Annotation Detail for ALOX5
Basic Information Top
| Gene Symbol: | ALOX5 ( 5-LO,5-LOX,5LPG,LOG5,MGC163204 ) |
|---|---|
| Gene Full Name: | arachidonate 5-lipoxygenase |
| Band: | 10q11.21 |
| Quick Links | Entrez ID:240; OMIM: 152390; Uniprot ID:LOX5_HUMAN; ENSEMBL ID: ENSG00000012779; HGNC ID: 435 |
| Relate to Another Database: | SFARIGene; denovo-db |
| Pathway ID | Pathway Name |
|---|---|
| PWY66-375 | leukotriene biosynthesis |
| Pathway ID | Pathway Name |
|---|---|
| hsa00590 | Arachidonic acid metabolism |
| hsa05145 | Toxoplasmosis |
| hsa01100 | Metabolic pathways |
| Pathway ID | Pathway Name |
|---|---|
| Hormone biosynthesis | |
| Metabolism of lipids and lipoproteins |
| No data |
| No data |
| Pathway ID | Pathway Name |
|---|---|
| 500771 | Leukotriene synthesis |
| No data |
| Desease ID | Desease Name |
|---|---|
| 1904 | Diabetes mellitus |
| 1918 | Atherosclerosis |
| 1934 | Cancer |
| 1997 | Dental plaque |
| 2029 | Tuberculosis |
| 2074 | Asthma |
| 2248 | Cytomegalovirus infection |
| Desease Name |
|---|
| colorectal cancer |
| CARDIOVASCULAR |
| myocardial infarct |
| CANCER |
| PHARMACOGENOMIC |
| Asthma |
| vascular disease |
| IMMUNE |
| Desease Name |
|---|
| Hematological and biochemical traits |
| Desease Name |
|---|
| Asthma, diminished response to antileukotriene treatment in |
| Atherosclerosis, susceptibility to |
| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| C025086 | 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid | ALOX5 protein results in increased metabolism of 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid | increases metabolic processing | 7929400 |
| C025086 | 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid | [ALOX5 protein results in increased metabolism of 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid] which results in increased abundance of Leukotriene B4 analog | increases abundance|increases metabolic processing | 7929400 |
| C062894 | 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid | 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid results in decreased expression of ALOX5 protein | decreases expression | 17056761 |
| C520323 | 1-oleoyl-2-acetoyl-sn-glycerol | 1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [1-Butanol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]] | decreases reaction|increases activity|increases localization | 18218859 |
| C520323 | 1-oleoyl-2-acetoyl-sn-glycerol | 1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [1-Butanol inhibits the reaction [Thapsigargin results in increased activity of and results in increased localization of ALOX5 protein]] | decreases reaction|increases activity|increases localization | 18218859 |
| C520323 | 1-oleoyl-2-acetoyl-sn-glycerol | 1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]] | decreases reaction|increases activity|increases localization | 18218859 |
| C520323 | 1-oleoyl-2-acetoyl-sn-glycerol | 1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [Propranolol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]] | decreases reaction|increases activity|increases localization | 18218859 |
| C400184 | 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine | 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of ALOX5 mRNA | increases expression | 16386258 |
| C036837 | 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone | 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [ALOX5 protein promotes the reaction [Receptors, IgE results in increased abundance of Reactive Oxygen Species]] | decreases reaction|increases abundance|increases reaction | 17982097 |
| C036837 | 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone | 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in decreased activity of ALOX5 protein | decreases activity | 7812673 |
| C548544 | 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid | 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid results in decreased activity of ALOX5 protein | decreases activity | 19934399 |
| C063918 | 2-(4-hydroxy-3,5-dimethylphenyl)-5-methoxy-3-methylindole | 2-(4-hydroxy-3,5-dimethylphenyl)-5-methoxy-3-methylindole results in decreased activity of ALOX5 protein | decreases activity | 7812673 |
| C079315 | 2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid | 2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid results in decreased activity of ALOX5 protein | decreases activity | 12954791 |
| C079315 | 2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid | 2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of ALOX5 protein] | decreases reaction|increases expression | 16033810 |
| C472791 | 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid | 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of ALOX5 mRNA | increases expression | 16788091 |
| C119130 | 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide | ALOX5 protein affects the reaction [4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide affects the expression of CCL2 mRNA] | affects expression|affects reaction | 17766677 |
| C116824 | 5-((1,5-bis(4-methoxyphenyl)pyrazol-3-yl)dimethoxymethyl)-2-chlorobenzamide | 5-((1,5-bis(4-methoxyphenyl)pyrazol-3-yl)dimethoxymethyl)-2-chlorobenzamide results in decreased activity of ALOX5 protein | decreases activity | 9831321 |
| C116824 | 5-((1,5-bis(4-methoxyphenyl)pyrazol-3-yl)dimethoxymethyl)-2-chlorobenzamide | [5-((1,5-bis(4-methoxyphenyl)pyrazol-3-yl)dimethoxymethyl)-2-chlorobenzamide results in decreased activity of ALOX5 protein] which results in decreased abundance of Eicosanoids | decreases abundance|decreases activity | 9831321 |
| C022022 | 5-hydroxy-6,8,11,14-eicosatetraenoic acid | ALOX5 protein results in increased chemical synthesis of 5-hydroxy-6,8,11,14-eicosatetraenoic acid | increases chemical synthesis | 18295198 |
| C047651 | 5-hydroxyeicosatetraenoic acid lactone | 5-hydroxyeicosatetraenoic acid lactone results in decreased activity of ALOX5 protein | decreases activity | 12629151 |
| C068314 | 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one | 1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]] | decreases reaction|increases activity|increases localization | 18218859 |
| C068314 | 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one | 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein] | decreases reaction|increases activity|increases localization | 18218859 |
| C082739 | A 78773 | [[A 78773 co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4 | affects cotreatment|decreases abundance|decreases activity | 11529688 |
| C082739 | A 78773 | A 78773 results in decreased activity of ALOX5 protein | decreases activity | 11529688 |
| D000082 | Acetaminophen | Acetaminophen affects the expression of ALOX5 mRNA | affects expression | 17562736 |
| D000227 | Adenine Nucleotides | Adenine Nucleotides binds to ALOX5 protein | affects binding | 7577949 |
| C049740 | alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol | alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol results in decreased activity of ALOX5 protein | decreases activity | 12629151 |
| C049740 | alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol | alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol results in decreased activity of ALOX5 protein | decreases activity | 18927292 |
| D000643 | Ammonium Chloride | Ammonium Chloride affects the expression of ALOX5 mRNA | affects expression | 16483693 |
| D016718 | Arachidonic Acid | ALOX5 protein results in increased metabolism of Arachidonic Acid | increases metabolic processing | 18295198 |
| D016718 | Arachidonic Acid | Arachidonic Acid inhibits the reaction [L 708714 binds to ALOX5 protein] | affects binding|decreases reaction | 7577949 |
| D016718 | Arachidonic Acid | CJ 13610 inhibits the reaction [ALOX5 protein results in increased metabolism of Arachidonic Acid] | decreases reaction|increases metabolic processing | 18295198 |
| D016718 | Arachidonic Acid | zileuton inhibits the reaction [ALOX5 protein results in increased metabolism of Arachidonic Acid] | decreases reaction|increases metabolic processing | 18295198 |
| D016718 | Arachidonic Acid | [zileuton results in decreased activity of ALOX5 protein] which affects the abundance of Arachidonic Acid | affects abundance|decreases activity | 9495842 |
| D016718 | Arachidonic Acid | [zileuton results in decreased activity of ALOX5 protein] which results in decreased susceptibility to Arachidonic Acid | decreases activity|decreases response to substance | 7592874 |
| D016718 | Arachidonic Acid | ALOX5 protein results in increased metabolism of Arachidonic Acid | increases metabolic processing | 18951527 |
| D001151 | Arsenic | Arsenic affects the expression of ALOX5 mRNA | affects expression | 18414638 |
| C038044 | baicalin | baicalin inhibits the reaction [Hydrogen Peroxide affects the localization of and results in increased activity of ALOX5 protein] | affects localization|decreases reaction|increases activity | 20139896 |
| D019324 | beta-Naphthoflavone | beta-Naphthoflavone results in increased expression of ALOX5 mRNA | increases expression | 19737606 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene promotes the reaction [Calcitriol results in increased expression of ALOX5 mRNA] | increases expression|increases reaction | 19244278 |
| C500927 | bolinaquinone | bolinaquinone inhibits the reaction [Calcimycin results in increased activity of ALOX5 protein] | decreases reaction|increases activity | 12604694 |
| D020001 | 1-Butanol | 1-Butanol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein] | decreases reaction|increases activity|increases localization | 18218859 |
| D020001 | 1-Butanol | 1-Butanol inhibits the reaction [Thapsigargin results in increased activity of and results in increased localization of ALOX5 protein] | decreases reaction|increases activity|increases localization | 18218859 |
| D020001 | 1-Butanol | 1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [1-Butanol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]] | decreases reaction|increases activity|increases localization | 18218859 |
| D020001 | 1-Butanol | 1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [1-Butanol inhibits the reaction [Thapsigargin results in increased activity of and results in increased localization of ALOX5 protein]] | decreases reaction|increases activity|increases localization | 18218859 |
| D002084 | Butylated Hydroxytoluene | Butylated Hydroxytoluene affects the localization of ALOX5 protein | affects localization | 12376474 |
| D002084 | Butylated Hydroxytoluene | celecoxib inhibits the reaction [Butylated Hydroxytoluene affects the localization of ALOX5 protein] | affects localization|decreases reaction | 12376474 |
| D020122 | tert-Butylhydroperoxide | tert-Butylhydroperoxide results in decreased expression of ALOX5 mRNA | decreases expression | 15336504 |
| C040048 | caffeic acid | caffeic acid inhibits the reaction [Hydrogen Peroxide affects the localization of ALOX5 protein] | affects localization|decreases reaction | 18951527 |
| C040048 | caffeic acid | caffeic acid inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein] | affects cotreatment|affects localization|decreases reaction | 18951527 |
| C040048 | caffeic acid | caffeic acid results in decreased activity of ALOX5 protein | decreases activity | 18951527 |
| D000001 | Calcimycin | 1-Butanol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein] | decreases reaction|increases activity|increases localization | 18218859 |
| D000001 | Calcimycin | 1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [1-Butanol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]] | decreases reaction|increases activity|increases localization | 18218859 |
| D000001 | Calcimycin | 1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]] | decreases reaction|increases activity|increases localization | 18218859 |
| D000001 | Calcimycin | 1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [Propranolol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]] | decreases reaction|increases activity|increases localization | 18218859 |
| D000001 | Calcimycin | 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein] | decreases reaction|increases activity|increases localization | 18218859 |
| D000001 | Calcimycin | bolinaquinone inhibits the reaction [Calcimycin results in increased activity of ALOX5 protein] | decreases reaction|increases activity | 12604694 |
| D000001 | Calcimycin | Calcimycin results in increased activity of and results in increased localization of ALOX5 protein | increases activity|increases localization | 18218859 |
| D000001 | Calcimycin | Propranolol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein] | decreases reaction|increases activity|increases localization | 18218859 |
| D000001 | Calcimycin | tert-Butyl Alcohol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein] | decreases reaction|increases activity|increases localization | 18218859 |
| D000001 | Calcimycin | [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Calcimycin results in increased abundance of Platelet Activating Factor] | decreases activity|decreases reaction|increases abundance | 8387780 |
| D000001 | Calcimycin | [[A 78773 co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4 | affects cotreatment|decreases abundance|decreases activity | 11529688 |
| D000001 | Calcimycin | Calcimycin results in increased activity of and results in increased localization of ALOX5 protein | increases activity|increases localization | 9445378 |
| D000001 | Calcimycin | [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein] which results in increased abundance of Leukotriene B4 | increases abundance|increases activity|increases localization | 9445378 |
| D000001 | Calcimycin | [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein] which results in increased abundance of Leukotriene C4 | increases abundance|increases activity|increases localization | 9445378 |
