinoin 3.6616636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.3916919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D011625 Pterygium Tretinoin 4.8816723453
MESH:D011656 Pulmonary Emphysema Curcumin 4.5819168576
MESH:D012004 Rectal Neoplasms Fluorouracil 4.0615538739 16160472 18286688 18722050
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.0818379247 10666014
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1616283617 16116481
MESH:D012509 Sarcoma Curcumin 4.1718462866
MESH:D018805 Sepsis Curcumin 4.1218389075
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6416192470
MESH:D012878 Skin Neoplasms Tretinoin 5.6416467112
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0416709447
MESH:D013274 Stomach Neoplasms Fluorouracil 2.5217522103 16951190 18396642 17172411 16424979 19015929 18567086 15786421 17498489 19084572
MESH:D013274 Stomach Neoplasms Tretinoin 2.5217261132
MESH:D013276 Stomach Ulcer Curcumin 3.5519188055 16631530
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.0617045167 16026305
MESH:D014062 Tongue Neoplasms Fluorouracil 10.0016280240
MESH:D014062 Tongue Neoplasms Tretinoin 10.0016051514
MESH:D014376 Tuberculosis Tretinoin 3.2616040207
MESH:D001749 Urinary Bladder Neoplasms Curcumin 2.9118593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.3518462866
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.6216803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.6216129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3614692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.7116752155
MESH:D014605 Uveitis Cyclosporine 4.081336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5914671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.1216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
MESH:D015430 Weight Gain Dietary Fats 3.7916723640
MESH:D009396 Wilms Tumor Tretinoin 4.0216287080
MESH:D014985 Xerophthalmia Cyclosporine 4.5417120751
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
REACT:22172 Chromosome Maintenance
REACT:383 DNA Replication
KEGG:03030 DNA replication
KEGG:01100 Metabolic pathways
KEGG:00230 Purine metabolism
KEGG:00240 Pyrimidine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA411
    • No data
    Releated disease ID Related disease Name
    PA445742Stomach Neoplasms
    Releated drug ID Related drug Name
    PA449748gemcitabine
    PA452621antineoplastic agents
    PA449957ibuprofen
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00851 other/unknown Dacarbazine Antineoplastic Agents;Antineoplastic Agents, Alkylating
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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