AutismKB 2.0

Annotation Detail for FRK


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Basic Information Top
Gene Symbol:FRK ( GTK,PTK5,RAK )
Gene Full Name: fyn-related kinase
Band: 6q22.1
Quick LinksEntrez ID:2444; OMIM: 606573; Uniprot ID:FRK_HUMAN; ENSEMBL ID: ENSG00000111816; HGNC ID: 3955
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00012Cadherin signaling pathway
P00049Parkinson disease
P00007Axon guidance mediated by semaphorins
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of FRK mRNAaffects expression 21346803
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in increased expression of FRK mRNAincreases expression 19901195
D000643 Ammonium Chloride Ammonium Chloride affects the expression of FRK mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of FRK mRNAdecreases expression 15761015
D003513 Cycloheximide Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of FRK mRNA]decreases expression|decreases reaction 11007951
D016572 Cyclosporine Cyclosporine results in decreased expression of FRK mRNAdecreases expression 20106945
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of FRK mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of FRK mRNAincreases expression 19619570
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of FRK mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of FRK mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of FRK mRNAincreases expression 17426115
D013749 Tetrachlorodibenzodioxin Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of FRK mRNA]decreases expression|decreases reaction 11007951
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of FRK mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of FRK mRNAdecreases expression 19619570
11007951
19901195
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.106195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.1015322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.5211798837 19825857
MESH:D000230 Adenocarcinoma Estradiol 4.5211473722
MESH:D018248 Adenoma, Liver Cell Phenobarbital 18.7417620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 18.7416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 18.7416835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 16.3116206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 16.3119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 16.3112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Estradiol 1.9217289903 14630087 12948864 19861407 16675129 17261762 18497071 17018787
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9220435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5111589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7016111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7816705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.7815073043 15553829 16217749 11135700 14691202
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.7816924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.7817173139 1701930 6705139 20007298 20935162
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1419014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2812490120
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518670907 16120746 18850075
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.9612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.9618566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.474080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Cyclosporine 8.1819486331
MESH:D002779 Cholestasis pirinixic acid 8.1819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.168697196 12621046 16354765 15340226 15668235
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2114669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5110525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5110048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2318551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2815213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5619279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 3.8421346803 18551238
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004421 Dystonia Phenobarbital 4.191851702
MESH:D004487 Edema pirinixic acid 7.1112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.1112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1715322242 16714409 18230668
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 8.1419148513
MESH:D016889 Endometrial Neoplasms Estradiol 8.1411473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1810568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.323659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.143922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.696401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.477750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.263659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3412903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver arsenic trioxide 14.0915073043
MESH:D005234 Fatty Liver Cyclosporine 14.0919224547
MESH:D005234 Fatty Liver pirinixic acid 14.0919236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis Cyclosporine 9.2112168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.2120067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4616904648
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4110048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly Phenobarbital 15.6916109766
MESH:D006529 Hepatomegaly pirinixic acid 15.6919176532 16221962 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.6912621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.3015709030
MESH:D019584 Hot Flashes Estradiol 4.0217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.318697196 18606429 15340226 16959395 16354765
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006973 Hypertension Cyclosporine 5.1410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1418670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312878042 12200463
MESH:D007333 Insulin Resistance Estradiol 7.5516627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.5516306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Cyclosporine 6.248314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 6.2415618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.2216705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.2212371664
MESH:D007680 Kidney Neoplasms Estradiol 13.2215610895
MESH:D007938 Leukemia arsenic trioxide 2.9115070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9717077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9319077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1616467208 20471514 17050201 16968895 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3215213294 17649720 17107899 15336539 19075265 17869043 11468182 16966277 16823087 17217047 9834237 11161223 19035177 12018890 16112521 16330433 19642359 15622746 17712046 16891316 15748426 19225113 16331271 12679006 12712474
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5516882451
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9821047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.4714716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4712878042
MESH:D008107 Liver Diseases Phenobarbital 2.2019363144
MESH:D008113 Liver Neoplasms arsenic trioxide 11.1714682389
MESH:D008113 Liver Neoplasms Phenobarbital 11.1719812893 8742319 15975961 21047994 19482888 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 11.1720007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.1716984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.4220377131
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.421399818 18308698 17172636 2563599 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.4212151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4815213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.3411798837 19825857
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3411884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6611408345 17203775 11807958 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.7519453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2214977855 19549372 15949261 19417148 11468182
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2316882451 16105982
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.6916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.6916411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.7117484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0918551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1616624393
MESH:D009369 Neoplasms pirinixic acid 2.0217405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4418481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 10.1411399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.1414600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2210525206
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5912819281 16049721
MESH:D010018 Osteomalacia Phenobarbital 4.6017016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.9812452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms Estradiol 4.9819401270
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.4815580305
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.4816965848
MESH:D010235 Paraganglioma arsenic trioxide 4.3519927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.4812371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.482563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311118676 11896295 11399792 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0620887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.1819131511
MESH:D011471 Prostatic Neoplasms Estradiol 3.1816740699
MESH:D019310 Pseudolymphoma Phenobarbital 4.7612752131
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1616646077
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3018551238
MESH:D012640 Seizures Phenobarbital 6.304039156 11442880 16876388 3137016
MESH:D003294 Seizures, Febrile Phenobarbital 5.066407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1116192470
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.6619014326
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.661399818
MESH:D013978 Tibial Fractures Estradiol 4.9519048282
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2015213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2816049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.2812973940 20435036 12845720 11780464
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5510091137
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28373
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450379mercaptopurine
    PA450428methotrexate
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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