AutismKB 2.0

Annotation Detail for FLRT2


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Basic Information Top
Gene Symbol:FLRT2 ( KIAA0405 )
Gene Full Name: fibronectin leucine rich transmembrane protein 2
Band: 14q31.3
Quick LinksEntrez ID:23768; OMIM: 604807; Uniprot ID:FLRT2_HUMAN; ENSEMBL ID: ENSG00000185070; HGNC ID: 3761
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of FLRT2 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of FLRT2 mRNAdecreases expression 20064835
D004958 Estradiol Estradiol affects the expression of FLRT2 mRNAaffects expression 14699072
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of FLRT2 mRNAaffects cotreatment|decreases expression 17404688
D005472 Fluorouracil FLRT2 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D008727 Methotrexate FLRT2 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
D015735 Mifepristone Mifepristone results in decreased expression of FLRT2 mRNAdecreases expression 17584828
D010672 Phenytoin Phenytoin results in increased expression of FLRT2 mRNAincreases expression 14741686
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of FLRT2 mRNAaffects cotreatment|decreases expression 17404688
C004648 testosterone enanthate testosterone enanthate affects the expression of FLRT2 mRNAaffects expression 17440010
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 10.1612039119
MESH:D000014 Abnormalities, Drug-Induced Phenytoin 10.166195326 9677735 9118846 10563481 3425630 8986270
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.3520127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 7.3511473722
MESH:D000230 Adenocarcinoma Fluorouracil 7.3517638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D000740 Anemia Fluorouracil 3.9017963324 15504547 16511603
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.1417286800
MESH:D050197 Atherosclerosis Phenytoin 4.0415136057
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.6617868700
MESH:D001930 Brain Injuries Progesterone 4.5215665606 15380490 15845082
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.4120146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 2.4112948864 19861407 17289903 16675129 17261762 17018787 18497071 14630087
MESH:D001943 Breast Neoplasms Fluorouracil 2.4115136595 18357371 19217205 16557594 16595493 18608205 16110121
MESH:D001943 Breast Neoplasms Methotrexate 2.4116978400
MESH:D001943 Breast Neoplasms Progesterone 2.4116175315 15562024 17614352
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7516111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.9916051944
MESH:D002277 Carcinoma Fluorouracil 3.7317121937
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.713084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7116924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.7116799960 16332177 17088986 17045692 17971768 18930000
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1018695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8120419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.8118986760 16757204 16280240 17066447
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.9118566989
MESH:D002493 Central Nervous System Diseases Phenytoin 5.564080065
OMIM:601042 CHOREOATHETOSIS/SPASTICITY, EPISODIC Phenytoin 6.1511748493
MESH:D002971 Cleft Lip Phenytoin 4.252227380
MESH:D002972 Cleft Palate Phenytoin 3.822227380 6862529 1687470 3877104 6856622 10789828
MESH:D003103 Coloboma Phenytoin 5.369212184
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2617725105 16510598 16340194 15001691 17287894 17169374 17018589 18772588 17172411 17016597
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0016391804 16303861 18802399 18509181 14970324 20501625 18448328 17401013 17594712 17454858 17255274 17695437 17094418 16524972 15289873 16282729 17016601 15148649 18949393 18383874 18288408 16331619
MESH:D000013 Congenital Abnormalities Phenytoin 4.8810627286
MESH:D019465 Craniofacial Abnormalities Methotrexate 3.4112039119 9562676
MESH:D019465 Craniofacial Abnormalities Phenytoin 3.419212184 8986270 19952982
MESH:D003550 Cystic Fibrosis Methotrexate 4.4319747007
MESH:D007644 Darier Disease Fluorouracil 5.0816733453
MESH:D003882 Dermatomyositis Methotrexate 5.3620191521
MESH:D003928 Diabetic Nephropathies Estradiol 3.5919279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.7517187935
OMIM:607208 DRAVET SYNDROME Phenytoin 5.6511748493
MESH:D003875 Drug Eruptions Phenytoin 5.7615024534
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6319164858 19739265 10774834 10915739 12594235 11834606 11739529 11461765 11743745 14550746 18713872 12705907 10663392 11421492 12392966 17906064 19420014 14986274 11529661 16781746 15619225 17522070 12153990 18071297 2444490 16177239 19923254 19085960 16081117 11287661 19370779 12958197 16393943 15968718 16485898 16227642 17562736 14725611 16109766 12540782 19416960
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Phenytoin 10.3917654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 10.3917692515
MESH:D016889 Endometrial Neoplasms Estradiol 3.1111473722 18566989 19148513
MESH:D004715 Endometriosis Mifepristone 10.0816134523
MESH:D004715 Endometriosis Progesterone 10.0816134523
MESH:D004816 Epidermal Necrolysis, Toxic Phenytoin 5.4420235791
MESH:D004820 Epidermolysis Bullosa Phenytoin 6.551399206 6251365
MESH:D004828 Epilepsies, Partial Phenytoin 5.2317116037 11558140
