AutismKB 2.0

Annotation Detail for SDF2L1


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Basic Information Top
Gene Symbol:SDF2L1 ( - )
Gene Full Name: stromal cell-derived factor 2-like 1
Band: 22q11.21
Quick LinksEntrez ID:23753; OMIM: 607551; Uniprot ID:SDF2L_HUMAN; ENSEMBL ID: ENSG00000128228; HGNC ID: 10676
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of SDF2L1 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of SDF2L1 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in decreased expression of SDF2L1 mRNAdecreases expression 20458559
C030123 coumarin coumarin results in increased expression of SDF2L1 mRNAincreases expression 18480146
D016572 Cyclosporine Cyclosporine results in increased expression of SDF2L1 mRNAincreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of SDF2L1 mRNAincreases expression 17823450
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of SDF2L1 mRNAaffects cotreatment|increases expression 17183730
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SDF2L1 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of SDF2L1 mRNAdecreases expression 17426115
D011374 Progesterone Progesterone results in increased expression of SDF2L1 mRNAincreases expression 18037150
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of SDF2L1 mRNAaffects cotreatment|increases expression 17183730
D014810 Vitamin E Vitamin E results in increased expression of SDF2L1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.688875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0719490988
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.5019825857 11798837
MESH:D000230 Adenocarcinoma Estradiol 4.5011473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.833712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6716434500
MESH:D000550 Amblyopia Valproic Acid 5.4517688650
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.6817497229
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8618985861 18396377 19232924 17688650 19460635 18940202 17507914 17157402 15238991 18177632 16609825 20603192 18775368 18316065 18558336
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.241440618 11289319
MESH:D001714 Bipolar Disorder Valproic Acid 3.1420046352 17594078
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.4716206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.4719483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.498888407
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.5617868700
MESH:D001930 Brain Injuries Progesterone 4.4315380490 15665606 15845082
MESH:D001943 Breast Neoplasms Estradiol 2.2012948864 18497071 14630087 17289903 17018787 16675129 17261762 19861407
MESH:D001943 Breast Neoplasms Progesterone 2.2016175315 15562024 17614352
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4811589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6616111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1116050911
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.723581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.723084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.7216217749 14691202 15553829 15073043 11135700
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.7216924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0919014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.737296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2512490120
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.707505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.7012371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.7018566989
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7520734317
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.9919486331 9022650
MESH:D002779 Cholestasis Cyclosporine 13.9919486331
MESH:D002779 Cholestasis pirinixic acid 13.9919176532
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.9310525206
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.938888407 17688650 16575769
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.9319769572
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2415213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.978156756 12868966 18759878 2524372 14531868 8970840 11298694 11906362
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.642952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 3.2219647726
MESH:D003928 Diabetic Nephropathies Estradiol 3.5419279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.6717187935
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.4218648102 18692083 9022650 6482804 9328219 11289319 7440962 18289764 6679447 8291058 9653073 1440618 16192314
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4216109766 14550746 16177239 12540782 19370779 11834606 19085960 16227642 11743745 19416960 16393943 12153990 19164858 11461765 12958197 18071297 17562736 19739265 11739529 18713872 12392966 10663392 19420014 11529661 19923254 14986274 12594235 12705907 16081117 11287661 15619225 15968718 10774834 17906064 2444490 17522070 16485898 11421492 14725611 16781746 10915739
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.4219641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004421 Dystonia Valproic Acid 4.201851702
MESH:C538011 Eales disease Vitamin E 4.929068938
MESH:D004487 Edema pirinixic acid 2.6212083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.9417692515
MESH:D016889 Endometrial Neoplasms Estradiol 3.0711473722 19148513 18566989
MESH:D004715 Endometriosis Progesterone 3.9016134523
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.3317275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.1316628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0018234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.716254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.477750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.263659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.583581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5812903497
MESH:D005234 Fatty Liver arsenic trioxide 19.9715073043
MESH:D005234 Fatty Liver Cyclosporine 19.9719224547
MESH:D005234 Fatty Liver pirinixic acid 19.9719236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 19.9714986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.1016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.298888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.246705139
MESH:D005355 Fibrosis Cyclosporine 3.3212168785 12639820
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4216904648
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.197505956
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0516080930
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.676705139