| D000001 | Calcimycin | Calcimycin results in increased expression of ALOX5 mRNA | increases expression | 18083043 |
| D000001 | Calcimycin | Calcimycin results in increased expression of ALOX5 protein | increases expression | 18083043 |
| D000001 | Calcimycin | Calcimycin results in increased localization of and results in increased activity of ALOX5 protein | increases activity|increases localization | 7665580 |
| D000001 | Calcimycin | CCL5 protein promotes the reaction [Calcimycin results in increased expression of ALOX5 mRNA] | increases expression|increases reaction | 18083043 |
| D000001 | Calcimycin | CCL5 protein promotes the reaction [Calcimycin results in increased expression of ALOX5 protein] | increases expression|increases reaction | 18083043 |
| D000001 | Calcimycin | [[CMI 392 co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4 | affects cotreatment|decreases abundance|decreases activity | 11529688 |
| D000001 | Calcimycin | Dexamethasone inhibits the reaction [[CCL5 protein co-treated with Calcimycin] results in increased expression of ALOX5 protein] | affects cotreatment|decreases reaction|increases expression | 18083043 |
| D000001 | Calcimycin | Nordihydroguaiaretic Acid inhibits the reaction [[CCL5 protein co-treated with Calcimycin] results in increased expression of ALOX5 mRNA] | affects cotreatment|decreases reaction|increases expression | 18083043 |
| D000001 | Calcimycin | Nordihydroguaiaretic Acid inhibits the reaction [[CCL5 protein co-treated with Calcimycin] results in increased expression of ALOX5 protein] | affects cotreatment|decreases reaction|increases expression | 18083043 |
| D000001 | Calcimycin | [[zileuton co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4 | affects cotreatment|decreases abundance|decreases activity | 11529688 |
| D000001 | Calcimycin | [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Calcimycin results in increased abundance of Leukotriene B4] | decreases activity|decreases reaction|increases abundance | 18475545 |
| D002118 | Calcium | Calcium promotes the reaction [L 708714 binds to ALOX5 protein] | affects binding|increases reaction | 7577949 |
| D002211 | Capsaicin | [Capsaicin co-treated with Curcumin] results in decreased activity of ALOX5 protein | affects cotreatment|decreases activity | 16956363 |
| D002211 | Capsaicin | Capsaicin results in decreased activity of ALOX5 protein | decreases activity | 16956363 |
| D002251 | Carbon Tetrachloride | 2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of ALOX5 protein] | decreases reaction|increases expression | 16033810 |
| D002251 | Carbon Tetrachloride | Carbon Tetrachloride results in increased expression of ALOX5 protein | increases expression | 16033810 |
| D017452 | Receptors, IgG | ALOX5 protein promotes the reaction [Receptors, IgG results in increased abundance of Reactive Oxygen Species] | increases abundance|increases reaction | 17982097 |
| D017455 | Receptors, IgE | 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [ALOX5 protein promotes the reaction [Receptors, IgE results in increased abundance of Reactive Oxygen Species]] | decreases reaction|increases abundance|increases reaction | 17982097 |
| D017455 | Receptors, IgE | ALOX5 protein promotes the reaction [Receptors, IgE results in increased abundance of Reactive Oxygen Species] | increases abundance|increases reaction | 17982097 |
| D017455 | Receptors, IgE | Nordihydroguaiaretic Acid inhibits the reaction [ALOX5 protein promotes the reaction [Receptors, IgE results in increased abundance of Reactive Oxygen Species]] | decreases reaction|increases abundance|increases reaction | 17982097 |
| D017455 | Receptors, IgE | zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Receptors, IgE results in increased abundance of Reactive Oxygen Species]] | decreases reaction|increases abundance|increases reaction | 17982097 |
| C105934 | celecoxib | celecoxib inhibits the reaction [Butylated Hydroxytoluene affects the localization of ALOX5 protein] | affects localization|decreases reaction | 12376474 |
| D017332 | Cetirizine | Cetirizine analog results in decreased activity of ALOX5 protein | decreases activity | 15482930 |
| C496810 | CJ 13610 | CJ 13610 inhibits the reaction [ALOX5 protein results in increased metabolism of Arachidonic Acid] | decreases reaction|increases metabolic processing | 18295198 |
| C496810 | CJ 13610 | CJ 13610 results in decreased activity of ALOX5 protein | decreases activity | 18295198 |
| C496810 | CJ 13610 | CJ 13610 results in decreased activity of ALOX5 protein | decreases activity | 17766677 |
| C496810 | CJ 13610 | CJ 13610 results in decreased activity of ALOX5 protein | decreases activity | 18295198 |
| C112433 | CMI 392 | [[CMI 392 co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4 | affects cotreatment|decreases abundance|decreases activity | 11529688 |
| C112433 | CMI 392 | CMI 392 results in decreased activity of ALOX5 protein | decreases activity | 9599246 11529688 |
| C423222 | cotylenin A | cotylenin A results in increased expression of ALOX5 mRNA | increases expression | 16129123 |
| C030123 | coumarin | coumarin results in increased expression of ALOX5 mRNA | increases expression | 18480146 |
| D003474 | Curcumin | [Capsaicin co-treated with Curcumin] results in decreased activity of ALOX5 protein | affects cotreatment|decreases activity | 16956363 |
| D003474 | Curcumin | Curcumin results in decreased activity of ALOX5 protein | decreases activity | 16956363 |
| D003474 | Curcumin | Curcumin results in decreased expression of ALOX5 | decreases expression | 18462866 |
| D003907 | Dexamethasone | Dexamethasone inhibits the reaction [[CCL5 protein co-treated with Calcimycin] results in increased expression of ALOX5 protein] | affects cotreatment|decreases reaction|increases expression | 18083043 |
| D015772 | 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine | 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine results in decreased activity of ALOX5 protein | decreases activity | 7990266 |
| D002117 | Calcitriol | Benzo(a)pyrene promotes the reaction [Calcitriol results in increased expression of ALOX5 mRNA] | increases expression|increases reaction | 19244278 |
| D002117 | Calcitriol | Calcitriol results in increased expression of ALOX5 mRNA | increases expression | 19244278 16002434 16129123 |
| C007488 | dinitrobenzenesulfonic acid | ALOX5 protein affects the reaction [dinitrobenzenesulfonic acid affects the localization of OCLN protein] | affects localization|affects reaction | 16670640 |
| C007488 | dinitrobenzenesulfonic acid | ALOX5 protein affects the reaction [dinitrobenzenesulfonic acid affects the localization of TJP1 protein] | affects localization|affects reaction | 16670640 |
| C007488 | dinitrobenzenesulfonic acid | ALOX5 protein affects the reaction [dinitrobenzenesulfonic acid results in increased activity of MPO protein] | affects reaction|increases activity | 15821759 |
| C007488 | dinitrobenzenesulfonic acid | ALOX5 protein affects the reaction [dinitrobenzenesulfonic acid results in increased expression of ICAM1 protein] | affects reaction|increases expression | 15821759 |
| C007488 | dinitrobenzenesulfonic acid | ALOX5 protein affects the reaction [dinitrobenzenesulfonic acid results in increased expression of SELE protein] | affects reaction|increases expression | 15821759 |
| C007488 | dinitrobenzenesulfonic acid | ALOX5 protein affects the reaction [dinitrobenzenesulfonic acid results in increased expression of SELP protein] | affects reaction|increases expression | 15821759 |
| C007488 | dinitrobenzenesulfonic acid | ALOX5 protein affects the reaction [dinitrobenzenesulfonic acid results in increased expression of VCAM1 protein] | affects reaction|increases expression | 15821759 |
| C007488 | dinitrobenzenesulfonic acid | ALOX5 protein affects the susceptibility to dinitrobenzenesulfonic acid | affects response to substance | 16670640 |
| D004281 | Docosahexaenoic Acids | Docosahexaenoic Acids results in decreased expression of ALOX5 protein | decreases expression | 17056761 |
| D004365 | Drugs, Chinese Herbal | Drugs, Chinese Herbal results in decreased activity of ALOX5 protein | decreases activity | 19066064 |
| C064507 | E 6080 | E 6080 results in decreased activity of ALOX5 protein | decreases activity | 7812673 |
| C042986 | ebselen | ebselen results in decreased activity of ALOX5 protein | decreases activity | 7590103 |
| C121361 | efletirizine | efletirizine analog results in decreased activity of ALOX5 protein | decreases activity | 15482930 |
| D015777 | Eicosanoids | [5-((1,5-bis(4-methoxyphenyl)pyrazol-3-yl)dimethoxymethyl)-2-chlorobenzamide results in decreased activity of ALOX5 protein] which results in decreased abundance of Eicosanoids | decreases abundance|decreases activity | 9831321 |
| D015777 | Eicosanoids | [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Eicosanoids | decreases abundance|decreases activity | 9831321 |
| D004958 | Estradiol | Estradiol results in decreased expression of ALOX5 protein | decreases expression | 17143502 |
| D005419 | Flavonoids | Flavonoids results in increased expression of ALOX5 mRNA | increases expression | 18035473 |
| D009240 | N-Formylmethionine Leucyl-Phenylalanine | ALOX5 protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein] | increases expression|increases reaction | 11116075 |
| D009240 | N-Formylmethionine Leucyl-Phenylalanine | [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Leukotriene C4] | decreases activity|decreases reaction|increases abundance | 9495842 |
| D005947 | Glucose | caffeic acid inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein] | affects cotreatment|affects localization|decreases reaction | 18951527 |
| D005947 | Glucose | [Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein | affects cotreatment|affects localization | 18951527 |
| D005947 | Glucose | phenylmethylpyrazolone inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein] | affects cotreatment|affects localization|decreases reaction | 18951527 |
| D005947 | Glucose | SB 203580 inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein] | affects cotreatment|affects localization|decreases reaction | 18951527 |
| D007975 | Leukotriene B4 | ALOX5 protein promotes the reaction [lipopolysaccharide, E. coli 026-B6 results in increased abundance of Leukotriene B4] | increases abundance|increases reaction | 15501964 |
| D007975 | Leukotriene B4 | ALOX5 protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4] | increases abundance|increases response to substance | 9609743 |
| D007975 | Leukotriene B4 | zileuton inhibits the reaction [ALOX5 protein promotes the reaction [lipopolysaccharide, E. coli 026-B6 results in increased abundance of Leukotriene B4]] | decreases reaction|increases abundance|increases reaction | 15501964 |
| D007975 | Leukotriene B4 | zileuton inhibits the reaction [ALOX5 protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]] | decreases reaction|increases abundance|increases response to substance | 9609743 |
| D007975 | Leukotriene B4 | [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4 | decreases abundance|decreases activity | 11286996 1781415 |
| D007975 | Leukotriene B4 | ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene B4] | increases abundance|increases reaction | 12794006 |
| D007975 | Leukotriene B4 | zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene B4]] | decreases reaction|increases abundance|increases reaction | 12794006 |
| D007975 | Leukotriene B4 | [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4 | decreases abundance|decreases activity | 9593866 |
| D007975 | Leukotriene B4 | [[A 78773 co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4 | affects cotreatment|decreases abundance|decreases activity | 11529688 |
| D007975 | Leukotriene B4 | ALOX5 protein promotes the reaction [IL8 protein results in increased abundance of Leukotriene B4] | increases abundance|increases reaction | 8058773 |
| D007975 | Leukotriene B4 | [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein] which results in increased abundance of Leukotriene B4 | increases abundance|increases activity|increases localization | 9445378 |
| D007975 | Leukotriene B4 | [[CMI 392 co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4 | affects cotreatment|decreases abundance|decreases activity | 11529688 |
| D007975 | Leukotriene B4 | [lipopolysaccharide, Escherichia coli 0111 B4 results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4 | decreases abundance|decreases activity | 12388339 |
| D007975 | Leukotriene B4 | [tepoxalin results in decreased activity of ALOX5 protein] inhibits the reaction [Indomethacin results in increased abundance of Leukotriene B4] | decreases activity|decreases reaction|increases abundance | 9223651 |
| D007975 | Leukotriene B4 | tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[lipopolysaccharide, Escherichia coli 0111 B4 results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4] | decreases abundance|decreases activity|decreases reaction | 12388339 |
| D007975 | Leukotriene B4 | [troglitazone results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4 | decreases abundance|decreases activity | 10694244 |
| D007975 | Leukotriene B4 | [[zileuton co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4 | affects cotreatment|decreases abundance|decreases activity | 11529688 |
| D007975 | Leukotriene B4 | [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Calcimycin results in increased abundance of Leukotriene B4] | decreases activity|decreases reaction|increases abundance | 18475545 |
| D007975 | Leukotriene B4 | [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Indomethacin results in increased abundance of Leukotriene B4] | decreases activity|decreases reaction|increases abundance | 9223651 |
| D007975 | Leukotriene B4 | [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4 | decreases abundance|decreases activity | 10694244 |
