AutismKB 2.0

Annotation Detail for RNASEH1


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Basic Information Top
Gene Symbol:RNASEH1 ( H1RNA,RNH1 )
Gene Full Name: ribonuclease H1
Band: 2p25.3
Quick LinksEntrez ID:246243; OMIM: 604123; Uniprot ID:RNH1_HUMAN; ENSEMBL ID: ENSG00000171865; HGNC ID: 18466
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03030DNA replication
No data
No data
Pathway IDPathway Name
P00017DNA replication
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of RNASEH1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of RNASEH1 mRNAaffects expression 21346803
C103505 AM 251 AM 251 results in increased expression of RNASEH1 mRNAincreases expression 16500647
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of RNASEH1 mRNAincreases expression 20498004
C006780 bisphenol A bisphenol A results in increased expression of RNASEH1 mRNAincreases expression 16474171
D016572 Cyclosporine Cyclosporine results in increased expression of RNASEH1 mRNAincreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of RNASEH1 mRNAincreases expression 16474171
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RNASEH1 mRNAaffects cotreatment|increases expression 17942748
D019833 Genistein Genistein results in increased expression of RNASEH1 mRNAincreases expression 16474171
D008628 Mercury Mercury results in decreased expression of RNASEH1 mRNAdecreases expression 16823088
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of RNASEH1 mRNAincreases expression 16474171
D012643 Selenium Selenium results in decreased expression of RNASEH1 mRNAdecreases expression 19244175
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RNASEH1 mRNAaffects cotreatment|increases expression 17942748
D014810 Vitamin E Vitamin E results in decreased expression of RNASEH1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9315322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0417505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 10.2820127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 10.2811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 10.2814692618
MESH:D000230 Adenocarcinoma Genistein 10.2811473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.686695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1519183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6915885639
MESH:D001321 Autistic Disorder Mercury 2.7817497416
MESH:D001327 Autoimmune Diseases Mercury 4.9416634805
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D001862 Bone Resorption bisphenol A 3.9211985600
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3417474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 2.3417123778
MESH:D001943 Breast Neoplasms Estradiol 2.3417289903 17261762 14630087 16675129 17018787 19861407 18497071 12948864
MESH:D001943 Breast Neoplasms Genistein 2.3417200150 16541309 16873071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3420435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5516111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0016050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.6516705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.6516705839
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.6516924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 6.6516924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.0717123778
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0620419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3916120746 18850075 18670907
MESH:D002311 Cardiomyopathy, Dilated Mercury 3.4710334427
MESH:D002318 Cardiovascular Diseases Genistein 3.3416332659
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.366135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.3612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.3618566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002779 Cholestasis Cyclosporine 7.9119486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.9117110522 11677210 17681005 15861022 16919318 17333356 16105132
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1215340226 16354765 15668235 8697196 12621046
MESH:D003092 Colitis Selenium 3.8517936198
MESH:D003110 Colonic Neoplasms Genistein 2.2917182828
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 2.7315531428
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5015322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5019769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.1418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.1418551238
MESH:D003704 Dementia Polychlorinated Biphenyls 4.7516140633
MESH:D017449 Dermatitis, Allergic Contact Mercury 3.8616823706
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.3716647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3717107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4619279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.1021346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.1021346803 18551238
MESH:D056486 Drug-Induced Liver Injury Selenium 9.1015131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.1020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:C538011 Eales disease Vitamin E 4.809068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0015322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2512538720
MESH:D004714 Endometrial Hyperplasia Genistein 4.6716402032
MESH:D016889 Endometrial Neoplasms Estradiol 7.6211473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Genistein 7.6211473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0710568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0216530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver Cyclosporine 7.7619224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.7615345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005355 Fibrosis Cyclosporine 8.7212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.7220067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.308708960
MESH:D005909 Glioblastoma Genistein 3.2916598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.2620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.2610048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 11.2616080930
MESH:D006333 Heart Failure Selenium 3.1117162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5015720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9615340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7216863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 5.1315709030
MESH:D019584 Hot Flashes Estradiol 10.3817088409
MESH:D019584 Hot Flashes Vitamin E 10.3814716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.148697196 15340226 16354765 18606429 16959395
MESH:D006973 Hypertension Cyclosporine 5.0110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0118670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8816945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5217937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8812878042 12200463
MESH:D007251 Influenza, Human Selenium 11.2916624496
MESH:D007251 Influenza, Human Vitamin E 11.2916624496
MESH:D007333 Insulin Resistance bisphenol A 7.5516393666
MESH:D007333 Insulin Resistance Estradiol 7.5516627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5415604871
MESH:D007674 Kidney Diseases Cyclosporine 14.738314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 14.7315618244
MESH:D007674 Kidney Diseases Mercury 14.7317934191
MESH:D007674 Kidney Diseases Vitamin E 14.7312488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9416518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 18.1316705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 18.1316705839
MESH:D007680 Kidney Neoplasms Cyclosporine 18.1312371664
MESH:D007680 Kidney Neoplasms Estradiol 18.1315610895
MESH:D007938 Leukemia Genistein 3.0517468513 18980019
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.0114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 5.0117823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0112878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 5.0116169303
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.477678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.4721137059 20195826
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.4716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.112876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 10.111423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.1112151625
MESH:D008171 Lung Diseases Vitamin E 3.2116863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.3917053015 18569708 18520028 18816296 20869020 20464547 6695378 20135361 20064080
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3911884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 3.3911062179
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.2016891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 10.2012929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Selenium 10.2015318939
MESH:D020149 Manganese Poisoning Estradiol 4.5819453300
MESH:D008654 Mesothelioma Selenium 2.8115107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8816801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2316381670
MESH:D009203 Myocardial Infarction Genistein 2.8817141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.6516810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.6517141266
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.6318551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.6318551238 7678174
MESH:D009369 Neoplasms Benzo(a)pyrene 2.1911141357
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8117289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3319348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 24.0211399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 24.0211399458 16427766
MESH:D009421 Nervous System Malformations Genistein 24.0216427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 24.0214600291
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.0612819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.0616049721
MESH:D010024 Osteoporosis Genistein 3.2819401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.1416169203
MESH:D010049 Ovarian Diseases bisphenol A 5.0711985600
MESH:D010051 Ovarian Neoplasms Estradiol 4.9519401270
MESH:D010051 Ovarian Neoplasms Genistein 4.9519005980
MESH:D010146 Pain AM 251 4.3318987195
MESH:D010190 Pancreatic Neoplasms AM 251 3.8616500647
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7511578682
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.4116702228
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D010954 Plasmacytoma Selenium 4.9915087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2712371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.7910548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.7911118676 11222880 11896295 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.7420887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.7420887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8917292933
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8916740699
MESH:D011471 Prostatic Neoplasms Estradiol 1.8916740699
MESH:D011471 Prostatic Neoplasms Genistein 1.8915256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 1.8915721890
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8915084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.3916919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D011629 Puberty, Precocious bisphenol A 4.8710548101
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012640 Seizures 2,4-dinitrotoluene 5.9918551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.9918551238
MESH:D012871 Skin Diseases Vitamin E 2.4518709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.5519755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0416709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D020521 Stroke Vitamin E 3.5616517955
MESH:D019966 Substance-Related Disorders bisphenol A 4.0716684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013978 Tibial Fractures Estradiol 4.7819048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.3816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.3816049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.3817053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.2710091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.2710091137
MESH:D014591 Uterine Diseases bisphenol A 5.1114652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3614692618
MESH:D014605 Uveitis Cyclosporine 4.081336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5914671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5417120751
Pathway ID Pathway Name
KEGG:03030 DNA replication
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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