MESH:D004827 Epilepsy Phenytoin 4.0311434505 821787 20417680
MESH:D017029 Epilepsy, Complex Partial Phenytoin 5.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenytoin 5.353659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.6416530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.6416337965 17638652 15173087 16481741 16785472
MESH:D005313 Fetal Death Phenytoin 5.3510627286
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005885 Gingival Hyperplasia Phenytoin 5.959029455
MESH:D019214 Gingival Overgrowth Phenytoin 6.5516390469 14659971
MESH:D005910 Glioma Fluorouracil 2.9416145905
MESH:D006086 Graft vs Host Disease Methotrexate 5.4116518429
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5218337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7520471113
MESH:D006558 Herpes Genitalis Estradiol 5.3515709030
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.0617440010
MESH:D019584 Hot Flashes Estradiol 4.0717088409
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D020138 Hyperhomocysteinemia Phenytoin 4.8510459572
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.6615869954
MESH:D007249 Inflammation Progesterone 2.6915869954
MESH:D007333 Insulin Resistance Estradiol 3.0916627594 16393666
MESH:D007674 Kidney Diseases Acetaminophen 6.2512587719 15629191
MESH:D007674 Kidney Diseases Estradiol 6.2515618244
MESH:D007680 Kidney Neoplasms Estradiol 8.0615610895
MESH:D007680 Kidney Neoplasms Fluorouracil 8.0616985049
MESH:D007805 Language Development Disorders Methotrexate 5.329562676
MESH:D008103 Liver Cirrhosis Methotrexate 3.8014986274
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6814659978 14716833
MESH:D008107 Liver Diseases Acetaminophen 4.4711587558 19014921 16610002 12969438 12587719 19784758 16611625 19460945
MESH:D008107 Liver Diseases Phenytoin 4.4714986274
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4317185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.8320195826 21137059
MESH:D008113 Liver Neoplasms Fluorouracil 4.8317045692 15113037 16603448 18383874
MESH:D017563 Lung Diseases, Interstitial Methotrexate 5.3418516814
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.5120135361 18569708 18520028 20464547 6695378 20869020 17053015 18816296 20064080
MESH:D008175 Lung Neoplasms Fluorouracil 2.5115246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0815086387
MESH:D008223 Lymphoma Methotrexate 4.0917352296
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.4817203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.4817203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.8019453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008607 Mental Retardation Phenytoin 3.729212184
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 9.0616381670
MESH:D009062 Mouth Neoplasms Fluorouracil 9.0616757204 18986760
MESH:D052016 Mucositis Methotrexate 5.5717488658
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4416810080
MESH:D020191 Myoclonic Epilepsies, Progressive Phenytoin 5.8117484760
MESH:D009224 Myotonia Congenita Phenytoin 5.691896199
MESH:D009369 Neoplasms Benzo(a)pyrene 5.3711141357
MESH:D009369 Neoplasms Fluorouracil 5.3718600527 16928823 18239605
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0217289903
MESH:D009421 Nervous System Malformations Estradiol 3.8911399458 16427766
MESH:D009436 Neural Tube Defects Phenytoin 4.259118846
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5716436463
MESH:D010018 Osteomalacia Phenytoin 5.6917016548
MESH:D010051 Ovarian Neoplasms Estradiol 8.3219401270
MESH:D010051 Ovarian Neoplasms Mifepristone 8.3216525653
MESH:D010051 Ovarian Neoplasms Progesterone 8.3217393432 16525653
MESH:D010146 Pain Acetaminophen 7.5616870215
MESH:D010146 Pain Phenytoin 7.5615215642
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7219003803 15113037 16929163 16500647
MESH:D017689 Polydactyly Phenytoin 5.239212184
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5017292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.5016740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.5019082440 18626508
MESH:D019310 Pseudolymphoma Phenytoin 5.868603615 1419762 12752131
MESH:D011565 Psoriasis Methotrexate 3.4917410198
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1918286688 18722050 16160472 15538739
MESH:D051437 Renal Insufficiency Methotrexate 4.9717352296
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9118045962
MESH:D012640 Seizures Phenytoin 3.879844417 3137016 19919933 15946322 16876388 11044598 3691417 10029267
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4519755658 10029692
MESH:D013119 Spinal Cord Injuries Progesterone 4.5615862959 16503802
MESH:D013262 Stevens-Johnson Syndrome Phenytoin 5.4120235791
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4620155912 2093021
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4619084572 17522103 17172411 16424979 19015929 18396642 16951190 17498489 18567086 15786421
MESH:D013576 Syndactyly Methotrexate 5.279562676
MESH:D013978 Tibial Fractures Estradiol 5.0019048282
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1816280240
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2417053015
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0716803524
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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