| D007975 | Leukotriene B4 | ALOX5 protein results in increased chemical synthesis of Leukotriene B4 | increases chemical synthesis | 20436887 |
| D007975 | Leukotriene B4 | [ALOX5 protein results in increased metabolism of 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid] which results in increased abundance of Leukotriene B4 analog | increases abundance|increases metabolic processing | 7929400 |
| D006632 | Histamine | ALOX5 protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4] | increases abundance|increases response to substance | 9609743 |
| D006632 | Histamine | zileuton inhibits the reaction [ALOX5 protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]] | decreases reaction|increases abundance|increases response to substance | 9609743 |
| D006861 | Hydrogen Peroxide | ALOX5 protein promotes the reaction [lysophosphatidic acid results in increased abundance of Hydrogen Peroxide] | increases abundance|increases reaction | 10698703 |
| D006861 | Hydrogen Peroxide | Nordihydroguaiaretic Acid inhibits the reaction [ALOX5 protein promotes the reaction [lysophosphatidic acid results in increased abundance of Hydrogen Peroxide]] | decreases reaction|increases abundance|increases reaction | 10698703 |
| D006861 | Hydrogen Peroxide | zileuton inhibits the reaction [ALOX5 protein promotes the reaction [lysophosphatidic acid results in increased abundance of Hydrogen Peroxide]] | decreases reaction|increases abundance|increases reaction | 10698703 |
| D006861 | Hydrogen Peroxide | baicalin inhibits the reaction [Hydrogen Peroxide affects the localization of and results in increased activity of ALOX5 protein] | affects localization|decreases reaction|increases activity | 20139896 |
| D006861 | Hydrogen Peroxide | caffeic acid inhibits the reaction [Hydrogen Peroxide affects the localization of ALOX5 protein] | affects localization|decreases reaction | 18951527 |
| D006861 | Hydrogen Peroxide | Hydrogen Peroxide affects the localization of ALOX5 protein | affects localization | 18951527 |
| D006861 | Hydrogen Peroxide | Hydrogen Peroxide affects the localization of and results in increased activity of ALOX5 protein | affects localization|increases activity | 20139896 |
| D006861 | Hydrogen Peroxide | Hydrogen Peroxide results in decreased activity of ALOX5 protein | decreases activity | 12388339 |
| D006861 | Hydrogen Peroxide | phenylmethylpyrazolone inhibits the reaction [Hydrogen Peroxide affects the localization of ALOX5 protein] | affects localization|decreases reaction | 18951527 |
| D006861 | Hydrogen Peroxide | SB 203580 inhibits the reaction [Hydrogen Peroxide affects the localization of ALOX5 protein] | affects localization|decreases reaction | 18951527 |
| D006877 | Hydroxamic Acids | Hydroxamic Acids analog results in decreased activity of ALOX5 protein | decreases activity | 7922131 |
| D006893 | Hydroxyeicosatetraenoic Acids | ALOX5 protein results in increased metabolism of Hydroxyeicosatetraenoic Acids metabolite | increases metabolic processing | 11861792 |
| D006893 | Hydroxyeicosatetraenoic Acids | L 663536 inhibits the reaction [ALOX5 protein results in increased metabolism of Hydroxyeicosatetraenoic Acids metabolite] | decreases reaction|increases metabolic processing | 11861792 |
| D006918 | Hydroxyurea | Hydroxyurea inhibits the reaction [L 708714 binds to ALOX5 protein] | affects binding|decreases reaction | 7577949 |
| C069794 | ICI 211965 | ICI 211965 results in decreased activity of ALOX5 protein | decreases activity | 8452572 |
| C075799 | ICI D2138 | ICI D2138 results in decreased activity of ALOX5 protein | decreases activity | 7522174 9580604 |
| C075799 | ICI D2138 | ICI D2138 inhibits the reaction [L 708714 binds to ALOX5 protein] | affects binding|decreases reaction | 7577949 |
| C075799 | ICI D2138 | ICI D2138 results in decreased activity of ALOX5 protein | decreases activity | 18475545 |
| C075799 | ICI D2138 | ICI D2138 results in decreased activity of ALOX5 protein | decreases activity | 11509739 |
| D007213 | Indomethacin | [tepoxalin results in decreased activity of ALOX5 protein] inhibits the reaction [Indomethacin results in increased abundance of Leukotriene B4] | decreases activity|decreases reaction|increases abundance | 9223651 |
| D007213 | Indomethacin | [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Indomethacin results in increased abundance of Leukotriene B4] | decreases activity|decreases reaction|increases abundance | 9223651 |
| C060893 | L 663536 | L 663536 results in decreased activity of ALOX5 protein | decreases activity | 8482329 |
| C060893 | L 663536 | L 663536 inhibits the reaction [ALOX5 protein results in increased metabolism of Hydroxyeicosatetraenoic Acids metabolite] | decreases reaction|increases metabolic processing | 11861792 |
| C060893 | L 663536 | L 663536 results in decreased activity of ALOX5 protein | decreases activity | 14726295 9445378 |
| C080279 | L 689065 | L 689065 results in decreased activity of ALOX5 protein | decreases activity | 8452572 |
| C096344 | L 708714 | Arachidonic Acid inhibits the reaction [L 708714 binds to ALOX5 protein] | affects binding|decreases reaction | 7577949 |
| C096344 | L 708714 | Calcium promotes the reaction [L 708714 binds to ALOX5 protein] | affects binding|increases reaction | 7577949 |
| C096344 | L 708714 | Hydroxyurea inhibits the reaction [L 708714 binds to ALOX5 protein] | affects binding|decreases reaction | 7577949 |
| C096344 | L 708714 | ICI D2138 inhibits the reaction [L 708714 binds to ALOX5 protein] | affects binding|decreases reaction | 7577949 |
| C096344 | L 708714 | L 708714 binds to and results in decreased activity of ALOX5 protein | affects binding|decreases activity | 7577949 |
| C096344 | L 708714 | zileuton inhibits the reaction [L 708714 binds to ALOX5 protein] | affects binding|decreases reaction | 7577949 |
| D017999 | Leukotriene E4 | [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene E4 | decreases abundance|decreases activity | 8621850 10764316 |
| D017999 | Leukotriene E4 | ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene E4] | increases abundance|increases reaction | 12794006 |
| D017999 | Leukotriene E4 | zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene E4]] | decreases reaction|increases abundance|increases reaction | 12794006 |
| D015289 | Leukotrienes | ALOX5 protein results in increased chemical synthesis of Leukotrienes | increases chemical synthesis | 18951527 |
| C433788 | lipopolysaccharide, E. coli 026-B6 | ALOX5 protein promotes the reaction [lipopolysaccharide, E. coli 026-B6 results in increased abundance of Leukotriene B4] | increases abundance|increases reaction | 15501964 |
| C433788 | lipopolysaccharide, E. coli 026-B6 | zileuton inhibits the reaction [ALOX5 protein promotes the reaction [lipopolysaccharide, E. coli 026-B6 results in increased abundance of Leukotriene B4]] | decreases reaction|increases abundance|increases reaction | 15501964 |
| C440499 | lipopolysaccharide, Escherichia coli 0111 B4 | lipopolysaccharide, Escherichia coli 0111 B4 affects the expression of ALOX5 protein | affects expression | 11561080 |
| C440499 | lipopolysaccharide, Escherichia coli 0111 B4 | lipopolysaccharide, Escherichia coli 0111 B4 results in decreased activity of ALOX5 protein | decreases activity | 12388339 |
| C440499 | lipopolysaccharide, Escherichia coli 0111 B4 | [lipopolysaccharide, Escherichia coli 0111 B4 results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4 | decreases abundance|decreases activity | 12388339 |
| C440499 | lipopolysaccharide, Escherichia coli 0111 B4 | tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[lipopolysaccharide, Escherichia coli 0111 B4 results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4] | decreases abundance|decreases activity|decreases reaction | 12388339 |
| C440499 | lipopolysaccharide, Escherichia coli 0111 B4 | zileuton inhibits the reaction [lipopolysaccharide, Escherichia coli 0111 B4 results in decreased activity of ALOX5 protein] | decreases activity|decreases reaction | 12388339 |
| C440499 | lipopolysaccharide, Escherichia coli 0111 B4 | zileuton inhibits the reaction [lipopolysaccharide, Escherichia coli 0111 B4 results in decreased expression of ALOX5 protein] | decreases expression|decreases reaction | 11561080 |
| C040527 | lipoxin A4 | ALOX5 protein affects the abundance of lipoxin A4 | affects abundance | 15326064 |
| C040527 | lipoxin A4 | zileuton inhibits the reaction [ALOX5 protein affects the abundance of lipoxin A4] | affects abundance|decreases reaction | 15326064 |
| D017336 | Loratadine | Loratadine analog results in decreased activity of ALOX5 protein | decreases activity | 15482930 |
| D017572 | Leukotriene A4 | ALOX5 protein results in increased chemical synthesis of Leukotriene A4 | increases chemical synthesis | 18295198 |
| D017997 | Leukotriene C4 | [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Leukotriene C4] | decreases activity|decreases reaction|increases abundance | 9495842 |
| D017997 | Leukotriene C4 | [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene C4 | decreases abundance|decreases activity | 10764316 |
| D017997 | Leukotriene C4 | ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene C4] | increases abundance|increases reaction | 12794006 |
| D017997 | Leukotriene C4 | zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene C4]] | decreases reaction|increases abundance|increases reaction | 12794006 |
| D017997 | Leukotriene C4 | [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein] which results in increased abundance of Leukotriene C4 | increases abundance|increases activity|increases localization | 9445378 |
| D017998 | Leukotriene D4 | ALOX5 protein results in increased abundance of Leukotriene D4 | increases abundance | 12629151 |
| D017998 | Leukotriene D4 | [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene D4 | decreases abundance|decreases activity | 10764316 |
| D017998 | Leukotriene D4 | ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene D4] | increases abundance|increases reaction | 12794006 |
| D017998 | Leukotriene D4 | zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene D4]] | decreases reaction|increases abundance|increases reaction | 12794006 |
| C032881 | lysophosphatidic acid | ALOX5 protein promotes the reaction [lysophosphatidic acid results in increased abundance of Hydrogen Peroxide] | increases abundance|increases reaction | 10698703 |
| C032881 | lysophosphatidic acid | Nordihydroguaiaretic Acid inhibits the reaction [ALOX5 protein promotes the reaction [lysophosphatidic acid results in increased abundance of Hydrogen Peroxide]] | decreases reaction|increases abundance|increases reaction | 10698703 |
| C032881 | lysophosphatidic acid | zileuton inhibits the reaction [ALOX5 protein promotes the reaction [lysophosphatidic acid results in increased abundance of Hydrogen Peroxide]] | decreases reaction|increases abundance|increases reaction | 10698703 |
| D008727 | Methotrexate | ALOX5 protein affects the susceptibility to Methotrexate | affects response to substance | 16217747 |
| C093875 | montelukast | ALOX5 gene SNP affects the susceptibility to montelukast | affects response to substance | 16293801 |
| C056614 | N-(3-phenoxycinnamyl)acetohydroxamic acid | N-(3-phenoxycinnamyl)acetohydroxamic acid results in decreased activity of ALOX5 protein | decreases activity | 11529688 |
| D009569 | Nitric Oxide | Nitric Oxide promotes the reaction [Reactive Oxygen Species results in decreased activity of ALOX5 protein] | decreases activity|increases reaction | 12388339 |
| C014707 | nitrosobenzylmethylamine | nitrosobenzylmethylamine results in increased expression of ALOX5 mRNA | increases expression | 17616710 |
| D009637 | Nordihydroguaiaretic Acid | Nordihydroguaiaretic Acid inhibits the reaction [ALOX5 protein promotes the reaction [lysophosphatidic acid results in increased abundance of Hydrogen Peroxide]] | decreases reaction|increases abundance|increases reaction | 10698703 |
| D009637 | Nordihydroguaiaretic Acid | Nordihydroguaiaretic Acid inhibits the reaction [ALOX5 protein promotes the reaction [Receptors, IgE results in increased abundance of Reactive Oxygen Species]] | decreases reaction|increases abundance|increases reaction | 17982097 |
| D009637 | Nordihydroguaiaretic Acid | Nordihydroguaiaretic Acid results in decreased activity of ALOX5 protein | decreases activity | 10698703 |
| D009637 | Nordihydroguaiaretic Acid | Nordihydroguaiaretic Acid inhibits the reaction [[CCL5 protein co-treated with Calcimycin] results in increased expression of ALOX5 mRNA] | affects cotreatment|decreases reaction|increases expression | 18083043 |
| D009637 | Nordihydroguaiaretic Acid | Nordihydroguaiaretic Acid inhibits the reaction [[CCL5 protein co-treated with Calcimycin] results in increased expression of ALOX5 protein] | affects cotreatment|decreases reaction|increases expression | 18083043 |
| D009822 | Oils, Volatile | Oils, Volatile results in decreased activity of ALOX5 protein | decreases activity | 19066064 |
| C484027 | oligofectamine | oligofectamine results in increased expression of ALOX5 mRNA | increases expression | 14668052 |
| D010047 | Ovalbumin | ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene B4] | increases abundance|increases reaction | 12794006 |
| D010047 | Ovalbumin | ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene C4] | increases abundance|increases reaction | 12794006 |
| D010047 | Ovalbumin | ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene D4] | increases abundance|increases reaction | 12794006 |
| D010047 | Ovalbumin | ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene E4] | increases abundance|increases reaction | 12794006 |
| D010047 | Ovalbumin | Ovalbumin results in increased expression of ALOX5 mRNA | increases expression | 12794006 |
| D010047 | Ovalbumin | zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene B4]] | decreases reaction|increases abundance|increases reaction | 12794006 |
