AutismKB 2.0

Annotation Detail for ALOX12


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Basic Information Top
Gene Symbol:ALOX12 ( 12-LOX,12S-LOX,LOG12 )
Gene Full Name: arachidonate 12-lipoxygenase
Band: 17p13.1
Quick LinksEntrez ID:239; OMIM: 152391; Uniprot ID:LOX12_HUMAN; ENSEMBL ID: ENSG00000108839; HGNC ID: 429
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00590Arachidonic acid metabolism
hsa01100Metabolic pathways
No data
No data
Pathway IDPathway Name
P00031Inflammation mediated by chemokine and cytokine signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
1934Cancer
2091Hypertension
2045Bipolar disorder
Desease Name
bipolar disorder
colorectal cancer
CARDIOVASCULAR
menopause
CANCER
PSYCH
bone density
hypertension
METABOLIC
REPRODUCTION
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016718 Arachidonic Acid ALOX12 protein results in increased metabolism of Arachidonic Acidincreases metabolic processing 17027136
C006680 baicalein baicalein inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid]decreases reaction|increases chemical synthesis 17027136
C006680 baicalein baicalein results in decreased activity of ALOX12 proteindecreases activity 17027136
D002945 Cisplatin Cisplatin results in increased expression of ALOX12 mRNAincreases expression 15464296
D002117 Calcitriol Calcitriol results in decreased expression of ALOX12 mRNAdecreases expression 16002434
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ALOX12 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ALOX12 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALOX12 mRNAaffects cotreatment|increases expression 17942748
D005419 Flavonoids Flavonoids results in decreased expression of ALOX12 mRNAdecreases expression 18035473
D019377 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acidincreases chemical synthesis 17027136
D019377 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid baicalein inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid]decreases reaction|increases chemical synthesis 17027136
D019377 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid kaempferol inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid]decreases reaction|increases chemical synthesis 17027136
D019377 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid Nordihydroguaiaretic Acid inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid]decreases reaction|increases chemical synthesis 17027136
D019377 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid Quercetin inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid]decreases reaction|increases chemical synthesis 17027136
D019377 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid resveratrol inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid]decreases reaction|increases chemical synthesis 17027136
C006552 kaempferol kaempferol inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid]decreases reaction|increases chemical synthesis 17027136
C006552 kaempferol kaempferol results in decreased activity of ALOX12 proteindecreases activity 17027136
D009151 Mustard Gas Mustard Gas results in increased expression of ALOX12 mRNAincreases expression 15674844
C085219 N-benzyl-N-hydroxy-5-phenylpentamide N-benzyl-N-hydroxy-5-phenylpentamide results in decreased activity of ALOX12 proteindecreases activity 9258337
D009637 Nordihydroguaiaretic Acid Nordihydroguaiaretic Acid inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid]decreases reaction|increases chemical synthesis 17027136
D009637 Nordihydroguaiaretic Acid Nordihydroguaiaretic Acid results in decreased activity of ALOX12 proteindecreases activity 17027136
D009637 Nordihydroguaiaretic Acid Nordihydroguaiaretic Acid results in decreased activity of ALOX12 proteindecreases activity 9258337
D010852 Picrotoxin Picrotoxin results in increased expression of ALOX12 mRNAincreases expression 15170462
D010972 Platelet Activating Factor Platelet Activating Factor results in increased expression of ALOX12 mRNAincreases expression 16386258
C025299 polyphenols polyphenols results in decreased expression of ALOX12 mRNAdecreases expression 16293270
D011794 Quercetin Quercetin inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid]decreases reaction|increases chemical synthesis 17027136
D011794 Quercetin Quercetin results in decreased activity of ALOX12 proteindecreases activity 17027136
C059514 resveratrol resveratrol inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid]decreases reaction|increases chemical synthesis 17027136
C059514 resveratrol resveratrol results in decreased activity of ALOX12 proteindecreases activity 17027136
D013629 Tamoxifen Tamoxifen affects the expression of ALOX12 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALOX12 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8115322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9117505938
MESH:D058186 Acute Kidney Injury Cisplatin 8.7512690470 15814532 17670903
MESH:D058186 Acute Kidney Injury resveratrol 8.7516538975
MESH:D000230 Adenocarcinoma Cisplatin 4.4211798837 17638652
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4214692618
MESH:D000236 Adenoma resveratrol 3.2915688382
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.3416835633
