AutismKB 2.0

Annotation Detail for SLC7A11


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Basic Information Top
Gene Symbol:SLC7A11 ( CCBR1,xCT )
Gene Full Name: solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
Band: 4q28.3
Quick LinksEntrez ID:23657; OMIM: 607933; Uniprot ID:XCT_HUMAN; ENSEMBL ID: ENSG00000151012; HGNC ID: 11059
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Transmembrane transport of small molecules
Amino acid and oligopeptide SLC transporters
Hemostasis
Metabolism of amino acids and derivatives
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C018855 2-tert-butylhydroquinone 2-tert-butylhydroquinone results in increased expression of SLC7A11 mRNAincreases expression 19183254
C026114 2-xylene 2-xylene results in increased expression of SLC7A11 mRNAincreases expression 20359517
D000082 Acetaminophen Acetaminophen affects the expression of SLC7A11 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SLC7A11 proteinaffects expression 20106945
C455846 aluminum citrate aluminum citrate results in decreased expression of SLC7A11 proteindecreases expression 16443240
C455846 aluminum citrate SLC7A11 protein results in increased uptake of aluminum citrateincreases uptake 16443240
D016718 Arachidonic Acid Arachidonic Acid results in increased expression of SLC7A11 mRNAincreases expression 16704987
C006632 arsenic trioxide arsenic trioxide results in increased expression of SLC7A11 mRNAincreases expression 19128835
D001554 Benzene Benzene results in increased expression of SLC7A11 mRNAincreases expression 20359517
D001564 Benzo(a)pyrene Benzo(a)pyrene affects the expression of SLC7A11 mRNAaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of SLC7A11 mRNAincreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC7A11 mRNAdecreases expression 20018196
19150397
C053541 bicalutamide bicalutamide results in increased expression of SLC7A11 mRNAincreases expression 15638997
C006780 bisphenol A bisphenol A affects the expression of SLC7A11 mRNAaffects expression 20170705
C006780 bisphenol A bisphenol A results in decreased expression of SLC7A11 mRNAdecreases expression 16474171
20678512
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of SLC7A11 mRNAincreases expression 12414654
D002104 Cadmium Cadmium results in increased expression of SLC7A11 mRNAincreases expression 21172416
C459604 candoxin candoxin results in increased expression of SLC7A11 mRNAincreases expression 16309724
D003474 Curcumin Curcumin results in increased expression of SLC7A11 mRNAincreases expression 17999991
D003474 Curcumin Curcumin results in increased expression of SLC7A11 mRNAincreases expression 19183254
C057862 cyanoginosin LR cyanoginosin LR results in increased expression of SLC7A11 mRNAincreases expression 17654400
D016572 Cyclosporine Cyclosporine results in increased expression of SLC7A11 mRNAincreases expression 20106945
D002945 Cisplatin SLC7A11 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of SLC7A11 mRNAincreases expression 15159206
D004178 Diquat Diquat results in increased expression of SLC7A11 mRNAincreases expression 21172416
D004958 Estradiol Estradiol results in decreased expression of SLC7A11 mRNAdecreases expression 16474171
D004958 Estradiol Estradiol results in increased expression of SLC7A11 mRNAincreases expression 20106945
15159206
D004964 Estriol Estriol results in increased expression of SLC7A11 mRNAincreases expression 15159206
D004970 Estrone Estrone results in increased expression of SLC7A11 mRNAincreases expression 15159206
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SLC7A11 mRNAaffects expression 20170705
C004912 ethylbenzene ethylbenzene results in increased expression of SLC7A11 mRNAincreases expression 20359517
C106014 gedunin gedunin results in increased expression of SLC7A11 mRNAincreases expression 17010675
D019833 Genistein Genistein results in decreased expression of SLC7A11 mRNAdecreases expression 16474171
C071834 glycidamide glycidamide results in increased expression of SLC7A11 mRNAincreases expression 17822822
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of SLC7A11 mRNAincreases expression 12414654
D007213 Indomethacin Indomethacin results in increased expression of SLC7A11 mRNAincreases expression 17401462
D008752 Methylene Chloride Methylene Chloride results in increased expression of SLC7A11 mRNAincreases expression 20359517
D020366 Methylmethacrylate Methylmethacrylate results in increased expression of SLC7A11 mRNAincreases expression 16916219
C025256 nonylphenol nonylphenol results in increased expression of SLC7A11 mRNAincreases expression 15159206
D010126 Ozone Ozone results in increased expression of SLC7A11 mRNAincreases expression 17095637
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of SLC7A11 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of SLC7A11 mRNAincreases expression 19482888
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in decreased expression of SLC7A11 mRNAdecreases expression 16474171
D011374 Progesterone Progesterone results in increased expression of SLC7A11 mRNAincreases expression 18037150
D020849 Raloxifene Raloxifene results in increased expression of SLC7A11 mRNAincreases expression 16497877
C064116 S-(1,1,2,2-tetrafluoroethyl)cysteine S-(1,1,2,2-tetrafluoroethyl)cysteine results in increased expression of SLC7A11 mRNAincreases expression 16678137
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of SLC7A11 mRNAaffects expression 20106945
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of SLC7A11 mRNAincreases expression 17200146
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of SLC7A11 mRNAincreases expression 17200146