| D010047 | Ovalbumin | zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene C4]] | decreases reaction|increases abundance|increases reaction | 12794006 |
| D010047 | Ovalbumin | zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene D4]] | decreases reaction|increases abundance|increases reaction | 12794006 |
| D010047 | Ovalbumin | zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene E4]] | decreases reaction|increases abundance|increases reaction | 12794006 |
| D010047 | Ovalbumin | zileuton inhibits the reaction [Ovalbumin results in increased expression of ALOX5 mRNA] | decreases reaction|increases expression | 12794006 |
| D010100 | Oxygen | caffeic acid inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein] | affects cotreatment|affects localization|decreases reaction | 18951527 |
| D010100 | Oxygen | [Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein | affects cotreatment|affects localization | 18951527 |
| D010100 | Oxygen | phenylmethylpyrazolone inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein] | affects cotreatment|affects localization|decreases reaction | 18951527 |
| D010100 | Oxygen | SB 203580 inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein] | affects cotreatment|affects localization|decreases reaction | 18951527 |
| D030421 | Peroxynitrous Acid | Peroxynitrous Acid results in decreased activity of ALOX5 protein | decreases activity | 12388339 |
| D030421 | Peroxynitrous Acid | Peroxynitrous Acid results in increased nitrosation of and affects the expression of ALOX5 protein | affects expression|increases nitrosation | 11561080 |
| D030421 | Peroxynitrous Acid | zileuton inhibits the reaction [Peroxynitrous Acid results in increased nitrosation of ALOX5 protein] | decreases reaction|increases nitrosation | 11561080 |
| D030421 | Peroxynitrous Acid | Peroxynitrous Acid results in increased nitrosation of ALOX5 protein | increases nitrosation | 12388339 |
| D030421 | Peroxynitrous Acid | zileuton inhibits the reaction [Peroxynitrous Acid results in increased nitrosation of ALOX5 protein] | decreases reaction|increases nitrosation | 12388339 |
| C015429 | phenidone | phenidone results in decreased activity of ALOX5 protein | decreases activity | 7990266 |
| C005435 | phenylmethylpyrazolone | phenylmethylpyrazolone inhibits the reaction [Hydrogen Peroxide affects the localization of ALOX5 protein] | affects localization|decreases reaction | 18951527 |
| C005435 | phenylmethylpyrazolone | phenylmethylpyrazolone inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein] | affects cotreatment|affects localization|decreases reaction | 18951527 |
| D010743 | Phospholipids | Phospholipids results in increased expression of ALOX5 protein | increases expression | 11937571 |
| C006253 | pirinixic acid | pirinixic acid analog results in decreased activity of ALOX5 protein | decreases activity | 19686721 19058328 18710209 |
| D010938 | Plant Oils | Plant Oils results in decreased activity of ALOX5 protein | decreases activity | 19066064 |
| D010972 | Platelet Activating Factor | Platelet Activating Factor results in increased expression of ALOX5 mRNA | increases expression | 16386258 |
| D010972 | Platelet Activating Factor | [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Calcimycin results in increased abundance of Platelet Activating Factor] | decreases activity|decreases reaction|increases abundance | 8387780 |
| C443641 | poly(propyleneimine) | poly(propyleneimine) analog results in decreased expression of ALOX5 mRNA | decreases expression | 16308212 |
| D011433 | Propranolol | 1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [Propranolol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]] | decreases reaction|increases activity|increases localization | 18218859 |
| D011433 | Propranolol | Propranolol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein] | decreases reaction|increases activity|increases localization | 18218859 |
| D017382 | Reactive Oxygen Species | 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [ALOX5 protein promotes the reaction [Receptors, IgE results in increased abundance of Reactive Oxygen Species]] | decreases reaction|increases abundance|increases reaction | 17982097 |
| D017382 | Reactive Oxygen Species | ALOX5 protein promotes the reaction [Receptors, IgE results in increased abundance of Reactive Oxygen Species] | increases abundance|increases reaction | 17982097 |
| D017382 | Reactive Oxygen Species | ALOX5 protein promotes the reaction [Receptors, IgG results in increased abundance of Reactive Oxygen Species] | increases abundance|increases reaction | 17982097 |
| D017382 | Reactive Oxygen Species | Nordihydroguaiaretic Acid inhibits the reaction [ALOX5 protein promotes the reaction [Receptors, IgE results in increased abundance of Reactive Oxygen Species]] | decreases reaction|increases abundance|increases reaction | 17982097 |
| D017382 | Reactive Oxygen Species | zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Receptors, IgE results in increased abundance of Reactive Oxygen Species]] | decreases reaction|increases abundance|increases reaction | 17982097 |
| D017382 | Reactive Oxygen Species | Nitric Oxide promotes the reaction [Reactive Oxygen Species results in decreased activity of ALOX5 protein] | decreases activity|increases reaction | 12388339 |
| D017382 | Reactive Oxygen Species | Reactive Oxygen Species results in decreased activity of ALOX5 protein | decreases activity | 12388339 |
| C067525 | S(alpha)-methyl-6-(2-quinolinylmethoxy)-2-naphthaleneacetic acid | S(alpha)-methyl-6-(2-quinolinylmethoxy)-2-naphthaleneacetic acid results in decreased activity of ALOX5 protein | decreases activity | 8482329 |
| C067525 | S(alpha)-methyl-6-(2-quinolinylmethoxy)-2-naphthaleneacetic acid | S(alpha)-methyl-6-(2-quinolinylmethoxy)-2-naphthaleneacetic acid results in decreased activity of ALOX5 protein | decreases activity | 8113982 |
| C093642 | SB 203580 | SB 203580 inhibits the reaction [Hydrogen Peroxide affects the localization of ALOX5 protein] | affects localization|decreases reaction | 18951527 |
| C093642 | SB 203580 | SB 203580 inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein] | affects cotreatment|affects localization|decreases reaction | 18951527 |
| C073135 | tepoxalin | tepoxalin results in decreased activity of ALOX5 protein | decreases activity | 12629151 |
| C073135 | tepoxalin | tepoxalin results in decreased activity of ALOX5 protein | decreases activity | 9223651 |
| C073135 | tepoxalin | [tepoxalin results in decreased activity of ALOX5 protein] inhibits the reaction [Indomethacin results in increased abundance of Leukotriene B4] | decreases activity|decreases reaction|increases abundance | 9223651 |
| D020002 | tert-Butyl Alcohol | tert-Butyl Alcohol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein] | decreases reaction|increases activity|increases localization | 18218859 |
| C480958 | tetrakis(4-benzoic acid)porphyrin | tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[lipopolysaccharide, Escherichia coli 0111 B4 results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4] | decreases abundance|decreases activity|decreases reaction | 12388339 |
| D019284 | Thapsigargin | 1-Butanol inhibits the reaction [Thapsigargin results in increased activity of and results in increased localization of ALOX5 protein] | decreases reaction|increases activity|increases localization | 18218859 |
| D019284 | Thapsigargin | 1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [1-Butanol inhibits the reaction [Thapsigargin results in increased activity of and results in increased localization of ALOX5 protein]] | decreases reaction|increases activity|increases localization | 18218859 |
| D019284 | Thapsigargin | Thapsigargin results in increased activity of and results in increased localization of ALOX5 protein | increases activity|increases localization | 18218859 |
| D014212 | Tretinoin | Tretinoin results in increased expression of ALOX5 mRNA | increases expression | 16129123 |
| C057693 | troglitazone | troglitazone results in decreased activity of ALOX5 protein | decreases activity | 10694244 17113579 |
| C057693 | troglitazone | [troglitazone results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4 | decreases abundance|decreases activity | 10694244 |
| C063449 | zileuton | zileuton results in decreased activity of ALOX5 protein | decreases activity | 1618819 |
| C063449 | zileuton | zileuton results in decreased activity of ALOX5 protein | decreases activity | 7644563 9738763 9105085 8482329 8081074 7522174 |
| C063449 | zileuton | ALOX5 gene SNP affects the susceptibility to zileuton | affects response to substance | 19214143 |
| C063449 | zileuton | zileuton inhibits the reaction [ALOX5 protein promotes the reaction [lipopolysaccharide, E. coli 026-B6 results in increased abundance of Leukotriene B4]] | decreases reaction|increases abundance|increases reaction | 15501964 |
| C063449 | zileuton | zileuton inhibits the reaction [ALOX5 protein promotes the reaction [lysophosphatidic acid results in increased abundance of Hydrogen Peroxide]] | decreases reaction|increases abundance|increases reaction | 10698703 |
| C063449 | zileuton | zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Receptors, IgE results in increased abundance of Reactive Oxygen Species]] | decreases reaction|increases abundance|increases reaction | 17982097 |
| C063449 | zileuton | zileuton inhibits the reaction [ALOX5 protein results in increased metabolism of Arachidonic Acid] | decreases reaction|increases metabolic processing | 18295198 |
| C063449 | zileuton | zileuton inhibits the reaction [ALOX5 protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]] | decreases reaction|increases abundance|increases response to substance | 9609743 |
| C063449 | zileuton | zileuton inhibits the reaction [L 708714 binds to ALOX5 protein] | affects binding|decreases reaction | 7577949 |
| C063449 | zileuton | zileuton results in decreased activity of ALOX5 protein | decreases activity | 8666909 15501964 7929400 10764316 10698703 10377029 9850156 9495842 9113110 18295198 8113982 8111568 8387780 12629151 7592874 8621850 11286996 10852428 1781415 |
| C063449 | zileuton | [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Calcimycin results in increased abundance of Platelet Activating Factor] | decreases activity|decreases reaction|increases abundance | 8387780 |
| C063449 | zileuton | [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Leukotriene C4] | decreases activity|decreases reaction|increases abundance | 9495842 |
| C063449 | zileuton | [zileuton results in decreased activity of ALOX5 protein] which affects the abundance of Arachidonic Acid | affects abundance|decreases activity | 9495842 |
| C063449 | zileuton | [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4 | decreases abundance|decreases activity | 1781415 11286996 |
| C063449 | zileuton | [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene C4 | decreases abundance|decreases activity | 10764316 |
| C063449 | zileuton | [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene D4 | decreases abundance|decreases activity | 10764316 |
| C063449 | zileuton | [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene E4 | decreases abundance|decreases activity | 8621850 10764316 |
| C063449 | zileuton | [zileuton results in decreased activity of ALOX5 protein] which results in decreased susceptibility to Arachidonic Acid | decreases activity|decreases response to substance | 7592874 |
| C063449 | zileuton | zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene B4]] | decreases reaction|increases abundance|increases reaction | 12794006 |
| C063449 | zileuton | zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene C4]] | decreases reaction|increases abundance|increases reaction | 12794006 |
| C063449 | zileuton | zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene D4]] | decreases reaction|increases abundance|increases reaction | 12794006 |
| C063449 | zileuton | zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene E4]] | decreases reaction|increases abundance|increases reaction | 12794006 |
| C063449 | zileuton | zileuton inhibits the reaction [Ovalbumin results in increased expression of ALOX5 mRNA] | decreases reaction|increases expression | 12794006 |
| C063449 | zileuton | zileuton results in decreased activity of ALOX5 protein | decreases activity | 8186192 15935457 15328337 11886531 15266012 12794006 7812673 9593866 11694324 7990266 |
| C063449 | zileuton | [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4 | decreases abundance|decreases activity | 9593866 |
| C063449 | zileuton | [zileuton results in decreased activity of ALOX5 protein] which results in decreased expression of NOS1 | decreases activity|decreases expression | 11694324 |
| C063449 | zileuton | zileuton results in decreased activity of ALOX5 protein | decreases activity | 9831321 |
| C063449 | zileuton | [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Eicosanoids | decreases abundance|decreases activity | 9831321 |
| C063449 | zileuton | zileuton binds to and results in decreased activity of ALOX5 protein | affects binding|decreases activity | 12649539 |
| C063449 | zileuton | [[zileuton co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4 | affects cotreatment|decreases abundance|decreases activity | 11529688 |
| C063449 | zileuton | zileuton inhibits the reaction [ALOX5 protein affects the abundance of lipoxin A4] | affects abundance|decreases reaction | 15326064 |
| C063449 | zileuton | zileuton inhibits the reaction [IL13 protein results in increased expression of ALOX5 mRNA] | decreases reaction|increases expression | 12654629 |
| C063449 | zileuton | zileuton inhibits the reaction [lipopolysaccharide, Escherichia coli 0111 B4 results in decreased activity of ALOX5 protein] | decreases activity|decreases reaction | 12388339 |
