AutismKB 2.0

Annotation Detail for OSBP2


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Basic Information Top
Gene Symbol:OSBP2 ( ORP-4,ORP4,OSBPL1,OSBPL4 )
Gene Full Name: oxysterol binding protein 2
Band: 22q12.2
Quick LinksEntrez ID:23762; OMIM: 606729; Uniprot ID:OSBP2_HUMAN; ENSEMBL ID: ENSG00000184792; HGNC ID: 8504
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000638 Amiodarone Amiodarone results in increased expression of OSBP2 mRNAincreases expression 19774075
D001104 Arbutin Arbutin results in decreased expression of OSBP2 mRNAdecreases expression 17103032
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of OSBP2 mRNAdecreases expression 19150397
C006780 bisphenol A bisphenol A results in decreased expression of OSBP2 mRNAdecreases expression 15223131
D004958 Estradiol Estradiol results in decreased expression of OSBP2 mRNAdecreases expression 15223131
C011890 kojic acid kojic acid results in decreased expression of OSBP2 mRNAdecreases expression 16595896
D012643 Selenium Selenium results in increased expression of OSBP2 mRNAincreases expression 19244175
C025643 vinclozolin vinclozolin affects the expression of OSBP2 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Estradiol 2.1411473722
MESH:D001008 Anxiety Disorders vinclozolin 3.8319015723
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.0318057881 20041841 18218290
MESH:D001281 Atrial Fibrillation Amiodarone 4.0818651412 19698954
MESH:D001778 Blood Coagulation Disorders Amiodarone 4.1419483382
MESH:D001862 Bone Resorption bisphenol A 4.1011985600
MESH:D001943 Breast Neoplasms bisphenol A 2.1917123778
MESH:D001943 Breast Neoplasms Estradiol 2.1917261762 17289903 17018787 12948864 14630087 16675129 19861407 18497071
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8016111702
MESH:D006528 Carcinoma, Hepatocellular Estradiol 1.7816924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.3317123778
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9619225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.4218974383
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.1820889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.1818566989
MESH:D003092 Colitis Selenium 4.0917936198
MESH:D003456 Cryptorchidism vinclozolin 4.6214966744
MESH:D003928 Diabetic Nephropathies Estradiol 3.6319279558
MESH:D056486 Drug-Induced Liver Injury Amiodarone 4.2818218290 15265979
MESH:D056486 Drug-Induced Liver Injury Selenium 4.2815131321
MESH:D016889 Endometrial Neoplasms Estradiol 3.1318566989 19148513 11473722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1220426865
MESH:D005234 Fatty Liver Amiodarone 3.7614986274
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6816417039
MESH:D006333 Heart Failure Selenium 3.2117162251
MESH:D006529 Hepatomegaly Amiodarone 4.0515265979
MESH:D006558 Herpes Genitalis Estradiol 5.4115709030
MESH:D019584 Hot Flashes Estradiol 4.1317088409
MESH:D006937 Hypercholesterolemia Amiodarone 4.129751232 8137927
MESH:D007037 Hypothyroidism Amiodarone 4.8217991464 18020914
MESH:D007248 Infertility, Male vinclozolin 3.1916467254
MESH:D007251 Influenza, Human Selenium 4.5716624496
MESH:D007333 Insulin Resistance bisphenol A 7.9316393666
MESH:D007333 Insulin Resistance Estradiol 7.9316393666 16627594
MESH:D007674 Kidney Diseases Estradiol 2.7115618244
MESH:D007676 Kidney Failure, Chronic Selenium 4.1316518626
MESH:D007680 Kidney Neoplasms Estradiol 3.1815610895
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0716417039
MESH:D008064 Lipidoses Amiodarone 3.6815342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6814716833 14659978
MESH:D008114 Liver Neoplasms, Experimental kojic acid 3.4718544905
MESH:D008133 Long QT Syndrome Amiodarone 3.7611989578 17391786 15350150
MESH:D008171 Lung Diseases Amiodarone 3.5312587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.8518516814
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.5111408345 16891317 17203775 11807958
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.5115318939
MESH:D020149 Manganese Poisoning Estradiol 4.8619453300
MESH:D008654 Mesothelioma Selenium 2.8715107826
MESH:D009181 Mycoses Amiodarone 5.2812754197 17974566
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4616810080
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0717289903
MESH:D009421 Nervous System Malformations bisphenol A 10.7016427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 10.7016427766 11399458
MESH:D010049 Ovarian Diseases bisphenol A 5.3311985600
MESH:D010051 Ovarian Neoplasms Estradiol 2.2819401270
MESH:D010954 Plasmacytoma Selenium 5.2715087411
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 10.9210548101
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.9218042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.2718220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 11.3820887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 11.3820887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.2116740699
MESH:D011471 Prostatic Neoplasms Estradiol 3.2116740699
MESH:D011472 Prostatitis vinclozolin 5.2718629315
MESH:D011629 Puberty, Precocious bisphenol A 5.1210548101
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9311597910 12490602 12832656
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.4218724381
MESH:D013276 Stomach Ulcer Amiodarone 3.5518087811
MESH:D019966 Substance-Related Disorders bisphenol A 4.3216045194 16684133
MESH:D013610 Tachycardia Amiodarone 4.5711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.4719225199
MESH:D013959 Thyroid Diseases Amiodarone 5.1319731979
MESH:D013971 Thyrotoxicosis Amiodarone 5.1718020914 19584973
MESH:D013978 Tibial Fractures Estradiol 5.0619048282
MESH:D016171 Torsades de Pointes Amiodarone 4.5317467628 11989578
MESH:D014591 Uterine Diseases bisphenol A 5.3814652134
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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