MESH:D000544 Alzheimer Disease resveratrol 2.5616162502 16183991
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9111748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.2017084956
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.2715885639
MESH:D001169 Arthritis, Experimental resveratrol 7.2717115116
MESH:D001249 Asthma Mustard Gas 2.7010378619
MESH:D001260 Ataxia Telangiectasia Quercetin 4.9415336622
MESH:D050197 Atherosclerosis resveratrol 3.2517967414 16873680
MESH:D001321 Autistic Disorder Arachidonic Acid 3.0318582451
MESH:D001327 Autoimmune Diseases Quercetin 4.3719761891
MESH:D001768 Blister Mustard Gas 5.1219167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7315746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.8614601052
MESH:D002545 Brain Ischemia resveratrol 4.2517600658
MESH:D001943 Breast Neoplasms Calcitriol 4.7111237771
MESH:D001943 Breast Neoplasms Cisplatin 4.7118382427 19526202
MESH:D001943 Breast Neoplasms kaempferol 4.7116756079
MESH:D001943 Breast Neoplasms Nordihydroguaiaretic Acid 4.7118418215
MESH:D001943 Breast Neoplasms Quercetin 4.7118628248
MESH:D001943 Breast Neoplasms resveratrol 4.7117534123 16393696 17651959
MESH:D001943 Breast Neoplasms Tamoxifen 4.7120544844 20065188 20005174 18997820 20859285 19066611 21152245 19155303 19487384 17242785 16873071 20135344 19200415 16818667 19410462 19244106 19103187 18351453 15565566 18425577 17261762 16273361 18984771 18821012 19115204 19289846 21138602 19059307 20390343 11161223 17049068 19189212 19288272 19189210 17440819 16202921 19084267 15668708 18629630 18855134 19011961 17893378 18815881 19142967 19221464
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.7120435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.1215286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.9517687719 10378619
MESH:D002105 Cadmium Poisoning Quercetin 5.5216962696
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4719066611
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 6.6017982673
MESH:D006528 Carcinoma, Hepatocellular Quercetin 6.6019519916 12508355
MESH:D006528 Carcinoma, Hepatocellular resveratrol 6.6019321006 16227395
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.6016924424
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.5616675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0212023789 16685392
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.9217234771
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 7.6311237771
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 7.636189445 18337622 17066447
MESH:D002294 Carcinoma, Squamous Cell resveratrol 7.6316227395
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.5717572228
MESH:D006332 Cardiomegaly Quercetin 6.7219794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.7218670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases kaempferol 7.8116756079
MESH:D002318 Cardiovascular Diseases resveratrol 7.8115458977
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.8416919318 17110522 16105132 15861022 11677210 17333356 17681005
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0812621046 16354765 15668235 8697196 15340226
MESH:D003092 Colitis resveratrol 4.0916474422
MESH:D003110 Colonic Neoplasms Nordihydroguaiaretic Acid 8.3815936596
MESH:D003110 Colonic Neoplasms polyphenols 8.3816293270
MESH:D003110 Colonic Neoplasms Quercetin 8.3811134977 17148506 19056647 15741050 17191121 16640504 19440933
MESH:D003110 Colonic Neoplasms resveratrol 8.3816338953
MESH:D015179 Colorectal Neoplasms Cisplatin 3.5615273666
MESH:D015179 Colorectal Neoplasms Quercetin 3.5618095365 18852136
MESH:D015179 Colorectal Neoplasms resveratrol 3.5616550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0217141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.7216507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2520055451 10048152 15322242
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3219031437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 8.4319496084
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 8.4316873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6617107852
MESH:D003928 Diabetic Nephropathies resveratrol 8.9116286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.9119279558
MESH:D056486 Drug-Induced Liver Injury polyphenols 3.9419370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9420420201
MESH:D004362 Drug Toxicity Cisplatin 8.0719839026 12231392 15033597 12649298
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.0711462148
MESH:D004487 Edema Arachidonic Acid 16.207990266 15177302 11698051 16716910 9831321 9599246
MESH:D004487 Edema Mustard Gas 16.2011402378 11428631 11428647 9260866
MESH:D004487 Edema resveratrol 16.208985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 16.2012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8718230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 21.6215138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 21.6212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 21.6217872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 21.6219031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.0220544844 17893378 19155303 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.989294722 10568697
