AutismKB 2.0

Annotation Detail for TMEFF2


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Basic Information Top
Gene Symbol:TMEFF2 ( CT120.2,HPP1,TENB2,TPEF,TR )
Gene Full Name: transmembrane protein with EGF-like and two follistatin-like domains 2
Band: 2q32.3
Quick LinksEntrez ID:23671; OMIM: 605734; Uniprot ID:TEFF2_HUMAN; ENSEMBL ID: ENSG00000144339; HGNC ID: 11867
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200171Validated targets of C-MYC transcriptional repression
No data
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Related Diseases/Disorders Top
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Desease Name
diabetes (incident)
METABOLIC
Desease Name
Diabetes (incident)
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TMEFF2 mRNAdecreases expression 20382639
20018196
D007213 Indomethacin Indomethacin results in decreased expression of TMEFF2 mRNAdecreases expression 16984733
D014212 Tretinoin Tretinoin results in increased expression of TMEFF2 mRNAincreases expression 16604517
D014635 Valproic Acid Valproic Acid results in increased expression of TMEFF2 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 4.118875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.3519490988
MESH:D000230 Adenocarcinoma Indomethacin 2.8516537180
MESH:D000236 Adenoma Indomethacin 3.6511497255
MESH:D000505 Alopecia Tretinoin 3.9415955085
MESH:D016301 Alveolar Bone Loss Indomethacin 6.0917225004
MESH:D000544 Alzheimer Disease Indomethacin 2.7717627676 15579461
MESH:D000550 Amblyopia Valproic Acid 5.9617688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.9017497229
MESH:D001014 Aortic Aneurysm Indomethacin 5.3610231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 5.4310388637
MESH:D018771 Arthralgia Indomethacin 5.892160914
MESH:D001169 Arthritis, Experimental Tretinoin 3.3016412693
MESH:D001172 Arthritis, Rheumatoid Indomethacin 5.0111248219
MESH:D001172 Arthritis, Rheumatoid Tretinoin 5.0116292516
MESH:D001249 Asthma Tretinoin 2.4316456186
MESH:D001321 Autistic Disorder Valproic Acid 1.9818177632 15238991 18396377 19460635 17157402 20603192 18940202 19232924 18316065 18558336 16609825 18985861 17688650 18775368 17507914
MESH:D001471 Barrett Esophagus Tretinoin 4.9116935849
MESH:D001477 Bartter Syndrome Indomethacin 5.5510684365
MESH:D001714 Bipolar Disorder Valproic Acid 3.2420046352 17594078
MESH:D001778 Blood Coagulation Disorders Tretinoin 4.0316197459 16206674
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.638888407
MESH:D001929 Brain Edema Indomethacin 5.7511481608
MESH:D002545 Brain Ischemia Indomethacin 5.0512524144
MESH:D001943 Breast Neoplasms Indomethacin 2.3617401462
MESH:D001943 Breast Neoplasms Tretinoin 2.3616443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.2216813970
MESH:D002056 Burns Indomethacin 5.2710459503
MESH:D002100 Cachexia Indomethacin 5.6415141370 15625704 16537180 11239499
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.8816168501
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 3.4016391822
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.401917145
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 5.3611053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.9811352223 18791128 14736730
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.5317341418
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 5.1615482327 12636206
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 5.1616096774 16051514
MESH:D002386 Cataract Tretinoin 3.3017460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9820889678
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.2216129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8220734317
MESH:D002764 Cholecystitis Indomethacin 5.8911181007
MESH:D002822 Choriocarcinoma Tretinoin 5.8816461808
MESH:D002972 Cleft Palate Tretinoin 2.809407595
MESH:D003092 Colitis Tretinoin 4.2617035595
MESH:D003110 Colonic Neoplasms Indomethacin 2.6415963497 15786552 15625704 15936596 15637740 11260862
MESH:D015179 Colorectal Neoplasms Indomethacin 2.3612606626 11197048 17054584 18059344
MESH:D018352 Coronavirus Infections Indomethacin 6.4417302372
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.779142499 8800419 9224671 14991402 17551590 9125849 10589399 9664655 9211117 16925845
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.778888407 16575769 17688650
MESH:D003967 Diarrhea Indomethacin 4.307237001 7907874
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.251733752 19641884
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.7817190690 18446180 16133044 12774134 18043480 16326151
MESH:D004381 Duodenal Ulcer Indomethacin 4.6416699067 10671773 17329845 17202747 17351913 17151854 11991626 17045617 11595415 11535926 11595431
MESH:D004421 Dystonia Valproic Acid 4.511851702
MESH:D004487 Edema Indomethacin 3.9219703484 16100529 10653021 7907874 8273558 8985016 7990266
MESH:D004489 Edema, Cardiac Tretinoin 5.1918230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3516569247
MESH:D004715 Endometriosis Indomethacin 4.5415652904
MESH:D019446 Endotoxemia Indomethacin 5.1318509659
MESH:D004751 Enteritis Indomethacin 5.4716328016 10567023 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 5.5517980183
MESH:D004802 Eosinophilia Indomethacin 4.6111298111
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.713659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.643922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.1120417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.966426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.867750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.693659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.9120426865
MESH:D004938 Esophageal Neoplasms Indomethacin 4.9111005569
MESH:D005124 Eye Abnormalities Tretinoin 3.879664655 16938888
MESH:D005234 Fatty Liver Valproic Acid 3.7214986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.6116575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.6418558336 8888407
MESH:D005334 Fever Indomethacin 4.5117627676 11852909 10431976
MESH:D005354 Fibrosarcoma Indomethacin 5.5210962813
MESH:D005355 Fibrosis Indomethacin 10.9717994277
MESH:D005355 Fibrosis Tretinoin 10.9717994277
MESH:D005499 Folliculitis Indomethacin 5.8911298111
MESH:D005756 Gastritis Indomethacin 5.4715046732
MESH:D005909 Glioblastoma Indomethacin 8.1312870263
MESH:D005909 Glioblastoma Tretinoin 8.1317312396
MESH:D005910 Glioma Indomethacin 3.3518371953 16487511
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.6111849393
MESH:D006073 Gout Indomethacin 5.9811248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 8.7815482327
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.7816096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.8816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0714991402 9664655
MESH:D006501 Hepatic Encephalopathy Indomethacin 5.0015633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 5.1915135802
MESH:D006849 Hydrocephalus Valproic Acid 5.5017688650
MESH:D006930 Hyperalgesia Indomethacin 9.1212727271
MESH:D006930 Hyperalgesia Tretinoin 9.1216870215
MESH:D034321 Hyperamylasemia Indomethacin 6.4417883296
MESH:D006940 Hyperemia Indomethacin 5.6412524144
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.1316778211
MESH:D006949 Hyperlipidemias Indomethacin 4.6217546600
MESH:D007077 Ileal Diseases Indomethacin 5.7510574470 18306037
MESH:D007079 Ileitis Indomethacin 5.9810651667 10647630 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 6.0916133044
MESH:D007249 Inflammation Indomethacin 3.1512568917 3291741 7812673
MESH:D007410 Intestinal Diseases Indomethacin 11.8215831440 17329856 10210152 18236018 11686837 11713966 15610444 11855677 17994277
MESH:D007410 Intestinal Diseases Tretinoin 11.8217994277
MESH:D019586 Intracranial Hypertension Indomethacin 6.0915241188
MESH:D007569 Jaw Abnormalities Tretinoin 4.3317551590 15992940
MESH:D007579 Jejunal Diseases Indomethacin 5.7518306037 16133968 10574470
MESH:D007674 Kidney Diseases Indomethacin 3.4717190690
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 4.2512228301 10320625 11703811
MESH:D007938 Leukemia Tretinoin 2.9317143497
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 4.2210785260 15631656 16572323
MESH:D007951 Leukemia, Myeloid Tretinoin 4.1216482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 6.5218360721
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 6.5217596541 19850784 16294345
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 6.5216294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3917294898 17712046 16891316 17368321 16823087 16140955 12679006 17217047 19225113 17339181 16788101 9834237 17649720 16935935 19029980 19642359 17506722 17301526 19075265 17107899 17361223 19035177 16331271 15748426 16766008
MESH:D007964 Leukocytosis Indomethacin 6.0916537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 6.4417980183
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.589224671
MESH:D008101 Liver Abscess, Amebic Indomethacin 6.4411479899
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 2.8118194892
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.8116248980 18397230
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.9817228818
MESH:D008175 Lung Neoplasms Indomethacin 2.3711497255 16537180 11053908
MESH:D008527 Medulloblastoma Tretinoin 2.9117453147
MESH:D008545 Melanoma Tretinoin 1.9816752155
MESH:D008591 Meningomyelocele Tretinoin 4.9916940565
MESH:D008881 Migraine Disorders Indomethacin 8.6511903285
MESH:D008881 Migraine Disorders Valproic Acid 8.6518765137 18803445
MESH:D009062 Mouth Neoplasms Indomethacin 4.3012636206
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.458888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 8.0717596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 8.0717596541
MESH:D009362 Neoplasm Metastasis Indomethacin 3.2916537180 11053908 11239499
MESH:D009369 Neoplasms Tretinoin 2.5716946489 16594593
MESH:D009374 Neoplasms, Experimental Indomethacin 4.6910663608 15625704
MESH:D009421 Nervous System Malformations Tretinoin 4.289125849
MESH:D009436 Neural Tube Defects Tretinoin 8.129142499
MESH:D009436 Neural Tube Defects Valproic Acid 8.1216359493 8888407
MESH:D019636 Neurodegenerative Diseases Indomethacin 4.2912349958
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.896374098
MESH:D010003 Osteoarthritis Indomethacin 3.887009135
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4416936753
MESH:D010146 Pain Indomethacin 8.1417627676 3291741 17440234 13679232
MESH:D010146 Pain Tretinoin 8.1416870215
MESH:D010149 Pain, Postoperative Indomethacin 5.4018702446 12538197
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5715976015
MESH:D010195 Pancreatitis Indomethacin 4.3817883296 15028970
MESH:D010257 Paraneoplastic Syndromes Indomethacin 6.4416537180
MESH:D020734 Parkinsonian Disorders Indomethacin 4.5112349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 6.4411903285
MESH:D010437 Peptic Ulcer Indomethacin 5.7811148446
MESH:D010518 Periodontitis Indomethacin 5.6417225004
MESH:D047928 Premature Birth Indomethacin 5.6917000239
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.4620603192
MESH:D011507 Proteinuria Indomethacin 10.9211849393
MESH:D011507 Proteinuria Tretinoin 10.9216636307
MESH:D019310 Pseudolymphoma Valproic Acid 5.2612752131 11422049
MESH:D011625 Pterygium Tretinoin 5.4216723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 12.4516283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 12.4519155313
MESH:D012559 Schizophrenia Valproic Acid 2.1015737665 19110320
MESH:D012640 Seizures Valproic Acid 2.9911044598 11738929 14763951 17978042 1511512 15475178 16876388 3137016
MESH:D012878 Skin Neoplasms Tretinoin 2.7616467112
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0919490988
MESH:D013226 Status Epilepticus Valproic Acid 5.2612833885
MESH:D013272 Stomach Diseases Indomethacin 5.0517160473 10192188 10486359 16184426 17207306 15472012 10215738 16113693 17638125 18209964 16280098 15038085 18545984
MESH:D013274 Stomach Neoplasms Indomethacin 2.7115609394
MESH:D013274 Stomach Neoplasms Tretinoin 2.7117261132
MESH:D013276 Stomach Ulcer Indomethacin 4.0011906479 17654042 18087811 16934674 16252198 12467913 18543354 10423059 17135157 17895592 18299717 11595431 11729361 12787963 17918041 16169175 10878458 18181030 16397915 18726076 15255614 17657623 15104355 18209962 17627676 18193104 18431645 16631530 12077510 17977527 12498302 11595415 16150113 12500499 18237397 10750652 14567935 11145282 1323529 15138204 16755016 11523592
MESH:D013964 Thyroid Neoplasms Indomethacin 8.4218791128 11352223 14736730
MESH:D013964 Thyroid Neoplasms Tretinoin 8.4216026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.1816051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.9617262798
MESH:D014376 Tuberculosis Tretinoin 3.4516040207
MESH:D014456 Ulcer Indomethacin 5.5210574470 17380554
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 5.153119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.208888407
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.0716129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.3316752155
MESH:D014820 Vitiligo Tretinoin 4.5616761959
MESH:D014839 Vomiting Indomethacin 5.4711897121
MESH:D009396 Wilms Tumor Tretinoin 4.3416287080
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36568
    • No data
    Releated disease ID Related disease Name
    PA443886Diabetes Mellitus
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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