AutismKB 2.0

Annotation Detail for ALOX5AP


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ALOX5AP ( FLAP )
Gene Full Name: arachidonate 5-lipoxygenase-activating protein
Band: 13q12.3
Quick LinksEntrez ID:241; OMIM: 603700; Uniprot ID:AL5AP_HUMAN; ENSEMBL ID: ENSG00000132965; HGNC ID: 436
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
No data
Pathway IDPathway Name
P00031Inflammation mediated by chemokine and cytokine signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1918Atherosclerosis
1954Stroke
2151Neuroblastoma
Desease Name
CARDIOVASCULAR
myocardial infarct
stroke, ischemic
Asthma
IMMUNE
Stroke
myocardial infarction and stroke
No data
Desease Name
Stroke, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063609 1,2-dimethyl-4-nitrobenzene 1,2-dimethyl-4-nitrobenzene results in decreased expression of ALOX5AP mRNAdecreases expression 19784758
C079315 2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid 2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid results in decreased activity of ALOX5AP proteindecreases activity 9113110
C079315 2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid [2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid results in decreased activity of ALOX5AP protein] which results in decreased abundance of Leukotriene C4decreases abundance|decreases activity 9113110
C079315 2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid 2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid binds to and results in decreased activity of ALOX5AP proteinaffects binding|decreases activity 12649539
C079315 2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid 2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of ALOX5AP protein]decreases reaction|increases expression 16033810
C079315 2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid 2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid results in decreased activity of ALOX5AP proteindecreases activity 16033810
D000082 Acetaminophen Acetaminophen affects the expression of ALOX5AP mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen affects the expression of ALOX5AP mRNAaffects expression 19784758
D000082 Acetaminophen Acetaminophen results in decreased expression of ALOX5AP mRNAdecreases expression 19784758
D000082 Acetaminophen Acetaminophen results in increased expression of ALOX5AP mRNAincreases expression 19784758
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ALOX5AP mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of ALOX5AP mRNAdecreases expression 19128835
C006632 arsenic trioxide arsenic trioxide results in increased expression of ALOX5AP mRNAincreases expression 15070760
15761015
D002251 Carbon Tetrachloride 2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of ALOX5AP protein]decreases reaction|increases expression 16033810
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of ALOX5AP mRNAaffects expression 12734012
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of ALOX5AP mRNAdecreases expression 19784758
16644059
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ALOX5AP proteinincreases expression 16033810
C055162 clopidogrel clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of ALOX5AP mRNA]decreases reaction|increases expression 19172522
D003513 Cycloheximide Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALOX5AP mRNA]decreases expression|decreases reaction 11007951
D003520 Cyclophosphamide Cyclophosphamide results in decreased expression of ALOX5AP mRNAdecreases expression 17403535
D002945 Cisplatin Cisplatin results in increased expression of ALOX5AP mRNAincreases expression 15471895
15464296
D019259 Lamivudine [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ALOX5AP mRNAaffects cotreatment|increases expression 16931933
D019259 Lamivudine [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ALOX5AP mRNAaffects cotreatment|increases expression 16931933
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in increased expression of ALOX5AP mRNAaffects cotreatment|increases expression 16931933
D004041 Dietary Fats Dietary Fats results in decreased expression of ALOX5AP mRNAdecreases expression 18042831
C472511 dimethylarsinous acid dimethylarsinous acid results in decreased expression of ALOX5AP mRNAdecreases expression 16507463
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ALOX5AP mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ALOX5AP mRNAincreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ALOX5AP mRNAaffects expression 16079270
D007975 Leukotriene B4 ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]increases abundance|increases response to substance 9609743
D007975 Leukotriene B4 L 655238 inhibits the reaction [ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]]decreases reaction|increases abundance|increases response to substance 9609743
D007975 Leukotriene B4 L 663536 inhibits the reaction [ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]]decreases reaction|increases abundance|increases response to substance 9609743
D006581 Hexachlorobenzene Hexachlorobenzene affects the expression of ALOX5AP mRNAaffects expression 15159207
D006632 Histamine ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]increases abundance|increases response to substance 9609743
D006632 Histamine L 655238 inhibits the reaction [ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]]decreases reaction|increases abundance|increases response to substance 9609743
D006632 Histamine L 663536 inhibits the reaction [ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]]decreases reaction|increases abundance|increases response to substance 9609743
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of ALOX5AP mRNAincreases expression 15761015
