AutismKB 2.0

Annotation Detail for CADM1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CADM1 ( BL2,DKFZp686F1789,IGSF4,IGSF4A,MGC149785,MGC51880,NECL2,Necl-2,RA175,ST17,SYNCAM,TSLC1,sTSLC-1,sgIGSF,synCAM1 )
Gene Full Name: cell adhesion molecule 1
Band: 11q23.3
Quick LinksEntrez ID:23705; OMIM: 605686; Uniprot ID:CADM1_HUMAN; ENSEMBL ID: ENSG00000182985; HGNC ID: 5951
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04514Cell adhesion molecules (CAMs)
Pathway IDPathway Name
Cell junction organization
No data
No data
Pathway IDPathway Name
500121Nectin/Necl trans heterodimerization
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers
Head and neck cancers
H00054Nasopharyngeal cancer
No data
No data
Desease Name
Cardiovascular disease risk factors
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of CADM1 mRNAaffects expression 18281256
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CADM1 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of CADM1 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of CADM1 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of CADM1 mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CADM1 mRNAdecreases expression 19150397
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CADM1 mRNAincreases expression 20382639
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of CADM1 mRNAincreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of CADM1 mRNAaffects expression 17484886
D003314 Corn Oil Corn Oil affects the expression of CADM1 mRNAaffects expression 16360708
D016572 Cyclosporine Cyclosporine results in decreased expression of CADM1 mRNAdecreases expression 20106945
C014347 decitabine decitabine affects the expression of CADM1 mRNAaffects expression 17260099
D004041 Dietary Fats Dietary Fats results in increased expression of CADM1 mRNAincreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of CADM1 proteinaffects cotreatment|decreases expression 21163286
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of CADM1 promoteraffects cotreatment|increases methylation 21163286
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of CADM1 mRNAdecreases expression 17428255
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of CADM1 proteindecreases expression 17428255
D004052 Diethylnitrosamine Diethylnitrosamine results in increased methylation of CADM1 5' UTRincreases methylation 17428255
D000431 Ethanol [Fish Oils co-treated with Ethanol] results in increased expression of CADM1 mRNAaffects cotreatment|increases expression 17347304
D005395 Fish Oils [Fish Oils co-treated with Ethanol] results in increased expression of CADM1 mRNAaffects cotreatment|increases expression 17347304
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of CADM1 proteinincreases expression 17326163
D007657 Ketone Bodies Ketone Bodies results in increased expression of CADM1 mRNAincreases expression 16807920
D008748 Methylcholanthrene [Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of CADM1 proteinaffects cotreatment|decreases expression 21163286
D008748 Methylcholanthrene [Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of CADM1 promoteraffects cotreatment|increases methylation 21163286
C041786 palm oil palm oil results in increased expression of CADM1 mRNAincreases expression 18042831
C006253 pirinixic acid pirinixic acid results in increased expression of CADM1 mRNAincreases expression 18301758
17426115
D011794 Quercetin Quercetin results in increased expression of CADM1 mRNAincreases expression 17103110
D014212 Tretinoin Tretinoin results in increased expression of CADM1 mRNAincreases expression 16054129
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 3.7917676605 18926900
MESH:D000138 Acidosis Ethanol 4.3711192467
MESH:D055371 Acute Lung Injury pirinixic acid 2.9918653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 1.9520464547 20127859
MESH:D000236 Adenoma 2-Acetylaminofluorene 20.2410737359
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 20.243712494
MESH:D000236 Adenoma Benzo(a)pyrene 20.246695378
MESH:D000236 Adenoma Diethylnitrosamine 20.2410737359 6695378
MESH:D000236 Adenoma Methylcholanthrene 20.2410545420 6695378
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 5.886705139
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.6619061943 17620307 19052882 18056438 17162532 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.6616434500
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.1915451040 15451039
MESH:D000505 Alopecia Tretinoin 3.5115955085