| C063449 | zileuton | zileuton inhibits the reaction [lipopolysaccharide, Escherichia coli 0111 B4 results in decreased expression of ALOX5 protein] | decreases expression|decreases reaction | 11561080 |
| C063449 | zileuton | zileuton inhibits the reaction [Peroxynitrous Acid results in increased nitrosation of ALOX5 protein] | decreases reaction|increases nitrosation | 11561080 |
| C063449 | zileuton | zileuton results in decreased activity of ALOX5 protein | decreases activity | 18475545 9445378 8058773 9223651 17113579 10694244 9599246 7665580 7922131 14726295 18295198 |
| C063449 | zileuton | [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Calcimycin results in increased abundance of Leukotriene B4] | decreases activity|decreases reaction|increases abundance | 18475545 |
| C063449 | zileuton | [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Indomethacin results in increased abundance of Leukotriene B4] | decreases activity|decreases reaction|increases abundance | 9223651 |
| C063449 | zileuton | [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4 | decreases abundance|decreases activity | 10694244 |
| C063449 | zileuton | zileuton results in decreased expression of ALOX5 mRNA | decreases expression | 19309543 |
| C063449 | zileuton | zileuton results in decreased activity of ALOX5 protein | decreases activity | 11509739 |
| C063449 | zileuton | zileuton inhibits the reaction [Peroxynitrous Acid results in increased nitrosation of ALOX5 protein] | decreases reaction|increases nitrosation | 12388339 |
| C063449 | zileuton | zileuton results in decreased activity of ALOX5 protein | decreases activity | 19309543 19503090 15935457 17827870 18927292 17118201 16908763 16670640 8598621 20436887 19823023 19657356 19544365 |
| C088450 | ZM 230487 | ZM 230487 results in decreased activity of ALOX5 protein | decreases activity | 7522174 |
| D015054 | Zymosan | ALOX5 protein affects the reaction [Zymosan results in increased expression of ICAM1 protein] | affects reaction|increases expression | 15241586 |
| D015054 | Zymosan | ALOX5 protein affects the reaction [Zymosan results in increased expression of SELP protein] | affects reaction|increases expression | 15241586 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000014 | Abnormalities, Drug-Induced | Capsaicin | 6.25 | 18926900 | |
| MESH:D000014 | Abnormalities, Drug-Induced | Methotrexate | 6.25 | 12039119 | |
| MESH:D000038 | Abscess | Drugs, Chinese Herbal | 5.38 | 15043669 | |
| MESH:D000138 | Acidosis | Ammonium Chloride | 2.66 | 18287403 | |
| MESH:D000152 | Acne Vulgaris | zileuton | 4.84 | 20436887 | |
| MESH:D058186 | Acute Kidney Injury | Capsaicin | 3.73 | 18460982 | |
| MESH:D055371 | Acute Lung Injury | Oxygen | 10.61 | 16759491 | |
| MESH:D055371 | Acute Lung Injury | pirinixic acid | 10.61 | 18653653 | |
| MESH:D055371 | Acute Lung Injury | zileuton | 10.61 | 17118201 | |
| MESH:D000230 | Adenocarcinoma | Benzo(a)pyrene | 5.09 | 20464547 20127859 | |
| MESH:D000230 | Adenocarcinoma | Estradiol | 5.09 | 11473722 | |
| MESH:D000230 | Adenocarcinoma | Indomethacin | 5.09 | 16537180 | |
| MESH:D000236 | Adenoma | marker/mechanism | 18927292 | ||
| MESH:D000236 | Adenoma | Benzo(a)pyrene | 7.71 | 6695378 | |
| MESH:D000236 | Adenoma | beta-Naphthoflavone | 7.71 | 19389873 | |
| MESH:D000236 | Adenoma | Indomethacin | 7.71 | 11497255 | |
| MESH:D018248 | Adenoma, Liver Cell | pirinixic acid | 2.58 | 16434500 | |
| MESH:D011125 | Adenomatous Polyposis Coli | celecoxib | 7.94 | 16215675 19003578 | |
| MESH:D011125 | Adenomatous Polyposis Coli | Leukotriene B4 | 7.94 | 17942926 | |
| MESH:D018246 | Adrenocortical Adenoma | Arsenic | 4.28 | 17306315 | |
| MESH:D019973 | Alcohol-Related Disorders | Curcumin | 4.15 | 17887948 | |
| OMIM:607154 | ALLERGIC RHINITIS | Loratadine | 4.91 | 16527031 | |
| MESH:D000505 | Alopecia | Capsaicin | 7.05 | 17569567 | |
| MESH:D000505 | Alopecia | Tretinoin | 7.05 | 15955085 | |
| MESH:D016301 | Alveolar Bone Loss | Indomethacin | 4.44 | 17225004 | |
| MESH:D000544 | Alzheimer Disease | Curcumin | 4.96 | 15590663 | |
| MESH:D000544 | Alzheimer Disease | Indomethacin | 4.96 | 17627676 15579461 | |
| MESH:D000544 | Alzheimer Disease | Nitric Oxide | 4.96 | 17556102 | |
| MESH:D000740 | Anemia | Drugs, Chinese Herbal | 6.94 | 15504547 17963324 | |
| MESH:D000740 | Anemia | Zymosan | 6.94 | 18664788 | |
| MESH:D000787 | Angina Pectoris | Drugs, Chinese Herbal | 4.49 | 11477813 | |
| MESH:D000799 | Angioedema | Acetaminophen | 9.11 | 10982225 | |
| MESH:D000799 | Angioedema | montelukast | 9.11 | 10982225 | |
| MESH:D000860 | Anoxia | Oxygen | 4.15 | 20872349 | |
| MESH:D001004 | Anus Diseases | Drugs, Chinese Herbal | 5.04 | 15043669 | |
| MESH:D001014 | Aortic Aneurysm | Indomethacin | 3.98 | 10231640 | |
| MESH:D017544 | Aortic Aneurysm, Abdominal | Benzo(a)pyrene | 8.76 | 19183758 | |
| MESH:D017544 | Aortic Aneurysm, Abdominal | Indomethacin | 8.76 | 10388637 | |
| MESH:D020261 | Arsenic Poisoning | Arsenic | 2.52 | 16835338 18414634 12569548 16251483 | |
| MESH:D018771 | Arthralgia | Indomethacin | 4.24 | 2160914 | |
| MESH:D001168 | Arthritis | Leukotriene B4 | 5.26 | 11006272 | |
| MESH:D001169 | Arthritis, Experimental | Dexamethasone | 8.75 | 17659584 | |
| MESH:D001169 | Arthritis, Experimental | Tretinoin | 8.75 | 16412693 | |
| MESH:D001169 | Arthritis, Experimental | Zymosan | 8.75 | 15944321 15142272 16872482 17659584 15188379 | |
| MESH:D015210 | Arthritis, Gouty | Drugs, Chinese Herbal | 4.84 | 19655406 | |
| MESH:D001172 | Arthritis, Rheumatoid | Curcumin | 10.43 | 16807698 | |
| MESH:D001172 | Arthritis, Rheumatoid | Indomethacin | 10.43 | 11248219 | |
| MESH:D001172 | Arthritis, Rheumatoid | Methotrexate | 10.43 | 17286800 | |
| MESH:D001172 | Arthritis, Rheumatoid | phenylmethylpyrazolone | 10.43 | 16390820 | |
| MESH:D001172 | Arthritis, Rheumatoid | Tretinoin | 10.43 | 16292516 | |
| MESH:D001249 | Asthma | marker/mechanism | |||
| MESH:D001249 | Asthma | Histamine | 16.68 | 16387687 | |
| MESH:D001249 | Asthma | Leukotriene B4 | 16.68 | 11006272 19667530 | |
| MESH:D001249 | Asthma | Leukotriene D4 | 16.68 | 8222486 9690572 | |
| MESH:D001249 | Asthma | Loratadine | 16.68 | 9196086 | |
| MESH:D001249 | Asthma | montelukast | 16.68 | 19681236 16293801 20332717 10852428 17895592 19667530 | |
| MESH:D001249 | Asthma | Tretinoin | 16.68 | 16456186 | |
| MESH:D001249 | Asthma | zileuton | 16.68 | 17944539 10764316 19214143 10181070 20332717 8598621 9620945 | |
| MESH:D055963 | Asthma, Aspirin-Induced | montelukast | 4.67 | 19667532 | |
| MESH:D001250 | Asthma, Exercise-Induced | Leukotriene B4 | 26.46 | 19667531 | |
| MESH:D001250 | Asthma, Exercise-Induced | Leukotriene E4 | 26.46 | 11953129 | |
| MESH:D001250 | Asthma, Exercise-Induced | Leukotrienes | 26.46 | 1554195 | |
| MESH:D001250 | Asthma, Exercise-Induced | montelukast | 26.46 | 19667531 10984370 | |
| MESH:D001250 | Asthma, Exercise-Induced | zileuton | 26.46 | 10984370 | |
| MESH:D001259 | Ataxia | 1-Butanol | 4.73 | 7820390 | |
| MESH:D050197 | Atherosclerosis | marker/mechanism | 16698924 | ||
| MESH:D050197 | Atherosclerosis | Arsenic | 10.68 | 12928151 19371607 | |
| MESH:D050197 | Atherosclerosis | Curcumin | 10.68 | 18704882 | |
| MESH:D050197 | Atherosclerosis | Oxygen | 10.68 | 16391483 | |
| MESH:D050197 | Atherosclerosis | Plant Oils | 10.68 | 16216721 | |
| MESH:D001321 | Autistic Disorder | Acetaminophen | 2.30 | 18445737 | |
| MESH:D001321 | Autistic Disorder | Arachidonic Acid | 2.30 | 18582451 | |
| MESH:D001321 | Autistic Disorder | Docosahexaenoic Acids | 2.30 | 18582451 | |
| MESH:D001321 | Autistic Disorder | Propranolol | 2.30 | 18766980 | |
| MESH:D001327 | Autoimmune Diseases | Curcumin | 3.60 | 19761891 | |
| MESH:D001471 | Barrett Esophagus | Tretinoin | 3.53 | 16935849 | |
| MESH:D001477 | Bartter Syndrome | Indomethacin | 4.09 | 10684365 | |
| MESH:D001778 | Blood Coagulation Disorders | pirinixic acid | 6.23 | 19483382 | |
| MESH:D001778 | Blood Coagulation Disorders | Tretinoin | 6.23 | 16206674 16197459 | |
| MESH:D001862 | Bone Resorption | Drugs, Chinese Herbal | 4.00 | 9881647 | |
| MESH:D001919 | Bradycardia | Capsaicin | 8.28 | 18207255 | |
| MESH:D001919 | Bradycardia | Propranolol | 8.28 | 6740701 | |
| MESH:D001929 | Brain Edema | Indomethacin | 9.81 | 11481608 | |
| MESH:D001929 | Brain Edema | zileuton | 9.81 | 19309543 | |
| MESH:D002545 | Brain Ischemia | Capsaicin | 11.98 | 19211983 | |
| MESH:D002545 | Brain Ischemia | Curcumin | 11.98 | 16770732 | |
| MESH:D002545 | Brain Ischemia | Indomethacin | 11.98 | 12524144 | |
| MESH:D001932 | Brain Neoplasms | Curcumin | 3.14 | 17596214 | |
| MESH:D001943 | Breast Neoplasms | Benzo(a)pyrene | 5.10 | 20146248 17474063 | |
| MESH:D001943 | Breast Neoplasms | Calcitriol | 5.10 | 11237771 | |
| MESH:D001943 | Breast Neoplasms | Curcumin | 5.10 | 18593918 16243823 19250217 18462866 | |
| MESH:D001943 | Breast Neoplasms | Estradiol | 5.10 | 19861407 12948864 14630087 17289903 16675129 17261762 17018787 18497071 | |
| MESH:D001943 | Breast Neoplasms | Indomethacin | 5.10 | 17401462 | |
| MESH:D001943 | Breast Neoplasms | Methotrexate | 5.10 | 16978400 | |
| MESH:D001943 | Breast Neoplasms | Nitric Oxide | 5.10 | 15631943 | |
| MESH:D001943 | Breast Neoplasms | Nordihydroguaiaretic Acid | 5.10 | 18418215 | |
| MESH:D001943 | Breast Neoplasms | Oxygen | 5.10 | 17263869 | |
| MESH:D001943 | Breast Neoplasms | Tretinoin | 5.10 | 16443354 16166294 16873071 | |
| MESH:D016535 | Bronchial Hyperreactivity | Leukotriene B4 | 23.16 | 12654629 12794006 | |
| MESH:D016535 | Bronchial Hyperreactivity | Leukotriene C4 | 23.16 | 12654629 | |
| MESH:D016535 | Bronchial Hyperreactivity | Leukotriene D4 | 23.16 | 12794006 12654629 | |
| MESH:D016535 | Bronchial Hyperreactivity | Leukotriene E4 | 23.16 | 12654629 | |
| MESH:D016535 | Bronchial Hyperreactivity | Ovalbumin | 23.16 | 12794006 | |
| MESH:D016535 | Bronchial Hyperreactivity | zileuton | 23.16 | 12794006 12388339 12654629 | |
| MESH:D001986 | Bronchial Spasm | Histamine | 4.90 | 18298128 | |
| MESH:D001997 | Bronchopulmonary Dysplasia | Tretinoin | 3.68 | 16813970 | |
| MESH:D002056 | Burns | Indomethacin | 3.81 | 10459503 | |
| MESH:D002100 | Cachexia | Indomethacin | 4.09 | 11239499 16537180 15141370 15625704 | |
| MESH:D002181 | Candidiasis, Vulvovaginal | Estradiol | 3.55 | 16111702 | |
| MESH:D002252 | Carbon Tetrachloride Poisoning | 2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid | 7.85 | 16033810 | |
| MESH:D002252 | Carbon Tetrachloride Poisoning | Carbon Tetrachloride | 7.85 | 18705752 15721981 16097048 16227642 16124888 10355542 16011737 3786805 16050911 15700767 16192424 15673190 | |
| MESH:D002277 | Carcinoma | Curcumin | 3.09 | 18593918 | |
| MESH:D002280 | Carcinoma, Basal Cell | Arsenic | 2.99 | 15504454 17687452 | |
| MESH:D018236 | Carcinoma, Embryonal | Tretinoin | 4.23 | 16168501 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Acetaminophen | 8.14 | 3084413 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Arsenic | 8.14 | 17306315 16507464 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Carbon Tetrachloride | 8.14 | 18788625 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Estradiol | 8.14 | 16924424 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Indomethacin | 8.14 | 16391822 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Tretinoin | 8.14 | 1917145 | |
| MESH:D018827 | Carcinoma, Lewis Lung | Indomethacin | 3.82 | 11053908 | |
| MESH:D018276 | Carcinoma, Medullary | Indomethacin | 4.44 | 14736730 18791128 11352223 | |
| MESH:D002289 | Carcinoma, Non-Small-Cell Lung | Curcumin | 2.58 | 18414057 | |
| MESH:D002292 | Carcinoma, Renal Cell | celecoxib | 5.40 | 16369983 | |
| MESH:D002292 | Carcinoma, Renal Cell | Indomethacin | 5.40 | 17341418 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Arsenic | 12.99 | 18922899 17687452 15504454 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Benzo(a)pyrene | 12.99 | 20419170 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Calcitriol | 12.99 | 11237771 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Curcumin | 12.99 | 18462866 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Indomethacin | 12.99 | 12636206 15482327 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Tretinoin | 12.99 | 16051514 16096774 | |
| MESH:D002295 | Carcinoma, Transitional Cell | Arsenic | 3.27 | 18640142 | |
| MESH:D002318 | Cardiovascular Diseases | Arsenic | 5.30 | 19152805 17938729 15738583 | |
| MESH:D002318 | Cardiovascular Diseases | Hydrogen Peroxide | 5.30 | 16936243 | |
| MESH:D002340 | Carotid Artery Diseases | Arsenic | 3.51 | 18022660 16973168 | |
| MESH:D002386 | Cataract | Acetaminophen | 5.15 | 10977129 | |
| MESH:D002386 | Cataract | Tretinoin | 5.15 | 17460283 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Estradiol | 2.12 | 18566989 | |
| MESH:D002543 | Cerebral Hemorrhage | phenylmethylpyrazolone | 4.94 | 19095969 | |
| MESH:D018290 | Cervical Intraepithelial Neoplasia | Tretinoin | 3.68 | 16129372 | |
| MESH:D002764 | Cholecystitis | Indomethacin | 4.24 | 11181007 | |
| MESH:D002779 | Cholestasis | Nitric Oxide | 5.92 | 16919318 | |
| MESH:D002779 | Cholestasis | pirinixic acid | 5.92 | 19176532 | |
| MESH:D002822 | Choriocarcinoma | Tretinoin | 4.23 | 16461808 | |
| MESH:D002972 | Cleft Palate | Tretinoin | 2.20 | 9407595 | |
| MESH:D003092 | Colitis | marker/mechanism | 15821759 | ||
| MESH:D003092 | Colitis | Curcumin | 11.25 | 16782535 18200517 16804969 | |
| MESH:D003092 | Colitis | dinitrobenzenesulfonic acid | 11.25 | 16680017 16670640 15821759 | |
| MESH:D003092 | Colitis | Tretinoin | 11.25 | 17035595 | |
| MESH:D003103 | Coloboma | Curcumin | 3.71 | 18809619 | |
| MESH:D003110 | Colonic Neoplasms | marker/mechanism | 18927292 | ||
| MESH:D003110 | Colonic Neoplasms | celecoxib | 10.35 | 16004971 | |
| MESH:D003110 | Colonic Neoplasms | Curcumin | 10.35 | 16340194 19359593 | |
| MESH:D003110 | Colonic Neoplasms | Dexamethasone | 10.35 | 15824018 | |