D019469 Indinavir [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ALOX5AP mRNAaffects cotreatment|increases expression 16931933
C075954 indolo(3,2-b)carbazole indolo(3,2-b)carbazole results in increased expression of ALOX5AP mRNAincreases expression 18762178
C095607 L 655238 L 655238 inhibits the reaction [ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]]decreases reaction|increases abundance|increases response to substance 9609743
C060893 L 663536 L 663536 results in decreased activity of ALOX5AP proteindecreases activity 7522174
C060893 L 663536 L 663536 binds to and results in decreased activity of ALOX5AP proteinaffects binding|decreases activity 8666909
C060893 L 663536 L 663536 inhibits the reaction [ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]]decreases reaction|increases abundance|increases response to substance 9609743
C060893 L 663536 L 663536 results in decreased activity of ALOX5AP proteindecreases activity 9609743
9113110
9850156
12629151
C060893 L 663536 [L 663536 results in decreased activity of ALOX5AP protein] which results in decreased abundance of Leukotriene C4decreases abundance|decreases activity 9113110
C060893 L 663536 L 663536 results in decreased activity of ALOX5AP proteindecreases activity 7990266
C060893 L 663536 L 663536 results in decreased activity of ALOX5AP proteindecreases activity 8058773
C060893 L 663536 L 663536 results in decreased activity of ALOX5AP proteindecreases activity 18951527
17827870
18037915
15888248
D008070 Lipopolysaccharides clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of ALOX5AP mRNA]decreases reaction|increases expression 19172522
D017997 Leukotriene C4 [2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid results in decreased activity of ALOX5AP protein] which results in decreased abundance of Leukotriene C4decreases abundance|decreases activity 9113110
D017997 Leukotriene C4 [L 663536 results in decreased activity of ALOX5AP protein] which results in decreased abundance of Leukotriene C4decreases abundance|decreases activity 9113110
C078266 MK 0591 MK 0591 binds to and results in decreased activity of ALOX5AP proteinaffects binding|decreases activity 8147271
C029938 nickel sulfate nickel sulfate results in decreased expression of ALOX5AP mRNAdecreases expression 16780908
D009578 Nitrobenzenes Nitrobenzenes analog results in decreased expression of ALOX5AP mRNAdecreases expression 19784758
C041786 palm oil palm oil results in decreased expression of ALOX5AP mRNAdecreases expression 18042831
D010278 Parathion Parathion results in decreased expression of ALOX5AP mRNAdecreases expression 19784758
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of ALOX5AP mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of ALOX5AP mRNAdecreases expression 19482888
D010852 Picrotoxin Picrotoxin results in increased expression of ALOX5AP mRNAincreases expression 15170462
C006253 pirinixic acid pirinixic acid results in decreased expression of ALOX5AP mRNAdecreases expression 17426115
D017382 Reactive Oxygen Species Reactive Oxygen Species affects the expression of ALOX5AP mRNAaffects expression 15761015
D019258 Saquinavir [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ALOX5AP mRNAaffects cotreatment|increases expression 16931933
C017947 sodium arsenite sodium arsenite results in decreased expression of ALOX5AP mRNAdecreases expression 16507463
D013629 Tamoxifen Tamoxifen affects the expression of ALOX5AP mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALOX5AP mRNA]decreases expression|decreases reaction 11007951
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ALOX5AP mRNAdecreases expression 11007951
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ALOX5AP mRNAincreases expression 18762178
D013752 Tetracycline Tetracycline results in decreased expression of ALOX5AP mRNAdecreases expression 16917069
D013853 Thioacetamide Thioacetamide results in decreased expression of ALOX5AP mRNAdecreases expression 19784758
D014212 Tretinoin Tretinoin results in increased expression of ALOX5AP mRNAincreases expression 17218384
C025643 vinclozolin vinclozolin affects the expression of ALOX5AP mRNAaffects expression 19015723
D014859 Warfarin Warfarin results in increased expression of ALOX5AP mRNAincreases expression 16698924
D015215 Zidovudine [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ALOX5AP mRNAaffects cotreatment|increases expression 16931933
D015215 Zidovudine [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ALOX5AP mRNAaffects cotreatment|increases expression 16931933
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in increased expression of ALOX5AP mRNAaffects cotreatment|increases expression 16931933
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.0814745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 6.806195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 6.8011752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.1118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.4817505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.389612607
MESH:D054058 Acute Coronary Syndrome clopidogrel 5.5519106084
MESH:D058186 Acute Kidney Injury Cisplatin 3.5615814532 17670903 12690470
MESH:D055371 Acute Lung Injury Lipopolysaccharides 12.9118653653 11850527
MESH:D055371 Acute Lung Injury nickel sulfate 12.9112718980 11954676 16100012 19131640
MESH:D055371 Acute Lung Injury pirinixic acid 12.9118653653
MESH:D000230 Adenocarcinoma arsenic trioxide 6.3419825857 11798837
MESH:D000230 Adenocarcinoma Cisplatin 6.3417638652 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.3414692618
