AutismKB 2.0

Annotation Detail for PPIL2


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Basic Information Top
Gene Symbol:PPIL2 ( CYC4,CYP60,Cyp-60,FLJ39930,MGC33174,MGC787,hCyP-60 )
Gene Full Name: peptidylprolyl isomerase (cyclophilin)-like 2
Band: 22q11.21
Quick LinksEntrez ID:23759; OMIM: 607588; Uniprot ID:PPIL2_HUMAN; ENSEMBL ID: ENSG00000100023; HGNC ID: 9261
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04120Ubiquitin mediated proteolysis
Pathway IDPathway Name
Hemostasis
No data
No data
Pathway IDPathway Name
500308Basigin interactions
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of PPIL2 mRNAaffects cotreatment|decreases expression 18164116
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of PPIL2 mRNAaffects cotreatment|decreases expression 18164116
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PPIL2 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PPIL2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PPIL2 mRNAaffects cotreatment|increases expression 17942748
C008493 methylselenic acid methylselenic acid results in decreased expression of PPIL2 mRNAdecreases expression 18548127
D012643 Selenium Selenium results in increased expression of PPIL2 mRNAincreases expression 19244175
D013629 Tamoxifen Tamoxifen affects the expression of PPIL2 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PPIL2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PPIL2 mRNAincreases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2415322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D000236 Adenoma beta-Naphthoflavone 7.3719389873
MESH:D000236 Adenoma Diethylnitrosamine 7.376695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.4116434500 19061943 18056438 19052882 17162532 17620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.4116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8217474063
MESH:D001943 Breast Neoplasms Tamoxifen 1.8215668708 19142967 19103187 19221464 19289846 19115204 19200415 18629630 17440819 11161223 18425577 15565566 19084267 20135344 17261762 18855134 20859285 18351453 20390343 18997820 19288272 16818667 19487384 19155303 20005174 18815881 17049068 17893378 21152245 19011961 18984771 19244106 19410462 18821012 16873071 20065188 21138602 19189210 17242785 16202921 19189212 16273361 20544844 19059307 19066611
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8220435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.1216807293 20514400 19701751 3084413 21159647 18056438 17428255 16569478 16288022 16502159 18506893 19418558 16830150 19052882 20935162 20214788 20007298 17761372 16779866 18393292 20512989 18971187 11831363 16935385 19171122 16328049 20101231 10737359 16698587 17055752 19107877 20727157 19822196 18788625 18978308 18665156 19519916 10672840 17162532 16681979 3581430 16878318 19394651 18691550 19335982 19208518 17173139 18210153 18494052 19919837 20084675 20432363 19383236 18785209 17978847 20524982 19539802 17138121 16540662
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.1216924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8817572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.047505956 21159647 2727394 17174075
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 10.1719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 10.1716835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0717110522 16105132 17681005 15861022 17333356 16919318 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2015340226 12621046 15668235 16354765 8697196
MESH:D003092 Colitis Selenium 4.1417936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 15322242 10048152
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.4120387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4117107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.7219279558
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.6119107877
MESH:D056486 Drug-Induced Liver Injury Selenium 6.6115131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.6120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3518230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.0612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.0619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2120544844 16202921 19155303 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.299294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.5616302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Diethylnitrosamine 14.8020387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.8015345470
MESH:D005234 Fatty Liver Tamoxifen 14.8019224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5819069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4610048152 11294989
MESH:D006333 Heart Failure Selenium 3.2317162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2515340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4916354765 16959395 8697196 18606429 15340226
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007249 Inflammation Diethylnitrosamine 9.0318785209
MESH:D007249 Inflammation Tamoxifen 9.0319457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 9.0312200463 12878042
MESH:D007251 Influenza, Human Selenium 4.6416624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007676 Kidney Failure, Chronic Selenium 4.1716518626
MESH:D007680 Kidney Neoplasms Tamoxifen 3.2718625569
MESH:D008064 Lipidoses Tamoxifen 3.3515342952 17567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9619638242 20032147 18407596 18665156 18522880
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3512878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1517034775
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 11.4619389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.4619850985 2422723 19427195 19642983 12112319 19294768 19073162 20452335 19833225 15175105 19426721 19551842 9163691 20501860 15885732 18648771 19255062 21071580 19256749 19638242 19996281 19812893 20583210 2862719 20137499 18644402 19499222 20101389 21278145 19254457 19690152 20118626 21167192 18978307 10737359 19090486 20492335 18977376 20405173 18754104 16942905 20434301 21047994 12771043
MESH:D008113 Liver Neoplasms Tamoxifen 11.4616684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.4616984957
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 10.8218164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.8219126423 18544905 18282651 2563599 18164116 19004024 21159647 19009564 18093689 18775883 16842330 18079962 17942915 17174075 18253720 9362446 18308698 16267830 3124819 19539802 17854601 19519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.8212151625
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.5120970405 6695378 20512841 21163286
MESH:D008175 Lung Neoplasms Tamoxifen 3.5118625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5119555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1519428831
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.6015318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.6014580682 19196723 11731420 16827153 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.9919453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5815990972
MESH:D008654 Mesothelioma Selenium 2.8815107826
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 6.043581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 6.0419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.4419189210 19196722 19200415
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.5620387270
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5016540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D010954 Plasmacytoma Selenium 5.3315087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.802563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911118676 11896295 11222880 11399792
MESH:D011471 Prostatic Neoplasms methylselenic acid 3.4116205645
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.4115067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.7115861022 16919318
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 13.0916709447
MESH:D013088 Spermatocele Tamoxifen 13.0916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.4319457130
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.197505956
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.4416712894 17572228 8653321
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
Pathway ID Pathway Name
REACT:604 Hemostasis
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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