| MESH:D003110 | Colonic Neoplasms | Indomethacin | 10.35 | 15963497 15936596 11260862 15786552 15625704 15637740 | |
| MESH:D003110 | Colonic Neoplasms | Nordihydroguaiaretic Acid | 10.35 | 15936596 | |
| MESH:D003110 | Colonic Neoplasms | zileuton | 10.35 | 18927292 | |
| MESH:D003111 | Colonic Polyps | marker/mechanism | 18927292 | ||
| MESH:D015179 | Colorectal Neoplasms | celecoxib | 2.83 | 18349538 11197048 | |
| MESH:D015179 | Colorectal Neoplasms | Indomethacin | 2.83 | 12606626 18059344 17054584 11197048 | |
| MESH:D003233 | Conjunctivitis, Allergic | Leukotrienes | 6.07 | 15351322 | |
| MESH:D016510 | Corneal Neovascularization | Curcumin | 4.00 | 18497527 | |
| MESH:D018352 | Coronavirus Infections | Indomethacin | 4.79 | 17302372 | |
| MESH:D003371 | Cough | Capsaicin | 4.26 | 10350223 | |
| MESH:D019465 | Craniofacial Abnormalities | Dexamethasone | 4.10 | 17728286 | |
| MESH:D019465 | Craniofacial Abnormalities | Methotrexate | 4.10 | 12039119 9562676 | |
| MESH:D019465 | Craniofacial Abnormalities | Reactive Oxygen Species | 4.10 | 15736158 | |
| MESH:D019465 | Craniofacial Abnormalities | Tretinoin | 4.10 | 16925845 10589399 9224671 14991402 9211117 8800419 9142499 9125849 9664655 17551590 | |
| MESH:D003550 | Cystic Fibrosis | Docosahexaenoic Acids | 6.56 | 19747007 | |
| MESH:D003550 | Cystic Fibrosis | Methotrexate | 6.56 | 19747007 | |
| MESH:D003665 | Decompression Sickness | zileuton | 5.30 | 18309904 | |
| MESH:D015140 | Dementia, Vascular | Nitric Oxide | 5.05 | 17556102 | |
| MESH:D003715 | Dengue | Hydroxyeicosatetraenoic Acids | 5.95 | 19427377 | |
| MESH:D017449 | Dermatitis, Allergic Contact | Dexamethasone | 2.60 | 12438553 | |
| MESH:D003876 | Dermatitis, Atopic | pirinixic acid | 1.91 | 18249437 | |
| MESH:D003882 | Dermatomyositis | Methotrexate | 4.25 | 20191521 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | coumarin | 5.52 | 19647726 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Curcumin | 5.52 | 18403477 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | troglitazone | 5.52 | 16023994 | |
| MESH:D003925 | Diabetic Angiopathies | troglitazone | 4.75 | 12601628 | |
| MESH:D003928 | Diabetic Nephropathies | Curcumin | 6.41 | 18204486 | |
| MESH:D003928 | Diabetic Nephropathies | Estradiol | 6.41 | 19279558 | |
| MESH:D003967 | Diarrhea | Dexamethasone | 5.45 | 7237001 | |
| MESH:D003967 | Diarrhea | Indomethacin | 5.45 | 7237001 7907874 | |
| MESH:D056486 | Drug-Induced Liver Injury | Acetaminophen | 7.92 | 18071297 19164858 12705907 10774834 11529661 19420014 10663392 18713872 17906064 12392966 19739265 11743745 12540782 11739529 11834606 15619225 16781746 12594235 14550746 16081117 14986274 2444490 16227642 16393943 19416960 17562736 10915739 19085960 12153990 19370779 11461765 12958197 14725611 17522070 11287661 16109766 16485898 19923254 11421492 16177239 15968718 | |
| MESH:D056486 | Drug-Induced Liver Injury | Carbon Tetrachloride | 7.92 | 7120509 2869522 19085960 6884620 16227642 11566570 3732212 19336974 21278145 15027814 16177239 7179309 9327722 10092053 7440962 17522070 6623471 4309450 15968718 15998439 3786805 10915739 | |
| MESH:D056486 | Drug-Induced Liver Injury | Drugs, Chinese Herbal | 7.92 | 15027814 | |
| MESH:D056486 | Drug-Induced Liver Injury | troglitazone | 7.92 | 14986274 | |
| MESH:D056486 | Drug-Induced Liver Injury | zileuton | 7.92 | 17944539 | |
| MESH:D056487 | Drug-Induced Liver Injury, Chronic | Acetaminophen | 3.17 | 19426721 | |
| MESH:D004362 | Drug Toxicity | phenylmethylpyrazolone | 4.13 | 12231392 12649298 | |
| MESH:D004374 | Ductus Arteriosus, Patent | Indomethacin | 4.24 | 18446180 17190690 18043480 16326151 12774134 16133044 | |
| MESH:D004381 | Duodenal Ulcer | Capsaicin | 10.52 | 11535926 10671773 | |
| MESH:D004381 | Duodenal Ulcer | Curcumin | 10.52 | 17351913 | |
| MESH:D004381 | Duodenal Ulcer | Indomethacin | 10.52 | 17202747 17151854 11595431 16699067 17045617 17329845 11535926 11595415 17351913 10671773 11991626 | |
| MESH:D004417 | Dyspnea | Oxygen | 3.92 | 20016425 | |
| MESH:D004485 | Eczema | Dexamethasone | 3.59 | 12438553 | |
| MESH:D004487 | Edema | 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone | 45.08 | 7812673 | |
| MESH:D004487 | Edema | 2-(4-hydroxy-3,5-dimethylphenyl)-5-methoxy-3-methylindole | 45.08 | 7812673 | |
| MESH:D004487 | Edema | 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine | 45.08 | 7990266 | |
| MESH:D004487 | Edema | Arachidonic Acid | 45.08 | 15177302 11698051 9599246 16716910 7990266 9831321 | |
| MESH:D004487 | Edema | CMI 392 | 45.08 | 11698051 9599246 | |
| MESH:D004487 | Edema | Dexamethasone | 45.08 | 19703484 | |
| MESH:D004487 | Edema | E 6080 | 45.08 | 7812673 | |
| MESH:D004487 | Edema | Indomethacin | 45.08 | 16100529 8985016 7907874 8273558 19703484 7990266 10653021 | |
| MESH:D004487 | Edema | L 663536 | 45.08 | 7990266 | |
| MESH:D004487 | Edema | phenidone | 45.08 | 7990266 | |
| MESH:D004487 | Edema | pirinixic acid | 45.08 | 12083418 | |
| MESH:D004487 | Edema | zileuton | 45.08 | 7812673 17118201 7990266 9831321 8273558 11698051 19703484 | |
| MESH:D004487 | Edema | Zymosan | 45.08 | 7907874 | |
| MESH:D004489 | Edema, Cardiac | Tretinoin | 3.54 | 18230668 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | Calcitriol | 3.08 | 15138306 | |
| MESH:D016889 | Endometrial Neoplasms | Estradiol | 5.20 | 11473722 18566989 19148513 | |
| MESH:D016889 | Endometrial Neoplasms | Tretinoin | 5.20 | 16569247 | |
| MESH:D004715 | Endometriosis | celecoxib | 7.09 | 15652904 | |
| MESH:D004715 | Endometriosis | Indomethacin | 7.09 | 15652904 | |
| MESH:D019446 | Endotoxemia | marker/mechanism | 15328337 | ||
| MESH:D019446 | Endotoxemia | Indomethacin | 23.32 | 18509659 | |
| MESH:D019446 | Endotoxemia | lipopolysaccharide, E. coli 026-B6 | 23.32 | 8368378 | |
| MESH:D019446 | Endotoxemia | lipopolysaccharide, Escherichia coli 0111 B4 | 23.32 | 12954792 | |
| MESH:D019446 | Endotoxemia | phenylmethylpyrazolone | 23.32 | 12954792 | |
| MESH:D019446 | Endotoxemia | zileuton | 23.32 | 15328337 | |
| MESH:D004751 | Enteritis | Indomethacin | 3.82 | 16328016 10567023 17763956 | |
| MESH:D020345 | Enterocolitis, Necrotizing | Indomethacin | 4.09 | 17980183 | |
| MESH:D004802 | Eosinophilia | Cetirizine | 32.86 | 12689652 1355641 | |
| MESH:D004802 | Eosinophilia | Histamine | 32.86 | 12689652 | |
| MESH:D004802 | Eosinophilia | Indomethacin | 32.86 | 11298111 | |
| MESH:D004802 | Eosinophilia | Leukotriene E4 | 32.86 | 15696079 | |
| MESH:D004802 | Eosinophilia | Leukotrienes | 32.86 | 12689652 | |
| MESH:D004802 | Eosinophilia | montelukast | 32.86 | 10335014 | |
| MESH:D004802 | Eosinophilia | Ovalbumin | 32.86 | 12689652 | |
| MESH:D004802 | Eosinophilia | zileuton | 32.86 | 8621850 10764316 | |
| MESH:D004935 | Esophageal Diseases | Capsaicin | 4.79 | 19566590 | |
| MESH:D004938 | Esophageal Neoplasms | Benzo(a)pyrene | 5.30 | 16530937 | |
| MESH:D004938 | Esophageal Neoplasms | Indomethacin | 5.30 | 11005569 | |
| MESH:D004938 | Esophageal Neoplasms | nitrosobenzylmethylamine | 5.30 | 15623463 15547733 15547721 15878914 16704527 16805852 15264214 15150132 16510608 | |
| MESH:D005124 | Eye Abnormalities | Tretinoin | 2.85 | 9664655 16938888 | |
| MESH:D005234 | Fatty Liver | Carbon Tetrachloride | 12.16 | 12631006 15959796 16045604 17595544 61145 12795759 16239168 19224547 | |
| MESH:D005234 | Fatty Liver | Curcumin | 12.16 | 19297423 | |
| MESH:D005234 | Fatty Liver | phenylmethylpyrazolone | 12.16 | 12795759 | |
| MESH:D005234 | Fatty Liver | pirinixic acid | 12.16 | 19236843 20131406 | |
| MESH:D005334 | Fever | Arachidonic Acid | 10.90 | 11852909 | |
| MESH:D005334 | Fever | Indomethacin | 10.90 | 17627676 11852909 10431976 | |
| MESH:D005334 | Fever | lipopolysaccharide, Escherichia coli 0111 B4 | 10.90 | 16997862 | |
| MESH:D005354 | Fibrosarcoma | Indomethacin | 3.98 | 10962813 | |
| MESH:D005355 | Fibrosis | baicalin | 18.53 | 19474275 | |
| MESH:D005355 | Fibrosis | Carbon Tetrachloride | 18.53 | 18705752 | |
| MESH:D005355 | Fibrosis | Curcumin | 18.53 | 18705752 | |
| MESH:D005355 | Fibrosis | Indomethacin | 18.53 | 17994277 | |
| MESH:D005355 | Fibrosis | Tretinoin | 18.53 | 17994277 | |
| MESH:D005499 | Folliculitis | Indomethacin | 4.24 | 11298111 | |
| MESH:D005534 | Foot Diseases | Arsenic | 4.63 | 6392382 | |
| MESH:D005596 | Fractures, Closed | marker/mechanism | 19544365 | ||
| MESH:D005596 | Fractures, Closed | montelukast | 10.20 | 19544365 | |
| MESH:D005596 | Fractures, Closed | zileuton | 10.20 | 19544365 | |
| MESH:D005739 | Gas Poisoning | Oxygen | 4.29 | 20016425 | |
| MESH:D005756 | Gastritis | Acetaminophen | 8.08 | 16983495 | |
| MESH:D005756 | Gastritis | Indomethacin | 8.08 | 15046732 | |
| MESH:D005770 | Gastrointestinal Neoplasms | Curcumin | 3.80 | 18462866 | |
| MESH:D005909 | Glioblastoma | Capsaicin | 11.58 | 18405923 | |
| MESH:D005909 | Glioblastoma | Curcumin | 11.58 | 17596214 | |
| MESH:D005909 | Glioblastoma | Indomethacin | 11.58 | 12870263 | |
| MESH:D005909 | Glioblastoma | Tretinoin | 11.58 | 17312396 | |
| MESH:D005910 | Glioma | Indomethacin | 2.77 | 16487511 18371953 | |
| MESH:D005923 | Glomerulosclerosis, Focal Segmental | Indomethacin | 3.52 | 11849393 | |
| MESH:D006073 | Gout | Indomethacin | 4.44 | 11248219 | |
| MESH:D006086 | Graft vs Host Disease | Methotrexate | 4.26 | 16518429 | |
| MESH:D006261 | Headache | Nitric Oxide | 8.68 | 11554966 11284996 | |
| MESH:D006261 | Headache | Plant Oils | 8.68 | 19121572 | |
| MESH:D006258 | Head and Neck Neoplasms | Curcumin | 9.10 | 18462866 18829502 | |
| MESH:D006258 | Head and Neck Neoplasms | Indomethacin | 9.10 | 15482327 | |
| MESH:D006258 | Head and Neck Neoplasms | Tretinoin | 9.10 | 16096774 | |
| MESH:D006317 | Hearing Loss, Noise-Induced | Tretinoin | 4.23 | 16084493 | |
| MESH:D006356 | Heartburn | Capsaicin | 4.79 | 19566590 | |
| MESH:D006330 | Heart Defects, Congenital | Benzo(a)pyrene | 4.73 | 20471113 | |
| MESH:D006330 | Heart Defects, Congenital | Tretinoin | 4.73 | 9664655 14991402 | |
| MESH:D006333 | Heart Failure | pirinixic acid | 5.40 | 20558911 | |
| MESH:D006333 | Heart Failure | Propranolol | 5.40 | 20082655 | |
| MESH:D006501 | Hepatic Encephalopathy | Indomethacin | 3.74 | 15633222 | |
| MESH:D006505 | Hepatitis | Carbon Tetrachloride | 10.97 | 19900420 19110552 | |
| MESH:D006505 | Hepatitis | Drugs, Chinese Herbal | 10.97 | 18339527 | |
| MESH:D006505 | Hepatitis | Zymosan | 10.97 | 19110552 | |
| MESH:D019698 | Hepatitis C, Chronic | Indomethacin | 3.81 | 15135802 | |
| MESH:D006529 | Hepatomegaly | pirinixic acid | 9.78 | 19176532 18467677 19772884 16221962 | |
| MESH:D006529 | Hepatomegaly | Propranolol | 9.78 | 16371745 | |
| MESH:D006529 | Hepatomegaly | zileuton | 9.78 | 8661344 | |
| MESH:D015417 | Hereditary Sensory and Motor Neuropathy | Curcumin | 4.15 | 17701891 | |
| MESH:D006548 | Hernia, Diaphragmatic | Dexamethasone | 2.66 | 7520565 | |
| MESH:D006558 | Herpes Genitalis | Estradiol | 4.10 | 15709030 | |
| MESH:D019584 | Hot Flashes | Estradiol | 2.84 | 17088409 | |
| MESH:D006930 | Hyperalgesia | Acetaminophen | 12.56 | 16870215 | |
| MESH:D006930 | Hyperalgesia | Capsaicin | 12.56 | 17043245 17434803 | |
| MESH:D006930 | Hyperalgesia | Indomethacin | 12.56 | 12727271 | |
| MESH:D006930 | Hyperalgesia | Tretinoin | 12.56 | 16870215 | |
| MESH:D034321 | Hyperamylasemia | Indomethacin | 4.79 | 17883296 | |
| MESH:D006932 | Hyperbilirubinemia | Carbon Tetrachloride | 3.62 | 16899240 | |
| MESH:D006937 | Hypercholesterolemia | Curcumin | 3.23 | 18704882 | |
| MESH:D006940 | Hyperemia | Indomethacin | 9.70 | 12524144 | |
| MESH:D006940 | Hyperemia | Nitric Oxide | 9.70 | 11156591 | |
| MESH:D017681 | Hypereosinophilic Syndrome | Tretinoin | 3.67 | 16778211 | |
| MESH:D006943 | Hyperglycemia | pirinixic acid | 2.38 | 20558911 | |
| MESH:D017488 | Hyperkeratosis, Epidermolytic | Arsenic | 3.64 | 17050553 | |
| MESH:D006949 | Hyperlipidemias | Indomethacin | 3.32 | 17546600 | |
| MESH:D006967 | Hypersensitivity | Butylated Hydroxytoluene | 3.71 | 17604070 | |
| MESH:D006973 | Hypertension | Arsenic | 4.09 | 11953799 16076760 9931084 | |
| MESH:D006973 | Hypertension | Dexamethasone | 4.09 | 17042910 | |
| MESH:D006975 | Hypertension, Portal | Carbon Tetrachloride | 3.20 | 15338365 | |
| MESH:D006976 | Hypertension, Pulmonary | marker/mechanism | 14726295 | ||
| MESH:D006976 | Hypertension, Pulmonary | L 663536 | 9.81 | 14726295 | |
| MESH:D006976 | Hypertension, Pulmonary | Nitric Oxide | 9.81 | 15838368 | |
| MESH:D006976 | Hypertension, Pulmonary | zileuton | 9.81 | 14726295 | |
| MESH:D017379 | Hypertrophy, Left Ventricular | phenylmethylpyrazolone | 4.59 | 15824197 | |
| MESH:D006987 | Hypesthesia | Arsenic | 4.63 | 16093927 | |
| MESH:D007021 | Hypospadias | Loratadine | 5.22 | 16407038 | |
| MESH:D007022 | Hypotension | Propranolol | 4.34 | 6740701 | |
| MESH:D007077 | Ileal Diseases | Indomethacin | 4.10 | 18306037 10574470 | |
| MESH:D007079 | Ileitis | Indomethacin | 4.44 | 16133968 10647630 10651667 | |
| MESH:D007235 | Infant, Premature, Diseases | Indomethacin | 4.44 | 16133044 | |
| MESH:D020244 | Infarction, Middle Cerebral Artery | marker/mechanism | 19309543 | ||
| MESH:D020244 | Infarction, Middle Cerebral Artery | zileuton | 4.75 | 19309543 | |
| MESH:D007249 | Inflammation | 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid | 39.59 | 19934399 | |
| MESH:D007249 | Inflammation | 2-(4-hydroxy-3,5-dimethylphenyl)-5-methoxy-3-methylindole | 39.59 | 7812673 | |
| MESH:D007249 | Inflammation | Arachidonic Acid | 39.59 | 9831321 15177302 17371808 | |
| MESH:D007249 | Inflammation | bolinaquinone | 39.59 | 12604694 | |
| MESH:D007249 | Inflammation | Capsaicin | 39.59 | 16956363 | |
| MESH:D007249 | Inflammation | CMI 392 | 39.59 | 11698051 | |
| MESH:D007249 | Inflammation | Curcumin | 39.59 | 18403477 16956363 17151092 | |
| MESH:D007249 | Inflammation | Dexamethasone | 39.59 | 11099482 8960868 | |
| MESH:D007249 | Inflammation | Flavonoids | 39.59 | 17296493 | |
| MESH:D007249 | Inflammation | Indomethacin | 39.59 | 7812673 3291741 12568917 | |