MESH:D018248 Adenoma, Liver Cell Phenobarbital 14.6617620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 14.6616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 14.6616835633
MESH:D011125 Adenomatous Polyposis Coli Leukotriene B4 5.0517942926
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.2415276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.4417306315 16712894
MESH:D000382 Agricultural Workers' Diseases Parathion 4.5617119214 11874814
MESH:D000505 Alopecia Tretinoin 3.2615955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.5611748828
MESH:D000799 Angioedema Acetaminophen 3.3810982225
MESH:D001008 Anxiety Disorders vinclozolin 3.2819015723
MESH:D001161 Arteriosclerosis Cyclophosphamide 14.5015014928
MESH:D001161 Arteriosclerosis Dietary Fats 14.5015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 14.5011256880
MESH:D001168 Arthritis Leukotriene B4 5.7111006272
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.2415885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.2416412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1516292516
MESH:D001249 Asthma Histamine 7.3716387687
MESH:D001249 Asthma Leukotriene B4 7.3719667530 11006272
MESH:D001249 Asthma Tretinoin 7.3716456186
MESH:D001250 Asthma, Exercise-Induced Leukotriene B4 5.4519667531
MESH:D050197 Atherosclerosis marker/mechanism 16698924
MESH:D001321 Autistic Disorder Acetaminophen 1.4718445737
MESH:D001471 Barrett Esophagus Tretinoin 3.9716935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 24.5116206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 24.5119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 24.5112125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 24.5119483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 24.5116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4615746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.4214601052
MESH:D001943 Breast Neoplasms Cisplatin 4.2818382427 19526202
MESH:D001943 Breast Neoplasms Cyclophosphamide 4.2817388661 11325840 18234424 18323546 15093573 12006526 17020986 16978400 15136595
MESH:D001943 Breast Neoplasms Dietary Fats 4.2820435547
MESH:D001943 Breast Neoplasms Hexachlorobenzene 4.2815061365 12709520
MESH:D001943 Breast Neoplasms Parathion 4.2812762645
MESH:D001943 Breast Neoplasms Tamoxifen 4.2819066611 21152245 18821012 20390343 17242785 19200415 18425577 19084267 20005174 17049068 20065188 15668708 18997820 20859285 18855134 19288272 16873071 19011961 19410462 17261762 21138602 19487384 18351453 17440819 16202921 19221464 19289846 11161223 16273361 19115204 19059307 20135344 19244106 15565566 19142967 17893378 19103187 19189212 16818667 18815881 18984771 20544844 18629630 19155303 19189210
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.2820435547
MESH:D001943 Breast Neoplasms Tretinoin 4.2816873071 16443354 16166294
MESH:D016535 Bronchial Hyperreactivity Leukotriene B4 8.5212794006 12654629
MESH:D016535 Bronchial Hyperreactivity Leukotriene C4 8.5212654629
MESH:D001986 Bronchial Spasm Histamine 5.3618298128
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.1416813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.9111589617
MESH:D002252 Carbon Tetrachloride Poisoning 2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid 9.3216033810
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 9.3216011737 15673190 18705752 15700767 16192424 10355542 16050911 3786805 16097048 16227642 16124888 15721981
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.4416835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.0619066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.6916168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 20.983084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 20.9815553829 11135700 16217749 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 20.9818788625
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 20.9817982673
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 20.9819701751
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 20.9820007298 6705139 1701930 17173139 20935162
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 20.9816507464 15276417 17306315
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 20.9816924424
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 20.9817997003
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 20.981917145
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.4416152834
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 2.8712023789 16685392
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.4119014326
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 3.3116201981
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.7212490120
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 6.7218337622 6189445 17066447
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 6.7218572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 6.7216051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.2217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1118850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases clopidogrel 6.9520180610
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 6.9516936243
MESH:D002386 Cataract Acetaminophen 6.3010977129
MESH:D002386 Cataract Tretinoin 6.3017460283
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 2.6819524636 20056578
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.814080065
MESH:D002543 Cerebral Hemorrhage Warfarin 5.4111061249
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.1416129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.2816835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 8.2818291259
MESH:D002779 Cholestasis Ethinyl Estradiol 6.6217110522 11677210 17333356 16105132 15861022 17681005 16919318