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.8117923197
MESH:D004890 Erythema Mustard Gas 5.129357497
MESH:D004938 Esophageal Neoplasms Cisplatin 2.7715464296 16481741 15173087 16785472 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9811564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.5615345470
MESH:D005234 Fatty Liver Tamoxifen 7.5614986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4211858732
MESH:D005334 Fever Arachidonic Acid 4.6211852909
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1519069698
MESH:D005355 Fibrosis baicalein 14.8519474275
MESH:D005355 Fibrosis Quercetin 14.8519474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.8520067830
MESH:D005909 Glioblastoma baicalein 7.8419804834
MESH:D005909 Glioblastoma Quercetin 7.8419804834
MESH:D005910 Glioma Quercetin 3.0417643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5710696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.6815102660 15464296
MESH:D034381 Hearing Loss Cisplatin 4.2619898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.3815464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3110048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2911000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8516120746 15340226 12621046
MESH:D006561 Herpes Simplex resveratrol 4.1416876885
MESH:D006689 Hodgkin Disease Cisplatin 3.5616170182 16200630
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0218606429 8697196 15340226 16959395 16354765
MESH:D006937 Hypercholesterolemia resveratrol 3.9617188708
MESH:D006943 Hyperglycemia kaempferol 9.7818262572
MESH:D006943 Hyperglycemia Quercetin 9.7818262572 11834736
MESH:D006949 Hyperlipidemias resveratrol 3.9916873680
MESH:D006973 Hypertension Quercetin 5.1718356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1718850075 18670907
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.2617488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7716945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.6117600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4617937319
MESH:D007249 Inflammation Arachidonic Acid 23.949831321 15177302 17371808
MESH:D007249 Inflammation Flavonoids 23.9417296493
MESH:D007249 Inflammation Mustard Gas 23.9411402378 9260866 16001271 11428631 11428647 11428620 9357497 8975870 17524151
MESH:D007249 Inflammation polyphenols 23.9416366677
MESH:D007249 Inflammation resveratrol 23.9416366677
MESH:D007249 Inflammation Tamoxifen 23.9419457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 23.9412200463 12878042
MESH:D007251 Influenza, Human Nordihydroguaiaretic Acid 18.7218473937
MESH:D007251 Influenza, Human Quercetin 18.7216624496
MESH:D007251 Influenza, Human resveratrol 18.7216624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2916580747
MESH:D007627 Keloid Quercetin 4.9217086741
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.1115464296
MESH:D007674 Kidney Diseases Cisplatin 6.3719839026 18289764 12231392 15190930 12649298
MESH:D007674 Kidney Diseases Quercetin 6.3716962696
MESH:D007680 Kidney Neoplasms Tamoxifen 3.0118625569
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.7711231351
MESH:D007938 Leukemia kaempferol 6.8817468513
MESH:D007938 Leukemia Quercetin 6.8817468513
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.5516087638
MESH:D008064 Lipidoses Tamoxifen 3.1215342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 3.4712741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.4718564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4712878042
MESH:D008107 Liver Diseases polyphenols 2.7716698588
MESH:D008113 Liver Neoplasms Quercetin 10.6018980244
MESH:D008113 Liver Neoplasms resveratrol 10.6019073162 20405173 19321006 19812893
MESH:D008113 Liver Neoplasms Tamoxifen 10.6016684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.6016984957
MESH:D008114 Liver Neoplasms, Experimental Quercetin 5.8319519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.8312151625
MESH:D008171 Lung Diseases Mustard Gas 3.4218161513 18702808
MESH:D008175 Lung Neoplasms Cisplatin 6.5517225452 6189445 11798837
MESH:D008175 Lung Neoplasms Mustard Gas 6.553148597 8781369
MESH:D008175 Lung Neoplasms Quercetin 6.5516280456
MESH:D008175 Lung Neoplasms Tamoxifen 6.5518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.5511884234 19555203
MESH:D016393 Lymphoma, B-Cell resveratrol 4.2617088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.8314749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 9.8815688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 9.8819428831
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 6.088985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.0819196722 14580682 16827153 11731420 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.5219453300
MESH:D008545 Melanoma Cisplatin 5.1718332650 16432458 12883367 18505091 16248763 16809738 12374674 17761969 15577323 17023156 12393984 11135225 18176117
MESH:D008545 Melanoma resveratrol 5.1717992120
MESH:D008545 Melanoma Tamoxifen 5.1719393235 12393984
MESH:D018328 Melanoma, Amelanotic Cisplatin 11.3915990972
MESH:D018328 Melanoma, Amelanotic Tamoxifen 11.3915990972
MESH:D008654 Mesothelioma Cisplatin 3.2317638057
MESH:D008659 Metabolic Diseases resveratrol 4.3417112576
