AutismKB 2.0

Annotation Detail for ALOX12B


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Basic Information Top
Gene Symbol:ALOX12B ( 12R-LOX )
Gene Full Name: arachidonate 12-lipoxygenase, 12R type
Band: 17p13.1
Quick LinksEntrez ID:242; OMIM: 603741; Uniprot ID:LX12B_HUMAN; ENSEMBL ID: ENSG00000179477; HGNC ID: 430
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00590Arachidonic acid metabolism
hsa01100Metabolic pathways
No data
Pathway IDPathway Name
200131IL23-mediated signaling events
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1990Skin disease, Genetic
1832Congenital abnormality
No data
No data
Desease Name
Ichthyosiform erythroderma, congenital, nonbullous, 1
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ALOX12B mRNAaffects expression 17562736
C014347 decitabine [decitabine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ALOX12B mRNAaffects cotreatment|decreases expression 15251184
C014347 decitabine decitabine results in decreased expression of ALOX12B mRNAdecreases expression 15251184
D007052 Ibuprofen Ibuprofen affects the expression of ALOX12B mRNAaffects expression 17070997
D013749 Tetrachlorodibenzodioxin [decitabine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ALOX12B mRNAaffects cotreatment|decreases expression 15251184
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ALOX12B mRNAdecreases expression 15251184
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ALOX12B mRNAincreases expression 17035482
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.4714514962 11752688 15322242
MESH:D058186 Acute Kidney Injury Ibuprofen 4.876375363
MESH:D000230 Adenocarcinoma Ibuprofen 3.3210697514
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.0116835633
MESH:D000544 Alzheimer Disease Ibuprofen 3.2318351690
MESH:D000707 Anaphylaxis Ibuprofen 5.819532969
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.3411748828
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0015746008
MESH:D002545 Brain Ischemia Ibuprofen 5.5115837124
MESH:D001943 Breast Neoplasms decitabine 2.0618320071 19208741
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0620435547
MESH:D002100 Cachexia Ibuprofen 6.1015141370
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.413084413
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6819215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5618670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5316835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.248697196 15340226 12621046 15668235 16354765
MESH:D003110 Colonic Neoplasms decitabine 2.3817616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1118981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2720055451 10048152 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7417107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8612705907 11287661 12958197 12540782 11421492 11739529 16781746 11529661 17522070 11743745 14725611 10915739 11461765 10663392 19416960 18713872 16227642 17906064 11834606 18071297 14986274 12153990 19739265 14550746 19085960 10774834 15619225 17562736 16485898 19420014 12392966 16081117 15968718 19923254 16109766 2444490 19164858 16393943 19370779 16177239 12594235
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0511462148
MESH:D004374 Ductus Arteriosus, Patent Ibuprofen 6.2418450898 18446180 16133044
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.8011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.6216714409 15322242 18230668
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.8419294695
MESH:D004715 Endometriosis Ibuprofen 10.5815652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 10.5810568697 9294722
MESH:D019446 Endotoxemia Ibuprofen 5.6011545620
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3111564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.0211858732
MESH:D005334 Fever Ibuprofen 4.9816997862
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.5120067830
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.3210696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.7419215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5110048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.4516120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.778697196 15340226 16959395 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0218850075 18670907
MESH:D006984 Hypertrophy Ibuprofen 5.4016672835
OMIM:242100 ICHTHYOSIFORM ERYTHRODERMA, CONGENITAL, NONBULLOUS, 1 marker/mechanism
MESH:D007235 Infant, Premature, Diseases Ibuprofen 6.5616133044
MESH:D007248 Infertility, Male decitabine 3.4517581917
MESH:D007249 Inflammation Ibuprofen 5.893291741
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.8912878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7616580747
MESH:D007674 Kidney Diseases Acetaminophen 2.4015629191 12587719
MESH:D007938 Leukemia decitabine 3.2418980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 4.4317236224 18454857 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4318460780 18206229 19010910 18704418 17679729 19387464
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 6.1918055864
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008107 Liver Diseases Acetaminophen 1.7016610002 11587558 19784758 12587719 19014921 16611625 12969438 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6317185352 16871587
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8316984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3312151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008223 Lymphoma decitabine 3.6919470736
MESH:D008325 Mammary Neoplasms, Experimental Ibuprofen 3.9410697514
MESH:D008545 Melanoma decitabine 2.2817785578 16505122
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D009101 Multiple Myeloma decitabine 3.6218172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.5819010910 16882708 18608210 19157545
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3412213967
MESH:D009369 Neoplasms decitabine 2.8719116145 17925555 19470736
MESH:D009395 Nephritis, Interstitial Ibuprofen 5.716375363
MESH:D009410 Nerve Degeneration Ibuprofen 4.6910961664
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.7214600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D010003 Osteoarthritis Ibuprofen 4.347009135
MESH:D010051 Ovarian Neoplasms decitabine 2.7419331143 19259094
MESH:D010146 Pain Acetaminophen 8.1216870215
MESH:D010146 Pain Ibuprofen 8.123291741
MESH:D010149 Pain, Postoperative Ibuprofen 5.8716678543
MESH:D010190 Pancreatic Neoplasms decitabine 6.1419294695
MESH:D010190 Pancreatic Neoplasms Ibuprofen 6.1412384795
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.9712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0718163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.8211896295 11222880 11118676 11399792
MESH:D055728 Primary Myelofibrosis decitabine 5.2917616702
MESH:D011471 Prostatic Neoplasms Ibuprofen 4.1717409433
MESH:D011507 Proteinuria Ibuprofen 5.096375363
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.3518990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.8719155313
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.2016192470
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.6212697716
MESH:D013964 Thyroid Neoplasms decitabine 3.6317967635
MESH:D001749 Urinary Bladder Neoplasms decitabine 2.8417616700 19087683
MESH:D014581 Urticaria Acetaminophen 3.4410982225
MESH:D014604 Uveal Neoplasms decitabine 5.6417785578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.3212125929
MESH:D020301 Vasospasm, Intracranial Ibuprofen 5.8219057314
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.9715886252
Pathway ID Pathway Name
KEGG:00590 Arachidonic acid metabolism
KEGG:01100 Metabolic pathways
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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