AutismKB 2.0

Annotation Detail for BRD1


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Basic Information Top
Gene Symbol:BRD1 ( BRL,BRPF1,BRPF2,DKFZp686F0325 )
Gene Full Name: bromodomain containing 1
Band: 22q13.33
Quick LinksEntrez ID:23774; OMIM: 604589; Uniprot ID:BRD1_HUMAN; ENSEMBL ID: ENSG00000100425; HGNC ID: 1102
Relate to Another Database: SFARIGene; denovo-db
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Chemical ID Chemical Name Interaction Interaction Action Publication
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of BRD1 mRNAaffects expression 21346803
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of BRD1 mRNAdecreases expression 19150397
D016572 Cyclosporine Cyclosporine results in increased expression of BRD1 mRNAincreases expression 20106945
C406082 monomethylarsonous acid [monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of BRD1 promoteraffects acetylation|affects methylation 18448484
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of BRD1 mRNAincreases expression 17560707
D012402 Rotenone Rotenone results in decreased expression of BRD1 mRNAdecreases expression 19013527
C017947 sodium arsenite [sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of BRD1 promoteraffects acetylation|affects methylation 18448484
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 4.347525203
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.1415276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.3516712894 17306315
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 2.0015276417 17306315 16507464
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4418572023
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.7814694615
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 17.6320889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 17.6312371664
MESH:D002471 Cell Transformation, Neoplastic monomethylarsonous acid 17.6319716837
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 17.6320056578 19524636
MESH:D002779 Cholestasis Cyclosporine 3.1219486331
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.4115095906
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 2.6921346803
MESH:D004487 Edema perfluorooctanoic acid 3.8617259670 12083418
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1320426865
MESH:D005234 Fatty Liver Cyclosporine 3.1419224547
MESH:D005355 Fibrosis Cyclosporine 3.5012168785 12639820
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.0816452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006529 Hepatomegaly perfluorooctanoic acid 4.453609246
MESH:D006689 Hodgkin Disease sodium arsenite 3.4012676792
MESH:D006930 Hyperalgesia perfluorooctanoic acid 4.0712083418
MESH:D006973 Hypertension Cyclosporine 2.1810903974
MESH:D007248 Infertility, Male sodium arsenite 3.1615346721 12646999
MESH:D007249 Inflammation perfluorooctanoic acid 3.1812083418
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007674 Kidney Diseases Cyclosporine 6.508314463 10903974 18776723
MESH:D007674 Kidney Diseases sodium arsenite 6.5020008137
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9712371664
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.638812269
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 5.1914757943 18709148
MESH:D008113 Liver Neoplasms sodium arsenite 5.1916712894 15276417
MESH:D008171 Lung Diseases sodium arsenite 3.3519095001
MESH:D008175 Lung Neoplasms sodium arsenite 1.8917306315 17077188 16712894 19931552 15276417
MESH:D008545 Melanoma sodium arsenite 2.0616487513 19082730
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
MESH:D009369 Neoplasms sodium arsenite 2.6111559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.0220056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5319348381 18481113
MESH:D009410 Nerve Degeneration Rotenone 4.0915790535 18619942 17356569
MESH:D009436 Neural Tube Defects sodium arsenite 3.3112854658
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 5.319802331
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 4.3614694615
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.5015276417 17306315
MESH:D010300 Parkinson Disease Rotenone 3.0619232380 16412576 18619942 15451049 19114014 16140633 11535288 18191903 11445065
MESH:D020734 Parkinsonian Disorders Rotenone 4.3415574749 15795934 15927086 18197244
MESH:D011230 Precancerous Conditions Cyclosporine 3.4712371664
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 4.7917132714
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2516039940
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D012871 Skin Diseases monomethylarsonous acid 3.4317431481
MESH:D012878 Skin Neoplasms sodium arsenite 2.8119524636 18572023
MESH:D016135 Spinal Dysraphism sodium arsenite 4.0112854658
MESH:D001749 Urinary Bladder Neoplasms monomethylarsonous acid 5.8320375083
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.8317306315 16712894 16452187 11723127
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.0311813266
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D014652 Vascular Diseases sodium arsenite 4.8217056641
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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