D014050 Toluene Toluene results in increased expression of SLC7A11 mRNAincreases expression 20359517
C034613 triacsin C triacsin C results in increased expression of SLC7A11 mRNAincreases expression 16704987
D014241 Trichloroethylene Trichloroethylene results in increased expression of SLC7A11 mRNAincreases expression 20359517
C050414 tripterine tripterine results in increased expression of SLC7A11 mRNAincreases expression 17010675
D014415 Tunicamycin Tunicamycin results in increased expression of SLC7A11 mRNAincreases expression 17127020
D024483 Vitamin K 3 Vitamin K 3 results in increased expression of SLC7A11 mRNAincreases expression 12414654
D015054 Zymosan Zymosan results in increased expression of SLC7A11 mRNAincreases expression 17200146
D015054 Zymosan SLC7A11 gene mutant form inhibits the reaction [Zymosan results in increased activity of CASP3 protein]decreases reaction|increases activity 17200146
D015054 Zymosan Zymosan results in increased expression of SLC7A11 mRNAincreases expression 17200146
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 6.596195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 6.5915322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.4117505938
MESH:D058186 Acute Kidney Injury Cisplatin 3.5012690470 15814532 17670903
MESH:D000230 Adenocarcinoma arsenic trioxide 18.3919825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 18.3920127859 20464547
MESH:D000230 Adenocarcinoma Cisplatin 18.3917638652 11798837
MESH:D000230 Adenocarcinoma Estradiol 18.3911473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 18.3914692618
MESH:D000230 Adenocarcinoma Genistein 18.3911473722
MESH:D000230 Adenocarcinoma Indomethacin 18.3916537180
MESH:D000236 Adenoma Benzo(a)pyrene 5.796695378
MESH:D000236 Adenoma Indomethacin 5.7911497255
MESH:D018248 Adenoma, Liver Cell Phenobarbital 8.3617620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.3616835633
MESH:D000419 Albuminuria Raloxifene 4.1017308373 17451421
MESH:D019973 Alcohol-Related Disorders Curcumin 4.5517887948
MESH:D016301 Alveolar Bone Loss Indomethacin 4.8417225004
MESH:D000544 Alzheimer Disease Curcumin 8.2615590663
MESH:D000544 Alzheimer Disease Indomethacin 8.2617627676 15579461
MESH:D000544 Alzheimer Disease Ozone 8.2615513908
MESH:D000544 Alzheimer Disease Raloxifene 8.2615800139
MESH:D000686 Amyloidosis Diethylstilbestrol 3.9915469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.5011748828
MESH:D000740 Anemia Zymosan 7.5018664788
MESH:D000741 Anemia, Aplastic Benzene 3.9714761424 11369114 17661222
MESH:D000799 Angioedema Acetaminophen 3.3210982225
MESH:D001014 Aortic Aneurysm Indomethacin 4.3610231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 10.0319183758
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 10.0310388637
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.9611256880
MESH:D018771 Arthralgia Indomethacin 4.642160914
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.4715885639
MESH:D001169 Arthritis, Experimental Zymosan 6.4715142272 16872482 15944321 15188379 17659584
MESH:D001172 Arthritis, Rheumatoid Curcumin 6.6416807698
MESH:D001172 Arthritis, Rheumatoid Indomethacin 6.6411248219
MESH:D001172 Arthritis, Rheumatoid Ozone 6.6415570426
MESH:D001249 Asthma Ozone 2.4717854713 16373670
MESH:D050197 Atherosclerosis Cadmium 5.9815687053
MESH:D050197 Atherosclerosis Curcumin 5.9818704882
MESH:D001321 Autistic Disorder Acetaminophen 2.2418445737
MESH:D001321 Autistic Disorder Arachidonic Acid 2.2418582451
MESH:D001327 Autoimmune Diseases Curcumin 3.9919761891
MESH:D001477 Bartter Syndrome Indomethacin 4.4810684365
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 7.4216206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.4212125929
MESH:D001836 Body Weight Changes 2-xylene 10.357457028
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 10.3515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4215746008
MESH:D001855 Bone Marrow Diseases Benzene 4.7016183116
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.3614601052
MESH:D001862 Bone Resorption bisphenol A 3.4011985600
MESH:D001929 Brain Edema Indomethacin 4.5011481608
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.8117868700
MESH:D001930 Brain Injuries Progesterone 9.2915665606 15380490 15845082
MESH:D001930 Brain Injuries Raloxifene 9.2916580743
MESH:D002545 Brain Ischemia Curcumin 8.6616770732
MESH:D002545 Brain Ischemia Indomethacin 8.6612524144
MESH:D001932 Brain Neoplasms Curcumin 3.4917596214
MESH:D001943 Breast Neoplasms Benzene 11.5717162533 11921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 11.5717474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 11.5717123778
MESH:D001943 Breast Neoplasms Cisplatin 11.5719526202 18382427
MESH:D001943 Breast Neoplasms Curcumin 11.5719250217 18593918 16243823 18462866
MESH:D001943 Breast Neoplasms Diethylstilbestrol 11.5717129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 11.5719861407 16675129 17289903 17261762 14630087 17018787 12948864 18497071
MESH:D001943 Breast Neoplasms Genistein 11.5717200150 16541309 16873071
MESH:D001943 Breast Neoplasms Indomethacin 11.5717401462
MESH:D001943 Breast Neoplasms Methylene Chloride 11.5715986119
MESH:D001943 Breast Neoplasms Progesterone 11.5715562024 16175315 17614352
MESH:D001943 Breast Neoplasms Raloxifene 11.5717242785 17952589 17595753 16912660 17440819 17261762 17049068 15572757 16837676 15775269 15758505 17893378
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 11.5720435547
MESH:D001943 Breast Neoplasms Trichloroethylene 11.5715986119
MESH:D016535 Bronchial Hyperreactivity Ozone 3.2718315731 14754758 17626835 19059883 18417511 15516495 16777450