MESH:D000743 Anemia, Hemolytic Quercetin 4.1217084956
MESH:D000799 Angioedema Acetaminophen 3.7110982225
MESH:D000853 Anophthalmos Ethanol 4.6915513904
MESH:D001008 Anxiety Disorders Ethanol 3.9011141031
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9419183758
MESH:D001161 Arteriosclerosis Dietary Fats 3.7615238619
MESH:D001169 Arthritis, Experimental Tretinoin 3.0016412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2316292516
MESH:D001249 Asthma Tretinoin 2.3116456186
MESH:D001260 Ataxia Telangiectasia Quercetin 4.8515336622
MESH:D050197 Atherosclerosis Methylcholanthrene 3.3811922910
MESH:D001321 Autistic Disorder marker/mechanism 18957284
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001327 Autoimmune Diseases Quercetin 4.2819761891
MESH:D001471 Barrett Esophagus Tretinoin 4.2716935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.8911289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.5719483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.5716197459 16206674
MESH:D001943 Breast Neoplasms marker/mechanism 17260099
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.6917474063 20146248
MESH:D001943 Breast Neoplasms decitabine 3.6918320071 19208741
MESH:D001943 Breast Neoplasms Dietary Fats 3.6920435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.6917474063
MESH:D001943 Breast Neoplasms Methylcholanthrene 3.6917474063
MESH:D001943 Breast Neoplasms Quercetin 3.6918628248
MESH:D001943 Breast Neoplasms Tretinoin 3.6916166294 16873071 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.4616813970
MESH:D002056 Burns Ethanol 4.5216374292
MESH:D002105 Cadmium Poisoning Quercetin 5.4216962696
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6518705752 16097048 16011737 16050911 15721981 16124888 15700767 16192424 15673190 3786805 16227642 10355542
MESH:D002277 Carcinoma Methylcholanthrene 3.8610545420
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.0316168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 19.5216705839
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 19.523581430 3084413 10737359 17761372 6705139
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 19.527296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 19.523084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 19.5218788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 19.523581430 19919837 19335982 19107877 19394651 18210153 18978308 20514400 19519916 18665156 16807293 16328049 20935162 20432363 17428255 20101231 20524982 17761372 18785209 20727157 16830150 18393292 11831363 19208518 16540662 20512989 20084675 18971187 16698587 18494052 17978847 16502159 16779866 19418558 3084413 18056438 21159647 19383236 18506893 18691550 17173139 18788625 19701751 17162532 16288022 16569478 19822196 10737359 19171122 19052882 19539802 16681979 17138121 16878318 20007298 20214788 16935385 17055752 10672840
MESH:D006528 Carcinoma, Hepatocellular Ethanol 19.5215763234 18788625 15289165
MESH:D006528 Carcinoma, Hepatocellular Quercetin 19.5212508355 19519916
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 19.521917145
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.8217234771
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.617296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.3220419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.3219215824
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.3216051514 16096774
MESH:D006332 Cardiomegaly Ethanol 6.9619332462
MESH:D006332 Cardiomegaly Quercetin 6.9619794523
MESH:D002386 Cataract Acetaminophen 6.9710977129
MESH:D002386 Cataract Tretinoin 6.9717460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 20.147505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 20.1420889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 20.1412371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 20.1417174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 20.1416192471
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.4616129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.5719052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.8219486331 9022650
MESH:D002779 Cholestasis Cyclosporine 12.8219486331
MESH:D002779 Cholestasis pirinixic acid 12.8219176532
MESH:D002822 Choriocarcinoma Tretinoin 5.0316461808
MESH:D002971 Cleft Lip Ethanol 3.5215513904
MESH:D002972 Cleft Palate Ethanol 5.9815513904
MESH:D002972 Cleft Palate Tretinoin 5.989407595
MESH:D003092 Colitis Tretinoin 3.5717035595
MESH:D003110 Colonic Neoplasms decitabine 3.8617616700
