AutismKB 2.0

Annotation Detail for IL17RA


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Basic Information Top
Gene Symbol:IL17RA ( CD217,CDw217,IL-17RA,IL17R,MGC10262,hIL-17R )
Gene Full Name: interleukin 17 receptor A
Band: 22q11.1
Quick LinksEntrez ID:23765; OMIM: 605461; Uniprot ID:I17RA_HUMAN; ENSEMBL ID: ENSG00000177663; HGNC ID: 5985
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04060Cytokine-cytokine receptor interaction
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of IL17RA mRNAaffects expression 17562736
D001554 Benzene Benzene results in decreased expression of IL17RA mRNAdecreases expression 15120971
15122651
D004958 Estradiol Estradiol affects the expression of IL17RA mRNAaffects expression 15598610
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of IL17RA mRNAincreases expression 12072388
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.6617505938
MESH:D000230 Adenocarcinoma Estradiol 4.4811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4814692618
MESH:D000741 Anemia, Aplastic Benzene 4.6811369114 14761424 17661222
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 4.0211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8915885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001855 Bone Marrow Diseases Benzene 5.9516183116
MESH:D001943 Breast Neoplasms Benzene 2.3411921183 17162533
MESH:D001943 Breast Neoplasms Estradiol 2.3412948864 18497071 17289903 17018787 17261762 19861407 16675129 14630087
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.0916111702
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.963084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 2.9616924424
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 3.0318566989
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1716105132 17110522 16919318 11677210 17681005 15861022 17333356
MESH:D019465 Craniofacial Abnormalities Benzene 2.4515643154
MESH:D003872 Dermatitis Benzene 5.3315902427
MESH:D003928 Diabetic Nephropathies Estradiol 3.7819279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6718713872 16227642 10663392 16781746 12392966 15968718 11743745 16177239 12153990 16109766 11739529 12705907 10774834 19739265 19923254 19085960 19420014 12958197 2444490 11421492 14550746 11834606 15619225 16081117 16485898 11461765 19164858 18071297 19370779 14986274 17562736 19416960 16393943 17906064 11529661 14725611 12540782 17522070 12594235 10915739 11287661
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.6912538720
MESH:D016889 Endometrial Neoplasms Estradiol 3.2211473722 19148513 18566989
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.2415345470
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D006402 Hematologic Diseases Benzene 5.1216183116
MESH:D006558 Herpes Genitalis Estradiol 5.7615709030
MESH:D019584 Hot Flashes Estradiol 4.4717088409
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D006973 Hypertension Benzene 3.2117940673
MESH:D007021 Hypospadias Ethinyl Estradiol 4.3716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.9212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7317937319
MESH:D007333 Insulin Resistance Estradiol 3.2116627594 16393666
MESH:D007674 Kidney Diseases Acetaminophen 6.5712587719 15629191
MESH:D007674 Kidney Diseases Estradiol 6.5715618244
MESH:D007680 Kidney Neoplasms Estradiol 3.3215610895
MESH:D007938 Leukemia Benzene 3.5617119257 18335105 15935818 14694614
MESH:D007951 Leukemia, Myeloid Benzene 4.7417506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.7419478238
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6814716833 14659978
MESH:D008107 Liver Diseases Acetaminophen 1.7016611625 12969438 11587558 19784758 16610002 19460945 12587719 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6316871587 17185352
MESH:D008114 Liver Neoplasms, Experimental Benzene 3.5112562636
MESH:D017563 Lung Diseases, Interstitial Benzene 5.5314698565
MESH:D008175 Lung Neoplasms Benzene 2.4312562636
MESH:D008223 Lymphoma Benzene 4.0117119257 17584886
MESH:D015674 Mammary Neoplasms, Animal Benzene 5.0712562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 7.0211921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 7.0211807958 16891317 17203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 5.2119453300
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D009101 Multiple Myeloma Benzene 3.9417119195
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.5916810080
MESH:D009389 Neovascularization, Pathologic Estradiol 4.3617289903
MESH:D009421 Nervous System Malformations Estradiol 4.1616427766 11399458
MESH:D009436 Neural Tube Defects Benzene 3.9115643154
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D009784 Occupational Diseases Benzene 4.5715576619 15935809 17119257 15727169 17178637 15612468 17479406 16737584 15913788
MESH:D010051 Ovarian Neoplasms Benzene 5.3612562636
MESH:D010051 Ovarian Neoplasms Estradiol 5.3619401270
MESH:D010146 Pain Acetaminophen 2.7316870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.1511578682
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.3120887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0216740699
MESH:D011537 Pruritus Ethinyl Estradiol 3.9415861022 16919318
MESH:D013088 Spermatocele Ethinyl Estradiol 4.6616709447
MESH:D013274 Stomach Neoplasms Benzene 2.4212562636
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.5215669648
MESH:D013953 Thymus Neoplasms Benzene 5.5910850423
MESH:D013978 Tibial Fractures Estradiol 5.4119048282
MESH:D014581 Urticaria Acetaminophen 3.4410982225
MESH:D014594 Uterine Neoplasms Benzene 11.3112562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 11.3114692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9714671159 15869587
Pathway ID Pathway Name
KEGG:04060 Cytokine-cytokine receptor interaction
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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