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.8511589617
MESH:D002056 Burns Indomethacin 4.2010459503
MESH:D002100 Cachexia Indomethacin 10.6715141370 16537180 15625704 11239499
MESH:D002100 Cachexia Ozone 10.6716183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9416111702
MESH:D002277 Carcinoma Curcumin 6.9118593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.9116835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 17.723084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 17.7221507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 17.7214691202 16217749 15073043 15553829 11135700
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 17.7217982673
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 17.7215948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 17.7216924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 17.7216924424
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 17.7216391822
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 17.7220935162 17173139 1701930 6705139 20007298
MESH:D002278 Carcinoma in Situ bisphenol A 4.4717123778
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.2111053908
MESH:D018276 Carcinoma, Medullary Indomethacin 4.8314736730 18791128 11352223
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 5.0916685392 12023789
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 5.0918414057
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.3519014326
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.1117341418
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.6612490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 12.4220419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 12.4217066447 18337622 6189445
MESH:D002294 Carcinoma, Squamous Cell Curcumin 12.4218462866
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 12.4212636206 15482327
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 12.4218922899
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 3.6217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.0716120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Genistein 10.1216332659
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 10.1216936243
MESH:D002318 Cardiovascular Diseases Raloxifene 10.1215775269
MESH:D002386 Cataract Acetaminophen 2.2610977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 13.0320889678
MESH:D002471 Cell Transformation, Neoplastic Cadmium 13.0317332340
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 13.0312371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 13.0318566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.754080065
MESH:D002547 Cerebral Palsy Toluene 5.339294310
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.7216835633
MESH:D002764 Cholecystitis Indomethacin 4.6411181007
MESH:D002779 Cholestasis Cyclosporine 6.4819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 6.4817110522 16919318 17681005 11677210 15861022 16105132 17333356
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.8715668235 16354765 15340226 8697196 12621046
MESH:D003072 Cognition Disorders Raloxifene 4.1115800139
MESH:D003092 Colitis Curcumin 3.6718200517 16782535 16804969
MESH:D003103 Coloboma Curcumin 4.0818809619
MESH:D003110 Colonic Neoplasms Curcumin 5.2316340194 19359593
MESH:D003110 Colonic Neoplasms Genistein 5.2317182828
MESH:D003110 Colonic Neoplasms Indomethacin 5.2315936596 15786552 15637740 15625704 15963497 11260862
MESH:D015179 Colorectal Neoplasms arsenic trioxide 4.3420501625
MESH:D015179 Colorectal Neoplasms Cisplatin 4.3415273666
MESH:D015179 Colorectal Neoplasms Indomethacin 4.3412606626 17054584 18059344 11197048
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 4.3415531428
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6214669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 4.3918497527
MESH:D023903 Coronary Restenosis arsenic trioxide 3.6912609071
MESH:D018352 Coronavirus Infections Indomethacin 5.1917302372
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 4.8610525206
MESH:D019465 Craniofacial Abnormalities Benzene 4.8615643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.8615322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Toluene 4.869294310
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.0612952375 16002989
MESH:D003643 Death Toluene 5.146431079
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.6215213294
MESH:D003704 Dementia Polychlorinated Biphenyls 4.2416140633
MESH:D003865 Depressive Disorder, Major Raloxifene 3.7217474826
MESH:D003872 Dermatitis Benzene 4.2615902427
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 6.2518403477
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.2516647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.2517107852
MESH:D003928 Diabetic Nephropathies Curcumin 12.5718204486
MESH:D003928 Diabetic Nephropathies Estradiol 12.5719279558
MESH:D003928 Diabetic Nephropathies Raloxifene 12.5715920148 17308373 17451421
MESH:D003929 Diabetic Neuropathies Progesterone 3.9917187935
MESH:D003967 Diarrhea Indomethacin 3.327907874 7237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 10.1019416960 19739265 11461765 11739529 12958197 12705907 16227642 11529661 15968718 14550746 12392966 11287661 14986274 15619225 16109766 10915739 19420014 19164858 19085960 16485898 16177239 16781746 11834606 19370779 17522070 12540782 16081117 12594235 11421492 12153990 18071297 17562736 10774834 17906064 2444490 14725611 18713872 19923254 16393943 10663392 11743745
MESH:D056486 Drug-Induced Liver Injury cyanoginosin LR 10.1017654400
MESH:D056486 Drug-Induced Liver Injury Diquat 10.1018164269 18445702
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 10.1020420201