MESH:D006529 Hepatomegaly pirinixic acid 3.1719176532 18467677 19772884 16221962
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7416863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 5.2515709030
MESH:D019584 Hot Flashes Estradiol 10.7917088409
MESH:D019584 Hot Flashes Vitamin E 10.7914716179
MESH:D006849 Hydrocephalus Valproic Acid 5.0617688650
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1115034207
MESH:D006973 Hypertension Cyclosporine 2.1410903974
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8016612254
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.5815869954
MESH:D007249 Inflammation Progesterone 2.6615869954
MESH:D007251 Influenza, Human Vitamin E 4.4316624496
MESH:D007333 Insulin Resistance Estradiol 7.4916627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.4916306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.249022650 8074119
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Acetaminophen 15.0515629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 15.0518776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 15.0515618244
MESH:D007674 Kidney Diseases Vitamin E 15.0512488133
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.066582329
MESH:D007680 Kidney Neoplasms Cyclosporine 13.0612371664
MESH:D007680 Kidney Neoplasms Estradiol 13.0615610895
MESH:D007938 Leukemia arsenic trioxide 2.8915070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9312560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9019077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.9820471514 19850784 17050201 16968895 16467208
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.9817596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3017649720 15622746 15213294 12018890 19225113 17869043 19035177 11468182 19642359 16112521 12679006 9834237 16891316 17217047 17107899 15336539 17712046 16330433 11161223 16331271 16966277 15748426 12712474 19075265 16823087
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5116882451
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2815034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5414716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5415474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.5416169303
MESH:D008107 Liver Diseases Acetaminophen 1.6619014921 11587558 19784758 12587719 12969438 16611625 19460945 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3716871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 4.6314682389
MESH:D008113 Liver Neoplasms pirinixic acid 4.6320007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.241399818 3712494 598648 6587162
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.2420377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4615213294
MESH:D008171 Lung Diseases Vitamin E 3.2716863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4817228818
MESH:D008175 Lung Neoplasms arsenic trioxide 2.5711798837 19825857
MESH:D008175 Lung Neoplasms Vitamin E 2.5711062179
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.3511807958 16891317 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.3517203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.7019453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D008881 Migraine Disorders Valproic Acid 3.2918803445 18765137
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2011468182 14977855 19549372 19417148 15949261
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.178888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.6716105982 16882451
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.6717596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.6116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.6116411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1216624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.523581430
MESH:D009369 Neoplasms pirinixic acid 2.0117405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9317289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4118481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 3.8116427766 11399458
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 12.656679447
MESH:D009436 Neural Tube Defects arsenic trioxide 12.6510525206
MESH:D009436 Neural Tube Defects Valproic Acid 12.6516359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.556482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.243988306
MESH:D010051 Ovarian Neoplasms arsenic trioxide 8.1316624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Estradiol 8.1319401270
MESH:D010051 Ovarian Neoplasms Progesterone 8.1316525653 17393432
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5715580305
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.667296757
MESH:D010235 Paraganglioma arsenic trioxide 4.3119927285
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.696228378
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.0220603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0220887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 17013881
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.5419131511
MESH:D011471 Prostatic Neoplasms Estradiol 2.5416740699
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5415084515
MESH:D019310 Pseudolymphoma Valproic Acid 4.7611422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.483692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3219155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9018045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1216646077
MESH:D012559 Schizophrenia Valproic Acid 2.0819110320 15737665
MESH:D012640 Seizures Valproic Acid 2.8314763951 11738929 16876388 15475178 1511512 3137016 11044598 17978042
MESH:D012871 Skin Diseases Vitamin E 2.4718709164
MESH:D013119 Spinal Cord Injuries Progesterone 4.4716503802 15862959
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.7612833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D020521 Stroke Vitamin E 3.6316517955
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.516582329 1399818 7505956 6587162 3712494
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.5119014326
MESH:D013978 Tibial Fractures Estradiol 4.9019048282
MESH:D016171 Torsades de Pointes arsenic trioxide 4.1515213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.4517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.713119515
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.248074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.2412973940 11780464 12845720 20435036
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.828888407
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D014689 Venous Insufficiency coumarin 5.9912708602
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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