MESH:D003110 Colonic Neoplasms Quercetin 3.8611134977 17148506 17191121 16640504 19056647 19440933 15741050
MESH:D015179 Colorectal Neoplasms decitabine 2.6718981723
MESH:D015179 Colorectal Neoplasms Quercetin 2.6718852136 18095365
MESH:D019465 Craniofacial Abnormalities Ethanol 2.8015513904 10194807 15451040 19302082 11198716 15451039 11873399
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.8016925845 8800419 9142499 9211117 17551590 9224671 10589399 14991402 9664655 9125849
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.8818551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.6812868966 11906362 18759878 11298694 8156756 8970840 2524372 14531868
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3718249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.373621924 2952479
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.6219496084
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.1620387270
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 14.7621346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 14.768291058 1440618 9328219 7440962 6482804 16192314 18648102 18289764 11289319 18692083 9653073 9022650 6679447
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 14.7619923254 10915739 16227642 11287661 15619225 19739265 11834606 16081117 19164858 11421492 19085960 16109766 19420014 17522070 12958197 17906064 2444490 15968718 16177239 19416960 12594235 16393943 14986274 10774834 11461765 16781746 11739529 17562736 11529661 16485898 14550746 12540782 12705907 19370779 10663392 11743745 12153990 14725611 12392966 18713872 18071297
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 14.7610915739 7440962 15027814 6623471 7179309 16177239 6884620 19085960 10092053 3732212 16227642 7120509 21278145 19336974 9327722 15998439 2869522 11566570 4309450 3786805 17522070 15968718
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 14.7619107877
MESH:D056486 Drug-Induced Liver Injury Ethanol 14.7611566570
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9719426721
MESH:D050171 Dyslipidemias Dietary Fats 3.3618367378
MESH:D004487 Edema pirinixic acid 2.3612083418
MESH:D004489 Edema, Cardiac Tretinoin 4.3418230668
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.9919294695
MESH:D016889 Endometrial Neoplasms Tretinoin 3.0216569247
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9916302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 10.123581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.1220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 10.1216530937
MESH:D004938 Esophageal Neoplasms Ethanol 10.1216704527
MESH:D005124 Eye Abnormalities Tretinoin 3.4816938888 9664655
MESH:D005234 Fatty Liver Carbon Tetrachloride 35.1516239168 12631006 15959796 12795759 16045604 19224547 17595544 61145
MESH:D005234 Fatty Liver Cyclosporine 35.1519224547
MESH:D005234 Fatty Liver Dietary Fats 35.1518296743 19551842 17967931 19004024
MESH:D005234 Fatty Liver Diethylnitrosamine 35.1521071580 20387270
MESH:D005234 Fatty Liver Ethanol 35.1519236843 18620774 16409862
MESH:D005234 Fatty Liver Fish Oils 35.1518620774
MESH:D005234 Fatty Liver pirinixic acid 35.1519236843 20131406
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.5417920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.1716946407 15513904 10194807 15451040
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.896705139
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.8110962813 14633661
MESH:D005355 Fibrosis Carbon Tetrachloride 26.3618705752
MESH:D005355 Fibrosis Cyclosporine 26.3612639820 12168785
MESH:D005355 Fibrosis Dietary Fats 26.3618296743
MESH:D005355 Fibrosis Quercetin 26.3619474275
MESH:D005355 Fibrosis Tretinoin 26.3617994277
MESH:D005756 Gastritis Acetaminophen 10.7016983495
MESH:D005756 Gastritis Ethanol 10.7015046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.098708960
MESH:D005909 Glioblastoma Quercetin 6.9719804834
MESH:D005909 Glioblastoma Tretinoin 6.9717312396
MESH:D005910 Glioma Quercetin 3.0017643826
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.917505956
MESH:D006258 Head and Neck Neoplasms decitabine 7.5419215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.5416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.0316084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.4320471113
MESH:D006330 Heart Defects, Congenital Tretinoin 6.439664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.4620558911
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.196705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 4.296705139
