AutismKB 2.0

Annotation Detail for PLXNB2


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Basic Information Top
Gene Symbol:PLXNB2 ( KIAA0315,MM1,Nbla00445,PLEXB2,dJ402G11.3 )
Gene Full Name: plexin B2
Band: 22q13.33
Quick LinksEntrez ID:23654; OMIM: 604293; Uniprot ID:PLXB2_HUMAN; ENSEMBL ID: ENSG00000196576; HGNC ID: 9104
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of PLXNB2 mRNAincreases expression 20406850
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of PLXNB2 proteinaffects expression 20106945
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of PLXNB2 mRNAdecreases expression 15336504
D004040 Dietary Carbohydrates Dietary Carbohydrates results in decreased expression of PLXNB2 mRNAdecreases expression 17490981
D010672 Phenytoin Phenytoin results in decreased expression of PLXNB2 mRNAdecreases expression 14741686
C006253 pirinixic acid pirinixic acid results in decreased expression of PLXNB2 mRNAdecreases expression 18445702
D012643 Selenium Selenium results in increased expression of PLXNB2 mRNAincreases expression 19244175
D017632 Asbestos, Serpentine Asbestos, Serpentine results in increased expression of PLXNB2 mRNAincreases expression 16251409
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PLXNB2 mRNAdecreases expression 15652763
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PLXNB2 mRNAincreases expression 17035482
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenytoin 9.649118846 9677735 6195326 8986270 3425630 10563481
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.6415322242 14514962 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.8716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.8716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D001195 Asbestosis Asbestos, Serpentine 5.9110751356
MESH:D050197 Atherosclerosis Phenytoin 4.0415136057
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.4619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.4612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6920435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.1116705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.1121507988 12907637 12619106
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4716120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.906135515
MESH:D002493 Central Nervous System Diseases Phenytoin 5.564080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis pirinixic acid 2.9719176532
OMIM:601042 CHOREOATHETOSIS/SPASTICITY, EPISODIC Phenytoin 6.1511748493
MESH:D002971 Cleft Lip Phenytoin 4.252227380
MESH:D002972 Cleft Palate Phenytoin 6.413877104 6862529 10789828 2227380 1687470 6856622
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.418697196 16354765 12621046 15668235 15340226
MESH:D003092 Colitis Selenium 4.0417936198
MESH:D003103 Coloboma Phenytoin 5.369212184
MESH:D000013 Congenital Abnormalities Phenytoin 10.0010627286
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 10.0014669216 17141729
MESH:D019465 Craniofacial Abnormalities Phenytoin 2.8919952982 8986270 9212184
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.8920055451 10048152 15322242
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.2818551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
OMIM:607208 DRAVET SYNDROME Phenytoin 5.6511748493
MESH:D003875 Drug Eruptions Phenytoin 5.7615024534
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.5021346803 18551238
MESH:D056486 Drug-Induced Liver Injury Selenium 6.5015131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema pirinixic acid 7.2312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.2312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2215322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Phenytoin 4.9117654737
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D004816 Epidermal Necrolysis, Toxic Phenytoin 5.4420235791
MESH:D004820 Epidermolysis Bullosa Phenytoin 6.551399206 6251365
MESH:D004828 Epilepsies, Partial Phenytoin 5.2311558140 17116037
MESH:D004827 Epilepsy Phenytoin 4.03821787 11434505 20417680
MESH:D017029 Epilepsy, Complex Partial Phenytoin 5.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenytoin 5.353659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver pirinixic acid 2.9719236843 20131406
MESH:D005313 Fetal Death Phenytoin 11.6210627286
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 11.6211858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D005885 Gingival Hyperplasia Phenytoin 5.959029455
MESH:D019214 Gingival Overgrowth Phenytoin 6.5516390469 14659971
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4311294989 10048152
MESH:D006333 Heart Failure pirinixic acid 7.3520558911
MESH:D006333 Heart Failure Selenium 7.3517162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly pirinixic acid 9.1416221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.1415340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.368697196 16354765 16959395 15340226 18606429
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D020138 Hyperhomocysteinemia Phenytoin 4.8510459572
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9512200463 12878042
MESH:D007251 Influenza, Human Selenium 4.5116624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007676 Kidney Failure, Chronic Selenium 4.0916518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.1516705839
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1912878042
MESH:D008107 Liver Diseases Phenytoin 3.2614986274
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.247678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 11.2415890375 18177683 9163691 2125692
MESH:D008113 Liver Neoplasms pirinixic acid 11.2415890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.2416984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.512876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.518603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.5112151625
MESH:D008171 Lung Diseases Asbestos, Serpentine 4.4817200189
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.6714755239
MESH:D008175 Lung Neoplasms Asbestos, Serpentine 3.6711198217
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.6719555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8815318939
MESH:D008607 Mental Retardation Phenytoin 3.729212184
MESH:D008654 Mesothelioma Selenium 2.8615107826
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenytoin 5.8117484760
MESH:D009224 Myotonia Congenita Phenytoin 5.691896199
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.157678174 18551238
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009374 Neoplasms, Experimental Asbestos, Serpentine 5.1011704859
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009436 Neural Tube Defects Phenytoin 4.259118846
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.6216049721
MESH:D010018 Osteomalacia Phenytoin 5.6917016548
MESH:D010146 Pain Phenytoin 4.1515215642
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D010954 Plasmacytoma Selenium 5.2115087411
MESH:D010995 Pleural Diseases Asbestos, Serpentine 5.9510923243
MESH:D017689 Polydactyly Phenytoin 5.239212184
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811118676 11222880 11896295 11399792
MESH:D019310 Pseudolymphoma Phenytoin 5.861419762 8603615 12752131
MESH:D011658 Pulmonary Fibrosis Asbestos, Serpentine 3.8915511213 18569384
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012640 Seizures 2,6-dinitrotoluene 6.7618551238
MESH:D012640 Seizures Phenytoin 6.769844417 10029267 19919933 11044598 3691417 15946322 16876388 3137016
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.888532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8816192470
MESH:D013262 Stevens-Johnson Syndrome Phenytoin 5.4120235791
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3516049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6010091137
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
Pathway ID Pathway Name
KEGG:04360 Axon guidance
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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