MESH:D009101 Multiple Myeloma resveratrol 3.4317935668 16267019 14749477 17164350 16490592 17049120
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.8317962980
MESH:D009203 Myocardial Infarction Quercetin 5.9919595682
MESH:D009203 Myocardial Infarction resveratrol 5.9916525036 17188708 17125593 17015251 16317513 16456233
MESH:D017202 Myocardial Ischemia resveratrol 8.8917125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.8912213967
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.7619207477
MESH:D009205 Myocarditis resveratrol 4.7217322642
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5019410462
MESH:D009369 Neoplasms Cisplatin 5.3416773208
MESH:D009369 Neoplasms Quercetin 5.3415185748
MESH:D009374 Neoplasms, Experimental resveratrol 3.968985016
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.9719196722 19189210 19200415
MESH:D009395 Nephritis, Interstitial Cisplatin 4.4615464296
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1714600291
MESH:D009447 Neuroblastoma Cisplatin 3.438761367
MESH:D019636 Neurodegenerative Diseases resveratrol 3.7717652729
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.668761367
MESH:D020078 Neurogenic Inflammation Quercetin 10.5617929310
MESH:D020078 Neurogenic Inflammation resveratrol 10.5617929310
MESH:D009503 Neutropenia Mustard Gas 3.9316761898 7688884
MESH:D010024 Osteoporosis kaempferol 4.3216756079
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 10.0719495926
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 10.0717513867
MESH:D010051 Ovarian Neoplasms Cisplatin 5.1415464296 17225452 19769630 6897625
MESH:D010051 Ovarian Neoplasms Quercetin 5.1419005980
MESH:D010190 Pancreatic Neoplasms Cisplatin 5.5519003803
MESH:D010190 Pancreatic Neoplasms Quercetin 5.5516965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2212520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.2715464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.3117638057
MESH:D011041 Poisoning Mustard Gas 3.7615727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5218163543
MESH:D011230 Precancerous Conditions Quercetin 3.9419056647
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 9.4716679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.4711896295 11118676 11399792 11222880
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.7415572423
MESH:D011471 Prostatic Neoplasms Calcitriol 1.9112479363 16289102 16644109 15754350 18247401
MESH:D011471 Prostatic Neoplasms Nordihydroguaiaretic Acid 1.9118491370
MESH:D011471 Prostatic Neoplasms Quercetin 1.9117292933 14715546
MESH:D011471 Prostatic Neoplasms resveratrol 1.9117636462 17675339 17804756 15767336 16731767 17718901
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.9115067354
MESH:D011537 Pruritus Ethinyl Estradiol 9.4116919318 15861022
MESH:D011537 Pruritus Mustard Gas 9.4118058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9117720292 17894541 17266442 17620002 10334151
MESH:D051437 Renal Insufficiency Cisplatin 4.3715464296
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.5516325855
MESH:D015427 Reperfusion Injury resveratrol 3.2516317513 16314181 17058453 17520802 15827377
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8018990726
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.3914601052
MESH:D012554 Schistosomiasis japonica Quercetin 5.5216862918
MESH:D012640 Seizures Picrotoxin 3.968954991 8635557
MESH:D012871 Skin Diseases Mustard Gas 2.7012880345 16961503 15451306
MESH:D012878 Skin Neoplasms resveratrol 5.6515837718 8985016
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6516192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.3115464296
MESH:D013088 Spermatocele Ethinyl Estradiol 11.4716709447
MESH:D013088 Spermatocele Tamoxifen 11.4716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0019457130
MESH:D013274 Stomach Neoplasms Cisplatin 2.3318396642 15958060 17522103
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.4416321402
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.2217997062
MESH:D013736 Testicular Neoplasms Cisplatin 4.5917225452 15464296
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8712697716
MESH:D014062 Tongue Neoplasms resveratrol 4.1716227395
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 8.3512973940 17225452 15464296
MESH:D001749 Urinary Bladder Neoplasms Quercetin 8.3516720314
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.3517572228 8653321 16712894
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 9.6016803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 9.6017473185
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.3614692618
MESH:D014594 Uterine Neoplasms resveratrol 9.3617044934
MESH:D014625 Vaginal Neoplasms Cisplatin 4.5715577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5014671159 15869587
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.2617488730
MESH:D014839 Vomiting Cisplatin 4.6911897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2215886252
Pathway ID Pathway Name
KEGG:00590 Arachidonic acid metabolism
KEGG:00591 Linoleic acid metabolism
KEGG:01100 Metabolic pathways
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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