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2915720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.806705139
MESH:D006505 Hepatitis Carbon Tetrachloride 8.8019110552 19900420
MESH:D006529 Hepatomegaly 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 8.5116109766
MESH:D006529 Hepatomegaly pirinixic acid 8.5119176532 18467677 19772884 16221962
MESH:D006930 Hyperalgesia Acetaminophen 12.4616870215
MESH:D006930 Hyperalgesia Ethanol 12.4618783367
MESH:D006930 Hyperalgesia Tretinoin 12.4616870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4016899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4721332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4416778211
MESH:D006943 Hyperglycemia pirinixic acid 8.8520558911
MESH:D006943 Hyperglycemia Quercetin 8.8518262572 11834736
MESH:D006949 Hyperlipidemias Dietary Fats 9.1421332399
MESH:D006949 Hyperlipidemias Fish Oils 9.1415752949
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8115034207
MESH:D006968 Hypersensitivity, Delayed Corn Oil 12.2611484837
MESH:D006968 Hypersensitivity, Delayed Fish Oils 12.2611484837
MESH:D006973 Hypertension Cyclosporine 5.1310903974
MESH:D006973 Hypertension Quercetin 5.1318356687
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9615338365
MESH:D007248 Infertility, Male decitabine 3.1217581917
MESH:D007249 Inflammation Dietary Fats 4.8820412841
MESH:D007249 Inflammation Diethylnitrosamine 4.8818785209
MESH:D007251 Influenza, Human Quercetin 4.3816624496
MESH:D007333 Insulin Resistance Dietary Fats 6.9618457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 6.9616306350
MESH:D007410 Intestinal Diseases Tretinoin 3.6417994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.899022650 8074119
MESH:D007569 Jaw Abnormalities Ethanol 9.9215513904
MESH:D007569 Jaw Abnormalities Tretinoin 9.9217551590 15992940
MESH:D007627 Keloid Quercetin 4.8217086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3115604871
MESH:D007674 Kidney Diseases Acetaminophen 9.6112587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.618314463 10903974 18776723
MESH:D007674 Kidney Diseases Quercetin 9.6116962696
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 11.7416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 11.746582329
MESH:D007680 Kidney Neoplasms Cyclosporine 11.7412371664
MESH:D007859 Learning Disorders Ethanol 4.0815451040
MESH:D007938 Leukemia decitabine 10.1718980019 19235587
MESH:D007938 Leukemia Quercetin 10.1717468513
MESH:D007938 Leukemia Tretinoin 10.1717143497
MESH:D007951 Leukemia, Myeloid decitabine 9.1618454857 17236224 19117987
MESH:D007951 Leukemia, Myeloid Tretinoin 9.1616482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.8917679729 19387464 18460780 18206229 19010910 18704418
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.8917596541 16294345 19850784
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.3318055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0719075265 16935935 17107899 19029980 16788101 17649720 17712046 16891316 19642359 16823087 17339181 17301526 19035177 17217047 16766008 16140955 16331271 17294898 17368321 17506722 9834237 12679006 15748426 17361223 19225113
MESH:D017880 Limb Deformities, Congenital Ethanol 8.0117676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 8.019224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 15.1911903743 17174718 16943688 21278145 11408273 17334410 16239168 17157831 16221502
MESH:D008103 Liver Cirrhosis Dietary Fats 15.1918296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 15.1920032147 19638242 18665156 18407596 18522880
MESH:D008103 Liver Cirrhosis Ethanol 15.1915289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.9718295389
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1115034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.5710355542 18472332 16027843 17922224 12546737 16015684 15818738 18420326 18156304 18472094 15925388 12445418 12667390 17900296 15673190 14716833 15876570 14748882 17698563 12649538 17721639 11481614 15338365 16638106 12445421 17481882 17708605 18395095 12666154 16097048 18251166 12609069 18429990 14724832 17805973 18277467 18418968 16136751 13678700 20821823 18210741 15931870 18006644 17869086 17640975 16033810 12898905 12958196 17525996 17565644 14716496 18317297 14512876 15052691 16248980 17976157 17714472 17944888 18279442 16192424 14620537 12632512 18412020 17631135 18376398 18263696 12389079 16116963 18205269 18705752 17761835 15057751 12632514 16011737 17823541 18339082 18054572 18187930 18395914 15362042 17557913 15123356 15370692 17766677 15730626 18166357 18481824 15959796 12741479 12586293 15893842 15650968 15996030
