AutismKB 2.0

Annotation Detail for GSPT2


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Basic Information Top
Gene Symbol:GSPT2 ( ERF3B,FLJ10441,GST2 )
Gene Full Name: G1 to S phase transition 2
Band: Xp11.22
Quick LinksEntrez ID:23708; OMIM: 300418; Uniprot ID:ERF3B_HUMAN; ENSEMBL ID: ENSG00000189369; HGNC ID: 4622
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Metabolism of proteins
Gene Expression
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Related Diseases/Disorders Top
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Desease Name
prostate cancer
CANCER
No data
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of GSPT2 mRNAincreases expression 18648102
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of GSPT2 mRNAincreases expression 15003993
14729362
D005031 Ethylenethiourea Ethylenethiourea results in increased expression of GSPT2 mRNAincreases expression 18801409
C494474 perchlorate perchlorate results in increased expression of GSPT2 mRNAincreases expression 18801409
D019772 Topotecan GSPT2 protein affects the susceptibility to Topotecanaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Ethylenethiourea 3.957955072
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.933712494
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.6311289319 1440618
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.777296757 3581430
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.817296757
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.997505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.419022650 19486331
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.2811906362 18759878 14531868 12868966 11298694 8156756 8970840 2524372
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.892952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.0318289764 18648102 16192314 11289319 9022650 1440618 18692083 8291058 9328219 7440962 9653073 6679447 6482804
MESH:D016889 Endometrial Neoplasms Ethylenethiourea 4.997955072
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.173581430
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.636705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 12.857505956
MESH:D006042 Goiter perchlorate 12.8518801409
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.956705139
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.4215034207
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.639022650 8074119
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.276582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.409327722 15034207
MESH:D008113 Liver Neoplasms Ethylenethiourea 4.0511940454
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.73598648 6587162 3712494 1399818
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.583581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.136679447
MESH:D009447 Neuroblastoma Topotecan 4.0015176712
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.776482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.633988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.977296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.086228378
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.643692021
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.838532709
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 8.666582329 1399818 7505956 3712494 6587162
MESH:D013964 Thyroid Neoplasms Ethylenethiourea 8.6611940454
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.398074119
Pathway ID Pathway Name
REACT:71 Gene Expression
REACT:17015 Metabolism of proteins
KEGG:03015 mRNA surveillance pathway
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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