MESH:D002779 Cholestasis pirinixic acid 6.6219176532
MESH:D002822 Choriocarcinoma Tretinoin 4.6916461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.088697196 15668235 15340226 16354765 12621046
MESH:D002972 Cleft Palate Tretinoin 5.089407595
MESH:D003092 Colitis Tretinoin 3.2617035595
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.5420501625
MESH:D015179 Colorectal Neoplasms Cisplatin 2.5415273666
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6814669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 10.0712609071
MESH:D023903 Coronary Restenosis Warfarin 10.0712872399
OMIM:122700 COUMARIN RESISTANCE Warfarin 5.4020497562 20579077
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 4.9410525206
MESH:D019465 Craniofacial Abnormalities Reactive Oxygen Species 4.9415736158
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.9415322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 4.9414991402 9224671 9664655 9142499 8800419 9211117 10589399 16925845 17551590 9125849
MESH:D003456 Cryptorchidism vinclozolin 3.9114966744
MESH:D003556 Cystitis Cyclophosphamide 4.5215276878 15643279 16989017 18093676 16614059 16413132 10498854 18372110 12388444 17979934 18295254 11948286 12161096 10700343 16651033 17010015 18433785 12913760 18483878 18710439
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.6815213294
MESH:D003711 Demyelinating Diseases Tamoxifen 3.9219031437
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.2616823706 16780908 11298694
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2018249437
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 3.7010990075 11751995 15331540
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 5.7018772604
MESH:D003922 Diabetes Mellitus, Type 1 Warfarin 5.7018772604
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.5517107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.1919279558
MESH:D003928 Diabetic Nephropathies Warfarin 8.1912644472
MESH:D003875 Drug Eruptions Warfarin 5.5414723717
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 10.3611529661 16393943 19739265 2444490 11739529 16485898 18713872 15619225 11461765 19164858 12153990 17562736 14550746 19085960 19416960 10774834 11743745 16177239 12540782 12594235 10663392 19923254 12958197 12392966 11287661 16109766 12705907 19370779 17522070 19420014 11421492 16081117 18071297 15968718 14725611 16781746 11834606 17906064 16227642 14986274 10915739
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 10.3610092053 16227642 6884620 21278145 2869522 19085960 7179309 15968718 15027814 7440962 9327722 16177239 19336974 10915739 6623471 3786805 7120509 11566570 4309450 15998439 3732212 17522070
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 10.3620420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 10.3617522070
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 10.3612963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6319426721
MESH:D004362 Drug Toxicity Cisplatin 16.9012649298 12231392 15033597 19839026
MESH:D004362 Drug Toxicity Lamivudine 16.9015040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 16.9011462148
MESH:D004362 Drug Toxicity Zidovudine 16.9015040536
MESH:D050171 Dyslipidemias Dietary Fats 3.1218367378
MESH:D004421 Dystonia Phenobarbital 3.591851702
MESH:D004487 Edema L 663536 9.327990266
MESH:D004487 Edema pirinixic acid 9.3212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.3212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.4015322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 10.4018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.5212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 7.5219031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.4319155303 16202921 17893378 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 6.4316569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.6310568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 3.9415328337 17637181 15821434
MESH:D004802 Eosinophilia Cyclophosphamide 8.1311006010
MESH:D004802 Eosinophilia Histamine 8.1312689652
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.673659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.413922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.6520417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.166401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.817750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.573659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.2712903497
MESH:D004938 Esophageal Neoplasms Cisplatin 4.2716481741 16785472 17638652 15464296 15173087
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.7011564622
MESH:D005124 Eye Abnormalities Tretinoin 7.7016938888 9664655
MESH:D005218 Fat Necrosis Thioacetamide 5.2616456712
MESH:D005234 Fatty Liver arsenic trioxide 36.2215073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 36.2217595544 16045604 15959796 61145 12795759 16239168 12631006 19224547
MESH:D005234 Fatty Liver Dietary Fats 36.2218296743 19004024 19551842 17967931
MESH:D005234 Fatty Liver Ethinyl Estradiol 36.2215345470
MESH:D005234 Fatty Liver pirinixic acid 36.2219236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 36.2219224547 14986274
MESH:D005234 Fatty Liver Tetracycline 36.2219224547 16917069
MESH:D005234 Fatty Liver Zidovudine 36.2218299183
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.9516709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0111858732
MESH:D005334 Fever Lipopolysaccharides 3.6211852909 9205823
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.0714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.7319069698
MESH:D005355 Fibrosis Carbon Tetrachloride 17.5218705752