| MESH:D007249 | Inflammation | montelukast | 39.59 | 18059327 | |
| MESH:D007249 | Inflammation | Plant Oils | 39.59 | 10432208 | |
| MESH:D007249 | Inflammation | zileuton | 39.59 | 8960868 8621850 18059327 9831321 18295198 18309904 17118201 7812673 | |
| MESH:D007249 | Inflammation | Zymosan | 39.59 | 11289658 8014878 | |
| MESH:D015212 | Inflammatory Bowel Diseases | Curcumin | 7.94 | 18596194 18200517 | |
| MESH:D015212 | Inflammatory Bowel Diseases | Leukotriene B4 | 7.94 | 11006272 | |
| MESH:D015212 | Inflammatory Bowel Diseases | zileuton | 7.94 | 15339030 | |
| MESH:D007251 | Influenza, Human | Nordihydroguaiaretic Acid | 4.81 | 18473937 | |
| MESH:D007333 | Insulin Resistance | Estradiol | 4.98 | 16393666 16627594 | |
| MESH:D007333 | Insulin Resistance | pirinixic acid | 4.98 | 16306350 | |
| MESH:D007410 | Intestinal Diseases | Indomethacin | 11.48 | 11686837 18236018 10210152 11713966 17994277 15610444 11855677 17329856 15831440 | |
| MESH:D007410 | Intestinal Diseases | Nitric Oxide | 11.48 | 11574821 10210152 11713966 | |
| MESH:D007410 | Intestinal Diseases | Tretinoin | 11.48 | 17994277 | |
| MESH:D007414 | Intestinal Neoplasms | Curcumin | 3.41 | 10783313 | |
| MESH:D002532 | Intracranial Aneurysm | phenylmethylpyrazolone | 8.01 | 19381132 | |
| MESH:D002532 | Intracranial Aneurysm | Reactive Oxygen Species | 8.01 | 19381132 | |
| MESH:D019586 | Intracranial Hypertension | Indomethacin | 4.44 | 15241188 | |
| MESH:D043183 | Irritable Bowel Syndrome | Zymosan | 4.92 | 17553498 | |
| MESH:D007511 | Ischemia | phenylmethylpyrazolone | 4.66 | 16301206 | |
| MESH:D007569 | Jaw Abnormalities | Tretinoin | 3.07 | 17551590 15992940 | |
| MESH:D007579 | Jejunal Diseases | Indomethacin | 4.10 | 10574470 18306037 16133968 | |
| MESH:D007642 | Keratosis | Arsenic | 4.08 | 16930632 12749816 | |
| MESH:D007674 | Kidney Diseases | Acetaminophen | 9.52 | 12587719 15629191 | |
| MESH:D007674 | Kidney Diseases | Estradiol | 9.52 | 15618244 | |
| MESH:D007674 | Kidney Diseases | Indomethacin | 9.52 | 17190690 | |
| MESH:D007674 | Kidney Diseases | phenylmethylpyrazolone | 9.52 | 18085390 | |
| MESH:D007676 | Kidney Failure, Chronic | Hydrogen Peroxide | 3.44 | 16518626 | |
| MESH:D007680 | Kidney Neoplasms | Estradiol | 2.24 | 15610895 | |
| MESH:D007683 | Kidney Tubular Necrosis, Acute | Calcium | 4.12 | 16316344 | |
| MESH:D007805 | Language Development Disorders | Methotrexate | 4.25 | 9562676 | |
| MESH:D007889 | Leiomyoma | Curcumin | 3.72 | 18555241 | |
| MESH:D007896 | Leishmaniasis | Nitric Oxide | 3.87 | 17218153 | |
| MESH:D016773 | Leishmaniasis, Cutaneous | Indomethacin | 3.14 | 11703811 12228301 10320625 | |
| MESH:D007938 | Leukemia | Curcumin | 4.65 | 18462866 | |
| MESH:D007938 | Leukemia | Tretinoin | 4.65 | 17143497 | |
| MESH:D004915 | Leukemia, Erythroblastic, Acute | troglitazone | 5.21 | 16085563 | |
| MESH:D015451 | Leukemia, Lymphocytic, Chronic, B-Cell | Drugs, Chinese Herbal | 3.45 | 15802533 | |
| MESH:D015459 | Leukemia-Lymphoma, Adult T-Cell | Curcumin | 7.45 | 16106398 | |
| MESH:D015459 | Leukemia-Lymphoma, Adult T-Cell | Docosahexaenoic Acids | 7.45 | 17077332 | |
| MESH:D015464 | Leukemia, Myelogenous, Chronic, BCR-ABL Positive | therapeutic | 19503090 19823023 | ||
| MESH:D015464 | Leukemia, Myelogenous, Chronic, BCR-ABL Positive | Indomethacin | 6.64 | 10785260 16572323 15631656 | |
| MESH:D015464 | Leukemia, Myelogenous, Chronic, BCR-ABL Positive | zileuton | 6.64 | 19503090 19823023 | |
| MESH:D007951 | Leukemia, Myeloid | Hydroxyurea | 7.18 | 16532439 | |
| MESH:D007951 | Leukemia, Myeloid | Tretinoin | 7.18 | 19285840 16482212 16932348 | |
| MESH:D015470 | Leukemia, Myeloid, Acute | Indomethacin | 3.19 | 18360721 | |
| MESH:D015470 | Leukemia, Myeloid, Acute | Tretinoin | 3.19 | 17596541 19850784 16294345 | |
| MESH:D015473 | Leukemia, Promyelocytic, Acute | Arsenic | 5.54 | 17339181 | |
| MESH:D015473 | Leukemia, Promyelocytic, Acute | Tretinoin | 5.54 | 17649720 19225113 16823087 16935935 12679006 16331271 16788101 15748426 17294898 19029980 17506722 17301526 16891316 16766008 19075265 16140955 17361223 9834237 19642359 17368321 19035177 17712046 17217047 17339181 17107899 | |
| MESH:D015458 | Leukemia, T-Cell | Curcumin | 3.89 | 16106398 | |
| MESH:D007964 | Leukocytosis | Indomethacin | 4.44 | 16537180 | |
| MESH:D007969 | Leukomalacia, Periventricular | Indomethacin | 4.79 | 17980183 | |
| MESH:D017880 | Limb Deformities, Congenital | Tretinoin | 2.61 | 9224671 | |
| MESH:D008064 | Lipidoses | Loratadine | 4.41 | 17567588 | |
| MESH:D008101 | Liver Abscess, Amebic | Indomethacin | 4.79 | 11479899 | |
| MESH:D008103 | Liver Cirrhosis | Carbon Tetrachloride | 7.83 | 11408273 16943688 16221502 11903743 16239168 21278145 17334410 17174718 17157831 | |
| MESH:D008103 | Liver Cirrhosis | Drugs, Chinese Herbal | 7.83 | 17163593 | |
| MESH:D008103 | Liver Cirrhosis | Methotrexate | 7.83 | 14986274 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | 2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid | 15.77 | 12958196 16033810 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide | 15.77 | 15876570 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | baicalin | 15.77 | 18187930 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Carbon Tetrachloride | 15.77 | 17869086 18705752 18472332 15650968 15925388 17944888 16136751 14724832 17557913 17565644 12632514 16015684 12898905 18166357 14512876 16033810 14748882 15893842 15370692 17823541 14620537 18317297 18054572 15057751 18472094 16116963 12546737 15052691 15730626 17900296 18277467 18481824 18006644 16097048 15673190 11481614 12649538 20821823 15931870 12666154 12389079 14716496 18210741 18279442 12445418 16011737 17698563 18420326 16248980 12586293 18395914 18251166 16638106 18156304 17922224 15362042 15338365 17976157 18412020 17640975 17481882 15876570 17805973 17631135 16027843 17766677 14716833 18205269 15996030 15818738 18429990 13678700 15959796 18187930 12445421 12667390 15123356 17708605 18263696 12632512 12609069 10355542 18418968 16192424 17761835 17714472 12741479 12958196 18395095 18339082 17525996 17721639 18376398 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Curcumin | 15.77 | 18006644 17355460 18705752 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Dexamethasone | 15.77 | 16718785 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Drugs, Chinese Herbal | 15.77 | 16610055 15763062 15744066 15864749 17881167 17348192 18371158 15849816 17036385 17629604 18237412 15383259 15818738 18567088 15641146 12632512 18606216 15754396 17666798 15339415 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Estradiol | 15.77 | 14659978 14716833 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Indomethacin | 15.77 | 18194892 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | pirinixic acid | 15.77 | 15474484 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Tretinoin | 15.77 | 18397230 16248980 | |
| MESH:D008107 | Liver Diseases | Acetaminophen | 13.83 | 16611625 16610002 19014921 12587719 19784758 11587558 19460945 12969438 | |
| MESH:D008107 | Liver Diseases | Arsenic | 13.83 | 11134558 | |
| MESH:D008107 | Liver Diseases | Capsaicin | 13.83 | 16956363 | |
| MESH:D008107 | Liver Diseases | Carbon Tetrachloride | 13.83 | 16246199 17285989 15830285 16964402 15720792 | |
| MESH:D008107 | Liver Diseases | Curcumin | 13.83 | 16956363 | |
| MESH:D008107 | Liver Diseases | Docosahexaenoic Acids | 13.83 | 17056761 | |
| MESH:D008107 | Liver Diseases | Drugs, Chinese Herbal | 13.83 | 17207593 | |
| MESH:D017093 | Liver Failure | Carbon Tetrachloride | 3.27 | 15123358 | |
| MESH:D017114 | Liver Failure, Acute | Acetaminophen | 6.71 | 17185352 16871587 | |
| MESH:D017114 | Liver Failure, Acute | Carbon Tetrachloride | 6.71 | 16899240 14706259 | |
| MESH:D008113 | Liver Neoplasms | Arsenic | 14.78 | 16368122 | |
| MESH:D008113 | Liver Neoplasms | Benzo(a)pyrene | 14.78 | 20195826 21137059 | |
| MESH:D008113 | Liver Neoplasms | beta-Naphthoflavone | 14.78 | 19389873 21295105 | |
| MESH:D008113 | Liver Neoplasms | Butylated Hydroxytoluene | 14.78 | 18177683 | |
| MESH:D008113 | Liver Neoplasms | Carbon Tetrachloride | 14.78 | 19294768 | |
| MESH:D008113 | Liver Neoplasms | Drugs, Chinese Herbal | 14.78 | 18339527 | |
| MESH:D008113 | Liver Neoplasms | pirinixic acid | 14.78 | 16377806 15890375 20007298 | |
| MESH:D008114 | Liver Neoplasms, Experimental | beta-Naphthoflavone | 4.05 | 18164116 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Carbon Tetrachloride | 4.05 | 15583823 12014681 | |
| MESH:D017563 | Lung Diseases, Interstitial | Methotrexate | 4.10 | 18516814 | |
| MESH:D055370 | Lung Injury | Nitric Oxide | 6.82 | 11395602 | |
| MESH:D055370 | Lung Injury | Oxygen | 6.82 | 18339021 | |
| MESH:D008175 | Lung Neoplasms | Arsenic | 9.42 | 17976673 19168569 17306315 | |
| MESH:D008175 | Lung Neoplasms | Benzo(a)pyrene | 9.42 | 6695378 17053015 20135361 20464547 18520028 18816296 20064080 18569708 20869020 | |
| MESH:D008175 | Lung Neoplasms | Butylated Hydroxytoluene | 9.42 | 11246140 15390079 19925653 18597497 11696405 16337739 19359593 | |
| MESH:D008175 | Lung Neoplasms | Curcumin | 9.42 | 19359593 16243823 18462866 | |
| MESH:D008175 | Lung Neoplasms | Dexamethasone | 9.42 | 15824018 11195469 | |
| MESH:D008175 | Lung Neoplasms | Drugs, Chinese Herbal | 9.42 | 18339527 | |
| MESH:D008175 | Lung Neoplasms | Indomethacin | 9.42 | 16537180 11497255 11053908 | |
| MESH:D008175 | Lung Neoplasms | L 663536 | 9.42 | 15899809 | |
| MESH:D008223 | Lymphoma | Curcumin | 8.75 | 18462866 | |
| MESH:D008223 | Lymphoma | Methotrexate | 8.75 | 17352296 | |
| MESH:D008223 | Lymphoma | Nitric Oxide | 8.75 | 16166326 | |
| MESH:D016399 | Lymphoma, T-Cell | Curcumin | 3.80 | 16173963 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Butylated Hydroxytoluene | 9.09 | 1500032 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | celecoxib | 9.09 | 19196722 12104042 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Drugs, Chinese Herbal | 9.09 | 14758024 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Estradiol | 9.09 | 11807958 11408345 16891317 17203775 | |
| MESH:D020149 | Manganese Poisoning | Estradiol | 3.56 | 19453300 | |
| MESH:D008527 | Medulloblastoma | Tretinoin | 2.32 | 17453147 | |
| MESH:D008545 | Melanoma | Curcumin | 6.97 | 18462866 17885582 | |
| MESH:D008545 | Melanoma | Glucose | 6.97 | 14993021 | |
| MESH:D008545 | Melanoma | Histamine | 6.97 | 17709802 | |
| MESH:D008545 | Melanoma | Reactive Oxygen Species | 6.97 | 17992120 | |
| MESH:D008545 | Melanoma | Tretinoin | 6.97 | 16752155 | |
| MESH:D008546 | Melanoma, Experimental | Acetaminophen | 2.68 | 19513568 | |
| MESH:D008569 | Memory Disorders | Curcumin | 3.29 | 17263510 | |
| MESH:D008591 | Meningomyelocele | Tretinoin | 3.53 | 16940565 | |
| MESH:D008659 | Metabolic Diseases | phenylmethylpyrazolone | 4.64 | 16301206 | |
| MESH:D008881 | Migraine Disorders | Indomethacin | 8.88 | 11903285 | |
| MESH:D008881 | Migraine Disorders | montelukast | 8.88 | 10759916 | |
| MESH:D008881 | Migraine Disorders | Nitric Oxide | 8.88 | 11701602 | |
| MESH:D020326 | Migraine without Aura | Nitric Oxide | 4.24 | 11304026 14659530 | |
| MESH:D009062 | Mouth Neoplasms | Benzo(a)pyrene | 6.20 | 16381670 | |
| MESH:D009062 | Mouth Neoplasms | Indomethacin | 6.20 | 12636206 | |
| MESH:D052016 | Mucositis | Methotrexate | 4.37 | 17488658 | |
| MESH:D009101 | Multiple Myeloma | Capsaicin | 11.65 | 17505005 | |
| MESH:D009101 | Multiple Myeloma | celecoxib | 11.65 | 16123214 | |
| MESH:D009101 | Multiple Myeloma | Curcumin | 11.65 | 19372569 | |
| MESH:D009101 | Multiple Myeloma | Dexamethasone | 11.65 | 15744524 15867202 16118317 | |
| MESH:D009102 | Multiple Organ Failure | marker/mechanism | 15241586 | ||
| MESH:D009102 | Multiple Organ Failure | Zymosan | 4.36 | 12879239 15241586 15213630 12130978 10890648 10479408 15834315 18160304 15259001 17724436 | |
| MESH:D009134 | Muscular Atrophy, Spinal | Curcumin | 4.01 | 17962980 | |
| MESH:D009135 | Muscular Diseases | pirinixic acid | 2.62 | 16239165 | |
| MESH:D009190 | Myelodysplastic Syndromes | Dexamethasone | 5.50 | 9809623 | |
| MESH:D009190 | Myelodysplastic Syndromes | Tretinoin | 5.50 | 17596541 | |
| MESH:D009203 | Myocardial Infarction | pirinixic acid | 1.68 | 19151258 | |
| MESH:D017202 | Myocardial Ischemia | Arsenic | 3.23 | 15371236 | |
| MESH:D015428 | Myocardial Reperfusion Injury | Estradiol | 5.79 | 16810080 | |
| MESH:D015428 | Myocardial Reperfusion Injury | pirinixic acid | 5.79 | 16411023 | |
| MESH:D009298 | Nasal Polyps | zileuton | 5.30 | 10665187 | |
| MESH:D009361 | Neoplasm Invasiveness | Curcumin | 3.50 | 18495463 | |
| MESH:D009362 | Neoplasm Metastasis | Indomethacin | 2.72 | 11053908 11239499 16537180 | |
| MESH:D009369 | Neoplasms | Benzo(a)pyrene | 5.05 | 11141357 | |
| MESH:D009369 | Neoplasms | pirinixic acid | 5.05 | 17405874 | |
| MESH:D009369 | Neoplasms | Tretinoin | 5.05 | 16594593 16946489 | |
| MESH:D009374 | Neoplasms, Experimental | Indomethacin | 3.26 | 10663608 15625704 | |
| MESH:D009376 | Neoplasms, Hormone-Dependent | celecoxib | 8.31 | 19196722 | |
| MESH:D009376 | Neoplasms, Hormone-Dependent | Curcumin | 8.31 | 12497104 | |
| MESH:D009389 | Neovascularization, Pathologic | Estradiol | 2.83 | 17289903 | |
| MESH:D009421 | Nervous System Malformations | Estradiol | 6.80 | 11399458 16427766 | |
| MESH:D009421 | Nervous System Malformations | Tretinoin | 6.80 | 9125849 | |
| MESH:D009423 | Nervous System Neoplasms | Curcumin | 4.70 | 18462866 | |
| MESH:D009436 | Neural Tube Defects | Arsenic | 5.22 | 16620997 | |
| MESH:D009436 | Neural Tube Defects | Tretinoin | 5.22 | 9142499 | |
| MESH:D019636 | Neurodegenerative Diseases | Acetaminophen | 5.84 | 18514411 | |
| MESH:D019636 | Neurodegenerative Diseases | Indomethacin | 5.84 | 12349958 | |
| MESH:D020078 | Neurogenic Inflammation | Arsenic | 8.13 | 17056641 | |
| MESH:D020078 | Neurogenic Inflammation | Capsaicin | 8.13 | 17961222 | |
