AutismKB 2.0

Annotation Detail for FKBP8


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Basic Information Top
Gene Symbol:FKBP8 ( FKBP38,FKBPr38 )
Gene Full Name: FK506 binding protein 8, 38kDa
Band: 19p13.11
Quick LinksEntrez ID:23770; OMIM: 604840; Uniprot ID:FKBP8_HUMAN; ENSEMBL ID: ENSG00000105701; HGNC ID: 3724
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200076Role of Calcineurin-dependent NFAT signaling in lymphocytes
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of FKBP8 mRNAaffects expression 21346803
C002202 4-oxoretinoic acid 4-oxoretinoic acid results in increased expression of FKBP8 mRNAincreases expression 15982314
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of FKBP8 mRNAdecreases expression 15336504
D004317 Doxorubicin Doxorubicin results in increased expression of FKBP8 mRNAincreases expression 16404146
D015741 Metribolone Metribolone results in decreased expression of FKBP8 proteindecreases expression 17152098
D015474 Isotretinoin Isotretinoin results in decreased expression of FKBP8 mRNAdecreases expression 15982314
C004648 testosterone enanthate testosterone enanthate affects the expression of FKBP8 mRNAaffects expression 17440010
D014212 Tretinoin Tretinoin results in decreased expression of FKBP8 mRNAdecreases expression 15982314
D014303 Trinitrotoluene Trinitrotoluene affects the expression of FKBP8 mRNAaffects expression 21346803
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 16.337525203
MESH:D000014 Abnormalities, Drug-Induced Isotretinoin 16.3318769834
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 16.337525203
MESH:D000015 Abnormalities, Multiple Isotretinoin 5.1818769834
MESH:D017486 Acneiform Eruptions Isotretinoin 6.6016232082
MESH:D000152 Acne Vulgaris Isotretinoin 5.8018769834 16185265
MESH:D000230 Adenocarcinoma Doxorubicin 2.6117418594
MESH:D000419 Albuminuria Doxorubicin 4.7821441931
MESH:D000505 Alopecia Tretinoin 3.7815955085
MESH:D001169 Arthritis, Experimental Tretinoin 3.1916412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D001471 Barrett Esophagus Tretinoin 4.6416935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.8116206674 16197459
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.0214601052
MESH:D001932 Brain Neoplasms Doxorubicin 4.0017150277
MESH:D001943 Breast Neoplasms Doxorubicin 2.3015136595 11325840 19526202 15939500 18628466 18234424 16115903 16595493 15668708 17983394 16096432 17369602 17426702 16826403 16935488 15994142 18695136 16264153 16322301 15634643 15567936 15993339 18382427 15692762
MESH:D001943 Breast Neoplasms Tretinoin 2.3016873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8816813970
MESH:D002276 Carcinoid Tumor Doxorubicin 5.1316051944
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4816168501
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 3.2618059187 16234567 17876044 16023760
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.261917145
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.2416201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 8.036189445
MESH:D002294 Carcinoma, Squamous Cell Isotretinoin 8.0311237771
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 8.0316096774 16051514
MESH:D009202 Cardiomyopathies Doxorubicin 3.6616731534 17007740 17308081 15811867 16109756 16612575 17351982 17974986 15476868 16455267 17329180 17382496 16651473 15792986 17131338 16278810 16364871 16952015 16242529 17928571 16269455 17924179 18627295 17519947 15505089
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0016243910 17334414
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 13.2014694615
MESH:D002386 Cataract Tretinoin 13.2017460283
MESH:D002386 Cataract Trinitrotoluene 13.2015817613 14694615
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8816129372
MESH:D002822 Choriocarcinoma Tretinoin 5.4816461808
MESH:D002972 Cleft Palate Tretinoin 2.749407595
MESH:D003092 Colitis Tretinoin 3.9617035595
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418802399 18259882
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 10.3015095906
MESH:D000013 Congenital Abnormalities Trinitrotoluene 10.3015095906
MESH:D019465 Craniofacial Abnormalities Isotretinoin 3.129879862 18769834
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.128800419 16925845 14991402 10589399 9224671 17551590 9125849 9664655 9211117 9142499
MESH:D003490 Cyanosis Trinitrotoluene 5.1818551238
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 6.8121346803
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 6.8117416283
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 6.8118551238 21346803
MESH:D004362 Drug Toxicity Doxorubicin 3.8218602426
MESH:D004489 Edema, Cardiac Tretinoin 4.7818230668
MESH:D016889 Endometrial Neoplasms Doxorubicin 8.0117359293
MESH:D016889 Endometrial Neoplasms Tretinoin 8.0116569247
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.4718037988
MESH:D005124 Eye Abnormalities Tretinoin 3.739664655 16938888
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.8719069698
MESH:D005355 Fibrosis Tretinoin 3.7717994277
MESH:D005909 Glioblastoma Doxorubicin 7.6717150277
MESH:D005909 Glioblastoma Tretinoin 7.6717312396
MESH:D006258 Head and Neck Neoplasms Doxorubicin 8.2915692506
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.2916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.9914991402 9664655