MESH:D005355 Fibrosis Dietary Fats 17.5218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 17.5220067830
MESH:D005355 Fibrosis Tretinoin 17.5217994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.8316904648
MESH:D005756 Gastritis Acetaminophen 3.2116983495
MESH:D006471 Gastrointestinal Hemorrhage Warfarin 6.2511794436
MESH:D005776 Gaucher Disease Warfarin 5.5212359135
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.4816973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.8416417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.2216452187
MESH:D005909 Glioblastoma Tretinoin 2.7117312396
MESH:D018316 Gliosarcoma Cyclophosphamide 5.0611389073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1310696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.5915172196 16376943 11014644
MESH:D006258 Head and Neck Neoplasms Cisplatin 6.8715102660 15464296
MESH:D006258 Head and Neck Neoplasms Tretinoin 6.8716096774
MESH:D034381 Hearing Loss Cisplatin 3.9119898482
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.6916084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.0515464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.7011294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 5.7014991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.2520558911
MESH:D006402 Hematologic Diseases Zidovudine 4.2912579204
MESH:D006406 Hematoma Warfarin 6.2517493413
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 3.9916366002
MESH:D006467 Hemophilia A Cyclophosphamide 4.8511918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 9.1511000095
MESH:D006470 Hemorrhage Warfarin 9.1518429757
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.1715929193 18665440 17276928
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.0714986274
MESH:D006505 Hepatitis Carbon Tetrachloride 8.0519900420 19110552
MESH:D006505 Hepatitis Thioacetamide 8.0516456712
MESH:D006509 Hepatitis B Lamivudine 4.6917703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 4.6916476009 15631357 12044531 15274664 15309715
MESH:D006529 Hepatomegaly Phenobarbital 11.8216109766
MESH:D006529 Hepatomegaly pirinixic acid 11.8216221962 19176532 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 11.8215340226 16120746 12621046
MESH:D015658 HIV Infections Indinavir 13.4511363243 15388451 11141242
MESH:D015658 HIV Infections Lamivudine 13.459296927 11141242 17530837 20032539
MESH:D015658 HIV Infections Saquinavir 13.4515388451 11141242
MESH:D015658 HIV Infections Zidovudine 13.4511363243 11141242 20032539 11698656 17358032
MESH:D006689 Hodgkin Disease Cisplatin 10.2016170182 16200630
MESH:D006689 Hodgkin Disease Cyclophosphamide 10.2017606976 16135485
MESH:D006689 Hodgkin Disease sodium arsenite 10.2012676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5816959395 18606429 8697196 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 6.4416870215
MESH:D006930 Hyperalgesia Tretinoin 6.4416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.0816899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.1921332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.1216778211
MESH:D006943 Hyperglycemia pirinixic acid 2.7920558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.2021332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.7318850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.6415338365
MESH:D006976 Hypertension, Pulmonary L 663536 8.1314726295
MESH:D006976 Hypertension, Pulmonary Warfarin 8.1312359135
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3716945680 16569931
MESH:D007154 Immune System Diseases Cyclophosphamide 4.8716076520
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0412013081
MESH:D007248 Infertility, Male Cyclophosphamide 17.867193160 16517039
MESH:D007248 Infertility, Male Ethinyl Estradiol 17.8617937319
MESH:D007248 Infertility, Male Parathion 17.8616029889
MESH:D007248 Infertility, Male sodium arsenite 17.8612646999 15346721
MESH:D007248 Infertility, Male vinclozolin 17.8616467254
MESH:D007249 Inflammation Dietary Fats 9.9020412841
MESH:D007249 Inflammation Lipopolysaccharides 9.9012878042 17963957 9205823 17255318 17237260
MESH:D007249 Inflammation Tamoxifen 9.9019457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 9.9012878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Leukotriene B4 4.2711006272
MESH:D007333 Insulin Resistance Dietary Fats 6.2411836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 6.2416306350
MESH:D007410 Intestinal Diseases Tretinoin 3.3317994277
MESH:D002532 Intracranial Aneurysm Reactive Oxygen Species 4.5819381132
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.2117255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.5816580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.5817551590 15992940
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.6815464296
MESH:D007674 Kidney Diseases Acetaminophen 8.5412587719 15629191
MESH:D007674 Kidney Diseases Cisplatin 8.5418289764 15190930 12231392 19839026 12649298
MESH:D007674 Kidney Diseases sodium arsenite 8.5420008137
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 3.8716518626
MESH:D007680 Kidney Neoplasms Tamoxifen 6.4718625569
MESH:D007680 Kidney Neoplasms Zidovudine 6.4712579204
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.3311231351
MESH:D007938 Leukemia arsenic trioxide 9.1615070760
MESH:D007938 Leukemia Cyclophosphamide 9.1610602166
MESH:D007938 Leukemia Tretinoin 9.1617143497
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.2917802794 17658394 17008537 18587576 18172266 17296974
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 8.4912560223 17077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 8.4920370541