| MESH:D009503 | Neutropenia | Leukotriene B4 | 4.49 | 8305713 | |
| MESH:D009765 | Obesity | Capsaicin | 5.55 | 19056576 | |
| MESH:D009765 | Obesity | Curcumin | 5.55 | 19297423 | |
| MESH:D009765 | Obesity | pirinixic acid | 5.55 | 20558911 | |
| MESH:D007752 | Obstetric Labor, Premature | Indomethacin | 4.24 | 6374098 | |
| MESH:D010003 | Osteoarthritis | Indomethacin | 3.04 | 7009135 | |
| MESH:D010024 | Osteoporosis | Calcium | 5.43 | 17882678 | |
| MESH:D010024 | Osteoporosis | Curcumin | 5.43 | 18719352 | |
| MESH:D015663 | Osteoporosis, Postmenopausal | Drugs, Chinese Herbal | 4.14 | 16548355 | |
| MESH:D010051 | Ovarian Neoplasms | Arsenic | 7.94 | 17306315 | |
| MESH:D010051 | Ovarian Neoplasms | Curcumin | 7.94 | 19020741 18462866 | |
| MESH:D010051 | Ovarian Neoplasms | Estradiol | 7.94 | 19401270 | |
| MESH:D010051 | Ovarian Neoplasms | Tretinoin | 7.94 | 16936753 | |
| MESH:D010146 | Pain | Acetaminophen | 16.70 | 16870215 | |
| MESH:D010146 | Pain | Capsaicin | 16.70 | 17043245 17434803 17084039 19081190 16996476 18987195 | |
| MESH:D010146 | Pain | Indomethacin | 16.70 | 3291741 17627676 13679232 17440234 | |
| MESH:D010146 | Pain | montelukast | 16.70 | 15935457 | |
| MESH:D010146 | Pain | Tretinoin | 16.70 | 16870215 | |
| MESH:D010146 | Pain | zileuton | 16.70 | 15935457 | |
| MESH:D010149 | Pain, Postoperative | Indomethacin | 3.76 | 18702446 12538197 | |
| MESH:D010190 | Pancreatic Neoplasms | Curcumin | 8.80 | 17440100 19401701 19196508 | |
| MESH:D010190 | Pancreatic Neoplasms | L 663536 | 8.80 | 12384795 | |
| MESH:D010190 | Pancreatic Neoplasms | Reactive Oxygen Species | 8.80 | 15580305 | |
| MESH:D010190 | Pancreatic Neoplasms | Tretinoin | 8.80 | 15976015 | |
| MESH:D010195 | Pancreatitis | Indomethacin | 6.30 | 17883296 15028970 | |
| MESH:D010195 | Pancreatitis | phenylmethylpyrazolone | 6.30 | 20035747 | |
| MESH:D010212 | Papilloma | Hydrogen Peroxide | 3.21 | 12065085 | |
| MESH:D010257 | Paraneoplastic Syndromes | Indomethacin | 4.79 | 16537180 | |
| MESH:D020734 | Parkinsonian Disorders | Indomethacin | 3.32 | 12349958 | |
| MESH:D051302 | Paroxysmal Hemicrania | Indomethacin | 4.79 | 11903285 | |
| MESH:D010437 | Peptic Ulcer | Indomethacin | 4.24 | 11148446 | |
| MESH:D010518 | Periodontitis | Indomethacin | 3.99 | 17225004 | |
| MESH:D010523 | Peripheral Nervous System Diseases | Arsenic | 3.32 | 16093927 | |
| MESH:D016491 | Peripheral Vascular Diseases | Arsenic | 4.08 | 16905509 6392382 15371236 | |
| MESH:D010538 | Peritonitis | zileuton | 7.88 | 17371808 | |
| MESH:D010538 | Peritonitis | Zymosan | 7.88 | 17371808 18557954 11985352 15979727 14761945 15259001 18760300 19088179 18977430 17826846 19641140 | |
| MESH:D010998 | Pleurisy | 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid | 6.30 | 19934399 | |
| MESH:D011014 | Pneumonia | Butylated Hydroxytoluene | 4.26 | 11893704 | |
| MESH:D011015 | Pneumonia, Aspiration | Nitric Oxide | 4.43 | 18573544 | |
| MESH:D054198 | Precursor Cell Lymphoblastic Leukemia-Lymphoma | Dexamethasone | 2.95 | 21297632 | |
| MESH:D047928 | Premature Birth | Indomethacin | 4.23 | 17000239 | |
| MESH:D011470 | Prostatic Hyperplasia | Calcitriol | 3.87 | 15572423 | |
| MESH:D019048 | Prostatic Intraepithelial Neoplasia | Estradiol | 3.05 | 20887781 | |
| MESH:D011471 | Prostatic Neoplasms | Arsenic | 2.08 | 16140617 | |
| MESH:D011471 | Prostatic Neoplasms | baicalin | 2.08 | 15714805 | |
| MESH:D011471 | Prostatic Neoplasms | Benzo(a)pyrene | 2.08 | 17292933 | |
| MESH:D011471 | Prostatic Neoplasms | Calcitriol | 2.08 | 16289102 18247401 12479363 15754350 16644109 | |
| MESH:D011471 | Prostatic Neoplasms | celecoxib | 2.08 | 15570007 17908994 | |
| MESH:D011471 | Prostatic Neoplasms | Curcumin | 2.08 | 11398177 18156803 18769126 18226269 15129424 12497104 10851300 | |
| MESH:D011471 | Prostatic Neoplasms | Estradiol | 2.08 | 16740699 | |
| MESH:D011471 | Prostatic Neoplasms | Nordihydroguaiaretic Acid | 2.08 | 18491370 | |
| MESH:D011507 | Proteinuria | 2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid | 15.21 | 12649539 | |
| MESH:D011507 | Proteinuria | Arsenic | 15.21 | 21343184 | |
| MESH:D011507 | Proteinuria | Indomethacin | 15.21 | 11849393 | |
| MESH:D011507 | Proteinuria | Tretinoin | 15.21 | 16636307 | |
| MESH:D011537 | Pruritus | L 663536 | 7.78 | 17827870 | |
| MESH:D011537 | Pruritus | zileuton | 7.78 | 17827870 19657356 | |
| MESH:D011565 | Psoriasis | Leukotriene B4 | 5.23 | 11006272 | |
| MESH:D011565 | Psoriasis | Methotrexate | 5.23 | 17410198 | |
| MESH:D011625 | Pterygium | Tretinoin | 3.88 | 16723453 | |
| MESH:D011654 | Pulmonary Edema | zileuton | 4.50 | 18309904 | |
| MESH:D011656 | Pulmonary Emphysema | Curcumin | 3.71 | 19168576 | |
| MESH:D011658 | Pulmonary Fibrosis | Drugs, Chinese Herbal | 4.98 | 16987627 | |
| MESH:D011658 | Pulmonary Fibrosis | troglitazone | 4.98 | 18162602 | |
| MESH:D012003 | Rectal Fistula | Drugs, Chinese Herbal | 5.04 | 15043669 | |
| MESH:D051437 | Renal Insufficiency | Methotrexate | 3.83 | 17352296 | |
| MESH:D015427 | Reperfusion Injury | marker/mechanism | 15266012 | ||
| MESH:D015427 | Reperfusion Injury | Capsaicin | 14.79 | 19211983 18460982 | |
| MESH:D015427 | Reperfusion Injury | Leukotriene C4 | 14.79 | 12967936 | |
| MESH:D015427 | Reperfusion Injury | phenylmethylpyrazolone | 14.79 | 16041266 15629865 16753835 15948865 15086910 14654979 | |
| MESH:D015427 | Reperfusion Injury | pirinixic acid | 14.79 | 19058328 | |
| MESH:D015427 | Reperfusion Injury | zileuton | 14.79 | 9865762 15266012 | |
| MESH:D012128 | Respiratory Distress Syndrome, Adult | Curcumin | 10.46 | 18379247 10666014 | |
| MESH:D012128 | Respiratory Distress Syndrome, Adult | Dexamethasone | 10.46 | 18379247 11700416 | |
| MESH:D012128 | Respiratory Distress Syndrome, Adult | Oxygen | 10.46 | 18339021 17627322 | |
| MESH:D012208 | Rhabdomyosarcoma | Tretinoin | 3.25 | 16283617 16116481 | |
| MESH:D012220 | Rhinitis | Cetirizine | 23.05 | 12167471 | |
| MESH:D012220 | Rhinitis | Histamine | 23.05 | 12689652 | |
| MESH:D012220 | Rhinitis | Leukotrienes | 23.05 | 12689652 | |
| MESH:D012220 | Rhinitis | montelukast | 23.05 | 20332717 | |
| MESH:D012220 | Rhinitis | Ovalbumin | 23.05 | 18298128 12689652 | |
| MESH:D012220 | Rhinitis | zileuton | 23.05 | 20332717 | |
| MESH:D012221 | Rhinitis, Allergic, Perennial | Drugs, Chinese Herbal | 4.35 | 15015336 | |
| MESH:D012509 | Sarcoma | Curcumin | 3.31 | 18462866 | |
| MESH:D012555 | Schistosomiasis mansoni | Nitric Oxide | 4.58 | 9673227 | |
| MESH:D018805 | Sepsis | Curcumin | 7.11 | 18389075 | |
| MESH:D018805 | Sepsis | Zymosan | 7.11 | 11441115 | |
| MESH:D012852 | Sinusitis | zileuton | 4.61 | 10665187 | |
| MESH:D012871 | Skin Diseases | Arsenic | 2.43 | 16759981 17453740 17050553 17938729 15952646 17548696 19834688 18709164 16702368 16353154 6392382 | |
| MESH:D012878 | Skin Neoplasms | Arsenic | 15.54 | 17976673 16251483 15504454 17029826 19538983 17050553 | |
| MESH:D012878 | Skin Neoplasms | Benzo(a)pyrene | 15.54 | 19755658 10029692 | |
| MESH:D012878 | Skin Neoplasms | Glucose | 15.54 | 14993021 | |
| MESH:D012878 | Skin Neoplasms | Hydrogen Peroxide | 15.54 | 12065085 | |
| MESH:D012878 | Skin Neoplasms | tert-Butylhydroperoxide | 15.54 | 8532709 | |
| MESH:D012878 | Skin Neoplasms | Tretinoin | 15.54 | 16467112 | |
| MESH:D020181 | Sleep Apnea, Obstructive | montelukast | 10.21 | 19118273 | |
| MESH:D020181 | Sleep Apnea, Obstructive | zileuton | 10.21 | 19118273 | |
| MESH:D013119 | Spinal Cord Injuries | montelukast | 8.97 | 18059327 | |
| MESH:D013119 | Spinal Cord Injuries | zileuton | 8.97 | 18059327 | |
| MESH:D013272 | Stomach Diseases | Dexamethasone | 7.37 | 15472012 | |
| MESH:D013272 | Stomach Diseases | Indomethacin | 7.37 | 18209964 15038085 18545984 16280098 16113693 15472012 17638125 16184426 10192188 17160473 10215738 17207306 10486359 | |
| MESH:D013274 | Stomach Neoplasms | Benzo(a)pyrene | 9.51 | 2093021 20155912 | |
| MESH:D013274 | Stomach Neoplasms | celecoxib | 9.51 | 15609394 | |
| MESH:D013274 | Stomach Neoplasms | Docosahexaenoic Acids | 9.51 | 19015929 | |
| MESH:D013274 | Stomach Neoplasms | Drugs, Chinese Herbal | 9.51 | 18339527 | |
| MESH:D013274 | Stomach Neoplasms | Indomethacin | 9.51 | 15609394 | |
| MESH:D013274 | Stomach Neoplasms | nitrosobenzylmethylamine | 9.51 | 17575124 12958204 | |
| MESH:D013274 | Stomach Neoplasms | Tretinoin | 9.51 | 17261132 | |
| MESH:D013274 | Stomach Neoplasms | troglitazone | 9.51 | 15930296 | |
| MESH:D013276 | Stomach Ulcer | Curcumin | 21.47 | 19188055 16631530 | |
| MESH:D013276 | Stomach Ulcer | Dexamethasone | 21.47 | 15138204 | |
| MESH:D013276 | Stomach Ulcer | Indomethacin | 21.47 | 12467913 11729361 11595431 11595415 17918041 16397915 17654042 15138204 18193104 11523592 17657623 15104355 12498302 12077510 17895592 18299717 11906479 16252198 18726076 18237397 17977527 15255614 18181030 18087811 16169175 11145282 18209962 12500499 16934674 16150113 12787963 10750652 14567935 18431645 16755016 10423059 18543354 1323529 17135157 16631530 17627676 10878458 | |
| MESH:D013276 | Stomach Ulcer | Leukotriene D4 | 21.47 | 1323529 | |
| MESH:D013276 | Stomach Ulcer | montelukast | 21.47 | 17895592 | |
| MESH:D013276 | Stomach Ulcer | Nitric Oxide | 21.47 | 15138204 | |
| MESH:D013276 | Stomach Ulcer | Plant Oils | 21.47 | 16252198 | |
| MESH:D013345 | Subarachnoid Hemorrhage | Drugs, Chinese Herbal | 4.84 | 17634840 | |
| MESH:D013398 | Sudden Infant Death | Oxygen | 4.63 | 12563064 | |
| MESH:D013576 | Syndactyly | Methotrexate | 4.16 | 9562676 | |
| MESH:D013705 | Temporomandibular Joint Disorders | Capsaicin | 4.80 | 17997062 | |
| MESH:D013964 | Thyroid Neoplasms | Indomethacin | 4.98 | 14736730 18791128 11352223 | |
| MESH:D013964 | Thyroid Neoplasms | Tretinoin | 4.98 | 16026305 17045167 | |
| MESH:D013978 | Tibial Fractures | Estradiol | 3.76 | 19048282 | |
| MESH:D014062 | Tongue Neoplasms | Tretinoin | 2.98 | 16051514 | |
| MESH:D014376 | Tuberculosis | Tretinoin | 2.59 | 16040207 | |
| MESH:D014456 | Ulcer | Indomethacin | 3.98 | 17380554 10574470 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Arsenic | 5.68 | 19429237 17976673 18640142 11144890 15987713 17306315 19322015 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Benzo(a)pyrene | 5.68 | 17053015 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Curcumin | 5.68 | 18593936 | |
| MESH:D014565 | Urogenital Neoplasms | Curcumin | 4.35 | 18462866 | |
| MESH:D014581 | Urticaria | Acetaminophen | 18.73 | 10982225 | |
| MESH:D014581 | Urticaria | Cetirizine | 18.73 | 2568013 14512923 2147912 14713918 | |
| MESH:D014581 | Urticaria | Histamine | 18.73 | 18298128 | |
| MESH:D014581 | Urticaria | Loratadine | 18.73 | 2568013 | |
| MESH:D014581 | Urticaria | montelukast | 18.73 | 10982225 | |
| MESH:D002583 | Uterine Cervical Neoplasms | Tretinoin | 2.87 | 16129372 | |
| MESH:D014594 | Uterine Neoplasms | celecoxib | 4.22 | 18645019 | |
| MESH:D014604 | Uveal Neoplasms | Tretinoin | 3.68 | 16752155 | |
| MESH:D014605 | Uveitis | Dexamethasone | 9.22 | 1336536 | |
| MESH:D014605 | Uveitis | Zymosan | 9.22 | 11006244 | |
| MESH:D014652 | Vascular Diseases | Arsenic | 3.83 | 17056641 | |
| MESH:D014689 | Venous Insufficiency | coumarin | 4.85 | 12708602 | |
| MESH:D014820 | Vitiligo | Tretinoin | 3.19 | 16761959 | |
| MESH:D014839 | Vomiting | Indomethacin | 3.82 | 11897121 | |
| MESH:D009396 | Wilms Tumor | Tretinoin | 3.17 | 16287080 | |
| MESH:D014947 | Wounds and Injuries | Drugs, Chinese Herbal | 10.32 | 16313111 | |
| MESH:D014947 | Wounds and Injuries | lysophosphatidic acid | 10.32 | 15541073 | |
| MESH:D014947 | Wounds and Injuries | Plant Oils | 10.32 | 16313111 |
| Pathway ID | Pathway Name |
|---|---|
| KEGG:00590 | Arachidonic acid metabolism |
| REACT:15314 | Hormone biosynthesis |
| KEGG:01100 | Metabolic pathways |
| REACT:22258 | Metabolism of lipids and lipoproteins |
| KEGG:05145 | Toxoplasmosis |
| No data |
| Releated disease ID | Related disease Name |
|---|---|
| PA443319 | Alzheimer Disease |
| PA447279 | Rhinitis, Allergic, Seasonal |
| PA445558 | Rhinitis, Allergic, Perennial |
| PA446155 | Precursor Cell Lymphoblastic Leukemia-Lymphoma |
| PA443425 | Arteriosclerosis |
| PA443450 | Asthma |
| Releated drug ID | Related drug Name |
|---|---|
| PA451955 | zileuton |
| PA449780 | glutathione |
| PA449789 | glycine |
| PA449345 | dinoprostone |
| PA449479 | epoprostenol |
| PA164712740 | Epoxides |
| PA452347 | glucocorticoids |
| PA452604 | xenobiotics |
| PA451949 | zafirlukast |
| PA450546 | montelukast |
| PA452626 | alox5-pathway modifiers |
| Drugbank ID | Action | Drug Name | Description |
|---|---|---|---|
| DB00163 | - | Vitamin E | Dietary supplement;Micronutrient;Antioxidants;Vitamins/minerals;Vitamins |
| DB00179 | inhibitor | Masoprocol | Antioxidants;Antineoplastics, topical;Cyclooxygenase Inhibitors;Keratolytic Agents;Lipoxygenase Inhibitors |
| DB00233 | antagonist | Aminosalicylic Acid | Antituberculosis Agents;Antitubercular Agents |
| DB00244 | inhibitor | Mesalazine | |
| DB00471 | other/unknown | Montelukast | Anti-Asthmatic Agents;Antiarrhythmic Agents;Leukotriene Antagonists |
| DB00711 | antagonist | Filaribits Plus 180/136mg Chewable Tablet | Lipoxygenase Inhibitors;Anthelmintics;Filaricides |
| DB00744 | antagonist | Zileuton | Lipoxygenase Inhibitors;Leukotriene Antagonists |
| DB00795 | inhibitor | Sulfasalazine | Antirheumatic Agents;Anti-Infective Agents;Sulfonamides;Gastrointestinal Agents |
| DB00939 | antagonist | Meclofenamic acid | Cyclooxygenase Inhibitors |
| DB01014 | antagonist | Balsalazide | Anti-Ulcer Agents;Gastrointestinal Agents |
| DB01017 | inhibitor | Minocycline | Anti-Bacterial Agents;Tetracyclines |
| DB01097 | inhibitor | Leflunomide | Antineoplastic Agents;Antirheumatic Agents;Antiviral Agents;Anti-inflammatory Agents;Enzyme Inhibitors;Immunosuppressive Agents;Antiparasitic Agents;Adjuvants |
| DB01892 | inhibitor | Hyperforin | |
| DB03014 | - | Heme |
| No data |
| No data |
| No data |