AutismKB 2.0

Annotation Detail for FLRT3


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Basic Information Top
Gene Symbol:FLRT3 ( - )
Gene Full Name: fibronectin leucine rich transmembrane protein 3
Band: 20p12.1
Quick LinksEntrez ID:23767; OMIM: 604808; Uniprot ID:FLRT3_HUMAN; ENSEMBL ID: ENSG00000125848; HGNC ID: 3762
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of FLRT3 mRNAincreases expression 19933214
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of FLRT3 proteinaffects expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of FLRT3 mRNAincreases expression 20382639
D016572 Cyclosporine Cyclosporine results in decreased expression of FLRT3 mRNAdecreases expression 20106945
D002117 Calcitriol Calcitriol results in increased expression of FLRT3 mRNAincreases expression 16002434
D008942 Mitoxantrone FLRT3 protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FLRT3 mRNAaffects binding|decreases expression|increases activity 19710929
D012402 Rotenone Rotenone results in decreased expression of FLRT3 mRNAdecreases expression 19013527
D012643 Selenium Selenium results in decreased expression of FLRT3 mRNAdecreases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of FLRT3 mRNAincreases expression 19933214
D014810 Vitamin E Vitamin E results in decreased expression of FLRT3 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0411752688 15322242 14514962
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.5616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.5616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.2419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.2412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Calcitriol 2.0911237771
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0920435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1116050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 1.9721507988 12619106 12907637
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6611237771
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4416120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.8720889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8712371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Cyclosporine 8.1019486331
MESH:D002779 Cholestasis pirinixic acid 8.1019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1515668235 15340226 12621046 8697196 16354765
MESH:D003092 Colitis Selenium 3.9517936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5220055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5219769572
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury Selenium 3.8915131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:C538011 Eales disease Vitamin E 4.929068938
MESH:D004487 Edema pirinixic acid 7.0012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.0012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1215322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.0915138306
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.159294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1020426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Cyclosporine 8.0319224547
MESH:D005234 Fatty Liver pirinixic acid 8.0319236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Cyclosporine 9.0712639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.0720067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8011294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 6.8016080930
MESH:D006331 Heart Diseases Mitoxantrone 4.2416019553
MESH:D006333 Heart Failure pirinixic acid 7.2220558911
MESH:D006333 Heart Failure Selenium 7.2217162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly pirinixic acid 8.8516221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.8515340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7416490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.1914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2618606429 8697196 16959395 15340226 16354765
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006973 Hypertension Cyclosporine 5.1010903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1018670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9212878042 12200463
MESH:D007251 Influenza, Human Selenium 11.7016624496
MESH:D007251 Influenza, Human Vitamin E 11.7016624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7216306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.278314463 10903974 18776723
MESH:D007674 Kidney Diseases Vitamin E 6.2712488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0216518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8512371664
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.8418172266
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4912878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.4916169303
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.639163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms pirinixic acid 7.6316377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.6316984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.088603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.0812151625
MESH:D008171 Lung Diseases Vitamin E 3.2716863852
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.4814755239
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4819555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 3.4811062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8515318939
MESH:D008654 Mesothelioma Selenium 2.8415107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009369 Neoplasms Mitoxantrone 5.4916640825
MESH:D009369 Neoplasms pirinixic acid 5.4917405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D009410 Nerve Degeneration Rotenone 3.9915790535 17356569 18619942
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010300 Parkinson Disease Rotenone 3.0215451049 16412576 11445065 18619942 19114014 16140633 11535288 18191903 19232380
MESH:D020734 Parkinsonian Disorders Rotenone 4.2115927086 15574749 15795934 18197244
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D010954 Plasmacytoma Selenium 5.1115087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811896295 11118676 11399792 11222880
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.9715572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.3716644109 18247401 15754350 16289102 12479363
MESH:D011471 Prostatic Neoplasms Vitamin E 3.3715084515
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012871 Skin Diseases Vitamin E 2.4718709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1016192470
MESH:D020521 Stroke Vitamin E 3.6316517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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