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.8516972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 7.4914633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 7.4910373061
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.1319077051
MESH:D007951 Leukemia, Myeloid Tretinoin 8.1316482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.5516467208 19850784 17050201 16968895 20471514
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.5519850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 6.6212679006 16823087 16966277 17107899 11161223 11468182 19225113 16112521 15213294 19075265 16891316 17649720 16330433 19642359 9834237 19035177 12018890 15748426 16331271 17869043 17217047 12712474 17712046 15336539 15622746
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 6.6217649720 15748426 17712046 17107899 9834237 17368321 16891316 16331271 17294898 17217047 16823087 17339181 16788101 19642359 12679006 19035177 19029980 16766008 19225113 16140955 17301526 16935935 19075265 17506722 17361223
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.9216882451
MESH:D007970 Leukopenia Cyclophosphamide 10.2610052129 11830472
MESH:D007970 Leukopenia Lipopolysaccharides 10.2615821434
MESH:D007984 Leydig Cell Tumor vinclozolin 4.2816417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 2.989224671
MESH:D008064 Lipidoses Tamoxifen 2.8317567588 15342952
MESH:D054068 Livedo Reticularis Warfarin 6.2518280355
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 9.5017334410 21278145 17174718 16239168 17157831 16221502 11903743 16943688 11408273
MESH:D008103 Liver Cirrhosis Dietary Fats 9.5018296743
MESH:D008103 Liver Cirrhosis Phenobarbital 9.5021047994
MESH:D008106 Liver Cirrhosis, Experimental 2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid 11.9916033810 12958196
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 11.9912898905 18481824 15673190 20821823 17766677 17805973 18251166 18210741 16192424 18277467 17557913 17869086 17525996 16136751 15818738 18006644 17708605 15931870 12958196 16116963 15876570 18472094 12632512 16638106 17761835 12666154 12667390 11481614 18418968 12445418 17640975 15338365 15730626 18317297 12445421 16248980 12632514 15370692 17714472 12649538 18156304 15650968 18376398 15893842 12546737 16015684 17631135 18705752 18187930 17481882 10355542 12389079 17721639 14716496 12586293 15057751 15052691 14620537 16033810 17944888 16097048 17823541 17900296 15925388 13678700 18054572 18205269 17922224 15362042 14748882 18420326 17698563 18339082 18412020 18395095 18166357 18429990 14512876 12609069 18395914 15996030 18472332 17976157 14724832 15123356 17565644 12741479 16011737 16027843 18279442 14716833 18263696 15959796
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 11.9912878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 11.9915474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 11.9918564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 11.9912878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 11.9912175628 18032466 10677585 17629604 17050028 11172339 15465738 18458672 16489207 12531686 16097051 16098781 16511523 15334695 12557150 14739098 18615449 15078482 18395095 18295389 15362042 15075984 17127702 11481614 18263696 15474484 17355460 11682029 12085344 15095483 15716488 15288473 15288472 15316131 17292413 18416461 12891558 12679928 18031379 16248980 18606216 16126171 18380797 16343077 15158331
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 11.9916248980 18397230
MESH:D008107 Liver Diseases marker/mechanism 19784758
MESH:D008107 Liver Diseases Acetaminophen 8.2412587719 19460945 16611625 19784758 11587558 12969438 19014921 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.2417285989 16246199 15830285 16964402 15720792
MESH:D008107 Liver Diseases Phenobarbital 8.2419363144
MESH:D008107 Liver Diseases Thioacetamide 8.2418374380 15158337 16337175
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 13.9717185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 13.9714706259 16899240
MESH:D017114 Liver Failure, Acute Thioacetamide 13.9712479984 15313186 15633222 17276928
MESH:D008113 Liver Neoplasms arsenic trioxide 18.9514682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 18.9519294768
MESH:D008113 Liver Neoplasms Phenobarbital 18.9519482888 8742319 21047994 19812893 19073162 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 18.9515890375 16377806 20007298
MESH:D008113 Liver Neoplasms sodium arsenite 18.9515276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 18.9516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.9516984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 15.5620377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 15.5615583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Hexachlorobenzene 15.561423854
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 15.561399818 6150874 18308698 17172636 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.5612151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.0015213294
MESH:D008171 Lung Diseases sodium arsenite 2.8619095001
MESH:D055370 Lung Injury Lipopolysaccharides 3.5721114838
MESH:D008175 Lung Neoplasms arsenic trioxide 9.6319825857 11798837
MESH:D008175 Lung Neoplasms Cisplatin 9.636189445 11798837 17225452
MESH:D008175 Lung Neoplasms L 663536 9.6315899809
MESH:D008175 Lung Neoplasms sodium arsenite 9.6317077188 19931552 15276417 16712894 17306315
MESH:D008175 Lung Neoplasms Tamoxifen 9.6318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 9.6319555203 11884234
MESH:D008175 Lung Neoplasms Zidovudine 9.6318800350
MESH:D008223 Lymphoma Cyclophosphamide 3.5112854902