MESH:D006331 Heart Diseases Doxorubicin 3.6217875725 18674790 17888722 16707910 16244371 12587719 16879835 16330681 16495754 16144979 14766674 16244372 18006777
MESH:D006333 Heart Failure Doxorubicin 3.4617481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.1115692506
MESH:D006529 Hepatomegaly Trinitrotoluene 4.4915817613
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.0617440010
MESH:D006689 Hodgkin Disease Doxorubicin 3.5918501091 15147373 17606976
MESH:D006930 Hyperalgesia Tretinoin 3.3716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.8316778211
MESH:D007248 Infertility, Male Trinitrotoluene 3.8012150543
MESH:D007410 Intestinal Diseases Tretinoin 4.0217994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.1117551590 15992940
MESH:D007674 Kidney Diseases Doxorubicin 3.1616775033 15699352 15369732
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.3616707910
MESH:D007938 Leukemia Tretinoin 2.8617143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.4716085563
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9016932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1016294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2812679006 17361223 17506722 9834237 17368321 19075265 19029980 16788101 17217047 19642359 16766008 19035177 16140955 17649720 15748426 16891316 16331271 17294898 19225113 17712046 16935935 16823087 17301526 17107899 17339181
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.459224671
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.6916439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.6916248980 18397230
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 3.1316842330 17085340
MESH:D008175 Lung Neoplasms Doxorubicin 3.0717418594 6189445
MESH:D008175 Lung Neoplasms Isotretinoin 3.0715899809
MESH:D008223 Lymphoma Doxorubicin 3.6016098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.9617654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.8315621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 3.1515458769
MESH:D008527 Medulloblastoma Tretinoin 2.8517453147
MESH:D008545 Melanoma Doxorubicin 5.4716827129
MESH:D008545 Melanoma Isotretinoin 5.4717237267
MESH:D008545 Melanoma Tretinoin 5.4716752155
MESH:D008591 Meningomyelocele Tretinoin 4.6816940565
MESH:D008654 Mesothelioma Doxorubicin 3.1317638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.7015792986
MESH:D052016 Mucositis Doxorubicin 5.0817415656
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1917596541
MESH:D009203 Myocardial Infarction Doxorubicin 3.0215857846 19429709
MESH:D009336 Necrosis Trinitrotoluene 5.0518551238
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0218259882
MESH:D009369 Neoplasms Tretinoin 2.4916594593 16946489
MESH:D009401 Nephrosis Doxorubicin 5.0316899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.1815640375 16889571
MESH:D009421 Nervous System Malformations Tretinoin 4.029125849
MESH:D009436 Neural Tube Defects Tretinoin 3.189142499
MESH:D009447 Neuroblastoma Doxorubicin 7.6815555623
MESH:D009447 Neuroblastoma Isotretinoin 7.6817368321
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 10.1214694615
MESH:D009784 Occupational Diseases Trinitrotoluene 10.1214694615 12819281 17852074
MESH:D012516 Osteosarcoma Doxorubicin 4.2815930896
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4016936753
MESH:D010146 Pain Tretinoin 3.0716870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5215976015
MESH:D003557 Phyllodes Tumor Doxorubicin 5.4717983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.4717638057
MESH:D011297 Prenatal Exposure Delayed Effects Isotretinoin 5.1718769834
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.5216868541 18437689 16888761 15897917 15749863 16729912
MESH:D011507 Proteinuria Tretinoin 3.8216636307
MESH:D011596 Psychomotor Disorders Isotretinoin 6.2018769834
MESH:D011625 Pterygium Tretinoin 5.0816723453
MESH:D051437 Renal Insufficiency Doxorubicin 4.4817922066
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.3216283617 16116481
MESH:D012509 Sarcoma Doxorubicin 4.1815625365 17710206 16767912 17203757 15675481 18313854
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.4814601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.0817846226
MESH:D012640 Seizures Trinitrotoluene 3.5718551238
MESH:D012878 Skin Neoplasms Doxorubicin 10.0615692506
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 10.068532709
MESH:D012878 Skin Neoplasms Tretinoin 10.0616467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.8317203757 16767912 15625365
MESH:D013163 Splenomegaly Trinitrotoluene 5.4615817613
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms Doxorubicin 7.8417909728 16010429
MESH:D013964 Thyroid Neoplasms Tretinoin 7.8417045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.9816051514
MESH:D014376 Tuberculosis Tretinoin 3.3416040207
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 2.8317653716
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8716129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.9316752155
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.4816364871 17638931 17334414 17678736
MESH:D014820 Vitiligo Tretinoin 4.2916761959
MESH:D009396 Wilms Tumor Tretinoin 4.1516287080
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28165
    • No data
    No data
    Releated drug ID Related drug Name
    PA451578tacrolimus
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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