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 6.5718166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.5715474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 6.5712741479
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.5718397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 6.2711587558 12969438 19460945 16611625 16610002 19014921 12587719 19784758
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.2715830285 17285989 16246199 16964402 15720792
MESH:D008107 Liver Diseases Diethylnitrosamine 6.2717034775
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.5217207112 17347304
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0315123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.0216871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.0216899240 14706259
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 17.3518001218 16273603 10672840 11376686 10737359 14678523
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 17.3520195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 17.3519294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 17.3520405173 19812893 2862719 20101389 20492335 18754104 10737359 15175105 19642983 18978307 21167192 20501860 21071580 18648771 19256749 19294768 21047994 19254457 9163691 18644402 19996281 20434301 19255062 19850985 20583210 2422723 12771043 20118626 20137499 15885732 19427195 19090486 19426721 18977376 19833225 20452335 19499222 19551842 16942905 12112319 19638242 19690152 21278145 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 17.3520007298 15890375 16377806
MESH:D008113 Liver Neoplasms Quercetin 17.3518980244
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 22.336150874 534488 1399818
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 22.336587162 3712494 1399818 598648
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 22.3312014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 22.3319126423 17174075 18775883 19539802 18093689 19009564 18282651 17854601 16842330 21159647 18253720 18544905 9362446 2563599 18164116 18079962 18308698 19004024 3124819 16267830 19519916 17942915
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 22.33598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Quercetin 22.3319519916
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 6.4511376686
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.4517053015 18816296 20464547 18569708 18520028 6695378 20869020 20064080 20135361
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.4520970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Methylcholanthrene 6.4515390079 6695378 20970405 20512841 16337739 9230183 16271038 11893704 1399818 21163286 10545420 17909032 7750092
MESH:D008175 Lung Neoplasms Quercetin 6.4516280456
MESH:D008223 Lymphoma decitabine 3.3319470736
MESH:D008527 Medulloblastoma Tretinoin 2.7317453147
MESH:D008545 Melanoma decitabine 3.3516505122 17785578
MESH:D008545 Melanoma Tretinoin 3.3516752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4419513568
MESH:D008569 Memory Disorders Ethanol 4.0615451040 18411066
MESH:D008591 Meningomyelocele Tretinoin 4.2916940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0916381670
MESH:D009101 Multiple Myeloma decitabine 3.2518172295
MESH:D009135 Muscular Diseases pirinixic acid 3.3816239165
MESH:D009190 Myelodysplastic Syndromes decitabine 7.2319157545 18608210 16882708 19010910
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.2317596541
MESH:D009203 Myocardial Infarction pirinixic acid 5.5519151258
MESH:D009203 Myocardial Infarction Quercetin 5.5519595682
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.1016411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 8.1019207477
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.7318551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.533581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.533581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 15.0511141357
MESH:D009369 Neoplasms decitabine 15.0519470736 17925555 19116145
MESH:D009369 Neoplasms pirinixic acid 15.0517405874
MESH:D009369 Neoplasms Quercetin 15.0515185748
MESH:D009369 Neoplasms Tretinoin 15.0516946489 16594593
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1719348381 18481113
MESH:D009421 Nervous System Malformations Tretinoin 3.659125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 6.946679447