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.1816675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 3.8011911406
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.3119428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.3414580682 19196723 11731420 19196722 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.0819453300
MESH:D008527 Medulloblastoma Tretinoin 2.5917453147
MESH:D008545 Melanoma Cisplatin 11.2211135225 15577323 12393984 16809738 12374674 16248763 12883367 18176117 18332650 16432458 17023156 18505091 17761969
MESH:D008545 Melanoma Histamine 11.2217709802
MESH:D008545 Melanoma Reactive Oxygen Species 11.2217992120
MESH:D008545 Melanoma sodium arsenite 11.2219082730 16487513
MESH:D008545 Melanoma Tamoxifen 11.2219393235 12393984
MESH:D008545 Melanoma Tretinoin 11.2216752155
MESH:D018328 Melanoma, Amelanotic Cisplatin 10.0015990972
MESH:D018328 Melanoma, Amelanotic Tamoxifen 10.0015990972
MESH:D008546 Melanoma, Experimental Acetaminophen 9.3619513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 9.3616388313
MESH:D008591 Meningomyelocele Tretinoin 3.9816940565
MESH:D008654 Mesothelioma Cisplatin 3.0517638057
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.3717358032
MESH:D009101 Multiple Myeloma arsenic trioxide 2.7819549372 15949261 11468182 14977855 19417148
MESH:D009135 Muscular Diseases pirinixic acid 3.0616239165
MESH:D009164 Mycobacterium Infections Indinavir 4.9521442799
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.2118349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.4916105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.4917596541
MESH:D009203 Myocardial Infarction pirinixic acid 1.9419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.6016411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.0217484760
MESH:D009336 Necrosis Warfarin 5.0914723717
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.5316624393
MESH:D009362 Neoplasm Metastasis clopidogrel 5.6511875746
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.6519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3519410462
MESH:D009369 Neoplasms Cisplatin 13.1916773208
MESH:D009369 Neoplasms Cyclophosphamide 13.1918854779
MESH:D009369 Neoplasms pirinixic acid 13.1917405874
MESH:D009369 Neoplasms sodium arsenite 13.1911559025
MESH:D009369 Neoplasms Tretinoin 13.1916594593 16946489
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.2320056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.5419196722 19189210 19200415
MESH:D009395 Nephritis, Interstitial Cisplatin 9.3015464296
MESH:D009395 Nephritis, Interstitial Tetracycline 9.309884423
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.0814600291
MESH:D009421 Nervous System Malformations Tretinoin 8.089125849
MESH:D009436 Neural Tube Defects arsenic trioxide 10.3910525206
MESH:D009436 Neural Tube Defects sodium arsenite 10.3912854658
MESH:D009436 Neural Tube Defects Tretinoin 10.399142499
MESH:D009447 Neuroblastoma Cisplatin 6.468761367
MESH:D009447 Neuroblastoma Cyclophosphamide 6.4616115947 8761367 15176712
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.5018514411
MESH:D017599 Neuroectodermal Tumors Cisplatin 10.018761367
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 10.018761367 12837982
MESH:D020258 Neurotoxicity Syndromes marker/mechanism 19784758
MESH:D009503 Neutropenia Cyclophosphamide 8.648291058
MESH:D009503 Neutropenia Leukotriene B4 8.648305713
MESH:D009765 Obesity Dietary Fats 3.9918457598 17217161 16723640 19632207 11836018 18674790 20132043 21332399 20518802
MESH:D009765 Obesity pirinixic acid 3.9920558911
MESH:D009845 Oligospermia Cyclophosphamide 4.2616517039
MESH:D010018 Osteomalacia Phenobarbital 3.9117016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 9.9719769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Cisplatin 9.9719769630 17225452 6897625 15464296
MESH:D010051 Ovarian Neoplasms sodium arsenite 9.9717306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 9.9716936753
MESH:D010146 Pain Acetaminophen 9.1816870215
MESH:D010146 Pain Cyclophosphamide 9.1818093676 12161096
MESH:D010146 Pain Tretinoin 9.1816870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 22.0815580305
MESH:D010190 Pancreatic Neoplasms Cisplatin 22.0819003803
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 22.0811332152
MESH:D010190 Pancreatic Neoplasms L 663536 22.0812384795
MESH:D010190 Pancreatic Neoplasms Phenobarbital 22.0816965848
MESH:D010190 Pancreatic Neoplasms Reactive Oxygen Species 22.0815580305
MESH:D010190 Pancreatic Neoplasms Tretinoin 22.0815976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2711578682
MESH:D010212 Papilloma Hydrogen Peroxide 3.6512065085
MESH:D010235 Paraganglioma arsenic trioxide 3.7419927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7812520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 4.9711026799
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 3.8815464296
MESH:D010997 Pleural Neoplasms Cisplatin 4.8817638057
MESH:D011014 Pneumonia Lipopolysaccharides 4.1011605937 12224865
MESH:D017119 Porphyria Cutanea Tarda Hexachlorobenzene 9.679918132
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 9.6718163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.242563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.5421297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 7.9811118676 11896295 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 7.9819015723 18220299 18042343
MESH:D017096 Prion Diseases Tetracycline 4.9610903871
MESH:D011469 Prostatic Diseases vinclozolin 4.4818220299
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.2119131511
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.2117136230