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 10.107120509
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5719426721
MESH:D004362 Drug Toxicity Cisplatin 6.8815033597 12649298 19839026 12231392
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.8811462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.6318446180 12774134 18043480 17190690 16326151 16133044
MESH:D004381 Duodenal Ulcer Curcumin 7.7917351913
MESH:D004381 Duodenal Ulcer Indomethacin 7.7917045617 17329845 17202747 11595415 11991626 11535926 11595431 17351913 10671773 16699067 17151854
MESH:D004421 Dystonia Phenobarbital 3.531851702
MESH:D004487 Edema Arachidonic Acid 21.117990266 15177302 9599246 9831321 11698051 16716910
MESH:D004487 Edema Indomethacin 21.118273558 19703484 8985016 7907874 7990266 16100529 10653021
MESH:D004487 Edema Raloxifene 21.1115860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 21.1112711302 11000095
MESH:D004487 Edema Tetradecanoylphorbol Acetate 21.118113982 15177302 11698051 9599246 16716910 8273558 7812673
MESH:D004487 Edema Zymosan 21.117907874
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.3716714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 12.5512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 12.5517692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 12.5515845917
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 17.3516402032
MESH:D004714 Endometrial Hyperplasia Estriol 17.3516402032
MESH:D004714 Endometrial Hyperplasia Genistein 17.3516402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 10.4816804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 10.4811473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Genistein 10.4811473722
MESH:D004715 Endometriosis Indomethacin 12.7015652904
MESH:D004715 Endometriosis Progesterone 12.7016134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 12.7010568697 9294722
MESH:D019446 Endotoxemia Indomethacin 3.9918509659
MESH:D004751 Enteritis Indomethacin 4.2217763956 10567023 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.4817980183
MESH:D004802 Eosinophilia Indomethacin 3.5611298111
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.603659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.3511558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.6120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.116401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.757750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.503659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 12.0820426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 12.0812903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 12.0816530937
MESH:D004938 Esophageal Neoplasms Cisplatin 12.0816785472 16481741 17638652 15464296 15173087
MESH:D004938 Esophageal Neoplasms Indomethacin 12.0811005569
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6211564622
MESH:D005234 Fatty Liver arsenic trioxide 19.7715073043
MESH:D005234 Fatty Liver Curcumin 19.7719297423
MESH:D005234 Fatty Liver Cyclosporine 19.7719224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.7715345470
MESH:D005234 Fatty Liver Raloxifene 19.7717473493
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.3216002989 16611131 15751030 16534752 16513791
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9511858732
MESH:D005334 Fever Arachidonic Acid 8.1011852909
MESH:D005334 Fever Indomethacin 8.1017627676 11852909 10431976
MESH:D005354 Fibrosarcoma Indomethacin 4.3810962813
MESH:D005355 Fibrosis Curcumin 17.0518705752
MESH:D005355 Fibrosis Cyclosporine 17.0512639820 12168785
MESH:D005355 Fibrosis Indomethacin 17.0517994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 17.0520067830
MESH:D005499 Folliculitis Indomethacin 4.6411298111
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.7716904648
MESH:D005756 Gastritis Acetaminophen 16.1216983495
MESH:D005756 Gastritis Diquat 16.1215046732
MESH:D005756 Gastritis Indomethacin 16.1215046732
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.1918462866
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.4316452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.708708960
MESH:D005909 Glioblastoma Curcumin 9.9917596214
MESH:D005909 Glioblastoma Genistein 9.9916598420
MESH:D005909 Glioblastoma Indomethacin 9.9912870263
MESH:D005910 Glioma Indomethacin 3.0018371953 16487511
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.8711849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0710696789
MESH:D006073 Gout Indomethacin 4.8311248219
MESH:D006258 Head and Neck Neoplasms Cisplatin 11.0215464296 15102660
MESH:D006258 Head and Neck Neoplasms Curcumin 11.0218462866 18829502
MESH:D006258 Head and Neck Neoplasms Indomethacin 11.0215482327
MESH:D034381 Hearing Loss Cisplatin 3.8619898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 3.9915464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.4720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.4710048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.1711110106
MESH:D006402 Hematologic Diseases Benzene 4.1816183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.9015720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8711000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.1015633222
MESH:D006505 Hepatitis Zymosan 4.2119110552
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.1915135802
MESH:D006529 Hepatomegaly 2-xylene 11.747457013 7457028
MESH:D006529 Hepatomegaly Phenobarbital 11.7416109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 11.7416120746 15340226 12621046
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.5317701891
MESH:D006558 Herpes Genitalis Estradiol 4.5015709030
MESH:D006689 Hodgkin Disease Cisplatin 3.1716200630 16170182
MESH:D019584 Hot Flashes Estradiol 3.2317088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.528697196 18606429 15340226 16354765 16959395
MESH:D006930 Hyperalgesia Acetaminophen 6.4716870215
MESH:D006930 Hyperalgesia Indomethacin 6.4712727271
MESH:D034321 Hyperamylasemia Indomethacin 5.1917883296
MESH:D006937 Hypercholesterolemia Curcumin 3.5918704882
MESH:D006940 Hyperemia Indomethacin 4.4912524144
MESH:D006949 Hyperlipidemias Indomethacin 3.6917546600
MESH:D006965 Hyperplasia Diethylstilbestrol 3.9314722030 12960047
MESH:D006973 Hypertension Benzene 10.5317940673
MESH:D006973 Hypertension Cyclosporine 10.5310903974
MESH:D006973 Hypertension Raloxifene 10.5317577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 10.5318670907 18850075
MESH:D007021 Hypospadias Diethylstilbestrol 9.5616002989
MESH:D007021 Hypospadias Ethinyl Estradiol 9.5616945680 16569931
MESH:D007077 Ileal Diseases Indomethacin 4.5010574470 18306037
MESH:D007079 Ileitis Indomethacin 4.8310651667 10647630 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 4.8416133044
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.9015869954
MESH:D007246 Infertility Diethylstilbestrol 3.8615036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.9812013081
MESH:D007248 Infertility, Male Diquat 5.944850670
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.9417937319
MESH:D007249 Inflammation Arachidonic Acid 19.789831321 15177302 17371808
MESH:D007249 Inflammation Curcumin 19.7818403477 16956363 17151092
MESH:D007249 Inflammation Indomethacin 19.783291741 12568917 7812673
MESH:D007249 Inflammation Progesterone 19.7815869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 19.7812878042 12200463
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 19.7815177302 11698051 8273558 7562506 7812673
MESH:D007249 Inflammation Zymosan 19.7811289658 8014878
MESH:D015212 Inflammatory Bowel Diseases Curcumin 2.9818596194 18200517
MESH:D007333 Insulin Resistance bisphenol A 6.2716393666
MESH:D007333 Insulin Resistance Estradiol 6.2716627594 16393666
MESH:D007410 Intestinal Diseases Indomethacin 3.8211686837 15831440 18236018 17329856 17994277 10210152 15610444 11855677 11713966
MESH:D007414 Intestinal Neoplasms Curcumin 3.7710783313
MESH:D019586 Intracranial Hypertension Indomethacin 4.8415241188
MESH:D043183 Irritable Bowel Syndrome Zymosan 5.3217553498
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.8716580747
MESH:D007579 Jejunal Diseases Indomethacin 4.5010574470 16133968 18306037
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.9115604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.6115464296
MESH:D007674 Kidney Diseases Acetaminophen 19.7612587719 15629191
MESH:D007674 Kidney Diseases Cadmium 19.7616962696 16226777 16322080
MESH:D007674 Kidney Diseases Cisplatin 19.7615190930 12649298 12231392 18289764 19839026
MESH:D007674 Kidney Diseases Cyclosporine 19.7618776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 19.7615618244
MESH:D007674 Kidney Diseases Indomethacin 19.7617190690
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 3.8116518626
MESH:D007680 Kidney Neoplasms Cyclosporine 14.3912371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 14.3914681315 15003126 16762066
MESH:D007680 Kidney Neoplasms Estradiol 14.3915610895
MESH:D007680 Kidney Neoplasms Estrone 14.3915610895
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.2711231351
MESH:D007859 Learning Disorders Diethylstilbestrol 3.5617184923
MESH:D007889 Leiomyoma Curcumin 9.5618555241
MESH:D007889 Leiomyoma Raloxifene 9.5616973256
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.4811703811 12228301 10320625
MESH:D007938 Leukemia arsenic trioxide 12.7015070760
MESH:D007938 Leukemia Benzene 12.7017119257 14694614 18335105 15935818
MESH:D007938 Leukemia Curcumin 12.7018462866
MESH:D007938 Leukemia Genistein 12.7018980019 17468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 8.2212560223 17077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 8.2216106398
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.7916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 7.2614633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 7.2615631656 10785260 16572323
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.1619077051
MESH:D007951 Leukemia, Myeloid Benzene 8.1617506065
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 5.5516968895 20471514 16467208 19850784 17050201
MESH:D015470 Leukemia, Myeloid, Acute Benzene 5.5519478238
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 5.5518360721
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 2.8712018890 11468182 17649720 17107899 15748426 19035177 17869043 16330433 15622746 19642359 16331271 9834237 11161223 12712474 19075265 16112521 15213294 17712046 16891316 16823087 15336539 16966277 17217047 12679006 19225113
MESH:D015458 Leukemia, T-Cell arsenic trioxide 10.0816882451
MESH:D015458 Leukemia, T-Cell Curcumin 10.0816106398
MESH:D007964 Leukocytosis Indomethacin 4.8416537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.1917980183
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.1911479899
MESH:D008103 Liver Cirrhosis Phenobarbital 2.6021047994
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 5.8717355460 18705752 18006644
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.8714716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 5.8717823541
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 5.8718194892
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.8712878042
MESH:D008107 Liver Diseases Acetaminophen 5.6012969438 12587719 19014921 11587558 16611625 16610002 19460945 19784758
MESH:D008107 Liver Diseases Curcumin 5.6016956363
MESH:D008107 Liver Diseases Phenobarbital 5.6019363144
MESH:D017114 Liver Failure, Acute Acetaminophen 2.7916871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 15.0518177683 15890375 2125692 9163691
MESH:D008113 Liver Neoplasms arsenic trioxide 15.0514682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 15.0521137059 20195826
MESH:D008113 Liver Neoplasms Diethylstilbestrol 15.0516712894 15890375
MESH:D008113 Liver Neoplasms Phenobarbital 15.0521047994 19812893 8742319 19482888 15975961 19073162
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 15.0516984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 23.098603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 23.0920377131
MESH:D008114 Liver Neoplasms, Experimental Benzene 23.0912562636
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 23.0918308698 2563599 17172636 6150874 1399818
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 23.091423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 23.0912151625
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 23.097955063
MESH:D008133 Long QT Syndrome arsenic trioxide 2.9515213294
MESH:D008171 Lung Diseases Ozone 3.0219066396 8266340
MESH:D017563 Lung Diseases, Interstitial Benzene 4.2814698565
MESH:D055370 Lung Injury Ozone 3.3520417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 18.4914755239
MESH:D008175 Lung Neoplasms arsenic trioxide 18.4919825857 11798837
MESH:D008175 Lung Neoplasms Benzene 18.4912562636
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 18.4917053015 18569708 20064080 20464547 6695378 18816296 20135361 18520028 20869020
MESH:D008175 Lung Neoplasms Cisplatin 18.4917225452 11798837 6189445
MESH:D008175 Lung Neoplasms Curcumin 18.4916243823 19359593 18462866
MESH:D008175 Lung Neoplasms Indomethacin 18.4911497255 16537180 11053908
MESH:D008175 Lung Neoplasms Methylene Chloride 18.4915172992
MESH:D008175 Lung Neoplasms Ozone 18.497614698 8597069
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 18.4911884234 19555203
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 18.4911807781
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.6315166399
MESH:D008223 Lymphoma Benzene 10.5017119257 17584886
MESH:D008223 Lymphoma Curcumin 10.5018462866
MESH:D008223 Lymphoma Diethylstilbestrol 10.5015700306
MESH:D016399 Lymphoma, T-Cell Curcumin 4.1916173963
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 4.9916002989
MESH:D015674 Mammary Neoplasms, Animal Benzene 3.9312562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 15.1711921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 15.1711807958 16891317 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Genistein 15.1712929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 15.1717203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 15.178985016
MESH:D020149 Manganese Poisoning Estradiol 3.9519453300
MESH:D008545 Melanoma Cisplatin 4.7218176117 17761969 12393984 12883367 15577323 12374674 18505091 16248763 16432458 11135225 16809738 18332650 17023156
MESH:D008545 Melanoma Curcumin 4.7217885582 18462866
MESH:D008545 Melanoma Vitamin K 3 4.7219082730
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.2615990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0619513568
MESH:D008569 Memory Disorders Curcumin 3.6717263510
MESH:D008607 Mental Retardation Toluene 3.469294310
MESH:D008654 Mesothelioma Cisplatin 3.0217638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.2616801185
MESH:D008679 Metaplasia Ozone 4.5810496685
MESH:D008881 Migraine Disorders Indomethacin 3.3011903285
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.0315863610
MESH:D019957 Motor Skills Disorders Toluene 4.759294310
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.3216381670
MESH:D009062 Mouth Neoplasms Indomethacin 7.3212636206
MESH:D009101 Multiple Myeloma arsenic trioxide 14.2111468182 15949261 19549372 19417148 14977855
MESH:D009101 Multiple Myeloma Benzene 14.2117119195
MESH:D009101 Multiple Myeloma Curcumin 14.2119372569
MESH:D009101 Multiple Myeloma Raloxifene 14.2116497877
MESH:D009102 Multiple Organ Failure Zymosan 4.7312879239 18160304 15241586 15213630 10890648 12130978 10479408 15834315 15259001 17724436
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.4017962980
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.1418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 2.8316105982 16882451
MESH:D009203 Myocardial Infarction Genistein 2.6317141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.1816810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 7.1817141266
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 3.9617484760
MESH:D009232 Myxoma Raloxifene 5.0316343187
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 8.6916624393
MESH:D009361 Neoplasm Invasiveness Curcumin 8.6918495463
MESH:D009362 Neoplasm Metastasis Indomethacin 2.9411239499 11053908 16537180
MESH:D009369 Neoplasms Benzo(a)pyrene 9.6611141357
MESH:D009369 Neoplasms Cisplatin 9.6616773208
MESH:D009369 Neoplasms Diethylstilbestrol 9.6615313581
MESH:D009369 Neoplasms Trichloroethylene 9.6611911487
MESH:D009374 Neoplasms, Experimental Indomethacin 3.6410663608 15625704
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.0112497104
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2217289903
MESH:D009395 Nephritis, Interstitial Cisplatin 3.9715464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.9117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.8519348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 25.5411399458 16427766
MESH:D009421 Nervous System Malformations Diethylstilbestrol 25.5411399458
MESH:D009421 Nervous System Malformations Estradiol 25.5416427766 11399458
MESH:D009421 Nervous System Malformations Genistein 25.5416427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 25.5414600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.1018462866
MESH:D009436 Neural Tube Defects arsenic trioxide 6.3610525206
MESH:D009436 Neural Tube Defects Benzene 6.3615643154
MESH:D009447 Neuroblastoma Cisplatin 3.168761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 6.9918514411
MESH:D019636 Neurodegenerative Diseases Indomethacin 6.9912349958
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.188761367
MESH:D009765 Obesity Curcumin 2.6019297423
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.646374098
MESH:D009784 Occupational Diseases Benzene 3.7317119257 17479406 15727169 15576619 15913788 15935809 16737584 17178637 15612468
MESH:D010003 Osteoarthritis Indomethacin 3.347009135
MESH:D010018 Osteomalacia Phenobarbital 3.8517016548
MESH:D010024 Osteoporosis Curcumin 10.0218719352
MESH:D010024 Osteoporosis Genistein 10.0219401787
MESH:D010024 Osteoporosis Raloxifene 10.0217882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Genistein 8.5616169203
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 8.5617823083 15758505 15579764 17893378
MESH:D010049 Ovarian Diseases bisphenol A 4.4711985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 19.9816624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Benzene 19.9812562636
MESH:D010051 Ovarian Neoplasms Cisplatin 19.9815464296 17225452 6897625 19769630
MESH:D010051 Ovarian Neoplasms Curcumin 19.9819020741 18462866
MESH:D010051 Ovarian Neoplasms Estradiol 19.9819401270
MESH:D010051 Ovarian Neoplasms Genistein 19.9819005980
MESH:D010051 Ovarian Neoplasms Progesterone 19.9817393432 16525653
MESH:D010146 Pain Acetaminophen 5.4116870215
MESH:D010146 Pain Indomethacin 5.4117627676 17440234 3291741 13679232
MESH:D010149 Pain, Postoperative Indomethacin 4.1518702446 12538197
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 14.0515580305
MESH:D010190 Pancreatic Neoplasms Cisplatin 14.0519003803
MESH:D010190 Pancreatic Neoplasms Curcumin 14.0519196508 19401701 17440100
MESH:D010190 Pancreatic Neoplasms Phenobarbital 14.0516965848
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 14.0515976015
MESH:D010195 Pancreatitis Indomethacin 3.4515028970 17883296
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2111578682
MESH:D010212 Papilloma Hydrogen Peroxide 7.9412065085
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 7.9412065085 18922899 8330346 18404319
MESH:D010235 Paraganglioma arsenic trioxide 3.6819927285
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.1916537180
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.1916702228
MESH:D020734 Parkinsonian Disorders Indomethacin 3.6712349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.1911903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7212520081
MESH:D010437 Peptic Ulcer Indomethacin 4.6311148446
MESH:D010518 Periodontitis Indomethacin 4.3917225004
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 3.8215464296
MESH:D016491 Peripheral Vascular Diseases Cadmium 4.8615687053
MESH:D010538 Peritonitis Ozone 8.7416369182
MESH:D010538 Peritonitis Zymosan 8.7419088179 14761945 17826846 18557954 19641140 18760300 18977430 15979727 17371808 11985352 15259001
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.6414722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.1615687265 16977796
MESH:D010997 Pleural Neoplasms Cisplatin 4.8117638057
MESH:D011014 Pneumonia Ozone 3.8818007984 18381685 18929643
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0718163543
MESH:D011230 Precancerous Conditions Cyclosporine 7.5212371664
MESH:D011230 Precancerous Conditions Phenobarbital 7.522563599
MESH:D047928 Premature Birth Indomethacin 4.6217000239
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 13.2910548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 13.2917184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 13.2911399792 11896295 11222880 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.0120887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.0120887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.8719131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.8717292933
MESH:D011471 Prostatic Neoplasms bicalutamide 3.8718487222 17914592 15638997 19240160 19011039
MESH:D011471 Prostatic Neoplasms bisphenol A 3.8716740699
MESH:D011471 Prostatic Neoplasms Cadmium 3.8717075824
MESH:D011471 Prostatic Neoplasms Curcumin 3.8718156803 18226269 18769126 11398177 12497104 15129424 10851300
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.8717136230 15046698 15846301
MESH:D011471 Prostatic Neoplasms Estradiol 3.8716740699
MESH:D011471 Prostatic Neoplasms Genistein 3.8716925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 3.8715721890
MESH:D011471 Prostatic Neoplasms Raloxifene 3.8715731164 16220300 16536755
MESH:D011507 Proteinuria Indomethacin 3.6911849393
MESH:D011537 Pruritus Ethinyl Estradiol 2.8015861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 3.9712752131
MESH:D011565 Psoriasis Cyclosporine 2.0316882103
MESH:D011629 Puberty, Precocious bisphenol A 4.2710548101
MESH:D011656 Pulmonary Emphysema Curcumin 4.0719168576
MESH:D011693 Purpura Raloxifene 5.0315770314
MESH:D051437 Renal Insufficiency Cisplatin 3.9015464296
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.5510666014 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3418990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6518045962
MESH:D012509 Sarcoma Curcumin 3.6718462866
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 8.7116646077
MESH:D012512 Sarcoma, Ewing's Cisplatin 8.7114601052
MESH:D012640 Seizures Phenobarbital 5.174039156 3137016 16876388 11442880
MESH:D012640 Seizures Toluene 5.179294310 6431079
MESH:D003294 Seizures, Febrile Phenobarbital 4.306407741
MESH:D018805 Sepsis Curcumin 8.2718389075
MESH:D018805 Sepsis Zymosan 8.2711441115
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 15.0819755658 10029692
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 15.0812065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 15.088532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 15.0816192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 15.0811807781 12065085 8330346 18404319 8985016
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 4.8115464296
MESH:D013088 Spermatocele Diethylstilbestrol 9.9616709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 9.9616709447
MESH:D013119 Spinal Cord Injuries Progesterone 3.7615862959 16503802
MESH:D013272 Stomach Diseases Indomethacin 3.9010486359 18545984 16113693 17160473 10192188 17638125 10215738 15038085 16280098 17207306 18209964 15472012 16184426
MESH:D013274 Stomach Neoplasms arsenic trioxide 5.6817007042
MESH:D013274 Stomach Neoplasms Benzene 5.6812562636
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 5.682093021 20155912
MESH:D013274 Stomach Neoplasms Cisplatin 5.6817522103 18396642 15958060
MESH:D013274 Stomach Neoplasms Indomethacin 5.6815609394
MESH:D013276 Stomach Ulcer Curcumin 6.0616631530 19188055
MESH:D013276 Stomach Ulcer Indomethacin 6.0612498302 18193104 18181030 18209962 15255614 1323529 18237397 17135157 18299717 16169175 16934674 16631530 17627676 17918041 18087811 17654042 12500499 17895592 18431645 12077510 11729361 12787963 11523592 15104355 16755016 17977527 10750652 11906479 11595415 16150113 16252198 18726076 14567935 11595431 11145282 10878458 12467913 17657623 15138204 18543354 10423059 16397915
MESH:D020521 Stroke Raloxifene 3.4116837676
MESH:D019966 Substance-Related Disorders bisphenol A 3.4716045194 16684133
MESH:D013733 Testicular Diseases Toluene 4.4410514026 10048760
MESH:D013736 Testicular Neoplasms Cisplatin 4.1517225452 15464296
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7215669648
MESH:D013953 Thymus Neoplasms Benzene 4.4410850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.3712697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 9.7619014326
MESH:D013964 Thyroid Neoplasms Indomethacin 9.7614736730 11352223 18791128
MESH:D013964 Thyroid Neoplasms Phenobarbital 9.761399818
MESH:D013978 Tibial Fractures Estradiol 11.9519048282
MESH:D013978 Tibial Fractures Raloxifene 11.9519048282
MESH:D016171 Torsades de Pointes arsenic trioxide 3.4515213294
MESH:D014456 Ulcer Indomethacin 4.3810574470 17380554
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 16.8920435036 12973940 12845720 11780464
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 16.8917053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 16.8917225452 15464296 12973940
MESH:D001749 Urinary Bladder Neoplasms Curcumin 16.8918593936
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 16.8917306315 16452187 16712894
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 16.8917572228
MESH:D014565 Urogenital Neoplasms Curcumin 4.7418462866
MESH:D014581 Urticaria Acetaminophen 2.5010982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 8.2116803524
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 8.2116175088
MESH:D014591 Uterine Diseases bisphenol A 12.0614652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 12.0614652134
MESH:D014594 Uterine Neoplasms Benzene 13.2612562636
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 13.2615809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 13.2614692618
MESH:D014605 Uveitis Cyclosporine 10.231336536
MESH:D014605 Uveitis Zymosan 10.2311006244
MESH:D014625 Vaginal Neoplasms Cisplatin 9.4015577323
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 9.4016002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0712125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.6816837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0714671159 15869587
MESH:D014839 Vomiting Cisplatin 9.7811897121
MESH:D014839 Vomiting Indomethacin 9.7811897121
MESH:D014846 Vulvar Neoplasms Raloxifene 5.0316343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7215886252
MESH:D014985 Xerophthalmia Cyclosporine 3.9117120751
Pathway ID Pathway Name
REACT:19419 Amino acid and oligopeptide SLC transporters
REACT:604 Hemostasis
REACT:13 Metabolism of amino acids and derivatives
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35919
    • Releated gene ID Related gene Name
    PA35919SLC7A11
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    Releated drug ID Related drug Name
    PA449789glycine
    PA448055l-alanine
    PA448478l-arginine
    PA449173l-cysteine
    PA450197l-leucine
    PA450280l-lysine
    PA451125l-proline
    PA451330l-serine
    PA451822l-tyrosine
    PA451843l-valine
    PA451590taurine
    PA452621antineoplastic agents
    PA449503estradiol
    PA451581tamoxifen
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00138 - L-Cystine Dietary supplement;Micronutrient;Non-Essential Amino Acids
    DB00142 - L-Glutamic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
    DB00740 agonist Riluzole Anticonvulsants;Neuroprotective Agents;Anesthetics;Excitatory Amino Acid Antagonists
    DB00795 inhibitor Sulfasalazine Antirheumatic Agents;Anti-Infective Agents;Sulfonamides;Gastrointestinal Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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