MESH:D009436 Neural Tube Defects Tretinoin 6.949142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.8218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.8220387270
MESH:D020078 Neurogenic Inflammation Quercetin 4.2417929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9920387270
MESH:D009765 Obesity Dietary Fats 4.3220518802 18674790 19632207 18457598 17217161 11836018 21332399 20132043 16723640
MESH:D009765 Obesity pirinixic acid 4.3220558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.4916049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.494026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.893988306
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.0919495926
MESH:D010051 Ovarian Neoplasms decitabine 7.7319331143 19259094
MESH:D010051 Ovarian Neoplasms Quercetin 7.7319005980
MESH:D010051 Ovarian Neoplasms Tretinoin 7.7316936753
MESH:D010146 Pain Acetaminophen 6.2316870215
MESH:D010146 Pain Tretinoin 6.2316870215
MESH:D010190 Pancreatic Neoplasms decitabine 15.8319294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 15.8316540662
MESH:D010190 Pancreatic Neoplasms Ethanol 15.8312384795
MESH:D010190 Pancreatic Neoplasms Quercetin 15.8316965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 15.8315976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.357296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.346228378
MESH:D011230 Precancerous Conditions Corn Oil 21.0214668109
MESH:D011230 Precancerous Conditions Cyclosporine 21.0212371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 21.022563599
MESH:D011230 Precancerous Conditions Quercetin 21.0219056647
MESH:D055728 Primary Myelofibrosis decitabine 4.6017616702
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.3417292933
MESH:D011471 Prostatic Neoplasms Quercetin 3.3414715546 17292933
MESH:D011507 Proteinuria Tretinoin 3.4816636307
MESH:D011565 Psoriasis Cyclosporine 2.1816882103
MESH:D011625 Pterygium Tretinoin 4.6616723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.3219058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.283692021
MESH:D012208 Rhabdomyosarcoma decitabine 10.5319155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.5316283617 16116481
MESH:D012554 Schistosomiasis japonica Quercetin 5.4216862918
MESH:D012640 Seizures 2,4-dinitrotoluene 5.8118551238
MESH:D012640 Seizures Ethanol 5.819754883
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.1219755658 10029692
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.128532709
MESH:D012878 Skin Neoplasms Tretinoin 9.1216467112
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 6.262093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 6.2619037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 6.2618456281
MESH:D013274 Stomach Neoplasms Ethanol 6.2618456281
MESH:D013274 Stomach Neoplasms Tretinoin 6.2617261132
MESH:D013276 Stomach Ulcer Ethanol 3.4117189318 9211565 17918041 9562338 11906479 16755016
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.149754883
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 16.286587162 1399818 3712494 7505956 6582329
MESH:D013964 Thyroid Neoplasms decitabine 16.2817967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 16.287505956
MESH:D013964 Thyroid Neoplasms Tretinoin 16.2816026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.6716051514
MESH:D014376 Tuberculosis Tretinoin 3.1516040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 19.2316049721
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 19.2315289314 1399818 15867355
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 19.238074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 19.2317053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 19.2317616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Quercetin 19.2316720314
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.1810091137
MESH:D014581 Urticaria Acetaminophen 2.8510982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.5616129372
MESH:D014604 Uveal Neoplasms decitabine 12.4017785578
MESH:D014604 Uveal Neoplasms Tretinoin 12.4016752155
MESH:D014605 Uveitis Cyclosporine 3.851336536
MESH:D014820 Vitiligo Tretinoin 3.9316761959
MESH:D015430 Weight Gain Dietary Fats 3.6216723640
MESH:D009396 Wilms Tumor Tretinoin 3.8516287080
MESH:D014985 Xerophthalmia Cyclosporine 4.3117120751
Pathway ID Pathway Name
KEGG:04514 Cell adhesion molecules (CAMs)
REACT:20676 Cell junction organization
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29764
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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