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.2116039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.2115067354
MESH:D011472 Prostatitis vinclozolin 4.4818629315
MESH:D020151 Protein C Deficiency Warfarin 5.8918376272
MESH:D011507 Proteinuria marker/mechanism 12649539
MESH:D011507 Proteinuria 2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid 8.6312649539
MESH:D011507 Proteinuria Tretinoin 8.6316636307
MESH:D011537 Pruritus Ethinyl Estradiol 8.5915861022 16919318
MESH:D011537 Pruritus L 663536 8.5917827870
MESH:D019310 Pseudolymphoma Phenobarbital 4.0312752131
MESH:D011565 Psoriasis Leukotriene B4 4.1611006272
MESH:D011625 Pterygium Tretinoin 4.3416723453
MESH:D011655 Pulmonary Embolism Warfarin 5.8919300499
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.1016636934
MESH:D051437 Renal Insufficiency Cisplatin 3.9715464296
MESH:D015427 Reperfusion Injury Leukotriene C4 6.3212967936
MESH:D015427 Reperfusion Injury pirinixic acid 6.3219058328
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.4310835634
MESH:D012135 Respiratory Sounds Parathion 4.8511874814 17119214
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4118990726
MESH:D012140 Respiratory Tract Diseases Parathion 5.0917119214
MESH:D012170 Retinal Vein Occlusion clopidogrel 5.6819371211
MESH:D012206 Rhabdomyolysis Lamivudine 5.089296927
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.6816116481 16283617
MESH:D012220 Rhinitis Histamine 4.5912689652
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 8.9116646077
MESH:D012512 Sarcoma, Ewing's Cisplatin 8.9114601052
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.4016636934
MESH:D012640 Seizures Phenobarbital 5.4311442880 3137016 4039156 16876388
MESH:D012640 Seizures Picrotoxin 5.438954991 8635557
MESH:D003294 Seizures, Febrile Phenobarbital 4.376407741
MESH:D012851 Sinus Thrombosis, Intracranial Warfarin 5.4212269725
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 11.6912065085
MESH:D012878 Skin Neoplasms sodium arsenite 11.6918572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 11.6916192470
MESH:D012878 Skin Neoplasms Tretinoin 11.6916467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 4.8815464296
MESH:D013088 Spermatocele Ethinyl Estradiol 10.0216709447
MESH:D013088 Spermatocele Tamoxifen 10.0216709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.0616517039
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.5819457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.4412854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.3217007042
MESH:D013274 Stomach Neoplasms Cisplatin 4.3218396642 17522103 15958060
MESH:D013274 Stomach Neoplasms Tretinoin 4.3217261132
MESH:D013274 Stomach Neoplasms Zidovudine 4.3217696246
MESH:D020521 Stroke Warfarin 4.6219300499
OMIM:601367 STROKE, ISCHEMIC marker/mechanism
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.6012837982
MESH:D013736 Testicular Neoplasms Cisplatin 4.2115464296 17225452
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.7715821434
MESH:D013923 Thromboembolism Warfarin 5.7016960144 18698879
MESH:D019851 Thrombophilia Ethinyl Estradiol 9.6311994571
MESH:D019851 Thrombophilia Warfarin 9.6317493413
MESH:D013927 Thrombosis Ethinyl Estradiol 8.1515669648
MESH:D013927 Thrombosis Warfarin 8.1511307788 15720958 11518727 19300499 17672075 17245631
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4412697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 9.9819014326
MESH:D013964 Thyroid Neoplasms Phenobarbital 9.981399818
MESH:D013964 Thyroid Neoplasms Tretinoin 9.9817045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.3916051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.5115213294
MESH:D014376 Tuberculosis Tretinoin 2.9416040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 13.7312845720 11780464 12973940 20435036
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 13.7312973940 15464296 17225452
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 13.7314692829
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 13.7311723127 17306315 16712894 16452187
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 13.738653321 16712894 17572228
MESH:D014581 Urticaria Acetaminophen 7.7410982225
MESH:D014581 Urticaria Histamine 7.7418298128
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 13.6316803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 13.6311813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 13.6316129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.8714692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.1516752155
MESH:D014625 Vaginal Neoplasms Cisplatin 9.7315577323
MESH:D014625 Vaginal Neoplasms Zidovudine 9.7312579204
MESH:D014652 Vascular Diseases sodium arsenite 3.9717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1312125929
MESH:D014657 Vasculitis Warfarin 5.4220337814
MESH:D054556 Venous Thromboembolism Warfarin 5.9018776969
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 9.3914671159 15869587
MESH:D020246 Venous Thrombosis Warfarin 9.3915733061 14723717
MESH:D014820 Vitiligo Tretinoin 3.6316761959
MESH:D014839 Vomiting Cisplatin 4.2611897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7815886252
MESH:D015430 Weight Gain Dietary Fats 3.3616723640
MESH:D009396 Wilms Tumor Tretinoin 3.5816287080
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA47
    • No data
    Releated disease ID Related disease Name
    PA443450Asthma
    PA447054Stroke
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA445019Myocardial Infarction
    PA445131Obesity
    Releated drug ID Related drug Name
    PA449345dinoprostone
    PA449479epoprostenol
    PA164712740Epoxides
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved